Digital Commons Network^™

The Incretin Response To Lifestyle Interventions In Young Adults And Youth With Obesity, Jared Rosenberg

Dissertations - ALL

Over the past few decades, the rates of type 2 diabetes (T2D) have seen a sharp rise in youth and young adults. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), the two known incretin hormones, have recently gained attention as pharmacological agents to treat T2D in both youth and young adults. Despite the efficacy of these pharmacological agents to treat T2D, lifestyle interventions are still the first-line treatment for youth and young adults at heightened risk of T2D. Therefore, we sought to assess the incretin response to lifestyle interventions in youth and young adults through separate longitudinal studies in each …

Subcultural Textuality: Skateboarding And The Politics Of Subcultural Media, Simon Vangel

Dissertations - ALL

Subcultural Textuality: Skateboarding and the Politics of Subcultural Media analyzes skateboarding media from the mid-1970s to the present, tracing how different textual strategies, material media formats, and discourses have formed shifting understandings of skateboarding’s potential meanings as well as what identity positions are presented as “authentic” within the subculture. Skateboard media rely on what I term a subcultural textuality, a set of narratives and aesthetics which, by engaging with material media form, distribution processes, and historically specific understandings of both genre and mode, present engagement with the text as a subcultural act in and of itself. As a result, such …

Three Studies On Chance In Post-Aristotelian Philosophy, Weiting Huang

Dissertations - ALL

This dissertation is a study of the concept of chance in post-Aristotelian philosophy, focused on the Stoics, the Neoplatonist commentators Philoponus and Simplicius, and Avicenna. These philosophers are all influenced by Aristotle’s seminal treatment of chance. The post-Aristotelian philosophers approach the concept of chance with two significant changes in their cosmology from Aristotle. They believe that chance events are not only causally determined but also brought into harmony with the cosmos by the divine nature. These new commitments lead these thinkers to propose that chance events are not a per accidens end of an individual subject, as Aristotle suggests. Instead, …

A New Hobbesian Constructivism, Stacy Lynn Kohls

Dissertations - ALL

Constructivism in metaethics asserts that moral truths are constructed from human attitudes and reasons rather than existing independently of them. “Why should I be moral?” is a philosophical question that is often taken for granted, but answering it is paramount in our society. This question, coined by Christine Korsgaard as the normative question, is one of the central projects of constructivists and moral philosophers in general. One long-standing but controversial answer is that there is a self-interested benefit to being moral. One of the best known proponents of this idea in the history of political philosophy was Thomas Hobbes. This …

Domestic Exertions: Soldier-Servants, Military Elites, And Securitized Labor In India, Taveeshi Singh

Dissertations - ALL

This dissertation explores the politics of gender, labor, national security, and social class in India through an examination of a coercive domestic labor regime in the Indian Army. Previous scholarship has focused on the neoliberal state-sponsored global care chains and immigrant women workers from formerly colonized nations, many in Asia, catering to wealthy ‘civilian’ households in the global North. However, little is known about the roles, relationalities, and infrastructures of servitude, inhabited primarily by racialized men, that endure within the domestic life of postcolonial state institutions long after the retreat of European colonial regimes. I present an intervention by providing …

Ud In The News Aug. 17-23, University Of Dayton

News Releases

Regional and local outlets highlighted UD in pieces about move-in weekend and the state’s announcement of onMain as Ohio’s second innovation hub. Several stories on political issues featured UD experts’ insights.

Nnmt Overexpression Is An Adverse Prognostic Factor In Uterine Leiomyosarcoma, Osman Türkmen, Kami̇l Hakan Müftüoğlu, Nazmi̇ye Di̇nçer, Zeli̇ha Esi̇n Çeli̇k, Serra Akar İnan

Turkish Journal of Medical Sciences

Background/Aim: Uterine leiomyosarcomas (uLMS) are extremely rare high-grade tumors with a poor prognosis. Their etiopathogenesis remains largely unknown. The uterus is the most frequent site for LMS. uLMS and uterine leiomyoma (uLM) must frequently be differentiated in patients with a uterine mass. Nicotinamide N-methyltransferase (NNMT), a cytoplasmic protein, is involved in the progression and spread of a variety of cancer types. The expression of NNMT in a mesenchymal malignancy was not examined previously. This study represents the first investigation into NNMT expression in uLMS, uLM and benign uterine myometrium and correlates NNMT overexpression with worse prognosis in uLMS. Materials/Methods: The …

