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Unraveling The Dynamics Of Stable And Curious Audiences In Web Systems, Rodrigo Alves, Antoine Ledent, Renato Assunção, Pedro Vaz-De-Melo, Marius Kloft Sep 2024

Unraveling The Dynamics Of Stable And Curious Audiences In Web Systems, Rodrigo Alves, Antoine Ledent, Renato Assunção, Pedro Vaz-De-Melo, Marius Kloft

Research Collection School Of Computing and Information Systems

We propose the Burst-Induced Poisson Process (BPoP), a model designed to analyze time series data such as feeds or search queries. BPoP can distinguish between the slowly-varying regular activity of a stable audience and the bursty activity of a curious audience, often seen in viral threads. Our model consists of two hidden, interacting processes: a self-feeding process (SFP) that generates bursty behavior related to viral threads, and a non-homogeneous Poisson process (NHPP) with step function intensity that is influenced by the bursts from the SFP. The NHPP models the normal background behavior, driven solely by the overall popularity of the …


Aligning Human And Computational Coherence Evaluations, Jia Peng Lim, Hady Wirawan Lauw Sep 2024

Aligning Human And Computational Coherence Evaluations, Jia Peng Lim, Hady Wirawan Lauw

Research Collection School Of Computing and Information Systems

Automated coherence metrics constitute an efficient and popular way to evaluate topic models. Previous work presents a mixed picture of their presumed correlation with human judgment. This work proposes a novel sampling approach to mining topic representations at a large scale while seeking to mitigate bias from sampling, enabling the investigation of widely used automated coherence metrics via large corpora. Additionally, this article proposes a novel user study design, an amalgamation of different proxy tasks, to derive a finer insight into the human decision-making processes. This design subsumes the purpose of simple rating and outlier-detection user studies. Similar to the …


Bugs In Pods: Understanding Bugs In Container Runtime Systems, Jiongchi Yu, Xiaofei Xie, Ceng Zhang, Sen Chen Sep 2024

Bugs In Pods: Understanding Bugs In Container Runtime Systems, Jiongchi Yu, Xiaofei Xie, Ceng Zhang, Sen Chen

Research Collection School Of Computing and Information Systems

Container Runtime Systems (CRSs), which form the foundational infrastructure of container clouds, are critically important due to their impact on the quality of container cloud implementations. However, a comprehensive understanding of the quality issues present in CRS implementations remains lacking. To bridge this gap, we conduct the first comprehensive empirical study of CRS bugs. Specifically, we gather 429 bugs from 8,271 commits across dominant CRS projects, including runc, gvisor, containerd, and cri-o. Through manual analysis, we develop taxonomies of CRS bug symptoms and root causes, comprising 16 and 13 categories, respectively. Furthermore, we evaluate the capability of popular testing approaches, …


Cluster-Wide Task Slowdown Detection In Cloud System, Feiyi Chen, Yingying Zhang, Lunting Fan, Yuxuan Liang, Guansong Pang, Qingsong Wen, Shuiguang Deng Sep 2024

Cluster-Wide Task Slowdown Detection In Cloud System, Feiyi Chen, Yingying Zhang, Lunting Fan, Yuxuan Liang, Guansong Pang, Qingsong Wen, Shuiguang Deng

Research Collection School Of Computing and Information Systems

Slow task detection is a critical problem in cloud operation and maintenance since it is highly related to user experience and can bring substantial liquidated damages. Most anomaly detection methods detect it from a single-task aspect. However, considering millions of concurrent tasks in large-scale cloud computing clusters, it becomes impractical and inefficient. Moreover, single-task slowdowns are very common and do not necessarily indicate a malfunction of a cluster due to its violent fluctuation nature in a virtual environment. Thus, we shift our attention to cluster-wide task slowdowns by utilizing the duration time distribution of tasks across a cluster, so that …


The Perceptions Of Teachers’ Beliefs And Attitudes On Technology Integration: A Suburban Middle School Case Study In The South-Central United States, Trina Lashell Valdez Sep 2024

The Perceptions Of Teachers’ Beliefs And Attitudes On Technology Integration: A Suburban Middle School Case Study In The South-Central United States, Trina Lashell Valdez

Electronic Theses and Dissertations

Schools have been increasingly challenged with preparing students via technology based on changing standards for students achieving academic success. However, technology integration has barriers, often including teachers’ beliefs and attitudes associated with integrating technology in their classrooms. Therefore, in this qualitative case study, I attempted to understand better the perceptions of teachers, administrators, and professional support staff at Model Middle School about teachers’ beliefs and attitudes regarding technology integration and how to use this knowledge to inform teacher professional development. Data collection consisted of semistructured interviews of teachers, administrators, and professional support staff at Model Middle School via the Zoom …


