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Articles 36331 - 36360 of 1195811
Full-Text Articles in Entire DC Network
Chatgpt’S Performance Evaluation In Spreadsheets Modeling To Inform Assessments Redesign, Michelle L. F. Cheong
Chatgpt’S Performance Evaluation In Spreadsheets Modeling To Inform Assessments Redesign, Michelle L. F. Cheong
Research Collection School Of Computing and Information Systems
Background: Increasingly, students are using ChatGPT to assist them in learning and even completing their assessments, raising concerns of academic integrity and loss of critical thinking skills. Many articles suggested educators to redesign assessments which are more “Generative-AI-resistant” and to focus on assessing students on higher order thinking skills. However, there is a lack of articles that attempt to quantify assessments at different cognitive levels to provide empirical study insights on ChatGPT’s performance at different levels, which will affect how educators redesign their assessments.Objectives: Educators need new information on how well ChatGPT performs to redesign future assessments to assess their …
On-Demand Scenario Generation For Testing Automated Driving Systems, Songyang Yan, Xiaodong Zhang, Kunkun Hao, Haojie Xin, Yonggang Luo, Jucheng Yang, Ming Fan, Chao Yang, Jun Sun, Zijiang Yang
On-Demand Scenario Generation For Testing Automated Driving Systems, Songyang Yan, Xiaodong Zhang, Kunkun Hao, Haojie Xin, Yonggang Luo, Jucheng Yang, Ming Fan, Chao Yang, Jun Sun, Zijiang Yang
Research Collection School Of Computing and Information Systems
The safety and reliability of Automated Driving Systems (ADS) are paramount, necessitating rigorous testing methodologies to uncover potential failures before deployment. Traditional testing approaches often prioritize either natural scenario sampling or safety-critical scenario generation, resulting in overly simplistic or unrealistic hazardous tests. In practice, the demand for natural scenarios (e.g., when evaluating the ADS's reliability in real-world conditions), critical scenarios (e.g., when evaluating safety in critical situations), or somewhere in between (e.g., when testing the ADS in regions with less civilized drivers) varies depending on the testing objectives. To address this issue, we propose the On-demand Scenario Generation (OSG) Framework, …
Large Language Model For Vulnerability Detection And Repair: Literature Review And The Road Ahead, Xin Zhou, Sicong Cao, Xiaobing Sun, David Lo
Large Language Model For Vulnerability Detection And Repair: Literature Review And The Road Ahead, Xin Zhou, Sicong Cao, Xiaobing Sun, David Lo
Research Collection School Of Computing and Information Systems
The significant advancements in Large Language Models (LLMs) have resulted in their widespread adoption across various tasks within Software Engineering (SE), including vulnerability detection and repair. Numerous studies have investigated the application of LLMs to enhance vulnerability detection and repair tasks. Despite the increasing research interest, there is currently no existing survey that focuses on the utilization of LLMs for vulnerability detection and repair. In this paper, we aim to bridge this gap by offering a systematic literature review of approaches aimed at improving vulnerability detection and repair through the utilization of LLMs. The review encompasses research work from leading …
Collaborative Tree Search For Enhancing Embodied Multi-Agent Collaboration, Lizheng Zu, Lin Lin, Song Fu, Na Zhao, Pan Zhou
Collaborative Tree Search For Enhancing Embodied Multi-Agent Collaboration, Lizheng Zu, Lin Lin, Song Fu, Na Zhao, Pan Zhou
Research Collection School Of Computing and Information Systems
Embodied agents based on large language models (LLMs) face significant challenges in collaborative tasks, requiring effective communication and reasonable division of labor to ensure efficient and correct task completion. Previous approaches with simple communication patterns carry erroneous or incoherent agent actions, which can lead to additional risks. To address these problems, we propose Cooperative Tree Search (CoTS), a framework designed to significantly improve collaborative planning and task execution efficiency among embodied agents. CoTS guides multi-agents to discuss long-term strategic plans within a modified Monte Carlo tree, searching along LLMdriven reward functions to provide a more thoughtful and promising approach to …
Through The Wire: Examining The Experiences Of Formerly Incarcerated Students In Prison Education Programs And The Wraparound Services Needed To Support Their Success, Isabel Castro
Dissertations
This qualitative study examines the experiences of formerly incarcerated individuals in Prison Education Programs (PEPs) and the wraparound services necessary to support their success. Through Schlossberg’s Transition Theory, this study explores how incarcerated students navigate educational transitions and how educators facilitate transformative learning. Using case study and narrative inquiry, interviews were conducted with fifteen formerly incarcerated PEP participants and seven educators.
