Digital Commons Network^™

Conformational Cycling Of The Wntless Transporter Drives Trafficking And Secretion Of Wnt Morphogens, Yunhui Ge, Taciani De Almeida Magalhaes, Hongjiang Wu, Dick J H Van Den Boomen, Thu Uyen Nguyen, Tongyi Dou, Gaya P Yadav, Sukyeong Lee, Zhao Wang, Andrew Lemoff, Xuemei Luo, Sumitha S Menon, Min Zhang, Jin Wang, Zhicheng Jin, Jiansen Jiang, Adrian Salic, Pengxiang Huang

Faculty, Staff and Students Publications

Wnt proteins are lipid-modified morphogens fundamental in development and disease. During Wnt biogenesis, the G-protein-coupled receptor (GPCR)-like transporter Wntless (WLS) escorts lipidated Wnts from the endoplasmic reticulum to the plasma membrane, then transfers them to extracellular carriers, forming active and soluble morphogen-carrier complexes. To dissect the mechanisms involved, we solve cryo-EM structures of Wnt-bound WLS and unliganded WLS, and perform structure-guided functional experiments. Wnts engage WLS via three conserved hairpins, which are all required for Wnt trafficking to the cell surface and carrier-mediated secretion. Wnt release from cells is driven by dramatic conformational changes in the WLS transmembrane domain, reminiscent …

Leadership Strategies Healthcare Leaders Use To Improve Organizational Performance, Rushell Latoya Bryce

Walden Dissertations and Doctoral Studies

No abstract provided.

Systems And Methods For Location-Verified Augmented Reality Tourism With Multi-Signal Presence Proof And Automated Creator Monetization, Olufemi Abioye

Defensive Publications Series

A web-delivered augmented-reality platform for location-based tourism is disclosed in which interactive story content is bound to real-world geographic locations and delivered through a standard web browser using WebXR, without installation of a native application. Physical presence at a location is established by a multi-signal verification engine that fuses geofence dwell detection, motion-trace analysis for spoofing detection, and cryptographic device attestation into a composite presence-confidence score; when the score exceeds a threshold, the system issues a signed completion token bound to a geofence hash and a time window to resist replay. Raw camera frames are retained on the user device, …

Systemic Integration Of Lifelong Agentic Mentorship, Contextual Scaffolding, And Sovereign Guardian Protocols In K-12 Pedagogy, Christopher L. Eckes

Defensive Publications Series

This specification details the architecture for a non-centralized, lifelong educational operating system that integrates machine learning as an individualized cognitive accelerator, psychometric auditor, and sovereign security layer. This protocol systematically replaces age-segregated, standardized instructional rotations with an immutable Dual-Focus Baseline Matrix paired with a localized Lifelong Cognitive Mentor.

By tracking an individual's development continuously from the primary entry point (K-1) through adulthood, the system implements Probabilistic Scaffolding—balancing automated aptitude mapping with deliberately engineered "negative learning" spaces. Furthermore, it incorporates an active Guardian Sensor Layerutilizing real-time linguistic and behavioral anomaly detection to insulate the child from predatory coercion and manipulative algorithm …

Assortment Analysis Of Ophthalmic Medicines In The Republic Of Uzbekistan, Zoya Usmonova, Shakhnoz Umarova, Nargiza Sultanbaeva, Marina Taryanikova

The Thai Journal of Pharmaceutical Sciences

Background: Ophthalmic diseases are a significant public health concern globally and in Uzbekistan, where approximately 1 million individuals are affected.
Objectives: The objectives are to conduct an assortment analysis of ophthalmic medicines registered in Uzbekistan (2010–2024), to identify trends in drug registration, composition, dosage forms, and manufacturing sources.
Materials and Methods: Based on State Register data, medicines classified under Anatomical Therapeutic Chemical S01 were analyzed using marketing and qualimetric methods, focusing on the International Nonproprietary Names, dosage forms, manufacturers, and countries of origin.
Results: The number of registered medicines peaked at 352 in 2022, and then declined to 279 in …