Diverse Pathways To Permanent Childlessness In Singapore: A Latent Class Analysis, Yanwen Wang, Bussarawan Teerawichitchainan, Christine Ho Sep 2024

Diverse Pathways To Permanent Childlessness In Singapore: A Latent Class Analysis, Yanwen Wang, Bussarawan Teerawichitchainan, Christine Ho

Research Collection School Of Economics

The proportions of adults reaching midlife without having children have been rising rapidly across the globe, particularly in Asia. However, little is known about the pathways to permanent childlessness within the region’s childless population. This study utilized latent class analysis (LCA) to typologize pathways to childlessness based on dynamic characteristics of multiple life domains (i.e., partnership, education, and occupation) among 489 childless Singaporeans aged 50 and above from a 2022 nationwide survey. Additionally, we utilized multinomial logistic regressions to examine the sociodemographic correlates of pathway profiles and Shannon’s entropy index to assess the heterogeneity in pathways to childlessness among successive …


Sin In Business: The Contributions Of Perversion, Defilement, And Idolatry, Jason M. Stansbury Sep 2024

Sin In Business: The Contributions Of Perversion, Defilement, And Idolatry, Jason M. Stansbury

University Faculty Publications and Creative Works

Far from being a parochial concern with the ritual observances of the faithful, sin is the fundamental problem of life for all people. It encompasses all of the violations of the peace that a person has or should have with God, themselves, others, and even the natural environment. These violations occur as people pervert parts of God’s good creation away from their created purposes and toward unworthy ones, disrupting the interdependent order of creation and defiling themselves and their objects in the process. It moreover is self-reinforcing, gaining a power over people that makes future sins more difficult to resist, …


Reclaiming Healing Spaces: A Phenomenological Study On The Transformative Power Of Outdoor Therapy From The Lived Experiences Of Black Clinicians Working With Black Clients, Lynn Murphy Sep 2024

Reclaiming Healing Spaces: A Phenomenological Study On The Transformative Power Of Outdoor Therapy From The Lived Experiences Of Black Clinicians Working With Black Clients, Lynn Murphy

Dissertations

This phenomenological study involved assessing the experiences of Black therapists who engaged Black clients in outdoor therapeutic contexts. The study was founded on the existing literature that shows the quality of the therapeutic relationship is pivotal for client retention and the Western standards that have historically favored treatment within indoor environments. To contextualize this research, a comprehensive literature review was commenced, covering topics such as the decolonization of therapy, the historical and present-day relationship between Blacks and the outdoors in the United States, sedentary lifestyles, the psychological benefits of time spent in nature, various types of outdoor therapy, and the …


What Does ‘Co-Production’ Look Like For Food System Transformation? Mapping The Evidence Across Transforming Uk Food Systems (Tukfs) Projects., Naomi Shaw, Charlotte A. Hardman, Neil Bernard Boyle, Joanne Craven, John Dooley, Bethan Mead, Lisa Morgans, Hannah Mumby, Clare Pettinger Sep 2024

What Does ‘Co-Production’ Look Like For Food System Transformation? Mapping The Evidence Across Transforming Uk Food Systems (Tukfs) Projects., Naomi Shaw, Charlotte A. Hardman, Neil Bernard Boyle, Joanne Craven, John Dooley, Bethan Mead, Lisa Morgans, Hannah Mumby, Clare Pettinger

School of Health Professions

Co-production is a collaborative way of working which emphasises the exchange of diverse forms of knowledge in an equal partnership for equal benefits. Co-produced research is a key strategic aim of the UK Research and Innovation (UKRI) Transforming UK Food Systems (TUKFS) Strategic Priorities Fund; this research programme brings together researchers, policymakers, industry and communities to create positive change in the way food is produced, accessed and consumed. However, more generally, there are diverse understandings of co-production and a lack of consensus on what ‘good practice’ looks like. Therefore, this study aimed to identify and map examples of co-production methods …


Exercise Referral Schemes In The Uk: Mapping Provision And Aims, Ben Jane, John Downey Sep 2024

Exercise Referral Schemes In The Uk: Mapping Provision And Aims, Ben Jane, John Downey