Thematic analysis revealed six major themes: Access to Education in Carceral Settings, the Impact of Education on Incarcerated Individuals, Wraparound Services and Student Support, Experiences of Formerly Incarcerated Students, the Role of Educators and Program Facilitators, and Best Practices …
Evaluating Student Driver Knowledge And Behaviors Through A University Driver Education Safety Refresher Program, Jason Jackman, Audrey Everett, Kayleigh Murray, Leomar White
Evaluating Student Driver Knowledge And Behaviors Through A University Driver Education Safety Refresher Program, Jason Jackman, Audrey Everett, Kayleigh Murray, Leomar White
CUTR Internal Grant Research Program
This pilot program utilized an online survey to identify driver behaviors among students, faculty, and staff on the University of South Florida (USF) Tampa campus. Adopting a social marketing approach, the program focused on identifying and addressing driver safety issues and behaviors. The research aimed to develop recommendations for creating a safer driving environment at USF by updating driver safety information for students and raising awareness about safety across all campus transportation modes.
As part of this initiative, the USF Student Government (SG) partnered with the Center for Urban Transportation Research (CUTR) to pilot a new student transportation officer position …
Recent Advances In Multitone Microwave Frequency Measurement, Md Abu Zobair, Behzad Boroomandisorkhabi, Mina Esmaeelpour
Recent Advances In Multitone Microwave Frequency Measurement, Md Abu Zobair, Behzad Boroomandisorkhabi, Mina Esmaeelpour
Electrical and Computer Engineering Faculty Research & Creative Works
This review explores various advanced photonic-assisted techniques for microwave frequency measurement, highlighting their distinct advantages and challenges in detecting multi-tone and broadband microwave frequency signals. Different optical processing techniques for instantaneous frequency measurement, including frequency-to-time mapping techniques, are discussed in detail. The application of multicore and few-mode fibers, artificial intelligence-enhanced, and complex modulation techniques are also discussed. These recent advances collectively push the boundaries of microwave frequency measurement, offering robust and scalable solutions for various applications.
Supreme Court Lgbtq Orthodoxy, Carlos A. Ball
Supreme Court Lgbtq Orthodoxy, Carlos A. Ball
Missouri Law Review
This Article argues that the Supreme Court has relied on two simplifying assumptions in First Amendment exemption cases involving LGBTQ issues. The first assumption is that the government’s interest in addressing and remedying discrimination is irrelevant to the matter at hand. The second assumption is that state officials, in enforcing sexual orientation antidiscrimination laws against individuals who object to them on religious or moral grounds, seek to force the dissenters to speak in ways they do not want to speak. As the Article explains, the Court has abided by neither simplifying assumption in exemption cases involving the application of race …
Toward A Politically Neutral Approach To K-12 Pedagogy, Cameron S. Kang, John M. Kang
Toward A Politically Neutral Approach To K-12 Pedagogy, Cameron S. Kang, John M. Kang
Missouri Law Review
Professors Linda McClain and James Fleming have written an intellectually stimulating book manuscript, “What Shall Be Orthodox” in Polarized Times? It is a privilege to have been afforded access to an early iteration of the book and an opportunity to share our thoughts about it. We (with “we” and its related “our” and “us” denoting Cameron and John) were inspired by Professors McClain and Fleming to reflect about the relationship between pedagogy and the Constitution.