Using Phenomenology To Investigate Digital Experience: An Empathic-Somatic Approach, Bismark Wiafe Bimpong, William Kesse Bimpong, Mercy Egyir Kwakye

Mid-Western Educational Researcher

This conceptual paper proposes the Empathic-Somatic Approach as a methodological contribution for conducting phenomenological research on digital technology experiences. The Empathic-Somatic Approach does not replace existing phenomenological methods but enriches them by operationalizing the insight that we understand others through our own bodies as instruments of empathy. The paper first establishes the essential philosophical and methodological foundations of phenomenology needed to situate this contribution, then develops the Empathic-Somatic Approach in detail, and finally provides practical guidance for its implementation in digital technology research. This approach offers researchers in fields such as human-computer interaction, digital health, and information systems a principled …

Adaptative And Structured Optimization Stockwell Transform For Robust Power-Quality Disturbances Detection, Moudjibatou Afoda, Séna Apeke, Filippo Gatti, Alessio Iovine, Léonce W. Tokam, Guy M. Toche Tchio, Ouro-Djobo S. Sanoussi

Mansoura Engineering Journal

The monitoring of electrical power quality requires advanced analysis techniques capable of accurately detecting and localizing non-stationary disturbances. This work proposes a structured and adaptive optimization of the Stockwell Transform (ST), referred to as Two-Power Optimization (TPO). A multiparametric Gaussian window governed by four parameters (m, p, k, r), is introduced, and a genetic algorithm is applied independently to each signal to optimize these parameters. The optimization process adapts the analysis scale to the local characteristics of the signal while preserving the physical consistency of the window function. Simulation results on synthetic power quality signals demonstrate that the proposed method …

False Claims, Real Reforms: Fortifying The Fca In The Face Of Article Ii Scrutiny, Celia Parry, David Chizewer, Roger Lewis

Tennessee Journal of Law and Policy

No abstract provided.

Looking To The Tools, Katie Terezakis

Dewey Studies

No abstract provided.

Philosophical Meditations On The Covid-19 Pandemic: What Have We Learned So Far?, Gregory Fernando Pappas

Dewey Studies

No abstract provided.

Preliminary Reflections On Democracy And Memory, Cory Mccall

Dewey Studies

No abstract provided.

Racial Justice And The Image Of Public Health, Marilyn Fischer

Dewey Studies

No abstract provided.

Virtue And Intelligence In A Democratic Republic, F. Thomas Burke

Dewey Studies

No abstract provided.

Toward A Culture Of Democracy, Thomas M. Alexander

Dewey Studies

No abstract provided.

Editor's Introduction, Leonard J. Waks

Dewey Studies

No abstract provided.

Dca 1, Lp V. Ferguson

All Decisions

In this holdover, the court declines to find that the VAWA statute covers occupants without tenancy rights. The decision is consistent with the court's prior ruling in CHV 690-738 Albany Avenue LP v Kandil (LT-330166-24/KI, Mar. 11, 2026), and contrasts with Stammtisch Associates LP v Wright (No. 321993-25/KI, June 11, 2026), where the same judge reached a different conclusion.

207-209 West 107th St V. De La Cruz

All Decisions

In this succession holdover, the court grants attorneys' fees to respondent after the parties settled the case with respondent obtaining succession rights. The court holds that RPAPL 702 does not abrogate the right to raise counterclaims for attorneys' fees pursuant to Real Property Law § 234.

