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The Role Of Damage-Associated Molecular Patterns In Human Diseases : Part I - Promoting Inflammation And Immunity, Walter G. Land

Sultan Qaboos University Medical Journal

There is increasing interest by physicians in the impact of the innate immune system on human diseases. In particular, the role of the molecules that initiate and amplify innate immune pathways, namely damage associated molecular patterns (DAMPs), is of interest as these molecules are involved in the pathogenesis of many human disorders. The first part of this review identifies five classes of cell stress/tissue injury-induced DAMPs that are sensed by various recognition receptor-bearing cells of the innate immune system, thereby mounting inflammation, promoting apoptosis and shaping adaptive immune responses. The DAMPs activate and orchestrate several innate immune machineries, including inflammasomes …

Hepatoblastomas In Oman : Unveiling Success, Fatma Rabah, Nagwa El-Banna, Dipali Al-Ghaithi, Ibrahim, Mohamed Al-Hinai, Amal Al-Sabahi, Nawal Al-Mashaikhi, Ismail Beshlawi

Sultan Qaboos University Medical Journal

Objectives: Primary malignant liver tumours account for more than 1% of all paediatric malignancies, with the most common form being hepatoblastomas (HB). Such malignancies among Arab populations have rarely been addressed in the literature. Using data from Oman’s sole national referral centre for childhood solid malignancies, this study aimed to present the nationwide Omani experience with HB over the past 21 years. Methods:This retrospective study reviewed the medical records of all children with HB who were managed in the Royal Hospital, Muscat, Oman, between January 1991 and April 2012. Clinical, radiological and laboratory characteristics were examined as well as treatments …

Here Come The Trade Secret Trolls, David S. Levine, Sharon K. Sandeen

Washington and Lee Law Review Online

Within the past few years, the U.S. federal government has been forced to confront the massive but hard-to-quantify problem of foreign and state-sponsored cyberespionage against U.S. corporations, from Boeing to small technology start-ups, and (as of this writing) perhaps Sony Pictures Entertainment. As part of that effort, Congress has taken up the Defend Trade Secrets Act and the Trade Secret Protection Act, which would create a private cause of action under the federal Economic Espionage Act. This Article addresses the possibility of introducing trolling behavior—using litigation as a means to extract settlement payments from unsuspecting defendants—to trade secret law through …

Jennings V. Stephens And Judicial Efficiency In Habeas Appeals, Eric O'Brien

Duke Journal of Constitutional Law & Public Policy Sidebar

This commentary previews the Supreme Court case Jennings v. Stevens which deals with several areas of federal habeas corpus law and procedure. The Court will consider, inter alia, whether a habeas petitioner who succeeds in federal district court nevertheless needs to request a certificate of appealability to bring an alternate grounds for habeas relief at the appellate level. Further, the Court can resolve a major circuit split on whether a court considering an ineffective assistance of counsel claim should consider each instance of ineffective assistance as a single claim or as all parts of one claim. Eric O'Brien suggests …

The Guardian, January 21, 2015, Wright State University Student Body

The Guardian Student Newspaper

Twelve page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

Factors Regulating Immunoglobulin Production By Normal And Disease-Associated Plasma Cells, David A. Jackson, Sherine F. Elsawa

Faculty Articles, Papers, and Other Scholarship

mmunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens. Immunoglobulin or antibody secreting cells are the mature form of B lymphocytes, which during their development undergo gene rearrangements and selection in the bone marrow ultimately leading to the generation of B cells, each expressing a single antigen-specific receptor/immunoglobulin molecule. Each individual immunoglobulin molecule has an affinity for a unique motif, or epitope, found on a given antigen. When presented with an …

Experimentally-Derived Fibroblast Gene Signatures Identify Molecular Pathways Associated With Distinct Subsets Of Systemic Sclerosis Patients In Three Independent Cohorts, Michael E. Johnson, J. Matthew Mahoney, Jaclyn Taroni, Jennifer L. Sargent, Eleni Marmarelis, Ming-Ru Wu, John Varga, Monique E. Hinchcliff, Michael L. Whitfield

Dartmouth Scholarship

Genome-wide expression profiling in systemic sclerosis (SSc) has identified four ‘intrinsic’ subsets of disease (fibroproliferative, inflammatory, limited, and normal-like), each of which shows deregulation of distinct signaling pathways; however, the full set of pathways contributing to this differential gene expression has not been fully elucidated. Here we examine experimentally derived gene expression signatures in dermal fibroblasts for thirteen different signaling pathways implicated in SSc pathogenesis. These data show distinct and overlapping sets of genes induced by each pathway, allowing for a better understanding of the molecular relationship between profibrotic and immune signaling networks. Pathway-specific gene signatures were analyzed across a …

Minutes From January 21 2015, University Senate

University Senate Minutes

Minutes from January 21 2015 University Senate Meeting

State V. Murphy Respondent's Brief Dckt. 41634

Not Reported

No abstract provided.