The Obviousness Paradox: Should Design And Utility Patents Play By The Same Rules?, Brooks W. Fleischmann
The Obviousness Paradox: Should Design And Utility Patents Play By The Same Rules?, Brooks W. Fleischmann
Missouri Law Review
The standard American grading system recognizes an A as the best possible grade, while an F represents failure. To achieve an A, the typical benchmark is anywhere above 90%. Falling well below this mark, any grade below 60% constitutes failure. Accordingly, a higher percentage in class equates to a better GPA. Following this same logic in the world of sports, the greatest free-throw shooter in NBA history holds the record at 91%. The greatest field goal kicker in NFL history holds the record at 89.1%. However, the highest batting average in MLB history sits at .366, or 36.6%. According to …
The Straw That Broke The Camel’S Back: How Expanding The Statute Of Limitations For Pre-Enforcement Challenges Filed Under The Apa Could Upset The Administrative System, Paige K. Harris
Missouri Law Review
Everyone has bad days. But certain days are the worst. The days where everything seems to go wrong. You set the alarm for 6:00 p.m., not 6:00 a.m. You didn’t set the coffee pot, and the café’s line was too long, so you walk into work with a severe lack of caffeine. Your project manager asks you a question you know you answered last week. That annoying co-worker talks over you in a meeting, the chips get stuck in a vending machine, and your rush hour commute takes forty-five minutes longer than expected. Finally, something happens that makes you snap. …
Vouching For Fair Housing: Landlords’ Duty To Accept Housing Vouchers As Reasonable Accommodations For Handicapped Tenants, Elly M. Lang
Vouching For Fair Housing: Landlords’ Duty To Accept Housing Vouchers As Reasonable Accommodations For Handicapped Tenants, Elly M. Lang
Missouri Law Review
Earning enough income to afford housing is challenging. Maintaining a steady job that covers both housing and basic essentials requires significant time and energy. Now, imagine you have a physical disability affecting your mobility. Suddenly, your job options are limited, and your health care costs increase. Now, imagine you suffer from a psychological disability as well. Your health care costs skyrocket because you must pay for medications to alleviate both your physical and psychological disabilities, equipment to assist your mobility, therapy fees, and other essential health care costs. In addition, your already limited job opportunities have again been significantly reduced. …
The Illusion Of Redemption: Examining Gubernatorial Pardons, Collateral Consequences, And The Ineligibility For Public Office In Missouri, Anna Claire Parker
The Illusion Of Redemption: Examining Gubernatorial Pardons, Collateral Consequences, And The Ineligibility For Public Office In Missouri, Anna Claire Parker
Missouri Law Review
Imagine you have just pled guilty to a felony offense in Missouri. While the court may inform you of certain rights that will be lost, additional rights remain unmentioned. Suddenly, you find yourself stripped of fundamental liberties such as voting, serving on a jury, holding public office, and owning firearms. Additionally, the right to a trial by jury, the assistance of a lawyer at trial, and protection against self-incrimination have been forfeited. In this bleak scenario, a glimmer of hope emerges: the possibility of a gubernatorial pardon. This pardon represents a chance at redemption, potentially restoring all the rights you …
Removing “Black Marks”: How States Can Preserve Wrongful Birth Suits Without Reliance On “Eugenic” Rhetoric, Paul J. Wuennenberg
Removing “Black Marks”: How States Can Preserve Wrongful Birth Suits Without Reliance On “Eugenic” Rhetoric, Paul J. Wuennenberg
Missouri Law Review
“[L]ebensunwertes Leben—Life Unworthy of Life.” Those words, used by the National Socialist (Nazi) Party in Germany to describe people with genetic disorders, ring throughout world history as a moral indictment of the Nazi German state and all those who collaborated with it. Unfortunately, Germany was not alone in its designation of some people as unworthy of life; the United States has also, throughout its history, given the same designation to portions of its population. From Japanese-Americans during the Second World War to people with disabilities in the era of eugenics, the American government has frequently singled out those whom it …
Impact Of Tyrosine Kinase Inhibitors On Thyroid Function In Chronic Myeloid Leukemia: A Systematic Review, Nana Sardarova, Tirath Patel, Tahani M. Abugoukh, Daniel Kim, Samad Yousuf, Mohammed Hammoude
Impact Of Tyrosine Kinase Inhibitors On Thyroid Function In Chronic Myeloid Leukemia: A Systematic Review, Nana Sardarova, Tirath Patel, Tahani M. Abugoukh, Daniel Kim, Samad Yousuf, Mohammed Hammoude
Student Publications
Tyrosine kinase inhibitors (TKIs) have significantly improved outcomes in chronic myeloid leukemia (CML), shifting it from a fatal to a manageable chronic condition. Despite their clinical benefits, TKIs have been increasingly associated with endocrine-related adverse effects, most notably thyroid dysfunction. This systematic review explores the prevalence, clinical features, underlying mechanisms, and prognostic implications of TKI-induced thyroid abnormalities in CML patients. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, a comprehensive literature search was conducted across four databases, namely, PubMed, Excerpta Medica database (Embase), ClinicalKey, and Google Scholar, yielding 4,803 records. After applying inclusion and exclusion criteria …
Assessment Of Autonomic Nervous System Functions In Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy: An Electrodiagnostic Study, Raghda Nidal Hathal, Farqad Bader Hamdan, Akram M. Al-Mahdawi
Assessment Of Autonomic Nervous System Functions In Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy: An Electrodiagnostic Study, Raghda Nidal Hathal, Farqad Bader Hamdan, Akram M. Al-Mahdawi
Pakistan Journal of Neurological Sciences (PJNS)
Background and Objective: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic immune-mediated neuropathy predominantly affecting the peripheral nervous system including the nerve roots. The objectives of this study were to assess autonomic dysfunction in patients with CIDP using electrodiagnostic techniques and to examine its relationship with clinical and demographic characteristics, COMPASS-31 scores, and the Hughes disability scale.
