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Economic Development In Cartersville, Ms: A Case Study Of A Non-Profit Organization's Community Development Projects, Mckenzie B. Perkins

Honors Theses

The Mississippi Delta Region has long faced significant economic, educational, and health challenges and a steady population decline since the 1940s. In response, community development projects have emerged as powerful tools to promote health, well-being, and social mobility. This thesis investigates the impact of community development initiatives in Cartersville, MS, focusing on the dental clinic, educational programs, and the economic development center established by a non-profit organization. Through the lens of community development theories, the research explores how community leadership, particularly partnerships between EverHope Ministries and Cartersville leaders, is pivotal in addressing health disparities in historically marginalized populations. By engaging …

A Local Assessment Of Glp-1 Use For Weight Loss: An Interview Study, Maci Bradley

Honors Theses

Glucagon-like peptide-1 (GLP-1) receptor agonists are a novel class of medications used primarily for the treatment of type 2 diabetes, as well as for chronic weight management. The first GLP-1 medication, exenatide, was FDA-approved in April of 2005 for glycemic control, however, it was not until December of 2014 when liraglutide became the first GLP-1 FDA-approved for weight loss. There are now eight FDA-approved GLP-1s, only two of which are approved for weight loss. GLP-1 use has become increasingly popular in recent years, even extending to the college-aged population. The purpose of this study is to examine the trends in …

Police Questioning In Hospitals: Custodial Interrogation Or Not?, Jessica Wisowaty

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

An Analysis Of The Armorettes’ Mission To Help The Atlanta Lgbtq+ Community, Edwin Hernandez

Master's Theses

The Armorettes are a self-proclaimed camp drag troupe that have been performing in the Atlanta drag scene since 1979. First formed as a cheer group for a softball team associated with The Armory, a well known gay bar at the time, they quickly added drag performance and charity work to their name. The group came to be as the HIV/AIDS epidemic began affecting Atlanta. Atlanta was hit hard by the disease. Several comorbid factors contributed to the disproportionate numbers seen in the city beginning in the 1980s. They quickly took on the mission of raising money for charities and organizations …

Have Modern Total Knee Arthroplasty Implant Improvements Affected Revision Rates? A Registry Review Of Modern Implants And Their Predecessors, Alan D. Lam, John Hobbs, Nihir Parikh, David Pipa, Arjun Saxena, Andrew Star

Student Publications

Introduction

Total knee arthroplasty (TKA) is a common orthopaedic procedure used to alleviate pain and restore mobility in patients with knee pain. Substantial resources are committed to updating and refining new knee implant designs to improve outcomes. The aim of this study was to compare revision rates and failure modes between newer implants and their older counterparts.

Methods

A systematic literature review of national registries was conducted to identify predecessor and successor implant designs from four manufacturers. Individual implant revision data points for each implant design across the registries were compared between generations by manufacturer. Reported revision rates of TKA …

Patterns Of Taxonomic, Functional, And Phylogenetic Diversity, And Ecological Drivers Of Stream Fish Assemblages In East Texas, Anastasia M. Umstott

Electronic Theses and Dissertations

Freshwater ecosystems in East Texas contain a rich freshwater biodiversity, with the Neches and Sabine River basins supporting some of the greatest freshwater fish diversity in the state. Given the heterogeneity of habitats and species diversity, these rivers serve as excellent natural systems for examining the ecological processes shaping biodiversity patterns and species distributions. In 2023-2024, 60 streams in the Neches and Sabine River basins were surveyed across three seasons to investigate the patterns and ecological drivers of taxonomic (TDβ), functional (FDβ), and phylogenetic β-diversity (PDβ) facets of freshwater fish assemblages. Additionally, I created two ecological niche models for a …

Disparities In Exposure To Atmospheric Polycyclic Aromatic Hydrocarbons (Pahs) And Their Contributions To Breast Cancer Risks Among African American Women, Namuun Batbaatar

Electronic Theses and Dissertations Archive

Exposure to atmospheric polycyclic aromatic hydrocarbons (PAHs) presents a ubiquitous public health risk and is often disproportionately high in disadvantaged communities. Understanding is still limited regarding the sources, disparities, and health effects of PAH exposures. This dissertation consists of three studies that address these knowledge gaps. The first study aimed to quantify the contributions of multiple exposure pathways to PAH-related cancer risks. Concentrations of PAHs in soil and air were measured in Memphis, TN, from 2016 to 2019. The cumulative cancer risk was 0.423×10-6 among children, with 75% from ingestion. For adults, the risk was 0.546×10-6, predominantly from dermal contact …

