Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Law (362298)
- Social and Behavioral Sciences (129593)
- Arts and Humanities (102140)
- Education (62350)
- Medicine and Health Sciences (40002)
-
- History (35351)
- Life Sciences (35233)
- Constitutional Law (35103)
- Physical Sciences and Mathematics (32537)
- Business (29898)
- Engineering (26632)
- Sociology (24341)
- Communication (23005)
- International Law (22863)
- Religion (21832)
- Criminal Law (20657)
- Higher Education (20124)
- Public Affairs, Public Policy and Public Administration (17593)
- Political Science (17373)
- United States History (15478)
- Psychology (14040)
- Courts (12608)
- Intellectual Property Law (12273)
- Civil Rights and Discrimination (12001)
- Library and Information Science (11554)
- State and Local Government Law (11283)
- Accounting (11261)
- Journalism Studies (11102)
- Environmental Law (10871)
- Comparative and Foreign Law (10811)
- Institution
-
- University of New Mexico (37085)
- Brigham Young University Law School (30303)
- Villanova University Charles Widger School of Law (28437)
- University of Mississippi (21463)
- University of South Florida (19011)
-
- University of Nebraska - Lincoln (18997)
- University of Colorado Law School (16871)
- University of Michigan Law School (16370)
- University of Montana (16150)
- Fordham Law School (13109)
- UC Law SF (12012)
- University of New Hampshire (11550)
- University of Kentucky (11455)
- University of Chicago Law School (10186)
- Southern Methodist University (10150)
- Brigham Young University (9890)
- San Jose State University (9637)
- Louisiana State University (9557)
- Duke Law (9478)
- University of Central Florida (9394)
- UIdaho Law (9228)
- University of Denver (9122)
- University of South Carolina (9044)
- William & Mary Law School (9044)
- Eastern Illinois University (9035)
- University of North Dakota (8918)
- City University of New York (CUNY) (8662)
- Murray State University (8351)
- Maurer School of Law: Indiana University (8092)
- Yeshiva University, Cardozo School of Law (7839)
- Keyword
-
- Newspaper (16162)
- Student newspaper (7458)
- Education (7069)
- History (6825)
- Newspapers (6049)
-
- EIU (5441)
- United States (5398)
- Law (5293)
- Spartan Daily (4490)
- Latin America (4437)
- Humans (4180)
- Bowling Green State University (4046)
- Spanish (4021)
- Constitutional law (3891)
- Pennsylvania (3891)
- University of New Mexico (3841)
- Eastern Illinois University (3831)
- Higher education (3818)
- UNM (3794)
- LADB (3792)
- LAII (3792)
- Latin American and Iberian Institute (3792)
- Daily Eastern News (3758)
- BG News (3691)
- Collegeville (3643)
- Politics (3324)
- Supreme Court (3269)
- N.M. (3259)
- Student newspapers (3190)
- Periodicals (3185)
- Publication Year
-
- 2026 (22781)
- 2025 (30313)
- 2024 (32702)
- 2023 (29225)
- 2022 (32379)
-
- 2021 (32082)
- 2020 (31251)
- 2019 (30725)
- 2018 (31175)
- 2017 (32224)
- 2016 (32930)
- 2015 (32860)
- 2014 (31680)
- 2013 (31605)
- 2012 (33112)
- 2011 (27175)
- 2010 (25838)
- 2009 (24430)
- 2008 (22488)
- 2007 (20267)
- 2006 (20516)
- 2005 (18705)
- 2004 (17710)
- 2003 (15837)
- 2002 (14560)
- 2001 (14542)
- 2000 (13875)
- 1999 (12641)
- 1998 (12791)
- 1992 (12440)
- Publication
-
- Theses and Dissertations (18297)
- Faculty Scholarship (15961)
- Faculty Publications (12452)
- Electronic Theses and Dissertations (10297)
- Articles (10018)
-
- Michigan Law Review (8430)
- Dissertations (7322)
- Idaho Supreme Court Records & Briefs, All (5567)
- Utah Court of Appeals Briefs (1996–2006) (5390)
- Utah Court of Appeals Briefs (through 1995) (5275)
- Walden Dissertations and Doctoral Studies (5177)
- Santa Fe New Mexican, 1883-1913 (5005)
- Utah Supreme Court Briefs (1965 –) (4915)
- Daily Mississippian (all digitized issues) (4788)
- North Carolina Law Review (4554)
- Spartan Daily (School of Journalism and Mass Communications) (4297)
- Fordham Law Review (4293)
- Theses (4252)
- Louisiana Law Review (4178)
- Journal of Criminal Law and Criminology (4145)
- Masters Theses (4116)
- St. John's Law Review (4050)
- Session Laws 2001-Present (4038)
- Montana Kaimin, 1898-present (4027)
- Master's Theses (3979)
- University of Chicago Law Review (3957)