Methods: This case–control observational study included 25 patients with CIDP and 26 age- and sex-matched healthy controls and was conducted at the Neurophysiology Unit of Baghdad Teaching Hospital, Baghdad from February to November, 2024. All participants underwent autonomic function assessment, including Ewing’s cardiovascular …
The Equal Rights Amendment: The 28th Amendment To The U.S. Constitution, Twiss Butler, Patrick Butler
The Equal Rights Amendment: The 28th Amendment To The U.S. Constitution, Twiss Butler, Patrick Butler
Dignity: A Journal of Analysis of Exploitation and Violence
This article reviews how Supreme Court interpretations of the 14th Amendment have allowed laws to discriminate against women. It aims to show that the Equal Rights Amendment, ratified as the 28th Amendment in 2020, offers a constitutional basis for eliminating all forms of legal sex discrimination against women. These forms include discrimination based on pregnancy and abortion, commodifying women’s bodies, and allowing men to intrude into women’s protected spaces. The review starts with the denial of protection for women by America’s Declaration of Independence in 1776, denounces the Supreme Court’s precedent-setting 1974 Geduldig decision, which ruled—quite illogically—that discrimination …
Post Soviet Russia: Challenges To Transition And Modernization, Chick Edmond
Post Soviet Russia: Challenges To Transition And Modernization, Chick Edmond
Political Science & Geography Faculty Publications
The dissolution of the Soviet Union in 1991 marked the beginning of a complex, often turbulent, period of transition and modernization for Russia. Unlike the anticipated linear path toward Western-style democracy and market economics, Russia’s post-Soviet experience has been defined by profound contradictions, reversals, and ongoing contestations over its political, economic, and social order (Minakov, 2016). The initial wave of reforms, particularly in the 1990s, brought about radical economic restructuring, privatization, and an attempted shift to a free-market system. Yet, these rapid changes led to significant economic dislocation, social inequality, and the rise of oligarchic power structures, which ultimately undermined …
Power Asymmetry Dynamics: Assessing Interdependence In France-Cameroon Relations Through Economic And Security Cooperation (2000–2024), Chick Edmond
Political Science & Geography Faculty Publications
This paper examines the dynamics of power asymmetry in the interdependent relationship between Cameroon and France from 2000 – 2024 with a focus on security and economic cooperation. The main research question asks: To what extent has power asymmetry reinforced or mitigated the interdependent relationship between Cameroon and France within the realm of economic and security cooperation? Based on the hypothesis that increased interdependence between these two states during this period has strengthened existing power disparity. The paper examines how such dynamics have restrained Cameroon’s autonomy and its capacity to pursue policy goals.
The theoretical framework combines dependency theory, postcolonial …
Defining The Logic And Risk Of Terrorist Uas Attacks In The United States, Austin C. Doctor, Suat Cubukcu, George Grispos, Joel S. Elson, Tyler Mccoid
Defining The Logic And Risk Of Terrorist Uas Attacks In The United States, Austin C. Doctor, Suat Cubukcu, George Grispos, Joel S. Elson, Tyler Mccoid
Reports, Projects, and Research
In support of the U.S. Department of Homeland Security, the interdisciplinary project team conducted a one-year study to characterize the logic and emerging trends in terrorist use of unmanned aerial systems (UAS). The project team completed three rapid review reports which focus on key dimensions of the issue. Following the completion of these reports, the team hosted an in-person subject matter expert focus group meeting in spring 2025. The interagency workshop brought together counterterrorism and counter-UAS partners from federal and state law enforcement as well as the intelligence community. This report identifies five core findings – i.e., high level analytical …
The Complex Interplay Between Intellectual Property And The Right To Science, Peter K. Yu
The Complex Interplay Between Intellectual Property And The Right To Science, Peter K. Yu
Faculty Scholarship
In April 2020, the U.N. Committee on Economic, Social and Cultural Rights released General Comment No. 25, which provides an authoritative interpretation of the right to science—a right that has hitherto not received much attention. In light of this publication and the recent celebration of the 75th anniversary of the Universal Declaration of Human Rights, this article examines the complex interplay between intellectual property and the right to science, with a view toward the human rights challenges brought about by both the COVID-19 pandemic and the arrival of generative AI.