School of Nursing and Midwifery

BackgroundExercise Referral Schemes (ERS) are designed so health professionals can refer certain patients to a supervised programme of physical activity. However, evaluations have questioned the effectiveness of these schemes/programmes. The aim of this study was to systematically review the provision of ERS in England and analyse related promotional material.MethodsContent analysis methods were used to analyse scheme websites and promotional material. A coding scheme was used to analyse the data, which included information on the programme’s aims, inclusion criteria, type of activities, accessibility and cost.ResultsThe study identified 625 sites offering ERS across 168 geographic areas. Findings highlighted a lack of clarity …


Teaching Application Of 3d-Printed Models For Nasal Analysis, Nneoma S. Wamkpah, Robert T. Cristel, Zachary O'Connor, Andrea Hanick, Dennis Nguyen, John J. Chi Sep 2024

Teaching Application Of 3d-Printed Models For Nasal Analysis, Nneoma S. Wamkpah, Robert T. Cristel, Zachary O'Connor, Andrea Hanick, Dennis Nguyen, John J. Chi

2020-Current year OA Pubs

BACKGROUND: A major challenge in learning rhinoplasty is correlating patients' external and internal nasal structures. We aim to explore the application of three dimensional (3D)-printed models of nasal bony-cartilaginous structures in identifying accurate nasal anatomy.

METHODS: Otolaryngology-head and neck surgery and plastic and reconstructive surgery residents matched patient photograph models, described relative nasal bony-cartilaginous anatomy, completed pre- and postactivity self-evaluations (based on otolaryngology "nasal deformity" milestones including "anatomy," "function," "aesthetic," and "etiology"), and rated the 3D-printed models' usefulness. Descriptive statistics were measured.

RESULTS: Thirty-seven residents correctly matched four of six model-photograph pairs and correctly described 15 of 30 anatomic relationships, …


Mutant Nrf2e79q Enhances The Promotion And Progression Of A Subset Of Oncogenic Ras Keratinocytes And Skin Tumors, John G Witherspoon, Jonathan R Hall, Dereje Jima, Hannah M Atkins, Nathan T Wamsley, Michael B Major, Bernard E Weissman, Robert C Smart Sep 2024

Mutant Nrf2e79q Enhances The Promotion And Progression Of A Subset Of Oncogenic Ras Keratinocytes And Skin Tumors, John G Witherspoon, Jonathan R Hall, Dereje Jima, Hannah M Atkins, Nathan T Wamsley, Michael B Major, Bernard E Weissman, Robert C Smart

2020-Current year OA Pubs

Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating mutations in NFE2L2 (NRF2). To determine the functional consequences of Nrf2 activation on skin SCC development, we assessed the effects of mutant Nrf2


Evaluating Bad Theology And Making A Case For The Ethical Priority Of Religious Diversity In Tolkien Studies, Nick Polk Aug 2024

Evaluating Bad Theology And Making A Case For The Ethical Priority Of Religious Diversity In Tolkien Studies, Nick Polk

Journal of Tolkien Research

Presented at Oxonmoot in 2024, the aim of this paper is to present a selection of theological Tolkien criticisms for the purpose of evaluating them through practical theologian Leah Robinson’s definition of bad theology. The point is argued that bad theology in Tolkien Studies needs to be identified and understood as unethical and replaced with the openness of theologian John Thatamanil’s criteria for religious diversity. Concluding will be a promotion of religious diversity as an ethical priority and evaluative tool for future theological engagements within Tolkien Studies.


Review Of Emily Sun’S On The Horizon Of World Literature, Jing Yang Aug 2024

Review Of Emily Sun’S On The Horizon Of World Literature, Jing Yang

CLCWeb: Comparative Literature and Culture

No abstract provided.


The Malvinas/Falklands War In Transatlantic Narratives: Exploring Collective Memory And Negotiating Self/Other Identity, Andrea R. Bellot Aug 2024

The Malvinas/Falklands War In Transatlantic Narratives: Exploring Collective Memory And Negotiating Self/Other Identity, Andrea R. Bellot

CLCWeb: Comparative Literature and Culture

In her article "The Malvinas/Falklands War in Transatlantic Narratives: Exploring Collective Memory and Negotiating Self/Other Identity", Andrea R. Bellot examines the remembrance of the Malvinas/Falklands War (1982) through cultural texts for children, presenting a comparative analysis of post-war narratives from both the United Kingdom and Argentina. Through a detailed exploration of "The Tin-Pot Foreign General and the Old Iron Woman" by British author and illustrator Raymond Briggs (1984), and the Argentine TV cartoon show "La Asombrosa Excursión de Zamba en las Islas Malvinas" (2012), broadcasted on Paka Paka, Bellot discusses how collective memory and national identity are crafted and contested …