- Denver Law Review (3842)
- BG News (Student Newspaper) (3708)
- Indiana Law Journal (3615)
- Faculty Articles (3484)
- Publication Type
Articles 40111 - 40140 of 1194892
Full-Text Articles in Entire DC Network
A Broken Record: A Statutory Solution To Fixing Music Copyright Infringement’S Biggest Problem, Jacob B. Hopkins
A Broken Record: A Statutory Solution To Fixing Music Copyright Infringement’S Biggest Problem, Jacob B. Hopkins
Georgia State University Law Review
In the intellectual property space, nothing quite grabs the eye of the public like music copyright infringement. The high reputational and monetary risks associated when an artist claims infringement— especially against that of a major artist—can have huge consequences, even when no infringement occurred. The two prevailing tests for copyright infringement recognize that the hearing court can determine there is not an appropriate level of substantial similarity between two copyrightable works, however this determination relies on specialized musical knowledge, something that the typical trial judge does not possess.
This Note examines the inefficiencies in our current scheme of music copyright …
Is Discrimination Unfair?, Jeff Sovern
Is Discrimination Unfair?, Jeff Sovern
Georgia State University Law Review
Though multiple federal laws explicitly bar discrimination in consumer transactions, many consumer transactions fall in the gaps between those laws. But recently, the Consumer Financial Protection Bureau (CFPB) and Federal Trade Commission (FTC) have attempted to plug those gaps on the theory that discrimination is unfair within the meaning of statutes they enforce prohibiting unfair practices (UDAAP statutes). Angered by this view, the U.S. Chamber of Commerce, joined by various banking trade groups, sued the CFPB in a federal court in Texas and persuaded a conservative judge to invalidate the Bureau’s interpretation. An appeal from the decision is pending.
But, …
A Legislative Foundation For Foundation Models, Steven Arango
A Legislative Foundation For Foundation Models, Steven Arango
Georgia State University Law Review
Artificial Intelligence (AI) is not some futuristic technology—it exists in everyday products like your Uber app or the Siri voice on your nightstand. Its development is meteoric; foundation models are the latest AI advancement. These models are a type of AI that not only produces a range of products but is also integrated into other AI models. This AI Swiss army knife is proving to be an incredible asset for economic development and national security. But, like other world- altering technology, there is a pernicious side of foundation models. Their flexibility offers adversaries, such as state and non-state actors, the …
Performance Optimization For Distributed Computing Via Gen Ai, Mingji Lou, Maksat Abasov, Fangfang Fu, Pragya Prakash, Venkata Siva Sai Manepalli
Performance Optimization For Distributed Computing Via Gen Ai, Mingji Lou, Maksat Abasov, Fangfang Fu, Pragya Prakash, Venkata Siva Sai Manepalli
Defensive Publications Series
Methods, systems, and computer program products for performance optimization of distributed computing resources using generative artificial intelligence (AI) are provided. An example method may include receiving data associated with performance metrics of a distributed computing system and data associated with a cost function for activities engaged in with the distributed computing system. The method may include providing, as an input to a generative AI algorithm, the data associated with performance metrics of the distributed computing system, the data associated with a cost function for activities engaged in with the distributed computing system, and data associated with a knowledge graph regarding …
We Are Our Brains: Disembodied Brain Films In 1950s Cold War America, David P. Pierson
We Are Our Brains: Disembodied Brain Films In 1950s Cold War America, David P. Pierson
Faculty, Staff, and Alumni Books
Personified Body Parts in Cinema, Literature, and Visual Culture investigates the power of personifying body parts in cinema, television, visual culture, literature, erotica, folklore, and mystique.