The article begins by documenting the historical evolution of the …
John R. Commons, Reasonable Value, And Power: A Critique, Jacob Powell
John R. Commons, Reasonable Value, And Power: A Critique, Jacob Powell
Working Papers
No abstract provided.
The Silicon Shrink: How Artificial Intelligence Made The World An Asylum By Daniel Oberhaus: Reviewed By Hannah Drayson, Hannah Drayson
The Silicon Shrink: How Artificial Intelligence Made The World An Asylum By Daniel Oberhaus: Reviewed By Hannah Drayson, Hannah Drayson
School of Art, Design and Architecture
No abstract provided.
Facial Recognition Ai, Margaret Hu
Facial Recognition Ai, Margaret Hu
Faculty Publications
The integration of algorithmic decisionmaking and artificial intelligence (“AI”) into facial recognition technology poses new, unprecedented risks to privacy and individual autonomy rights, particularly in urban settings. The murder of Brian Thompson, CEO of UnitedHealthcare, in New York City on December 4, 2024, provides a timely case study to examine the deployment of facial recognition systems by the New York Police Department and other law enforcement agencies to identify the suspect. New York City deploys some of the most sophisticated surveillance architecture in the nation, put into place following the terrorist attacks of September 11, 2001. This Article explores the …
Tamtsīlāt Muqāwamah An-Nisā’ Fī Riwayah Al-Mar’Ah Fī Nuqtat As-Sifr Lil-Kātibah Nawāl Sa‘Dāwī Wa-Fīlm Muntasaf Al-Layl Fī Qasr Bīrā (Musalsal Netflix): Dirāsah Adabiyyah Muqāranah, Rofiqoh Rofiqoh, Ida Nursida, Ahmad Habibi Syahid
Tamtsīlāt Muqāwamah An-Nisā’ Fī Riwayah Al-Mar’Ah Fī Nuqtat As-Sifr Lil-Kātibah Nawāl Sa‘Dāwī Wa-Fīlm Muntasaf Al-Layl Fī Qasr Bīrā (Musalsal Netflix): Dirāsah Adabiyyah Muqāranah, Rofiqoh Rofiqoh, Ida Nursida, Ahmad Habibi Syahid
Al-Arabi: Journal of Teaching Arabic as a Foreign Language
تسلط هذه الدراسة الضوء على أشكال مقاومة النساء للنظام الأبوي كما تنعكس رواية "المرأة في نقطة الصفر" لنوال سعداوي ومسلسل "منتصف الليل في قصر بيرا" لإيمري شاهين. باستخدام أساليب وصفية نوعية ونهج أدبي مقارن أمريكي مقترن بنظرية نسوية راديكالية، تبحث هذه الدراسة في كيفية تأثير السياقات الاجتماعية والثقافية في مصر وتركيا على طرق مقاومة الشخصيات النسائية للقمع القائم على النوع الاجتماعي. تظهر نتائج الدراسة أن فردوس تناضل من أجل حريتها من خلال الوعي الذاتي والسيطرة على جسدها ورفض الأعراف الاجتماعية التقييدية، بينما تقدم إسرا شكلاً حديثاً من أشكال المقاومة من خلال الذكاء والتصميم والشجاعة للتعبير عن رأيها في الأماكن العامة. …
The Origins Of German Industrialization: The Transition To Capitalism In Prussian Agriculture, Daniel C. Colligan
The Origins Of German Industrialization: The Transition To Capitalism In Prussian Agriculture, Daniel C. Colligan
Dissertations, Theses, and Capstone Projects
This dissertation seeks to explain the origins of German industrialization. Historical accounts of German industrialization often chronicle the process of its development but leave reasons for its initiation unexplained. Theories that have attempted to locate the roots of rapid German economic growth have been found to be empirically unsatisfactory, and thus the accepted story has defaulted to a gradualist narrative which conceptualizes economic behavior as fundamentally unchanging throughout German history. This dissertation challenges this reigning view, attempting to provide an explanation for why Germany embarked on a rapid economic growth trajectory in the nineteenth century whereas many other similarly situated …
The "Self" In Crisis: A Study Of Audre Lorde's The Cancer Journals, Golnaz Salehkarimi
The "Self" In Crisis: A Study Of Audre Lorde's The Cancer Journals, Golnaz Salehkarimi
Dissertations, Theses, and Capstone Projects