Chinese Ideas And American Politics: Confucius As A Guideline For Leadership, Alfred Hornung Aug 2024

Chinese Ideas And American Politics: Confucius As A Guideline For Leadership, Alfred Hornung

CLCWeb: Comparative Literature and Culture

In his article "Chinese Ideas and American Politics: Confucius as a Guideline for Leadership", Alfred Hornung traces the influence of Chinese ideas on American politics with a focus on the works of Confucius. The more than 2.500-year-old impact of the Chinese philosopher on public conduct and his pursuit of virtuous perfection has served as a guideline for leadership emanating from China to Europe and America. For this trajectory of ideas, the historic and the new Silk Road play a decisive role. The exchange of goods along the land-based and maritime routes, which inform Xi Jinping's Belt and Road Initiative, also …


Translation As Creative Writing: Rewriting The Chinese Maze Murders In Contemporary China, Xiaoquan Raphael Zhang Aug 2024

Translation As Creative Writing: Rewriting The Chinese Maze Murders In Contemporary China, Xiaoquan Raphael Zhang

CLCWeb: Comparative Literature and Culture

In his article “Translation as Creative Writing: Rewriting The Chinese Maze Murders in Contemporary China,” Xiaoquan Raphael Zhang examines four groups of selected writings centered on one of Robert van Gulik’s more well-known Judge Dee novels, The Chinese Maze Murders (written first in English but not published until 1956). Different from most publications on van Gulik and his novels, Zhang examines the impact of censorship and self-censorship on the writing, rewriting, and (re)adapting, “literal” and “liberal/free” translation of the Judge Dee stories traveling between Chinese and English, between China and the West, for Chinese and non-Chinese audiences. Focus is given …


Precarious Refugee: Self-Optimization And Neoliberal Rationality In Rawi Hage’S Cockroach, Shahab Nadimi Aug 2024

Precarious Refugee: Self-Optimization And Neoliberal Rationality In Rawi Hage’S Cockroach, Shahab Nadimi

CLCWeb: Comparative Literature and Culture

In his article "Precarious Refugee: Self-Optimization and Neoliberal Rationality in Rawi Hage’s Cockroach," Shahab Nadimi examines Rawi Hage’s Cockroach as an example of refugee literature in the light of current debates about neoliberal biopolitics and the idea of a new form of life. Refugees, who are neither identified as citizens nor totally as strangers, are forced to compete in unequal circumstances of economic mobility with other citizens, often leaving them in a condition of personal debts, unemployment, and mental distress. Nadimi investigates Cockroach’s depiction of psychological breakdown, suicidal attempts, and metamorphosis as symptomatic of and critical to the neoliberal …


Multi-Label Classification Using Conformal Prediction, Chhavi Tyagi Aug 2024

Multi-Label Classification Using Conformal Prediction, Chhavi Tyagi

Dissertations

In many machine learning applications, such as image tagging, document classi-fication, and medical diagnosis, a data instance can be associated with multiple classes in parallel so that each instance is associated with multiple response variables simultaneously defining multi-label classification. Standard multi-label classification methods that provide point predictions have been developed. They lack in quantifying the uncertainty of predictions. These methods also lack in accounting for label dependencies and are very computationally expensive. This dissertation develops two methods of multi-label classification using conformal prediction that quantify the uncertainty of predictions. Chapter 1 introduces notations and tools that have been used in …


A Micromagnetic Study Of Skyrmions In Thin-Film Multilayered Ferromagnetic Materials, Nicholas J. Dubicki Aug 2024

A Micromagnetic Study Of Skyrmions In Thin-Film Multilayered Ferromagnetic Materials, Nicholas J. Dubicki

Dissertations

Magnetic skyrmions are topologically protected, localized, nanoscale spin textures in non-centrosymmetric thin ferromagnetic materials and heterostructures. At present they are of great interest to physicists for potential applications in information technology due to their particle-like properties and stability. In a system of multiple thin ferromagnetic layers, the stray field interaction was typically treated with various simplifications and approximations. It is shown that extensive analysis of the micromagnetic equations leads to an exact representation of the stray field interaction energy in the form of layer interaction kernels, a so-called 'finite thickness' representation. This formulation reveals the competition between perpendicular magnetic anisotropy …