Between Classic Social Contract Theory And Hegelian State: A Case For Freedom’S Broader Conception, Gerald Chibueze Azike

Electronic Theses and Dissertations Archive

The classic social contract theorized by Hobbes, Rousseau, and Locke advocates for establishing the state based on individual freedom; for them, a contractual agreement rather than nature serves as the foundation for the state. In his Philosophy of Rights, Hegel rejects this classic view of the social contract, which sees freedom and consent as the basis of the state. While the perspectives of the classic social contract and Hegel yield differing interpretations of freedom, the dissertation explores their relationship against contemporary challenges to freedom. It investigates the extent to which the classic social contract' s conception of subjective freedom, which …

Pan-Cancer Universal Targets For Immunotherapy Resulted From Transposable Elements Activation, Yonghao Liang

Arts & Sciences Graduate Student Theses and Dissertations

Transposable elements (TEs) contribute to nearly half of the human genome yet have been overlooked in genomic medicines due to the stereotypic impression as “junk DNA” and technical challenges. However, studies in the last two decades demonstrated that dysregulation of the epigenome in cancer cells resurrects the cis-regulatory functions of TEs, including the promoter activities. The tumor-specific TE activation events along with the resulting tumor-specific RNA and protein molecules, provide a potential “gold mine” for identifying tumor-specific therapeutic targets for cancer treatments, including immunotherapy. Here, I present a series of works to investigate the potential of providing actionable, pan-cancer, and …

Reverse Engineering Of Binary Programs Using Graph Attention Networks, Sai Nikhila Kanigiri

Master's Theses

Understanding the functionality and behavior of binary code is essential for many software engineering tasks, including malware analysis, vulnerability detection, and program optimization. However, automating this process is challenging due to the complexity of machine code and the significant manual effort required from experienced software engineers. In this paper, we present BinGAT (Reverse Engineering of Binary Programs using Graph Attention Networks), a method for classifying binary programs into algorithmic categories using Graph Attention Neural Networks (GNNs) based on their Control-Flow Graphs (CFGs). Given a binary program, BinGAT extracts its CFG through static analysis and transforms the assembly instructions within each …

A Subset Of Senescent Myofibroblasts Orchestrates Immunosuppression In Pancreatic Cancer., Jad Belle

Arts & Sciences Graduate Student Theses and Dissertations

Pancreatic Ductal Adenocarcinoma (PDAC) is the most lethal solid malignancy with a 12% 5-year survival rate. Most tumors are detected at metastatic stages that are extremely resistant to therapy. PDAC recalcitrance is driven by a unique tumor microenvironment (TME) comprising dense collagenous fibrosis embedded with an abundance of cancer associated fibroblasts (CAFs) and infiltrating leukocytes. Preclinical studies have indicated that PDAC CAFs can have both pro- and anti-tumorigenic effects. This is likely owed to CAF phenotypic heterogeneity which was recently uncovered by single cell transcriptomics. Three major CAF subpopulations have been identified in mouse and human PDAC thus far: myofibroblastic …

Disrupting Nrf2-Driven Cancer Biology Through One-Carbon Metabolism Inhibition, Julius Chembo

Arts & Sciences Graduate Student Theses and Dissertations

Cancer remains a leading cause of mortality worldwide, with treatment resistance and recurrence posing major barriers to long-term survival. Despite advancements in targeted therapies, many cancers develop resistance to chemotherapy, radiation, and immunotherapy, significantly limiting their effectiveness. One key driver of therapeutic resistance is nuclear factor erythroid 2-related factor 2 (NFE2L2/NRF2), a transcription factor that regulates antioxidant responses and drug detoxification. While NRF2 protects normal cells from oxidative stress, its aberrant activation in cancer promotes tumor progression, metabolic reprogramming, and resistance to standard treatments. Alarmingly, NRF2 hyperactivation is implicated in some of the most aggressive and refractory malignancies, yet no …

Induced Cd8a Identifies Enhanced Human Nk Cell Il-15-Induced Proliferation And Metabolism And Modulates Nk Cell Activation, Celia Cubitt