In this thesis, I focus on The Cancer Journals and explore how Audre Lorde articulates the chaos followed by breast cancer in her life: what is the nature of the crises? What aspects of her life are largely affected by it? How it unsettles her understanding of time and place, how her daily life, work, relationships, and future plans get affected, and how her self-image and her agency and subjectivity are threatened. Relying on theories of women’s autobiographies, women’s writings, and illness narratives, I explore Lorde’s ways of writing about her body and emotions to regain her sense of self …
Moving The Needle: The Policy Of Change On Syringe Access, New York City And State, 1988–2023, Joyce Rivera
Moving The Needle: The Policy Of Change On Syringe Access, New York City And State, 1988–2023, Joyce Rivera
Dissertations, Theses, and Capstone Projects
By the mid-1980s, the HIV/AIDS epidemic breached a longstanding consensus between the political class and its bureaucratic alliances that had relied for decades on attitudes and orientations that championed punitive prohibition toward drugs as a bedrock principle of policy making. This ‘focusing event’ created an opening for HIV/AIDS activists to build a movement that offered an alternative, a more effective and just approach to how government policies and practices can manage illegal drugs and the persons who use drugs.
The dissertation uses several theoretical and methodological tools to address the central research objective that highlights the critical role played by …
Cll Cell-Derived Exosomes Alter The Immune And Hematopoietic Systems, Ivo Veletic, David M Harris, Uri Rozovski, Maria Teresa S Bertilaccio, George A Calin, Ping Li, Taghi Manshouri, Rares-Constantin Drula, Ken Furudate, Muharrem Muftuoglu, Anwar Hossain, William G Wierda, Michael J Keating, Zeev Estrov
Cll Cell-Derived Exosomes Alter The Immune And Hematopoietic Systems, Ivo Veletic, David M Harris, Uri Rozovski, Maria Teresa S Bertilaccio, George A Calin, Ping Li, Taghi Manshouri, Rares-Constantin Drula, Ken Furudate, Muharrem Muftuoglu, Anwar Hossain, William G Wierda, Michael J Keating, Zeev Estrov
Faculty, Staff and Student Publications
The origins of immunosuppression, neutropenia, and anemia in patients with chronic lymphocytic leukemia (CLL) are not fully understood. Because in patients with CLL, circulating exosomes, which participate in cell-to-cell interactions, are CLL cell-derived, we examined whether those exosomes contribute to abnormal features of this disease. Our data revealed that CLL cell-derived exosomes engulfed by healthy donors’ monocytes, fibrocytes, and lymphocytes altered target-cell gene and protein expression and suppressed normal hematopoiesis. CLL cell-derived exosomes increased normal monocytes’ CD14 and CD16 expression such that it mimicked the accessory cell profile and upregulated T cells’ checkpoint PD-1 and CD160 protein levels, potentially reducing …
Emerging Technologies Of Single-Cell Multi-Omics, Yi June Kim, Koichi Takahashi
Emerging Technologies Of Single-Cell Multi-Omics, Yi June Kim, Koichi Takahashi
Faculty, Staff and Student Publications
The heterogeneity of the hematopoietic system was largely veiled by traditional bulk sequencing methods, which measure the averaged signals from mixed cellular populations. In contrast, single-cell sequencing has enabled the direct measurement of individual signals from each cell, significantly enhancing our ability to unveil such heterogeneity. Building on these advances, numerous single-cell multi-omics techniques have been developed into high-throughput, routinely accessible platforms, delineating the precise relationships among different layers of the central dogma in molecular biology. These technologies have uncovered the intricate landscape of genetic clonality and transcriptional heterogeneity in both normal and malignant hematopoietic systems, highlighting their roles in …