Digital Commons Network^™

Does Reduced Taper Canal Preparation Increase The Load Capacity Of Endodontically Treated Teeth?, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Objectives: The aim of this in-vitro study is to assess and compare the load capacity of teeth with canals prepared using progressive taper versus regressive taper.

Methods: Twenty-seven extracted mandibular molars were categorized into three equal groups. The negative control group involved teeth that were accessed and restored with composite resin without canal preparation. The regressive canal preparation group used the TruNatomy file system, while the progressive canal preparation group employed the ProTaper Gold system. Subsequently, all samples underwent loading using a universal testing machine until tooth fracture occurred. The force required to fracture each tooth was recorded in Newton. …

The Cerebellum Modulates Thirst, Ila Mishra, Bing Feng, Bijoya Basu, Amanda M Brown, Linda H Kim, Tao Lin, Mir Abbas Raza, Amelia Moore, Abigayle Hahn, Samantha Bailey, Alaina Sharp, Juan C Bournat, Claire Poulton, Brian Kim, Amos Langsner, Aaron Sathyanesan, Roy V Sillitoe, Yanlin He, Atul R Chopra

Duncan NRI Faculty and Staff Publications

The cerebellum, a phylogenetically ancient brain region, has long been considered strictly a motor control structure. Recent studies have implicated the cerebellum in cognition, sensation, emotion and autonomic function, making it an important target for further investigation. Here, we show that cerebellar Purkinje neurons in mice are activated by the hormone asprosin, leading to enhanced thirst, and that optogenetic or chemogenetic activation of Purkinje neurons induces rapid manifestation of water drinking. Purkinje neuron-specific asprosin receptor (Ptprd) deletion results in reduced water intake without affecting food intake and abolishes asprosin's dipsogenic effect. Purkinje neuron-mediated motor learning and coordination were unaffected by …

Prudence, Role Morality, And Restraint: Judge Wilkinson On The Separation Of Powers, Katherine Mims Crocker, Jack Goldsmith

Faculty Scholarship

Caution in reviewing the actions of the legislative and executive branches has been a hallmark of the jurisprudence of Judge J. Harvie Wilkinson III. The Constitution “at most gives judges specific authority to redress violations of specific provisions,” Judge Wilkinson writes in his book Cosmic Constitutional Theory. But even when doing so, “courts must exercise great caution before injecting themselves into the vortex of varied political questions,” for “[i]t is often far preferable to allow the political institutions under our Constitution to struggle among themselves, with each bringing to bear the respective arsenal of powers the Framers accorded them.” …

Complicity, Eliana Luxemburg-Peck

Dissertations, Theses, and Capstone Projects

What does it mean to be complicit in diffuse collective wrongs like structural racism, gender-based oppression, or environmental damage, and what responsibilities are entailed by complicity? Moral philosophers have often understood complicity to consist in some degree of inherited culpability, arising from knowing or intentional contributions to the bad acts of a primary wrongdoer. But these theories fail to explain complicity in the foregoing contexts, and cannot justify needed efforts to hold individuals accountable for unwitting contributions to systemic wrongs and injustices. In response to this gap, my dissertation defends a novel reconceptualization of complicity as participation in collectively perpetrated …

A Multilevel Approach To The Analysis And Visualization Of Timbral Brightness In Post-Tonal Music, Stephen Spencer

Dissertations, Theses, and Capstone Projects

This dissertation develops a method for the analysis and visualization of timbral brightness in post-tonal music. Brightness, a salient timbral attribute correlated with the prominence of high frequencies in the sound spectrum, is crucial for distinguishing sounds and discerning how they fit together in music. The dissertation employs a multilevel analytical approach, measuring differences in brightness at multiple “textural levels” and temporal scales. The analytical utility of the approach is demonstrated through four case studies, each one closely examining the score and audio of a piece of instrumental music written in the first quarter of the twentieth century.