Effect Of Vascularized Jejunal Conduit Flap On Peripheral Nerve Regeneration In Rats, Maji̇d Ismayilzade, Bi̇lsev Ince, Pembe Oltulu, Zi̇krullah Baycar, Münür Selçuk Kendi̇r, Mehmet Dadaci

Turkish Journal of Medical Sciences

Background/ Aim: In the literature, almost all of the propounded nerve conduits for obtaining better nerve recovery were applied as graft materials. In this study, we aimed to define a new nerve conduit model in a flap pattern and evaluate the effect of pedicled vascularized jejunal flap on nerve regeneration after wrapping around a sciatic nerve.Materials and Methods: A total of 90 Wistar albino rats were randomly divided into nine groups each with 10 rats. The first three groups constituted the control groups, whereas groups 4-6 were the jejunum conduit (JC) - applied groups. A mucosa resected JC (MRJC) was …

Prognostic And Diagnostic Utility Of Pancreatic Stone Protein In Pediatric Sepsis And Mortality, Mehmet Aki̇f Dündar, Emi̇n Ceran, Başak Nur Akyildiz

Turkish Journal of Medical Sciences

Background/aim: Early detection and prognosis of sepsis in critically ill children is crucial. The aim of this research was to investigate the prognostic ability of pancreatic stone protein (PSP) in validating sepsis and predicting mortality in a prospective observational study.Materials and methods: In a single-center study, pediatric intensive care unit patients were divided into cohorts of confirmed and suspected sepsis, as well as survivors and nonsurvivors. Patients with positive blood culture growth were considered to have confirmed sepsis, while their negative counterparts were considered to have suspected sepsis. Comparisons were made between complete blood counts, laboratory parameters, mortality indices, and …

Configurations Of Blackness: Stories Of British Actvists, Jala A. Grant

Theses - ALL

Configurations of Blackness: Stories of British Activists explores the configurations of Blackness amongst contemporary Black British activists and their significance in resistance against injustice. It employs oral histories, archives, and participant observation to document narratives of Black Britons whose activism has employed varied configurations of Blackness and sits within a history of resistance amongst Black people in Britain. The thesis is particularly concerned with three primary themes: the localization of racial oppression within global anti-Blackness, the incorporation and challenging of the intersectionality of race, class, and gender, and the implications of political Blackness in Black activist realms. While Black activism …

Technology Policy For Meeting Net-Zero Carbon Goals By 2050: Accelerating Innovation In Complementary Technologies To Decarbonize The Electrical Grid, Myriam Gregoire0zawilski

Dissertations - ALL

In this dissertation, I examine the link between technology standards and innovation in green energy technologies. The first paper investigates the effects of compatibility standards on follow-on innovation at the firm-level in smart grid technology. Using data on the adoption of standards in 19 OECD countries and weights that capture the unique composition of each firm’s country markets, we find that higher exposure to changes in standardization causes a decline in firms’ patenting activity. This negative effect is concentrated in large incumbents and is partially offset by an increase in the quality of inventions. This suggests a tradeoff in the …

An Investigation Of The Processes Of Teachers' Decisions To Choose And Sequence Examples In The Teaching And Learning Of Mathematics, Emmanuel Nsadha

Dissertations - ALL

Abstract This study aimed to investigate secondary mathematics teachers’ decision-making process and the influences of their decision-making as they planned and implemented instructions. Previous studies on teachers' use of curriculum materials have focused on the general interaction with the curriculum. The literature also indicates that curriculum materials significantly influence what mathematics content teachers cover and how they teach it (Drake & Sherin, 2006; Remillard & Byrans, 2004). Such materials include examples that, in mathematics teaching, play a vital role in developing mathematical concepts and procedures (Bills & Watson, 2008; Zodik & Zaslavsky, 2008). This literature has reported a limited understanding …

The Shaping Of Masculinity In Jamaica: A Historical Perspective, Jovanne Josephine O'Connor

Theses - ALL

ABSTRACT Jamaica, strategically located in the Western Caribbean, has historically been a coveted prize for European colonial powers due to its geopolitical positioning and reliance on tourism and agriculture (The World Factbook 2023, pg. 23). This research delves into the complex dynamics of masculinity in Jamaica, exploring how historical, cultural, and socioeconomic factors intersect to shape gender identities and behaviors. The colonial history of Jamaica, transitioning from Spanish to English rule, has left indelible marks on its culture, including language and social hierarchies. The evolution of Jamaican Patois reflects a history of linguistic and cultural exchange, serving as a marker …