Culturally, socially, and poetically exposing hidden aspects and subtleties of human existentialism, this book vigorously questions and problematizes numerous artistic, aesthetic, technological, naïve, and macabre manipulations of body parts for various purposes. A diverse team of authors explore how scribing human traits to limbs, eyes, brains, genitalia, hearts, and other inner organs is grotesque and aesthetic, repealing and appealing, intimidating and intimate, rude and enjoyable, material and spiritual, surprising and mundane. Personified organs are …
Analyzing The Drivers Of Airline Profitability, Brady Noble
Analyzing The Drivers Of Airline Profitability, Brady Noble
Honors Theses
The commercial aviation industry, despite its transformative impact on global connection and economy, has historically struggled with consistent profitability. This thesis investigates the drivers of financial success within the airline industry, with a particular focus on the relationship between passenger load factors and profitability. Passenger load factors, defined as the percentage of available seats occupied by paying customers, have emerged as a key performance indicator, offering important insights into operational efficiency and revenue generation.
The study utilizes comprehensive data from the Bureau of Transportation Statistics, encompassing quarterly metrics on revenue, load factors, operating costs, and fuel prices from 2002 to …
Book Of Abstracts: 2025 Honors College Research Symposium, Honors College, North Carolina Agricultural And Technical State University
Book Of Abstracts: 2025 Honors College Research Symposium, Honors College, North Carolina Agricultural And Technical State University
2025 Honors College Research Symposium
This booklet contains the collection of research abstracts presented at the 2025 Honors College Research Symposium, held on April 17, 2025, at North Carolina Agricultural and Technical State University. The symposium highlights original undergraduate research across disciplines including science, engineering, humanities, health, education, business, and agriculture. The publication documents the scholarly contributions of Honors students through both oral and poster presentations.
Comparison Of The Effectiveness Of Different Scoring Systems And Biochemical Markers Indetermining The Severity And Complications Of Acute Pancreatitis, Ahmet Ali̇ Aktaş, Deni̇z Siğirli, Pinar Taşar, Sadik Ayhan Kiliçturgay
Comparison Of The Effectiveness Of Different Scoring Systems And Biochemical Markers Indetermining The Severity And Complications Of Acute Pancreatitis, Ahmet Ali̇ Aktaş, Deni̇z Siğirli, Pinar Taşar, Sadik Ayhan Kiliçturgay
Turkish Journal of Medical Sciences
Background and study aim: The aim of the study is to demonstrate the effectiveness of different scoring systems and inflammatorymarkers in predicting the severity, local complications, pancreatic necrosis, and mortality of acute pancreatitis (AP).
Materials and methods: The data of 357 patients whom the severity of pancreatitis was classified according to the Revised AtlantaClassification System diagnosed with AP were retrospectively examined. Also The APACHE II, BISAP, mCTSI, and Ranson scores ofall patients were calculated. After determining the cut-off values for scoring systems and inflammatory markers with ROC analysis,comparison for AP severity, local complication, necrosis, and mortality.
