Digital Commons Network^™

Alzheimer’S Disease Protective Allele Of Clusterin Modulates Neuronal Excitability Through Lipid-Droplet-Mediated Neuron-Glia Communication, Xiaojie Zhao, Yan Li, Siwei Zhang, Ari Sudwarts, Hanwen Zhang, Alena Kozlova, Matthew J Moulton, Lindsey D Goodman, Zhiping P Pang, Alan R Sanders, Hugo J Bellen, Gopal Thinakaran, Jubao Duan

Duncan NRI Faculty and Staff Publications

Background: Genome-wide association studies (GWAS) of Alzheimer's disease (AD) have identified a plethora of risk loci. However, the disease variants/genes and the underlying mechanisms have not been extensively studied.

Methods: Bulk ATAC-seq was performed in induced pluripotent stem cells (iPSCs) differentiated various brain cell types to identify allele-specific open chromatin (ASoC) SNPs. CRISPR-Cas9 editing generated isogenic pairs, which were then differentiated into glutamatergic neurons (iGlut). Transcriptomic analysis and functional studies of iGlut co-cultured with mouse astrocytes assessed neuronal excitability and lipid droplet formation.

Results: We identified a putative causal SNP of CLU that impacted neuronal chromatin accessibility to transcription-factor(s), with …

Variant Minds: Designing For Neurodiversity In Office Spaces, Maya Schiltz

Bachelor of Architecture Theses - 5th Year

By recognizing and accommodating the natural diversity in human cognition, neurodiversity, Variant Minds proposes an inclusive office design strategy that supports both neurotypical and neurodivergent individuals alike.

Originally used in reference to Autism, the term “neurodiversity” now encompasses a broader range of conditions, including ADHD, dyslexia, dyspraxia, Alzheimer’s, depression, epilepsy, bipolar disorder, and Tourette’s syndrome. With an estimated 1 in 5 of the global population being neurodivergent, designing for inclusivity is both a moral imperative and a strategic advantage. Neurodiverse individuals bring unique strengths to the workplace, such as innovative thinking, strong pattern recognition, and heightened attention to detail. Studies …

A Multi-Modal Intervention To Improve Identification, Management, And Prevention Of Early Childhood Caries In The Primary Care Setting, Rieley M. Hull

Evidence-Based Practice Project Reports

Early childhood caries (ECC) is the most prevalent chronic childhood disease and, if untreated, can lead to significant long-term health and social consequences, posing a substantial healthcare burden (AAPD, 2023; ADA, 2023; USPSTF, 2021; WHO, 2022). This evidence-based practice (EBP) project aimed to implement a multi-modal intervention to reduce ECC risk factors, prevent new dental caries, and halt the progression of existing dental caries. Conducted in a pediatric primary care setting in West Michigan, the project included patients five and under who received an oral examination and dental caries risk assessment following the AAP’s guidelines. Based on their oral health …

The Model Minority Victim, Chiu, Elaine M.

Santa Clara Law Review

The rise in xenophobia, hate and violence against AAPI Americans inspired by the COVID-19 pandemic was an opportunity to assess the effectiveness of the criminal legal system as a tool of anti-racism. This Article traces the legal aftermath when Asian New Yorkers reported 276 possible hate crimes to the police in 2021. The analysis takes an empirical approach and a narrative approach. It relies on a unique database that followed what happened to civilian complaints of anti- Asian crimes from beginning to end. Using metrics such as arrest rates and conviction rates, the Article draws initial conclusions about the systemic …

Leading Elca Lutheran Colleges And Universities: Lutheranism, Purpose, And Alignment, Ian K. Mcmichael

Doctorate in Education

The colleges and universities affiliated with the Evangelical Lutheran Church in America (ELCA) occupy a unique space within the higher education market. To varying degrees, each school currently professes to be a school of the “third path” between sectarian dogmatism and secular relativism. However, the mission of these schools has shifted dramatically since their founding and whether there is anything markedly different between them and secular liberal arts schools remains an open question. While research has addressed mission, values, and purpose in this context, what has not been extensively explored previously is the role the leaders of these institutions play …

Doctor Of Medicine Commencement: May 3, 2025, University Of North Dakota

UND Commencement Programs

UND Doctor of Medicine Commencement program from May 3, 2025.