Bridging Heritage And Identity: Integrated Platform Design For Chinese American History Exploration, Zhiru Chen

Theses - ALL

Local history museums play a key role in historical education, identity strengthening, and community connections. However, many Chinese Americans are unwilling to visit these museums, which weakens the museums’ positive impact on these communities, and they miss out on opportunities to connect with local history and culture. I focused on 3 important factors that can impact minorities’ engagement—cultural representative, low-cost participation, and interactive visiting experience. I conducted semi-structured individual interviews with 10 U.S. born Asian American adults and conducted case study on several design projects. Inspired by research and user feedback, I created Origin Story Project (OSP) - an integrated …

Pulling Up The Tangled Roots Of Rural Nostalgia: A Rhetorical Study Of Story And Space, Nature And Nation, Emily Pifer

Dissertations - ALL

Drawing from queer and feminist methodologies, Pulling Up the Tangled Roots of Rural Nostalgia engages rhetorical analysis of popular culture texts, specifically the film The Power of the Dog (2021) and television shows Schitt’s Creek (2015-2020) and Reservation Dogs (2021- ), and material spaces, specifically Yellowstone National Park, to develop a framework for tracing how particular constructions of rural nostalgia (such as “the small town,” “the frontier,” “the cowboy,” “the Indian Other,” “the wilderness”) circulate back and forth across widely consumed digital texts, collective imaginaries, political structures, and material spaces. As my dissertation pulls up and examines the tangled roots …

Examining Dataset Fair Compliance In The Research Data Management Lifecycle, Denise L. Devine

Dissertations - ALL

This thesis investigates the relationship between data curation and FAIR (Findable, Accessible, Interoperable, and Reusable) compliance in research data management, with a focus on the role of metadata. Through case investigations on Data.gov and Google Dataset Search platforms, the research assesses their efficacy in dataset discovery and the impact of metadata. The thesis examines how data curation influences FAIR compliance throughout the research data lifecycle and explores metadata’s role in FAIR Principles compliance for both curated traditional research datasets and open datasets. Findings reveal a disparity in FAIR compliance between different dataset types and platforms, with open datasets, particularly those …

Investigating Undergraduates’ Learning Of Reading Strategies To Comprehend Mathematical Proofs, Hillary Bermudez

Dissertations - ALL

In this dissertation, I report results from a study that investigated the impact of students’ engagement in a series of tasks in an introductory proof course that was designed to stimulate their learning of reading strategies to support their comprehension of mathematics proofs. Specifically, I investigated the impact of the design of five self-explanation tasks, designed through principles of variation, on undergraduates’ discernment of reading strategies; and if students’ learning of specific reading strategies influenced their comprehension of the proofs they read. The goal of this study was to answer two questions: How do undergraduate students in an introductory proof …

Three Essays On Socio-Spatial Exclusion Of Disabled People, Fitore Hyseni

Dissertations - ALL

This dissertation consists of three papers that document socio-spatial exclusion of disabled people. In the first paper, titled “The Disability Penalty: Evidence of Housing Discrimination from a Correspondence Audit Study,” I investigated disability discrimination in the U.S. rental housing market. Access to housing is a necessity that can further exacerbate socio-economic challenges experienced by disabled people. Despite reports of differential treatment of disabled tenants by landlords being on the rise, there have been no rigorous studies investigating them. Using a correspondence audit study, I investigated if landlords in the U.S. discriminate against disabled people. Findings show that disabled applicants were …

Expressions Of The Satellite Repeat Hsat5 And Transposable Elements Are Implicated In Disease Progression And Survival In Glioma, Sila Naz Köse, Tutku Yaraş, Ahmet Bursali, Yavuz Oktay, Ci̇hangi̇r Yandim, Gökhan Karakülah

Turkish Journal of Biology

The glioma genome encompasses a complex array of dysregulatory events, presenting a formidable challenge in managing this devastating disease. Despite the widespread distribution of repeat and transposable elements across the human genome, their involvement in glioma's molecular pathology and patient survival remains largely unexplored. In this study, we analysed the expression levels of satellite repeats and transposons along with genes in low-grade glioma (LGG) and high-grade glioma (HGG). Endogenous transposable elements LTR5 and HERV_a-int exhibited higher expression in HGG patients, along with immune response-related genes. Altogether, 16 transposable elements were associated with slower progression of disease in LGG patients. Conversely, …