Data Driven Decision Making For Sustainable Planning And Operations Of Large Scale Networks, Bahareh Kargar Aug 2024

Data Driven Decision Making For Sustainable Planning And Operations Of Large Scale Networks, Bahareh Kargar

Dissertations

This dissertation explores data-driven decision-making networks, focusing on sustainable planning and operations for large-scale systems such as healthcare supply chains and power systems. One significant application in healthcare is the optimization of vaccine supply chains. An agent-based simulation-optimization modeling framework is developed to enhance the efficiency and sustainability of vaccine distribution. First, an agent-based epidemiological model of COVID-19 is extended to capture disease transmission dynamics and forecast the number of susceptible individuals and infections. Then, a sustainable vaccine supply chain considering the impacts of greenhouse gases is developed and integrated with the simulation model to minimize total costs and environmental …


Order-Picking Strategies And Efficiency Models For The Fulfillment Of Multi-Line E-Commerce Grocery Orders, Zijia Wang Aug 2024

Order-Picking Strategies And Efficiency Models For The Fulfillment Of Multi-Line E-Commerce Grocery Orders, Zijia Wang

Dissertations

The fulfillment process for Buy Online Pickup from Store grocery orders (BOPS-Grocery) is particularly challenging, given the large item count per order and the low-profit margins. This research investigates the BOPS-Grocery model and pursues the following objectives: (i) Defining and specifying the BOPS-Grocery fulfillment process. Differentiating the process from classical warehouse order picking., identifying performance objectives, and characterizing design options and facility layout. (ii) Modelling and developing order picking algorithms specific to the straight aisle section. Formulated as an order hatching problem with picker movement minimization. No order splitting, and (iii) modeling and developing order picking algorithms specific to the …


Collision Dynamics Of Compound Droplets In Microchannels: A Combined Numerical And Data-Driven Study, S M Abdullah Al Mamun Aug 2024

Collision Dynamics Of Compound Droplets In Microchannels: A Combined Numerical And Data-Driven Study, S M Abdullah Al Mamun

Dissertations

Understanding and predicting the hydrodynamic interactions of micron-scale droplets is crucial in a wide range of industrial and real-life applications, including microfluidics, pharmaceutics, drug delivery, food science, and enhanced oil recovery. These multi-phase and multi-scale phenomena are further complicated by the presence of core droplets of an immiscible fluid within shell droplets, known as compound droplets. The collisions and interactions of droplets in emulsions are influenced by various physical and geometric parameters, leading to distinct rheological and dynamic responses. This research employs numerical methods for a systematic parametric study of both simple and compound droplet pair collisions under confined shear …


No. 01: South Africa At War: Food Insecurity, Migrant Exclusion And Covid-19 Policies, Jonathan Crush, Sean Sithole Aug 2024

No. 01: South Africa At War: Food Insecurity, Migrant Exclusion And Covid-19 Policies, Jonathan Crush, Sean Sithole

Migration and Food Security (MiFOOD) Network

The policy audit critically examines the South African government’s response to the COVID-19 pandemic, particularly focusing on the militaristic enforcement of lockdowns and the resulting food insecurity and exclusion of migrant populations. The report aims to inform policy-makers about the impacts of these policies and provide recommendations for crisis management.

On 27 March 2020, South Africa imposed a nationwide lockdown to combat the spread of COVID-19. This lockdown, enforced by the police and the military, was characterized by stringent measures including curfews, bans on inter-provincial travel, and the closure of non-essential businesses. These measures, while necessary to control the pandemic, …


Settling Dust, Unsettling Ground, Olivia Newroz Aug 2024

Settling Dust, Unsettling Ground, Olivia Newroz

Masters Theses

Understanding dust as a material system that blurs the line between ground and atmosphere, I developed a dust machine as a tool for making dust legible at the human scale. While the blurriness of ground is visualized at both particle and planetary scales, at the human scale, it becomes less evident. Drawing from Lisa’s Moffitt’s discussion of “environmental models”–that is, models that don’t merely simulate phenomena, in this case dust, but rather produce the underlying force itself––I produced visualizations of how dust, as both a grounded and atmospheric element, intertwines ground and weather across scales, through a cyclical process of …


Analysis Of Fluid Intake During Pregnancy, Irem Dilaver, Busra Parlak Somuncu, Murat Topbas, Kubra Sahin, Medine Gozde Ustundag, Cansu Agrali Gundogmus, Gamze Can, Nazim Ercument Beyhun Aug 2024

Analysis Of Fluid Intake During Pregnancy, Irem Dilaver, Busra Parlak Somuncu, Murat Topbas, Kubra Sahin, Medine Gozde Ustundag, Cansu Agrali Gundogmus, Gamze Can, Nazim Ercument Beyhun

Makara Journal of Health Research

Background: Pregnancy is an important process that affects the body’s daily water requirements through various mechanisms. Adequate fluid intake also plays a critical role in pregnancy. This research aimed to determine levels of water/fluid intake and influencing factors among pregnant women presenting to a university hospital in Trabzon, Türkiye.