Results: In the study, …
Effect Of Police Corruption On Former Residents Of The Philippines Upon Their Return To Their Homeland, Larry Dean Doyle
Effect Of Police Corruption On Former Residents Of The Philippines Upon Their Return To Their Homeland, Larry Dean Doyle
Walden Dissertations and Doctoral Studies
Corruption in law enforcement is particularly heinous because it deprives the citizens living under the threat of police corruption of the rule of law and takes away the constitutional protections that are guaranteed and enforced by the courts. The purpose of this qualitative phenomenological study was to explore the perceptions of former residents of the Philippines regarding the effect of police corruption on them. Schultz’s behavioral theories and the reward neurophysiology provided this study's framework. Data were collected from twenty-four surveys of former residents of the Philippines when they visited their homeland. Findings indicated that former residents of the Philippines …
2025-04-17 Draft Of Hb 424, Morehead State University. Faculty Senate.
2025-04-17 Draft Of Hb 424, Morehead State University. Faculty Senate.
Faculty Senate Records
Unofficial copy of House Bill 424 submitted to the Faculty Senate on April 17, 2025.
Colloidal Control Via Micellar Solutions, Timothy F. Niper
Colloidal Control Via Micellar Solutions, Timothy F. Niper
Theses
Mesoscale colloids composed of polyoctahedral silsesquioxanes (POSS) are promising candidates for the self-assembly of hierarchical structures as a continuum of size and morphology can be readily synthesized. However, there are substantial challenges in creating customized colloids that exhibit specific structural features, programmable binding, and stimuli responsiveness. Here, we explore a novel route to gain structural and directable control of these colloids by pairing them with thermoresponsive, polymeric micelles. These polymeric micelles cannot only swell the interstices of oligomeric colloidal droplets with the accuracy provided by the well-defined polymer micellization transition, but also act as absorbable colloidal depletants—a new class of …
A Comparison Of Turp, Holep, And Rfa For Nonneurogenic Luts In Men, Turgay Ebi̇loğlu, Özgür Çinar, Selçuk Sarikaya, Adem Emrah Coğuplugi̇l, Bahadir Topuz, Cengi̇z Kara, Selahatti̇n Bedi̇r
A Comparison Of Turp, Holep, And Rfa For Nonneurogenic Luts In Men, Turgay Ebi̇loğlu, Özgür Çinar, Selçuk Sarikaya, Adem Emrah Coğuplugi̇l, Bahadir Topuz, Cengi̇z Kara, Selahatti̇n Bedi̇r
Turkish Journal of Medical Sciences
Background/aim: The effect of transurethral resection of the prostate (TURP) for nonneurogenic male lower urinary tract symptoms (LUTS) is well known. However, recent advancements have come into use, so studies have been done to compare these new techniques to the gold standard TURP technique. The aim of this study was to compare the results of TURP, holmium laser enucleation of the prostate (HoLEP), and radiofrequency ablation (RFA) in men.
Materials and methods: The patients who had the TURP procedure were defined as group 1 (G1), those who had HoLEP were in group 2 (G2), and those who had RFA were …
Validity, Reliability, And Norming Of The Novel Psychodynamic Diagnostic Inventory Of Personality Organization, Andrew L. Candreva
Validity, Reliability, And Norming Of The Novel Psychodynamic Diagnostic Inventory Of Personality Organization, Andrew L. Candreva
Doctor of Psychology (PsyD)
The purpose of this study was to develop a psychometrically sound self-report personality assessment derived from the Psychodynamic Diagnostic Manual’s (PDM-2) diagnostic framework of personality organization. This assessment, the Psychodynamic Diagnostic Inventory of Personality Organization (PDIPO), was developed from the longstanding history of psychodynamic personality theory. The PDIPO provides a comprehensive evaluation of how clients perceive their own level of personality organization, defined as a continuum from healthy to disturbed or impaired personality functioning. The PDIPO was normed on a representative sample of adults (ages 20–70) in the United States through an online participant recruitment service, Prolific. The 78 items …
Faith-Based Charter Schools And The Establishment Clause: Like The Pig With Wings, They Look Good On Paper, But Can Or Should They Get Off Of The Ground?, Charles J. Russo
Faith-Based Charter Schools And The Establishment Clause: Like The Pig With Wings, They Look Good On Paper, But Can Or Should They Get Off Of The Ground?, Charles J. Russo
Louisiana Law Review
No abstract provided.