Chapter …

Liberal Attitude Reports, Tomasz Zyglewicz

Dissertations, Theses, and Capstone Projects

Attitude reports are sentences such as “Tomasz thinks the Earth is flat” or “Susan wantsvice cream.” It is commonly assumed that the main reason people use them is to make sense of the reportee’s behavior: to explain their past actions, or predict future ones. To play this role effectively, attitude reports have to accurately describe what is going on in the reportee’s head. Let’s call attitue reports that do not meet this condition “Liberal attitude reports.” For example: Alice is a vegan doctor who thinks that every vegan should take a B12 supplements. It is felicitous to say to your …

Ethnoracial Inequality In Egalitarian Sweden: Swedish Exceptionalism And Racial Legacies, Beiyi Hu

Dissertations, Theses, and Capstone Projects

Ethnoracial Inequality in Egalitarian Sweden: Swedish Exceptionalism and Racial Legacies investigates the persistence of ethno-racial disparities in Sweden, a country often celebrated for its humanitarianism, egalitarianism, and tolerance. I explore several key questions: How do ethnic and racial minorities, as well as majority Swedes, perceive and understand race and ethno-racial inequalities in a country that does not officially recognize race? What sociohistorical legacies and institutionalized practices have contributed to contemporary ethnoracial inequalities in Sweden? And for ethnic and racial minorities, what are their day-to-day experiences of racism? Combining analysis of governmental data and in-depth interviews as well as exploratory spatial …

On The Lower Levels Of The Ivory Tower: What Color Collars Do Adjunct Faculty Wear?, Frederick Tucker

Dissertations, Theses, and Capstone Projects

Institutional reliance on tenure-line faculty reached a historic low after the Great Recession in 2009, remaining at approximately a third of all faculty through 2022. Postsecondary institutions have steadily increased their reliance on full-time adjunct faculty over the last two decades. Part-time adjuncts, meanwhile, were hired in great numbers before and during the Great Recession, as student enrollment increased, but have steadily declined since 2012, as college enrollment waned. Almost all evidence suggests that tenure expansion would benefit both the recipients of tenure and their students, but would come at a cost. There are few studies, however, that distinguish between …

Overcoming Egfr-Tki Resistance By Targeting The Tumor Microenvironment, Jinsong Zhang, Natalie Vokes, Man Li, Jiachen Xu, Hua Bai, Zhijie Wang

Faculty, Staff and Student Publications

Targeted therapy has ushered in a new era of precision medicine for non-small cell lung cancer (NSCLC). Currently, epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) stand as the recommended first-line therapy for advanced NSCLC harboring sensitive EGFR mutations. Nevertheless, most patients inevitably confront the challenge of drug resistance. This phenomenon arises not solely from intrinsic alterations within cancer cells but also from the intricate dynamics of the tumor microenvironment and the complex interactions that occur between cancer cells and their immediate surroundings. This review consolidates the current knowledge regarding EGFR-TKI resistance mechanisms, with a specific emphasis on unraveling the …

Co-Targeting Sos1 Enhances The Antitumor Effects Of Krasg12c Inhibitors By Addressing Intrinsic And Acquired Resistance, Venu Thatikonda, Hengyu Lyu, Sabine Jurado, Kaja Kostyrko, Christopher A Bristow, Donat Alpar, Oliver Bergner, Karin Bosch, Ningping Feng, Sisi Gao, Daniel Gerlach, Michael Gmachl, Melanie Hinkel, Simone Lieb, Astrid Jeschko, Annette A Machado, Thomas Madensky, Ethan D Marszalek, Mikhila Mahendra, Gabriella Melo-Zainzinger, Jessica M Molkentine, Philipp A Jaeger, David H Peng, Robyn L Schenk, Alexey Sorokin, Sandra Strauss, Francesca Trapani, Scott Kopetz, Christopher P Vellano, Mark Petronczki, Norbert Kraut, Timothy P Heffernan, Joseph R Marszalek, Mark Pearson, Irene C Waizenegger, Marco H Hofmann

Faculty, Staff and Student Publications

Combination approaches are needed to strengthen and extend the clinical response to KRASG12C inhibitors (KRASG12Ci). Here, we assessed the antitumor responses of KRASG12C mutant lung and colorectal cancer models to combination treatment with a SOS1 inhibitor (SOS1i), BI-3406, plus the KRASG12C inhibitor, adagrasib. We found that responses to BI-3406 plus adagrasib were stronger than to adagrasib alone, comparable to adagrasib with SHP2 (SHP2i) or EGFR inhibitors and correlated with stronger suppression of RAS-MAPK signaling. BI-3406 plus adagrasib treatment also delayed the emergence of acquired resistance and elicited antitumor responses from adagrasib-resistant models. Resistance to KRASG12Ci seemed to be driven by …