Arts & Sciences Graduate Student Theses and Dissertations

Natural Killer (NK) cells are cytotoxic innate lymphoid cells that play an important role in the surveillance and elimination of virally-infected and malignantly-transformed cells. These primary effector functions are achieved by producing cytokines and chemokines which activate and recruit additional immune effectors, as well as direct cytotoxic killing via perforin and granzymes. NK cell function is tightly regulated by a balance of germ-line encoded activating, inhibitory, co-stimulatory, and cytokine receptors expressed at the cell surface. Through these activating and inhibitory receptors, NK cells recognize and kill targets without prior sensitization through the loss of self-identifying molecules such as major histocompatibility …

Mechanisms Of Mll-Rearranged Infant Leukemogenesis, Jonny Mendoza-Castrejon

Arts & Sciences Graduate Student Theses and Dissertations

Infant leukemias arise as either B cell acute lymphoblastic leukemia (B-ALL) or acute myeloid leukemia (AML) and are primarily driven by MLL/KMT2A-rearrangements (MLLr). Prior work has shown that MLLr transform fetal/neonatal hematopoietic progenitors more efficiently than adult progenitors. However, the genetics and epidemiology of MLLr leukemias present an important paradox. MLLr arise during late gestation under conditions that would seemingly favor leukemic transformation (i.e., fetal/neonatal progenitors have high proliferation rates and self-renewal). Furthermore, MLLr infant leukemias require very few cooperating mutations for transformation. Yet congenital leukemias are 10-fold less common than infant leukemias and >100-fold less common than childhood leukemias …

Oxycodone Self-Administration Modulates Ventral Pallidal Neuron Activity And Plasticity, Jessica Tooley

Arts & Sciences Graduate Student Theses and Dissertations

Opioid use disorder is an urgent public health crisis in the United States. Over 800,000 Americans have died from opioid-related overdoses since 2000. Nearly 30% of people who misuse opioids begin with prescription oral opioids, such as oxycodone, and continue misusing to avoid the immediate aversive state of withdrawal and the persistent dysphoria associated with protracted abstinence from opioids. The persistency of these dysphoric symptoms increases the risk of relapse even after long periods of abstinence. Treatment for opioid use disorder currently consists of pharmacological opioid treatment to reduce withdrawal symptoms and behavioral counseling. However, these strategies have significant real-world …

Parapinopsin: A Photoswitchable Inhibitory Gpcr For Two-Photon Optogenetics, Bobbie J. Brown

Arts & Sciences Graduate Student Theses and Dissertations

The development of optogenetic tools has greatly advanced the capability of researchers to understand the connection between neuronal activity and behavior. Optogenetics makes use of opsins, which are light activated ion-channels, ion pumps, or G-Protein coupled receptor (GPCR-based) proteins used to regulate cellular activity. Coupled with technological advances in genetics and optical physics/microscopy, optogenetics can be used to control specific populations of cells in a time-locked, spatially specific manner. The experiments possible with optogenetics depend largely on the capabilities and limitations of the opsin used; thus, there have been continuous efforts to design and employ new opsins with a variety …

African American Men’S Perception Of Fear Of A Deadly Encounter With Police During Traffic Stops In Detroit, Delshawn King

Walden Dissertations and Doctoral Studies

This qualitative, phenomenological study is an examination of the fear of deadly encounters during traffic stops as experienced by seven African American men in Detroit. This fear is rooted in the historical context of slavery, where laws permitted the use of force to control African Americans. Using the critical race theory framework, the impact of traffic stops on African American men was explored, including how these encounters contribute to fear, psychological distress, and potential escalation of violence in interactions with law enforcement. The study shows that the fear of police encounters significantly impacts the psychological well-being, trust, and security of …

Developing Organizational Leaders’ Personal Mastery Through Emotional Intelligence Training In The Workplace: An Interpretive Phenomenological Analysis, Billie Bruce Relyea

Walden Dissertations and Doctoral Studies

Mayer and Salovey, seminal researchers of emotional intelligence (EI), indicated that the ability measures of EI are still evolving, and the mental abilities involved in EI remain to be determined. Organizational leaders should understand this intention as the key to developing EI and personal mastery, resting firmly upon attaining accurate self-awareness as a prerequisite for human behavior. The purpose of this interpretive phenomenological analysis was to gain an understanding of the socially constructed realities of the lived experiences of organizational leaders and organizational development specialists who have completed Ennea International’s 5 Lens Development Platform (5LDP). Bandura’s social cognitive theory grounded …