Your Data, Modern Times, And The Fourth Amendment: What Would Jefferson And Orwell Do?, Sterling, Ken

Santa Clara High Technology Law Journal

The ongoing challenge of balancing individual data privacy with the government's need for user data through national security efforts has long plagued courts and policymakers. This tension intensifies as technology advances, permeating daily life, and global uncertainty fuels government demand for additional data. This study explores this tension by examining the Fourth Amendment's protection against unreasonable searches and seizures in the context of user data obtained by the government through third-party providers. I argue that the Fourth Amendment provides a sufficient framework to balance these competing interests. While acknowledging the government's responsibility for national security, we contend that this does …

Site U1309, A. M. Mccaig, S. Q. Lang, P. Blum, N. Abe, W. Brazelton, R. Coltat, J. R. Deans, K. L. Dickerson, M. Godard, B. E. John, F. Klein, R. Kuehn, K. Y. Lin, C. J. Lissenberg, H. Liu, E. L. Lopes, T. Nozaka, A. J. Parsons, V. Pathak, M. K. Reagan, J. A. Robare, I. P. Savov, E. Schwarzenbach, O. J. Sissmann, G. Southam, F. Wang, C. G. Wheat

School of Geography, Earth and Environmental Sciences

No abstract provided.

Expedition 399 Methods, S. Q. Lang, A. M. Mccaig, P. Blum, N. Abe, W. Brazelton, R. Coltat, J. R. Deans, K. L. Dickerson, M. Godard, B. E. John, F. Klein, R. Kuehn, K. Y. Lin, C. J. Lissenberg, H. Liu, E. L. Lopes, T. Nozaka, A. J. Parsons, V. Pathak, M. K. Reagan, J. A. Robare, I. P. Savov, E. Schwarzenbach, O. J. Sissmann, G. Southam, F. Wang, C. G. Wheat

School of Geography, Earth and Environmental Sciences

No abstract provided.

Healthcare Leadership In Western Societies: Religion, Politics, And Rhetoric, Nelly D. Figueroa-Herrera

Pepperdine Journal of Communication Research

No abstract provided.

Why Fair Elections Get Fouled In Lesotho: A Search For Solutions, Richard F. Weisfelder

Journal of African Policy Studies

No abstract provided.

Mass Media, Civil Society And Democratization Of Politics In Botswana, James J. Zaffiro

Journal of African Policy Studies

No abstract provided.

Elections As A Cornerstone Of Democracy The Namibian Experience, Heribert Weiland

Journal of African Policy Studies

No abstract provided.

Electoral Manipulation In A Neo-Authoritarian Regime: The Case Of Zimbabwe, Daniel Compagnon

Journal of African Policy Studies

No abstract provided.

Democratic Consolidation And The ‘Normalization’ Of Politics Political Parties In South Africa’S 1999 Elections, David Pottie

Journal of African Policy Studies

No abstract provided.

Democracy Without A Credible Opposition: The Case Of Botswana, Staffon Darnolf, John D. Holm

Journal of African Policy Studies

No abstract provided.

Introduction, William Lindeke

Journal of African Policy Studies

No abstract provided.

The Current Neo-Isolationism In United States African Policy, Richard A. Fredland

Journal of African Policy Studies

No abstract provided.

The Political Economy Of The Public Sector And Privatization In Liberia, James S. Guseh

Journal of African Policy Studies

No abstract provided.

Policy Management In Africa’S Democracies, Michael Bratton, Harry Garnett, Julie Koenen-Grant, Catherine Rielly

Journal of African Policy Studies

No abstract provided.

Government In Nigeria: The Criminalization Of A Nation, Nonso Okeafoezeke

Journal of African Policy Studies

No abstract provided.

Colonial Heritage And Language Identity In Africa, Raymond Mopoho

Journal of African Policy Studies

No abstract provided.

Structural Adjustment Programs (Saps) In Ghana: Interrogating Pndc’S Implementation, Kwame Boafo-Arthur

Journal of African Policy Studies

No abstract provided.

Book Reviews, Gloria I. Chuku

Journal of African Policy Studies

No abstract provided.

Public Policy And The New Patterns Of Governance For Industrial Change In Nigeria, Robert Dibie

Journal of African Policy Studies

No abstract provided.

National Identity, Democracy, And The Politics Of Language In Malawi And Tanzania, Sam A. Mchombo

Journal of African Policy Studies

No abstract provided.

The Clinton Administration And Humanitarian Intervention In Africa, Earl Conteh-Morgan

Journal of African Policy Studies

No abstract provided.

Land Inheritance And Subdivision In Kenya: A Policy Dilemma, Nyaga Mwaniki

Journal of African Policy Studies

No abstract provided.

Book Reviews, Apollos O. Nwauwa

Journal of African Policy Studies

No abstract provided.

Entrepreneurship As An Outcome Of Economic Hardship Policy In Nigeria, Robert Dibie, Patrick Okonkwo

Journal of African Policy Studies

No abstract provided.