Metabolic Cell Death In Cancer: Ferroptosis, Cuproptosis, Disulfidptosis, And Beyond, Chao Mao, Min Wang, Li Zhuang, Boyi Gan

Faculty, Staff and Student Publications

Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism. This review discusses the mechanisms of metabolic cell death-ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, and alkaliptosis-and explores their potential in cancer therapy. Our review underscores the complexity of the metabolic cell death pathways and offers insights into innovative therapeutic avenues for cancer treatment.

A Guideline On The Molecular Ecosystem Regulating Ferroptosis, Enyong Dai, Xin Chen, Andreas Linkermann, Xuejun Jiang, Rui Kang, Hülya Bayir, Ana J Garcia-Saez, Maria S Ioannou, Tobias Janowitz, Qitao Ran, Wei Gu, Boyi Gan, Dmitri V Krysko, Xiaofeng Zhu, Jiayi Wang, Stefan Krautwald, Shinya Toyokuni, Yangchun Xie, Florian R Greten, Qing Yi, Joel Schick, Jiao Liu, Dmitry I Gabrilovich, Jinbao Liu, Herbert J Zeh, Donna D Zhang, Minghua Yang, Juan Iovanna, Manfred Kopf, Timon E Adolph, Jen-Tsan Chi, Changfeng Li, Hidenori Ichijo, Michael Karin, Vijay G Sankaran, Weiping Zou, Lorenzo Galluzzi, Ashley I Bush, Binghui Li, Gerry Melino, Eric H Baehrecke, Michael T Lotze, Daniel J Klionsky, Brent R Stockwell, Guido Kroemer, Daolin Tang

Faculty, Staff and Student Publications

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Proton Therapy Toxicity Outcomes For Localized Prostate Cancer: Long-Term Results At A Comprehensive Cancer Center, Alan J Sosa, Michael K Rooney, Howard D Thames, Jeremiah W Sanders, David M Swanson, Quynh-Nhu Nguyen, Deborah A Kuban, X Ron Zhu, Shalin Shah, Lauren L Mayo, Karen E Hoffman, Chad Tang, Sean E Mcguire, Narayan Sahoo, Xiaodong Zhang, Andrew K Lee, Thomas J Pugh, Usama Mahmood, John W Davis, Brian F Chapin, Paul Corn, Reena Kudchadker, Noveen Ausat, Steven J Frank

Faculty, Staff and Student Publications

BACKGROUND: Proton therapy (PT) has unique biologic properties with excellent clinical outcomes for the management of localized prostate cancer. Here, we aim to characterize the toxicity of PT for patients with localized prostate cancer and propose mitigation strategies using a large institutional database.

METHODS: We reviewed medical records of 2772 patients with localized prostate cancer treated with definitive PT between May 2006 through January 2020. Disease risk was stratified according to National Comprehensive Cancer Network guidelines as low [LR, n = 640]; favorable-intermediate [F-IR, n = 849]; unfavorable-intermediate [U-IR, n = 851]; high [HR, n = 315]; or very high …

Landmark-Based Auto-Contouring Of Clinical Target Volumes For Radiotherapy Of Nasopharyngeal Cancer, Carlos Sjogreen, Tucker J Netherton, Anna Lee, Moaaz Soliman, Skylar S Gay, Raymond Mumme, Dong Joo Rhee, Carlos E Cardenas, Mary K Martel, Beth M Beadle, Laurence Edward Court

Faculty, Staff and Student Publications

Background: The delineation of clinical target volumes (CTVs) for radiotherapy for nasopharyngeal cancer is complex and varies based on the location and extent of disease.

Purpose: The current study aimed to develop an auto-contouring solution following one protocol guidelines (NRG-HN001) that can be adjusted to meet other guidelines, such as RTOG-0225 and the 2018 International guidelines.