Discovery Of Novel, Potent, And Orally Bioavailable Smarca2 Proteolysis-Targeting Chimeras With Synergistic Antitumor Activity In Combination With Kirsten Rat Sarcoma Viral Oncogene Homologue G12c Inhibitors, Sasikumar Kotagiri, Yawen Wang, Yanyan Han, Xiaobing Liang, Nicholas Blazanin, Manu Sebastian, Yongying Jiang, Yonathan Lissanu

Faculty, Staff and Student Publications

Cancer genomic studies have identified frequent mutations in subunits of the SWI/SNF chromatin remodeling complex, including SMARCA4 in nonsmall cell lung cancer with a frequency of up to 33% in advanced-stage disease, making it the most frequently mutated complex. We and others have identified SMARCA2 to be synthetic lethal to SMARCA4, indicating that SMARCA2 is a high-value therapeutic target. Here, we disclose the discovery and characterization of potent, selective, and orally bioavailable cereblon-based SMARCA2 PROTACs. Biochemically, we showed that YDR1 and YD54 are potent SMARCA2 degraders. Further, we showed the antitumor growth inhibitory activity of YDR1 and YD54 in SMARCA4 …

Metabolic Reprogramming Driven By Ant2 Deficiency Augments T Cell Function And Anti-Tumor Immunity In Mice, Omri Yosef, Leonor Cohen-Daniel, Oded Shamriz, Zahala Bar-On, Wajeeh Salaymeh, Ifat Abramovich, Veronika Lutz, Joseph Tam, Anna Permyakova, Eyal Gottlieb, Magdalena Huber, Michael Berger

Faculty, Staff and Student Publications

T cell activation requires a substantial increase in NAD+ production, often exceeding the capacity of oxidative phosphorylation (OXPHOS). To investigate how T cells adapt to this metabolic challenge, we generate T cell-specific ADP/ATP translocase-2 knockout (Ant2-/-) mice. Loss of Ant2, a crucial protein mediating ADP/ATP exchange between mitochondria and cytoplasm, induces OXPHOS restriction by limiting ATP synthase activity, thereby impeding NAD+ regeneration. Interestingly, Ant2-/- naïve T cells exhibit enhanced activation, proliferation and effector functions compared to wild-type controls. Metabolic profiling reveals that these T cells adopt an activated-like metabolic program with increased mitobiogenesis and anabolism. Lastly, pharmacological inhibition of ANT …

"Significant Bodily Intrusions": Investigations Into Law Enforcement Phlebotomy, Anne Kathleen Johnson

Dissertations and Theses

This three-paper dissertation explores law enforcement phlebotomy, the ability of law enforcement officers to draw blood. Phlebotomy is both a ubiquitous, invasive diagnostic tool as well as a social site with complex relational dynamics at play between phlebotomist and patient. Through law enforcement phlebotomy, the blood draw is co-opted from the medical field into the policing field, and the normative framework through which it is used changes: whereas medical edicts instruct providers to work with patients through an ethics of care--respecting consent and refusal--policing is not similarly bound, instead operating through a prioritization of security and efficiency. In the articles …

Recent Trends In Medical Education To Sustain An Effective Practice - A Systematic Review, Sharon Pricilla Jeevan Kumar Leela Ms., Amtuz Zehra Dr, Ayesha Siddiqhha Mukthar Ms

International Journal of Health and Allied Sciences

Learning processes in medical practices in medicinal schools put more emphasis on the hard sciences than they do on developing soft skills like empathy and communication. For this reason, the medical humanities emerged to provide a "different" take on the creative process. Medical ethics, the doctor-patient relationship, clinical research, mental illness, and professionalism are just a few of the topics that have been utilized to discuss in medical school. A strong connection between classroom learning and clinical experience is crucial for medical school graduates. Students graduating from a medical program are expected to have experience with patient care, clinical procedures, …

Uncommon Controversy, David Getches

Maine Law Review

In the mid-nineteenth century the Indians of the Northwest were pressured by government agents into signing treaties ceding most of the land they had historically occupied to the United States. In each treaty, besides reserving small tracts of land for themselves, the Indians specifically reserved the right to fish "at all usual and accustomed grounds and stations." Because the lands which the Indians were permitted to reserve were selected so as "not to interfere with existing [non-Indian] claims, or with the progress of settlements," many traditional fishing places were located outside the reservations. The Indians' grudging acceptance of the treaties …