Leadership Coaching In The Fourth Industrial Revolution, Ray Forbes

All Faculty and Staff Scholarship

Today’s world of extraordinary change follows a long history of technology-driven industrial revolutions. Author Alvin Toffler eloquently identified, categorized, and named the first three of them: Agricultural, Industrial, and Informational. Likening these revolutions to major waves of change, Toffler also described their impact on the social, political, economic and environmental ethos of the times in which they occurred. Recently, a number of knowledgeable commentators have suggested that we are now on the cusp of a fourth industrial wave. This large-scale transformational groundswell is being propelled by a dramatic acceleration in the rate of change itself. It is characterized by major …

Examining Strategies, Interactions, And Level Of Learning In Synchronous Instructional Sessions Of Equivalent Course Sections: A Mixed Methods Study Of Faculty-Of-Record [For] Vs. Adjunct Faculty [Adjf], Gary E. La Point

Dissertations - ALL

Online instruction in higher education continues to gain popularity leading to a rise in demand for online course seats. This increase in enrollments has required universities to develop strategies to maintain quality instruction while accommodating larger numbers of online students. With best practices in online instruction suggesting smaller class sizes to foster active interaction, the increase in student enrollment has placed stress on the institution and the Faculty of Record [FoR] who developed the online courses from the main campus classes they generally teach themselves. The ideal online class size for effective learning has been well researched. These classes are …

Spinal Stabilization Exercises For Transversus Abdominis And Lumbar Multifidus Thickness Via Telerehabilitation And Face-To-Face Approaches In Patients With Nonspecific Chronic Neck Pain: A Randomized Controlled Trial, Di̇lara Onan, Erkan Demi̇rci̇, Egemen Turhan, Özlem Ülger

Turkish Journal of Medical Sciences

Background/aim: Strengthening the muscles of the lumbar region in individuals with neck pain may be protective against future back problems. In addition, telerehabilitation applications, which gained momentum in the literature and clinical practice during the COVID-19 pandemic, are among the applications preferred by patients thanks to their various advantages. This study aimed to compare the effects of telerehabilitation and spinal stabilization exercises applied with face-to-face approaches on the thickness of the transversus abdominis (M.TrA) and lumbar multifidus (M.LM) muscles in patients with nonspecific neck pain.Materials and methods: The primary outcomes were the thickness of the M.TrA and M.LM. Neck pain …

Comparison Of Bulut Index-Beta Method And Global Health Security Index: Results From World Countries, Tevfi̇k Bulut, Mehmet Top, Murat Atan, Burkay Genç

Turkish Journal of Medical Sciences

Background/aimThe Global Health Security Index (GHSI), which is used to assess global health security preparedness level of countries, and Bulut Index-Beta (BI-β) method, developed as a multi-criteria decision-making method, were compared in terms of global health security in the context of world countries. Thus, it is aimed to demonstrate feasibility of BI-β method by testing it on GHSI datasets and then to contribute to methodological development of GHSI.Materials and methodsData set of the study consists of the publicly available GHSI data set, which allows for comparative evaluation of countries. BI-β method and GHSI were used to compare countries in terms …

Complete Dose Of Hepatitis B Vaccination Among Children In Indonesia And Factors Associated: A Community-Based Study, Putri Bungsu Machmud, Dwi Gayatri, Erni Astutik

Kesmas

Hepatitis B vaccination is widely recognized as the most effective way to prevent hepatitis B infection, yet the rate of complete vaccination among Indonesian children remains low. This study aimed to evaluate the extent of hepatitis B vaccination coverage among children and identify potential associated factors in Indonesia. A community-based cross-sectional study was conducted. The study involved 7,860 Indonesian mothers of children aged 12-59 months, providing data on their children's hepatitis B vaccination status and other relevant factors from the 2017 Indonesian Demographic Health Survey. Overall, the rate of complete hepatitis B vaccination among children was relatively high (89.8%). Several …

Exploring Forgiveness Through Theologically Informed Education: Lessons From Judaism, Yitzhak Ben Yair, Sarel Ohayon, Natti Ronel, Suzanne Freedman