Wmu Board Of Trustees Formal Session Thursday April 17, 2025, Wmu Board Of Trustees
Wmu Board Of Trustees Formal Session Thursday April 17, 2025, Wmu Board Of Trustees
WMU Board of Trustees Meetings
Acceptance of the Agenda
Approval of the Minutes (February 6, 2025)
Recognition of President Ed Montgomery
Remarks by the Chair of the Board
Remarks by the President
Updates by the Faculty Senate President
Updates by the Western Student Association President
Updates by the Graduate Student Association President
International Congress on Medieval Studies and Experiential Learning
Public Comments Regarding Action Items
Action Items
- Naming the New Valley Residence Hall “Golden Oaks” at “The Valleys”
Consent Item
- Personnel Report
- Curriculum Proposals
- Sale of BTR Parcel (Unit 30)
- Liquor Licenses – Multiple Events (July 10, 2025, August 7, 2025, November 7, 2025)
- Annuity …
Understanding Dialogic Interactions In Online Religious Education, Isaac Munoz Moreno
Understanding Dialogic Interactions In Online Religious Education, Isaac Munoz Moreno
Theses and Dissertations
In this study, I explored how Latter-day Saint higher education professors experienced and facilitated dialogic interactions in online religion courses. Seven instructors who taught synchronous and asynchronous virtual courses at Brigham Young University participated in semi-structured interviews focused on their pedagogical approaches, relational practices, and perceptions of student engagement. Guided by hermeneutic phenomenology and drawing on principles of dialogic pedagogy, I explored how religion instructors cultivated dialogue in virtual classrooms grounded in doctrinal instruction. The findings revealed how professors created a relational presence, navigated institutional constraints, and fostered deep learning and spiritual growth environments. While some participants viewed online dialogue …
Treatments For Opioid Use Disorder: Perspectives Of Patients In Long-Term Recovery, Robert Florian
Treatments For Opioid Use Disorder: Perspectives Of Patients In Long-Term Recovery, Robert Florian
Walden Dissertations and Doctoral Studies
The contemporary landscape of substance use disorders, particularly opioid use disorder, presents a complex and pressing public health concern, marked by escalating rates of mortality and morbidity worldwide. Although extensive research has been conducted on the efficacy of interventions for opioid use disorder, a notable research gap exists concerning the perspectives of individuals in long-term recovery (defined as exceeding 2 years). Specifically, how these individuals view pharmacological and non-pharmacological treatment approaches remains largely unexplored in the existing literature. Grounded in the biopsychosocial model, this study investigates patients’ perceptions of medication-assisted treatment and abstinence-based therapies. Purposive sampling was utilized, and participants …
Benzyl Alcohol Improves Ang Ii-Induced Vascular And Renal Injury, Qi Hua, Zhenyu Gu
Benzyl Alcohol Improves Ang Ii-Induced Vascular And Renal Injury, Qi Hua, Zhenyu Gu
Turkish Journal of Medical Sciences
Background/aim: The etiology of hypertension in pediatric populations is complex and multifactorial, with metabolic abnormalitiesplaying a fundamental role in the pathogenesis of the condition. This study investigates the therapeutic effects of Benzyl alcohol (BA),identified through metabolomics analysis of pediatric hypertension serum, on Angiotensin II (Ang II)-induced vascular and renalinjury in murine models.