Methods: The study used 2-channel 3-dimensional U-Net and nnU-Net framework to auto-contour 27 normal structures in the head and neck (H&N) region that are used to define CTVs in the protocol. To define the CTV-Expansion (CTV1 and CTV2) and CTV-Overall (the outer envelope of …

Smyd5 Is A Ribosomal Methyltransferase That Catalyzes Rpl40 Lysine Methylation To Enhance Translation Output And Promote Hepatocellular Carcinoma, Bisi Miao, Ling Ge, Chenxi He, Xinghao Wang, Jibo Wu, Kun Chen, Shenghui Xing, Lingnan Ren, Zhennan Shi, Shengnan Liu, Yajun Hu, Jiajia Chen, Yanyan Yu, Lijian Feng, Natasha M Flores, Zhihui Liang, Xinyi Xu, Ruoxin Wang, Jian Zhou, Jia Fan, Bin Xiang, En Li, Yuanhui Mao, Jingdong Cheng, Kehao Zhao, Pawel K Mazur, Jiabin Cai, Fei Lan

Faculty, Staff and Student Publications

While lysine methylation is well-known for regulating gene expression transcriptionally, its implications in translation have been largely uncharted. Trimethylation at lysine 22 (K22me3) on RPL40, a core ribosomal protein located in the GTPase activation center, was first reported 27 years ago. Yet, its methyltransferase and role in translation remain unexplored. Here, we report that SMYD5 has robust in vitro activity toward RPL40 K22 and primarily catalyzes RPL40 K22me3 in cells. The loss of SMYD5 and RPL40 K22me3 leads to reduced translation output and disturbed elongation as evidenced by increased ribosome collisions. SMYD5 and RPL40 K22me3 are upregulated in hepatocellular carcinoma …

Automatic Vessel Attenuation Measurement For Quality Control Of Contrast-Enhanced Ct: Validation On The Portal Vein, Kevin Mccoy, Sujay Marisetty, Dominique Tan, Corey T Jensen, Jeffrey H Siewerdsen, Moiz Ahmad

Faculty, Staff and Student Publications

Background: Adequate image enhancement of organs and blood vessels of interest is an important aspect of image quality in contrast-enhanced computed tomography (CT). There is a need for an objective method for evaluation of vessel contrast that can be automatically and systematically applied to large sets of CT exams.

Purpose: The purpose of this work was to develop a method to automatically segment and measure attenuation Hounsfield Unit (HU) in the portal vein (PV) in contrast-enhanced abdomen CT examinations.

Methods: Input CT images were processed by a vessel enhancing filter to determine candidate PV segmentations. Multiple machine learning (ML) classifiers …

Understanding Climate Change Adaptation And Gentrification Through The Framework Of Uneven Coastal Development In Keansburg, New Jersey, Zachary Paganini

Dissertations, Theses, and Capstone Projects

This study examines the rapid acceleration of coastal development in the United States despite projections of climate change-induced sea level rise. Like no other developed country, the U.S. has transformed its fragile coastline into sites for leisure, consumption, and retirement. These spaces now face the prospect of more frequent and severe storms, as well as land loss and inundation, due to climate change. This dilemma has sparked debates around coastal resilience, adaptation, retreat, and climate gentrification.

While many studies seek to measure perceptions of climate change risk and vulnerability, this dissertation reverses the question by positioning risk perceptions as an …

Limit Theorems For L-Functions In Analytic Number Theory, Asher Roberts

Dissertations, Theses, and Capstone Projects

We use the method of Radziwill and Soundararajan to prove Selberg’s central limit theorem for the real part of the logarithm of the Riemann zeta function on the critical line in the multivariate case. This gives an alternate proof of a result of Bourgade. An upshot of the method is to determine a rate of convergence in the sense of the Dudley distance. This is the same rate Selberg claims using the Kolmogorov distance. We also achieve the same rate of convergence in the case of Dirichlet L-functions. Assuming the Riemann hypothesis, we improve the rate of convergence by using …

Harnessing Neural Activity To Prevent Non-Apoptotic Spinal Neurons From Microglial Phagocytosis After Motor System Injury, Jasmine L. Pathan

Dissertations, Theses, and Capstone Projects

Producing skilled, voluntary movements in humans and many animals requires the corticospinal tract, the direct motor pathway connecting the cerebral cortex with spinal cord interneurons and motor neurons in humans and many non-human primates. Spinal cord injury (SCI) typically results in corticospinal tract damage, leading to transneuronal degeneration of its interneuron targets. Complement protein C1q triggers this degenerative process and induces microglia, the innate immune cells of the central nervous system, to phagocytose non-apoptotic interneurons. We examined two classes of premotor interneurons, cholinergic (ChAT) and glutamatergic (Chx10), essential to the spinal motor circuit as they receive direct corticospinal tract inputs …