Methods: A total of 1,082 pregnant women were included in this cross-sectional research. A questionnaire was used during the face-to-face interviews to collect data. SPSS version 23.0 software was employed during data analysis, and logistic regression was applied to identify factors that affect adequate daily fluid intake.

Results: …


Evolving Notions Of Public Interest: A New Perspective On Land Acquisition In Indonesia, Bakhrul Amal, Yusriadi Yusriadi, Ana Silviana Aug 2024

Evolving Notions Of Public Interest: A New Perspective On Land Acquisition In Indonesia, Bakhrul Amal, Yusriadi Yusriadi, Ana Silviana

Indonesia Law Review

Indonesia relating to land issues. The meaning of public interest in land acquisition which is expected to be able to help realize justice, prosperity and welfare for the community turns out that in its implementation it actually causes conflict because it is not in accordance with the principles of balance and justice. The problems that the research tries to answer are: (1) What is meant by public interest according to the applicable laws and regulations? (2) How is the reconstruction of the meaning of public interest in land acquisition for development in the public interest based on the principles of …


Personal Data Protection Law In Indonesia: Challenges And Opportunities, Moody Rizqy Syailendra, Gunardi Lie, Ahmad Sudiro Aug 2024

Personal Data Protection Law In Indonesia: Challenges And Opportunities, Moody Rizqy Syailendra, Gunardi Lie, Ahmad Sudiro

Indonesia Law Review

This research identifies challenges, obstacles and opportunities related to the issuance of Law No. 27 of 2022. Protection of personal data is crucial, especially in the use of information and communication technology in the current modern era. The contents of this article were analyzed using qualitative methods and secondary data in analyzing it. The research results show that: although the PDP Law was only implemented in 2022, regulations regarding PDP can actually be found in various pre-existing regulations, then there are principles and provisions that can be included in the PDP Law to better accommodate the need for protecting people's …


Investigation On Production, Kinetic Modelling, Downstream Processing, And Characterization Of Microbial Dextran Using Sucrose-Rich Alternate Feedstocks, Sameeha Syed Ar Aug 2024

Investigation On Production, Kinetic Modelling, Downstream Processing, And Characterization Of Microbial Dextran Using Sucrose-Rich Alternate Feedstocks, Sameeha Syed Ar

Theses and Dissertations

Microbial exopolysaccharides (EPS) synthesized by microorganisms have a wide range of applications from thickener agents in the field of food to formulations in the field of pharmaceuticals. Owing to their rheological, structural, and physicochemical characteristics in addition to its biodegradability, low antigenicity, antioxidant activities, etc., several EPS have gained research focus in recent years. Dextran is one such example of EPS, which is synthesized by lactic acid bacteria (LAB). However, its production is limited to utilization of sucrose medium with a yield of 0.3-0.4 g dextran/ g sucrose. Hence, this thesis work focuses on dextran production using sucrose-rich alternate feedstocks …


Horizontal Gene Transfer In Intergenomic Conflicts Between Bacteria And Their Genetic Parasites, Pavithra A.S Aug 2024

Horizontal Gene Transfer In Intergenomic Conflicts Between Bacteria And Their Genetic Parasites, Pavithra A.S

Theses and Dissertations

Bacteria are constantly infected by obligate acellular genetic parasites, such as plasmids and phages. The genetic conflicts between bacteria and their parasites, aggravated by horizontal gene transfer, exert significant ecological and evolutionary pressure on their respective genomes. The eco-evolutionary significance of parasite-derived elements on bacterial genomes is not well understood.

This study explored the genomics of plasmid-derived genetic elements such as antimicrobial resistance genes (ARGs), type II endonuclease toxin-antitoxin systems (TAs) and endonuclease colicin-like bacteriocin (CLB) operons, and phage-derived prophages of Escherichia coli using bioinformatics and developing novel hybrid agent-based models. We sequenced eight E. coli isolated from local wastewater …