Materials and methods: Male C57BL/6 mice were used to establish a vascular remodeling model by continuous 4-week Ang II infusionusing a subcutaneous osmotic pump. Bioinformatics was used to identify target metabolites. The tail artery, common carotid arterydiastolic, and systolic pressures in mice were determined with a blood pressure …
Vigilante Justice Violence In Ghana: Does A Visible Police Force Reduce Support For Instant Justice?, John Ampomah
Vigilante Justice Violence In Ghana: Does A Visible Police Force Reduce Support For Instant Justice?, John Ampomah
Theses
Vigilante justice remains a persistent issue in Ghana, with a significant portion of Ghanaians subscribing to it to address their grievances. While existing research has examined the social and cultural drivers of vigilante justice in Ghana, the role of visible police presence (i.e., police station and police patrol) on vigilante justice has received limited attention. This study seeks to add to the literature by exploring the relationship between visible police presence and support for vigilante justice by drawing on Black’s (1983) Self-Help Theory. First, I argue that a visible police force directly reduces public support for vigilante justice and indirectly …
Lipid Dysregulation In Sebaceous Gland Disorders And The Impact Of Sphingolipid Metabolism On Acne Pathogenesis, Kaitlyn Miner, Ryan Murphy, Samantha Steiss, Mckenzie Burian, Hannah Welp, Alexandra Loperfito, Ashley O'Malley, Radhika Misra, Kelly Frasier
Lipid Dysregulation In Sebaceous Gland Disorders And The Impact Of Sphingolipid Metabolism On Acne Pathogenesis, Kaitlyn Miner, Ryan Murphy, Samantha Steiss, Mckenzie Burian, Hannah Welp, Alexandra Loperfito, Ashley O'Malley, Radhika Misra, Kelly Frasier
Student Publications
Lipid dysregulation within sebaceous glands is a critical factor underlying the pathogenesis of sebaceous gland disorders, particularly acne vulgaris. Sebaceous glands synthesize and secrete a complex mixture of lipids, including triglycerides, wax esters, free fatty acids, and sphingolipids, which contribute to skin barrier function and microbial homeostasis. Dysregulated lipid production, characterized by increased sebum secretion and altered lipid composition, has been implicated in promoting Cutibacterium acnes proliferation, hyperkeratinization, and inflammation, key processes in acne pathogenesis. Recent research highlights the pivotal role of sphingolipid metabolism, particularly ceramides, in modulating sebaceous gland activity and skin inflammation. Ceramide deficiencies in acne-prone skin contribute …
Senescent Cancer-Associated Fibroblasts Mediate Immunosuppression And Promote Breast Cancer Progression, Jiayu Ye
Arts & Sciences Graduate Student Theses and Dissertations
Breast cancer is the most frequently diagnosed cancer among women worldwide, and aging is the largest risk factor for breast cancer development. The process of aging is typically accompanied by a progressive accumulation of senescent cells, which are characterized by a series of markers such as p16INKA4 (p16) positivity and a distinctive profile of secretory factors including mitogens, cytokines, and extracellular matrix (ECM) proteins that are collectively recognized as senescence-associated secretory phenotype (SASP). Numerous data so far have shown that senescent stromal cells play critical roles in modulating tumor microenvironment and progression. For example, senescent fibroblasts induced in vitro could …
Sunset Park Lp V. Roberts
All Decisions
In this nuisance holdover proceeding, the landlord alleged two isolated incidents involving the tenant's guests "one in October 2023 involving a guest who banged on the apartment door, and one in February 2024 involving a verbal dispute in the lobby. The tenant moved to dismiss under CPLR § 3211(a)(7), arguing that the termination notice failed to state a cause of action for nuisance under Rent Stabilization Code § 2524.3(b). The court agreed, citing the settled principle that nuisance requires a pattern of recurring objectionable conduct. It found that the two incidents, months apart and involving guests rather than the tenant, …
Spectator 2025-04-17, Editors Of The Spectator
April 17, 2025, The Daily Mississippian
April 17, 2025, The Daily Mississippian
Daily Mississippian (all digitized issues)
No abstract provided.