Ameliorating Chromium-Induced Stress In Maize Through Phosphorus And Melatonin Application, Zunaira Zafar, Shoaib Ahmad, Muhammad Akhtar, Shafaqat Ali, Sarah Owdah Alomrani, Muhammad Ali Alshehri

Turkish Journal of Agriculture and Forestry

Chromium (Cr+6)  toxicity is a significant environmental stress factor that severely hampers plant growth and productivity. This study aimed to evaluate whether the combined application of phosphorus fertilizer and melatonin could alleviate chromium induced stress in maize  (Zea mays L.).  A foliar spray of melatonin (50 µM) was applied alongside two phosphorus sources—phosphoric acid (PA) and diammonium phosphate (DAP), each at 60% of the recommended rate. Two maize cultivars (FH-1046 and YH-1898) were grown under chromium stress (0, 15, and 30 mg kg–1) to assess treatment effects. The results demonstrated that FH-1046 plants treated with PA + melatonin under noncontaminated …

Unveiling Resistance Mechanisms To Fusarium Wilt Through Comparative Transcriptome Analysis Of Cicer Arietinum And Cicer Reticulatum, Özlem Tuna, Yasi̇n Kaymaz, Talap Talapov, Canan Can, Muhammed Bahatti̇n Tanyolaç, Duygu Ateş

Turkish Journal of Agriculture and Forestry

Developing resistant chickpea cultivars is essential for managing Fusarium wilt caused by Fusarium oxysporum, a major pathogen responsible for substatial yield losses. In this study, we conducted RNA-seq–based transcriptome analysis to characterize gene expression changes in resistant and susceptible genotypes of Cicer arietinum L. and C. reticulatum following inoculation with Fusarium oxysporum f. sp. ciceris race 0. Susceptible genotypes exhibited markedly higher numbers of differentially expressed genes compared with resistant genotypes. Defense-related genes were induced in all plants upon infection; however, resistant genotypes specifically upregulated genes functioning in the apoplast or extracellular region while downregulating intracellular processes—a pattern not observed …

Ozonated Water Delays The Microbial Growth And Sensory Quality Loss Of Capia Pepper Fruit During Cold Storage, Yasi̇n Şi̇mşek, Mehmet Ali̇ Koyuncu, Derya Erbaş

Turkish Journal of Agriculture and Forestry

The aim of the present research was to evaluate, for the first time, the effect of ozonated water treatments on the postharvest quality of capia pepper (Capsicum annuum L. ‘Kaptan’). The peppers were harvested at the optimum time and transported to the laboratory immediately. Uniform and quality fruit was selected and precooled. After precooling, the fruit was divided into four groups. The first three groups were immersed in ozonated water at three different concentrations (1.0, 2.0 and 3.0 ppm) for 15 min. The last group (control) was immersed in distilled water for 15 min. The peppers were kept at room …

Electrochemical Biosensing Of Alpha-Fetoprotein Based On Carboxylated Multi-Walled Nanotube-Polyazur A (In Des)-Gold Nanoparticles, Merve Yilmaz Çilçar, Meli̇ke Bi̇lgi̇ Kamaç

Turkish Journal of Chemistry

AFP, a cancer biomarker, is monitored during fetal development and in the serum of pregnant women. Sensitive and rapid monitoring of AFP is crucial for effective management. In this study, screen-printed carbon electrodes (SPCEs) modified with multi-walled carbon nanotubes (MWCNT-COOH), polyAzur A (PAA), which was prepared in a deep eutectic solution (DES), and gold nanoparticles (AuNP) were fabricated. AFP biosensors were developed for practical, sensitive, low-cost, and rapid detection of AFP. Optimizations of nanostructures (MWCNT-COOH, AuNP) and polymers (PAADES) were performed. The MWCNT-COOH, PAADES, and AuNP-modified SPCEs were characterized by FE-SEM-EDX, FTIR, and XRD techniques. The amounts of 6-MOH, APTES, …

Identification Of Small Molecules That Enhance Aminoglycoside-Mediated Suppression Of Cftr And Nf1 Nonsense Mutations, Joshua Sammons, Jianguo Chen, Kari Thrasher, Lianwu Fu, Ming Du, Hui Wen, J. Robert Bostwick, Paige Vinson, Omar Moukha-Chafiq, Corinne Augelli-Szafran, Kim M. Keeling, Deeann Wallis, Robert A. Kesterson, Steven M. Rowe, David M. Bedwell