Guardians Of The Bacterial Genome: Mechanistic Insights Of The Ner Atpase Uvra With Damaged Dnas; Molecular Interactions Between The V.Cholerae Initiator Rctb With Cognate Oricii Dna, Devon Semoy

Dissertations, Theses, and Capstone Projects

Nucleotide excision repair (NER) is one of the fundamental DNA repair pathways in all organisms. A unique facet of NER is the large set of DNA lesions the pathway is capable of repairing (Truglio, Croteau, et al. 2006). The NER proteins may thus be responding to global features of native DNA such as changes in thermodynamic stability, geometry and kinetic properties (Maillard et al. 2007). In this study we set out to investigate the first and primary responder to NER in bacteria, UvrA (Kraithong et al. 2021). UvrA is a homo-dimeric ABC ATPase; proteins that are known to transduce the …

Early And Enduring: Targeting The Endothelium For Blood-Brain Barrier Protection, Silin Wu, Xuefang Sophie Ren, Yejie Shi

Faculty, Staff and Student Publications

The disruption of the blood-brain barrier marks a pivotal early pathological event in ischemic stroke that significantly contributes to subsequent permanent damage. Here we delve into the ramifications of a study conducted by Xu and colleagues, which underscores the essential role of the protein peroxiredoxin-4 in cerebrovascular endothelial cells. Peroxiredoxin-4 was shown to preserve blood-brain barrier integrity during the early stages after cerebral ischemia and reperfusion, ultimately leading to improved long-term outcomes.

Lifr Regulates Cholesterol-Driven Bidirectional Hepatocyte-Neutrophil Cross-Talk To Promote Liver Regeneration, Yalan Deng, Zilong Zhao, Marisela Sheldon, Yang Zhao, Hongqi Teng, Jie Zhang, Yutong Sun, Fan Yao, Michael A Curran, Hao Zhu, Li Ma

Faculty, Staff and Student Publications

Liver regeneration is under metabolic and immune regulation. Despite increasing recognition of the involvement of neutrophils in regeneration, it is unclear how the liver signals to the bone marrow to release neutrophils after injury and how reparative neutrophils signal to hepatocytes to reenter the cell cycle. Here we report that loss of the liver tumour suppressor Lifr in mouse hepatocytes impairs, whereas overexpression of leukaemia inhibitory factor receptor (LIFR) promotes liver repair and regeneration after partial hepatectomy or toxic injury. In response to physical or chemical damage to the liver, LIFR from hepatocytes promotes the secretion of cholesterol and CXCL1 …

The Intellectual Roots Of Hindutva: Influences From Early German Romantics And Mahatma Gandhi, Johannes Scheuer

Dissertations, Theses, and Capstone Projects

The economic and political ascent under the leadership of the Bharatiya Janata Party (BJP) and Narendra Modi has not only increased interest in Indian politics but also highlighted the dominance of Hindu nationalism (Hindutva) as a political ideology in contemporary India. Many scholars and journalists have drawn parallels between European fascist movements of the past and reactionary movements in today's political landscape to understand the rise and dominance of Hindutva. However, this paper takes a different approach by tracing the intellectual roots of Hindutva through the political philosophy of the Early German Romantics, particularly Johann Gottfried Herder, and the philosophy …

Autophagy And Meiotic Fidelity In C. Elegans, Kaitlin E. Kosinski

Dissertations, Theses, and Capstone Projects

Autophagy is an evolutionarily conserved multi-step recycling process in which cellular material is enclosed in the double membrane-bound autophagosome, which fuses with the lysosome to degrade its contents. Autophagy is essential for development and cellular adaptation to environmental or intracellular stress and is an important regulator of germline stem cell homeostasis in the model nematode C. elegans. We sought to determine if autophagy is important for genome stability during meiosis and found that the core adult C. elegans autophagy genes bec-1, atg-7, unc-51, and atg-18 were all required for proper meiotic development of oocytes. Loss of these …

Mind Your Business Or Be Your Brother's Keeper? Managing Vulnerability In The New York City Subway, Maria Barrera-Vilert

Dissertations, Theses, and Capstone Projects

This qualitative study investigates the management of safety and vulnerability in the New York City subway by analyzing public communication campaigns focused on counterterrorism, COVID-19, and deviance awareness. It explores how New Yorkers navigate the tension between adhering to a dominant New York cultural imperative to mind one’s business and being called upon to be their “brother’s keepers” and intervene when something risky happens.