Montana Kaimin, April 17, 2025, Students Of The University Of Montana, Missoula
Montana Kaimin, April 17, 2025, Students Of The University Of Montana, Missoula
Montana Kaimin, 1898-present
Student newspaper of the University of Montana, Missoula.
Novel Therapeutics For Myeloid Malignancies, Tim Kong
Novel Therapeutics For Myeloid Malignancies, Tim Kong
Arts & Sciences Graduate Student Theses and Dissertations
Myeloid malignancies are a group of heterogenous and clonal disorders that include myeloproliferative neoplasms (MPNs) and acute myeloid leukemia (AML). These blood cancers are driven by characteristic oncogenes and propagated by pro-inflammatory niches; MPNs demonstrate hyperactive JAK-STAT signaling and upregulate cytokines including TNF, IL-6, and IL-8. Current therapeutics such as ruxolitinib targeting JAK2 providing symptomatic benefit to MPN patients but are not curative and do not prevent disease transformation to acute myeloid leukemia (AML). As such, greater understanding of the underlying disease biology is still required with means of uncover cancer dependencies. Here, we utilize a series of multi-omic approaches …
A Nuclear Rna Degradation Code Is Recognized By Paxt For Eukaryotic Transcriptome Surveillance, Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela M Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li, Yongsheng Shi
A Nuclear Rna Degradation Code Is Recognized By Paxt For Eukaryotic Transcriptome Surveillance, Lindsey V Soles, Liang Liu, Xudong Zou, Yoseop Yoon, Shuangyu Li, Lusong Tian, Marielle Valdez, Angela M Yu, Hong Yin, Wei Li, Fangyuan Ding, Georg Seelig, Lei Li, Yongsheng Shi
Faculty, Staff and Students Publications
The RNA exosome plays critical roles in eukaryotic RNA degradation, but how it specifically recognizes its targets remains unclear. The poly(A) tail exosome targeting (PAXT) connection is a nuclear adaptor that recruits the exosome to polyadenylated RNAs, especially transcripts polyadenylated at intronic poly(A) sites. Here, we show that PAXT-mediated RNA degradation is induced by the combination of a 5' splice site (ss) and a poly(A) junction (PAJ) but not by either sequence alone. These sequences are bound by U1 small nuclear ribonucleoprotein particle (snRNP) and cleavage/polyadenylation factors, which, in turn, cooperatively recruit PAXT. As the 5' ss-PAJ combination is typically …
Age-Related Meningeal Extracellular Matrix Remodeling Compromises Cns Lymphatic Function, Kate Hitpass Romero, Taylor J Stevenson, Leon C D Smyth, Ben Watkin, Samuel J C Mccullough, Luca Vinnell, Amy M Smith, Patrick Schweder, Jason A Correia, Jonathan Kipnis, Mike Dragunow, Justin Rustenhoven
Age-Related Meningeal Extracellular Matrix Remodeling Compromises Cns Lymphatic Function, Kate Hitpass Romero, Taylor J Stevenson, Leon C D Smyth, Ben Watkin, Samuel J C Mccullough, Luca Vinnell, Amy M Smith, Patrick Schweder, Jason A Correia, Jonathan Kipnis, Mike Dragunow, Justin Rustenhoven
2020-Current year OA Pubs
Efficient clearance of central nervous system (CNS) waste proteins and appropriate immune surveillance is essential for brain health. These processes are facilitated by lymphatic networks present in the meninges that drain cerebrospinal fluid (CSF). Age-related impairments to meningeal lymphatic drainage contribute to CNS waste accumulation and immune dysfunction, yet the underlying mechanisms remain poorly understood. Here, we identify extracellular matrix (ECM) remodeling in the aged dura as a key driver of CSF clearance deficits, demonstrating that peri-lymphatic collagen accumulation disrupts lymphatic function. Exploring immune-derived factors contributing to this ECM remodeling, we identify transforming growth factor beta 1 (TGFβ1) as a …