State V. Gould Respondent's Brief Dckt. 42051

Not Reported

No abstract provided.

Ay 2014/2015 Fs Meeting Minutes, 2015-01-21, Faculty Senate

Faculty Senate Archives

No abstract provided.

Narrow-Band Search Of Continuous Gravitational-Wave Signals From Crab And Vela Pulsars In Virgo Vsr4 Data, J. Aasi, Matthew Benacquista, Teviet Creighton, Louis Percy Dartez, Mario C. Diaz, Soumya D. Mohanty, Malik Rakhmanov, Joseph D. Romano, Soma Mukherjee, Volker Quetschke

Physics & Astronomy Faculty Publications

In this paper we present the results of a coherent narrow-band search for continuous gravitational-wave signals from the Crab and Vela pulsars conducted on Virgo VSR4 data. In order to take into account a possible small mismatch between the gravitational-wave frequency and two times the star rotation frequency, inferred from measurement of the electromagnetic pulse rate, a range of 0.02 Hz around two times the star rotational frequency has been searched for both the pulsars. No evidence for a signal has been found and 95% confidence level upper limits have been computed assuming both that polarization parameters are completely unknown …

Structural And Thermal Stability Characterization Of Protein-Fatty Acid Adducts, Dhurga Dharmaraj

Master's Theses

ABSTRACT

Proteins are biological molecules that have an important application as a catalyst for various reactions. The sensitivity of protein to denature at high temperature limits its industrial application where a catalyst that works at high temperature is required. Some protein denature even at optimal room temperature. The primary interest of this study is to protect the protein for thermal denaturation by stabilizing proteins within the capric acid (a ten-carbon chain fatty acid) micelle. The protein-Capric acid adducts showed reversible thermal denaturation when the Capric acid (CA) concentration was present above the critical micellar concentration (CMC). Although the secondary structure …

Wizards At Making A Virtue Of Necessity': Street Vendors In India, Abhayraj Naik

Socio-Legal Review

Street vending is ambivalent in India’s imagination of law, space, and self. This essay attempts to excavate street vending in India as an interstice: an enquiry directed towards how street vending is entangled with specific theoretical and ideological positions concerning culture, citizenship, commodification, consumption, globalization, legality, modernity, neoliberalism, poverty, politics, public space, and social movements. The focus of my excavation of interstitial street vending in India is twofold. First, a methodological front-staging of the interconnections between law, space and time in India. Second, an acknowledgment of the importance of revisionist accounts of Indian modernity; accounts that note emergent politics of …

Gene Expression Patterns That Support Novel Developmental Stress Buffering In Embryos Of The Annual Killifish Austrofundulus Limnaeus, Josiah T. Wagner, Jason E. Podrabsky

Biology Faculty Publications and Presentations

Background: The cellular signaling mechanisms and morphogenic movements involved in axis formation and gastrulation are well conserved between vertebrates. In nearly all described fish, gastrulation and the initial patterning of the embryonic axis occur concurrently with epiboly. However, annual killifish may be an exception to this norm. Annual killifish inhabit ephemeral ponds in South America and Africa and permanent populations persist by the production of stress-tolerant eggs. Early development of annual killifish is unique among vertebrates because their embryonic blastomeres disperse randomly across the yolk during epiboly and reaggregate several days later to form the embryo proper. In addition, annual …

Yes, Actually Subjugation Is A Vocabulary Word, Susan E. Dwoskin Ms.

Journal of Praxis in Multicultural Education

Abstract.

Teaching today is driven by calls for accountability in the form of high-stakes testing and relies on a standardized, de-contextualized approach to education. The results are "one size fits all" curriculum that ignore local contexts of students' lived experience, discourage student engagement and ultimately work against deep understanding of the content. In contrast, a praxis of ethical caring and place-based education that includes a radical-democratic approach, recognizes teaching as political and utilizes the students’ stories, local knowledge, culture, language and community as an integrating context for learning.