Wallace V. Coca-Cola Bottling Plants, Inc.: Defective Products, Expanded Liability, And The Demise Of The Impact Rule, Robert A. Whidden

Maine Law Review

During the last decade there has been a rapid change in the theories of recovery in cases involving defective products. A majority of jurisdictions has adopted strict products liability as a tort. Others still employ implied warranty, a device, apparently tort, borrowed from contract law. A minority still holds that a plaintiff must prove his claim in negligence. In a recent decision, Wallace v. Coca-Cola Bottling Plants, Inc., the Maine Supreme Judicial Court addressed the question of the extent of a manufacturer's liability for a defective product and the nature of the proof necessary to show a compensable injury. This …

Beaulieu V. Beaulieu: An Obituary For Lex Loci And An Approach To Interest Analysis, David C. Shonka

Maine Law Review

Clifford Beaulieu, a guest in his father's automobile, was injured when the vehicle struck a telephone pole in Massachusetts. Both parties were residents of Maine. The trip had originated in Maine and was to terminate there. The son filed an action against his father in the Maine Superior Court, alleging negligent operation of the vehicle. On an agreed statement of facts, the case was reported to the Maine Supreme Judicial Court where the defendant argued for dismissal of the action on the grounds that the doctrine of lex loci delictus, the law of the place of the tort, was applicable …

Extending The Smith V. Hooey Duty To The Holding Jurisdiction, Ronald D. Russell

Maine Law Review

The right to a speedy trial has been an integral part of the Anglo-American legal system since its foundation. The first statement of this guarantee seems to be in the codification of basic rights included in the Magna Charta. It was incorporated into the earliest laws of colonial America and later expressed in the sixth amendment to the Constitution. In Klopfer v. North Carolina, the United States Supreme Court stated, "The history of the right to a speedy trial and its reception in this country clearly establish that it is one of the most basic rights preserved by our Constitution." …

Bernier V. State - The Right To Counsel In Entrustment Revocation Proceedings, Peter J. Detroy

Maine Law Review

Theodore Bernier was adjudicated a juvenile offender in September, 1966, and was subsequently committed to the Boys Training Center (BTC) for the term of his minority. In February, 1968, he was released on entrustment to his parents. Almost a year and a half later, Bernier was questioned by local police regarding his possible involvement in the theft of greenstamps from a local store. Although he was released without the police taking further action, they notified an aftercare and placement worker assigned to the BTC of the questioning. As a result, the BTC revoked the entrustment, and the police took him …

Law Of Rebuttable Presumptions In Maine, Curtis L. Bourdon

Maine Law Review

In Hinds v. John Hancock Mut. Life Ins. Co., the Maine Supreme Judicial Court sought to clarify and simplify the law of rebuttable presumptions as to the quantum of evidence that must be introduced before a presumption is dispelled. The Maine court adopted a rule which states that a presumption is rebutted when the probability of the nonexistence of the presumed fact is as probable as its existence. Stated another way, a presumption is rebutted when the jurors' minds are placed in equilibrium. Ten years later, in State v. O'Clair, the court expressly incorporated the Hinds rule into criminal procedure. …

Constitutional Dilemmas Posed By State Policies Against Marine Pollution - The Maine Example, Daniel Wilkes

Maine Law Review

The physical fact about coastal pollution is that, since many of its harms are irreversible, it must be prevented and not just dealt with as it arises. The legal fact about coastal pollution is that legislation which aims to prevent pollutants must survive attacks under the due process, equal protection, commerce, and privileges and immunities clauses of the federal Constitution if we are not to lose entirely the enjoyment of our coastal waters. As the following discussion of the "Environmental Protection Package" passed by the First Special Session of the 104th Maine Legislature and the earlier Wetlands Act shows, judicial …

Conservation, Policy And The Role Of Counsel, David J. Halperin

Maine Law Review

The conservation interests in the State of Maine have been roused to a furor by the decision of Maine's highest court in State v. Johnson. The case, in substance, holds that Maine's Wetlands Act is unconstitutional when applied to prohibit the filling of a specific segment of salt water marsh. While both the decision and the underlying statute are of considerable substantive interest, the case deserves particular study for the light it sheds on the role of counsel in helping the legal process accommodate new policy concerns. A note of caution must, of course, be sounded before seeking to generalize …