Faculty Publications

Education serves as the primary line of defense against crime and other psychological difficulties. Children exposed to adversity and emotional challenges may be susceptible to various risks, potentially leading to criminal activities. Forgiveness has been demonstrated as a healing influence in the lives of individuals who have experienced hurt and accumulated negative emotions due to life events. Understanding forgiveness from a young age, in both theory and practice, may facilitate improved relationships and psychological well-being. This article underscores the significance of forgiveness education, advocating for a culturally and theologically sensitive approach. In this article we will offer an example of …

Examining The Impact Of Stand Your Ground Laws In Alabama, Bruce Litaker

Walden Dissertations and Doctoral Studies

It is not known whether gun death rates vary with the implementation of Stand Your Ground (SYG) laws in Alabama. The purpose of this quantitative study was to examine differences in the rate of gun deaths in Alabama since the implementation of SYG laws. Policy feedback theory (PFT) served as a foundational framework and a lens to interpret the research findings. The study was to determine whether there was a statistically significant difference in the firearm homicide rates in all 67 counties in Alabama after SYG implementation, and if there is a statistically significant difference in the firearm homicide rates …

Sexually Dimorphic Computational Histopathological Signatures Prognostic Of Overall Survival In High-Grade Gliomas Via Deep Learning, Manmeet Ahluwalia

All Publications

High-grade glioma (HGG) is an aggressive brain tumor. Sex is an important factor that differentially affects survival outcomes in HGG. We used an end-to-end deep learning approach on hematoxylin and eosin (H&E) scans to (i) identify sex-specific histopathological attributes of the tumor microenvironment (TME), and (ii) create sex-specific risk profiles to prognosticate overall survival. Surgically resected H&E-stained tissue slides were analyzed in a two-stage approach using ResNet18 deep learning models, first, to segment the viable tumor regions and second, to build sex-specific prognostic models for prediction of overall survival. Our mResNet-Cox model yielded C-index (0.696, 0.736, 0.731, and 0.729) for …

The Icf Syndrome Protein Cdca7 Harbors A Unique Dna Binding Domain That Recognizes A Cpg Dyad In The Context Of A Non-B Dna, Swanand Hardikar, Ren Ren, Zhengzhou Ying, Jujun Zhou, John R Horton, Bin Liu, Bigang Liu, Luis Della Coletta, Jianjun Shen, Jiameng Dan, Xing Zhang, Xiaodong Cheng, Taiping Chen

Faculty, Staff and Student Publications

CDCA7, encoding a protein with a carboxyl-terminal cysteine-rich domain (CRD), is mutated in immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a disease related to hypomethylation of juxtacentromeric satellite DNA. How CDCA7 directs DNA methylation to juxtacentromeric regions is unknown. Here, we show that the CDCA7 CRD adopts a unique zinc-binding structure that recognizes a CpG dyad in a non-B DNA formed by two sequence motifs. CDCA7, but not ICF mutants, preferentially binds the non-B DNA with strand-specific CpG hemi-methylation. The unmethylated sequence motif is highly enriched at centromeres of human chromosomes, whereas the methylated motif is distributed throughout …

“Two Is Company, Three Is A Crowd” – A Case Presentation Of Cardiac Amyloidosis, Hypertrophic Cardiomyopathy Plus Coronary Heart Disease, ​Carolina Miguel Gonçalves, Mariana Carvalho, Celia Domingues, Fatima Saraiva, ​​Joao ​ ​​Morais​

Journal of the Saudi Heart Association

A 76-year-old man was referred to our appointment with complaints of exertional dyspnea. He had a medical history consisting of chronic coronary syndrome, hypertrophic cardiomyopathy, and an implantable cardioverter-defibrillator for primary prevention. A transthoracic echocardiogram revealed features suspicious for cardiac amyloidosis. Haematologic and genetic tests were negative, and scintigraphy was positive, confirming wild-type transthyretin amyloidosis, not eligible for tafamidis. Several months later with optimized medical therapy, he had two worsening heart failure events.

This clinical case highlights the importance of differential diagnosis. Our patient had both hypertrophic cardiomyopathy and transthyretin amyloidosis, a rare association that constitutes a diagnostic and treatment …

On Demand Digital Card Display, Anup Tripathi, Imo Akpan, Haven Vu, Suresh Kalakrishnan

Defensive Publications Series

Disclosed herein is an outline of processes for accessing account information linked to a payment card, free from dependence on an issuer application. In this process a computing device first acquires a deep link from the payment network and then receives input from the user. Subsequently, an application clip is invoked in response to the user input, prompting the user for identity verification. Upon successful verification, the account information is displayed through the application clip, deep link or with in the native application.