Using Game-Based Learning To Foster Critical Thinking In Student Discourse, Marc I. Cicchino

Interdisciplinary Journal of Problem-Based Learning

Previous research indicates the importance of student discourse in the construction of knowledge and the fostering of critical thinking skills, especially in the field of problem-based learning (PBL). Further, a growing body of research on game-based learning (GBL) draws parallels between playing certain types of games and the solving of ill-structured problems, citing similar conditions for learning (student centered, small student groups, teachers as facilitators, problems as vehicles for development), and similar learning outcomes (communication, problem-solving, critical thinking, collaboration) as PBL. However, there is a gap in understanding how GBL affects critical thinking as embodied by student discourse when implemented …

An Increasing Usefulness For Managerial Communication Research On The Main Topics Of Management, Reginald L. Bell, Deborah Roebuck

Faculty Articles

Effective communication is necessary across all management tiers and functions. In addition, it is an integral part of managerial decision-making. Over the last 10 years, interest in the nuances of communication as related to management has intensified. These studies have fostered diverse approaches to linking management and communication. Our investigation, using 2x5 and 2x4 factorial ANOVAs, reveals that differences exist among the means of five professional communication fields. Numerous articles published between 2004 and 2013 were examined, and we found an increasing usefulness for managerial communication research on the main topic of management.

A Glimpse Into Secondary Students’ Understanding Of Functions, Jonathan L. Brendefur, Gwyneth Hughes, Robert Ely

Curriculum, Instruction, and Foundational Studies Faculty Publications and Presentations

In this article we examine how secondary school students think about functional relationships. More specifically, we examined seven students’ intuitive knowledge in regards to representing two real-world situations with functions. We found students do not tend to represent functional relationships with coordinate graphs even though they are able to do so. Instead, these students tend to represent the physical characteristics of the situation. In addition, we discovered that middleschool students had sophisticated ideas of dependency and covariance. All the students were able to use their models of the situation to generalize and make predictions. These findings suggest that secondary students …

January 20, 2015, James Madison University

The Breeze, 2010-2019

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Punishment And Inclusion: Race, Membership, And The Limits Of American Liberalism, Andrew Dilts

Faculty Pub Night

No abstract provided.

The Prospector, January 20, 2015, Utep Student Publications

The Prospector

Headline: Welcome Back Issue

Conflict In Families And Nursing Home Placement: A Phenomenological Study, Stephen John Pidwysocky

Department of Conflict Resolution Studies Theses and Dissertations

In the limited qualitative research about families who have placed a family member in a nursing home, conflict is identified as a significant problem (Lashewicz & Keating, 2009; Lashewicz et al., 2007). Whether it is related to absence of filial responsibility on the part of adult children, (Ganong & Coleman, 2005; Piercy, 1998), adult child ambivalence (Bengtson et al., 2002; Lüscher & Pillemer, 1998), female and male gender caregiving roles (Spitze & Trent, 2006; Dayton-Ingersoll, 2003; Aronson, 1992), differences in levels of commitment on the part of adult children to assist older parents (Silverstein et al., 2008), adult children being …

2015-January-20-Civil Rights Panel, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Usa V. George Georgiou

2015 Decisions

USDC for the Eastern District of Pennsylvania

Dorothy Daniels V. Philadelphia School District

2015 Decisions

USDC for the Eastern District of Pennsylvania

Joe Kannikal V. Attorney General United States

2015 Decisions

USDC for the Western District of Pennsylvania

Edvin Perez Chinchilla V. Attorney General United States

2015 Decisions

Agency

Rewriting The Break Event: Mennonites And Migration In Canadian Literature By Robert Zacharias, Jenny Kerber

The Goose

Review of Rewriting the Break Event: Mennonites and Migration in Canadian Literature by Robert Zacharias.

A Cross-Cultural Study On Consumers' Sentiments Of The Marketing Mix Variables And Consumers' Perceptions Toward Marketing Ethics, Ghensy Antoine

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Marketing ethics continues to be viewed as tampered by unethical practices. This cross-cultural quantitative research surveys 186 consumers in the New Orleans Metropolitan area to gain insights into their perceptions of marketing ethics. The predictive ability of consumers' demographic variables, cultural dimensions, and sentiments toward marketing mix elements vis-a-vis their perceptions of marketing ethics are explored, as well as significant differences within these dominant constructs.

The study integrates a conceptual framework blended with Hofstede's cultural dimensions, McCarthy's marketing mix, and the Hunt-Vitell's general theory of marketing ethics. Psychometric characteristics of the instruments were confirmed through exploratory factor analyses. Results show …