The study is structured around three central elements that align with the three primary processes of public communication campaigns: representation, interpretation, and reaction. This study analyzes visual images associated with public communication campaigns and 43 …

Bodies For Catastrophe: A Montage Study Of Palestinian Digital Labor, Francisco Ramos

Dissertations, Theses, and Capstone Projects

This thesis investigates Palestinian digital labor through the method of montage. Digital labor, understood as bodily activity transfigured by digital machines into exploitable information, is examined within the context of Israeli surveillance technologies used against Palestinians. The study critically explores the dual political functions of these technologies: as tools of settler-colonial domination aiming to dispossess Palestinians, and as neoliberal mechanisms seeking to profit from the surveillance of Palestinian bodies. The second half of the thesis turns to the ways Palestinians engage with such technologies and unsettle the economic and colonial logics embedded in them.

The research is structured nonlinearly using …

Exploring The Correlation Between Google Trends And Crime Statistics: A Focus On Motor Vehicle Theft In The United States, Yu-Hsuan Liu

Dissertations, Theses, and Capstone Projects

This dissertation examines the linear relationships between motor vehicle theft (MVT) estimates from Google Trends--a form of digital trace data--and official crime statistics, including the Uniform Crime Reports (UCR), National Crime Victimization Survey (NCVS), National Insurance Crime Bureau (NICB), National Incident-Based Reporting System (NIBRS), and 911 calls for service (CFS 911). It offers a comprehensive analysis of the limitations inherent in current crime statistics, discusses measurement errors, and explores statistical models to mitigate the impact of measurement error, applying these methods to validate Google Trends MVT data and other official MVT statistics. Furthermore, this study incorporates social disorganization theory and …

Building Networks, Producing Spaces For Play: Local Geographies And National Organizing In The History Of Adventure Playgrounds In The United States, 1949-1999, Reilly B. Wilson

Dissertations, Theses, and Capstone Projects

This dissertation provides an historical analysis of repurposed material adventure playgrounds in the United States between 1949 and 1999. Three microhistories of adventure playgrounds (The Yard, in Minneapolis, M.N., and several playgrounds in New York City, N.Y., and Houston, T.X.) are framed against the wider socio-economic changes that shaped more than thirty-five adventure playgrounds in the United States over the period of study. By focusing on the relationships mobilized by adventure playground advocates at different scales and across different points of view, and how these networks shaped the local production of spaces for play, this dissertation's method underlines the importance …

Measuring Intersectional Strength And Stigma Among Racially Minoritized Gender Diverse Young Adults, Joseph Carter

Dissertations, Theses, and Capstone Projects

Background: Racially minoritized transgender and gender expansive young adults (RMTGEYA; aged 18-26) experience mental health inequities due to intersectional, multilevel stigma. RMTGEYA communities embody intersectional strength and resilience that can mitigate the impact of stigma. Understanding and capturing strength and stigma factors to address these inequities has significant implications for clinical science research and practice. There is, however, a complete absence of instruments that are validated to do so. Objective: The goal of this study is to conduct a three-phase, mixed methods study that centers intersectional and community engaged methods of psychometric development for a measure that captures daily experiences …

Preschoolers’ Generation Of Quantity Implicatures, André Eliatamby

Dissertations, Theses, and Capstone Projects

This dissertation uses the developing child as a window into the mechanisms and representations that allow us to understand the meaning of utterances in their contexts. I present three studies investigating 4- and 5-year-olds’ ability to generate two types of “quantity implicatures,” classic scalar implicatures with some that imply not all, and free choice inferences that arise with sentences like “Larry is allowed to have cake or ice-cream.” Together, the studies suggest a close relationship between pragmatic development and word learning, something not appreciated in existing literature. In the first study investigating some, I show that preschoolers interpret …