Genetically Engineered Models Core Publications

Nonsense suppression rescues functional protein from mRNAs containing in-frame premature termination codons (PTCs). This approach employs small molecules that promote insertion of tRNAs at a PTC during translation (called “readthrough”), enabling translation to continue past the PTC to generate a full-length, functional protein. Some aminoglycosides such as G418 promote readthrough; however, their long-term use is thwarted by toxicity and modest potency. ELX-02, a novel synthetic aminoglycoside, was developed to have both enhanced readthrough activity and reduced toxicity in mammalian cells compared to traditional aminoglycosides. Recent studies suggest that at safe doses, aminoglycosides like ELX-02 may not possess sufficient efficacy to …

Gold Medal Girl: Media Representations Of Aly Raisman During The Larry Nassar Scandal Through Lenses Of Whiteness, Vulnerability, And "Good" Patriarchy, Anna Mischelle Dean

Electronic Theses and Dissertations Archive

This thesis analyzed two media texts about former Olympic gymnast Aly Raisman and how these texts constructed her identity during and after the Larry Nassar scandal. I analyzed these texts through the lenses of whiteness, vulnerability, and carceral feminism. Looking at how the media acts as a disciplinary apparatus in this case, I argue that women athletes’ bodies are portrayed as having a vulnerability to abuse that only the "good" patriarchy can address. I seek to show that the media use depictions of women’s vulnerability and need for patriarchal help to remind women athletes that, in cases of abuse, who …

Subjection To Chivalry: Agency, Consent, And Assault In Roman De Silence And Sir Gawain And The Green Knight, Jeremy Clay Birchfield

ETDs from 2020-2029

Violations of consent and sexual assault occurred frequently within the genre of romance popular across medieval England and France during the late Middle Ages. While many of the characters who experienced sexual assault in these pieces of literature were women, “Subjection to Chivalry” investigates two masculine characters whose consent is violated within their respective romances. The essay explores how the experiences of Silence, the Roman de Silence’s protagonist, and Sir Gawain of Sir Gawain and the Green Knight can read as violations of consent and assault at the hands of both male and female aggressors, and questions how those violations …

Mindfulness Across Media: Examining The Effects Of Audio, Audio-Visual, And Virtual Reality Mindfulness Interventions On Social Media Mindsets And Psychological Wellbeing, Rashmi Salian

ETDs from 2020-2029

Social media is so deeply ingrained and integrated into daily life that concerns about its impact on psychological wellbeing continue to grow, prompting pressing questions about how to foster healthier and more intentional use of technology. Recent studies suggest that low-agency mindsets toward social media lead users to develop habitual usage patterns and ambiguous information consumption behaviors, both of which negatively impact psychological outcomes. However, limited research is available on mechanisms that could effectively alter these mindsets. This study uses an experimental methodology to investigate whether mindfulness interventions delivered through varying levels of media immersion can improve psychological mindsets toward …

Bringing Clarity To Tutors' Work: Designing An Effective Writing Center Staff Handbook, Maria Bunting

ETDs from 2020-2029

Writing center literature often focuses on the documents used to justify a center’s role in the larger institution while largely ignoring internal documents that aid in training. By also answering Babcock & Thonus (2012) and Driscoll & Perdue (2014)’s call for more replicable, aggregable, and data-based (RAD) research in writing centers, this study addresses this literature gap by conducting a qualitative study about a newly-implemented handbook at a public R1 university. The author first includes a description of the collaborative document creation process before describing the empirical methods used to assess the handbook’s effectiveness. The findings illustrate how effective handbooks …

Holding The Dying: Worldview, Community, And The Practice Of End-Of-Life Doula Care, Amy J. Shields

ETDs from 2020-2029

As populations age and chronic illness increasingly characterizes the final stages of life in the United States, end-of-life doulas (EOLDs) have emerged as non-medical practitioners who support dying people and their families through education, companionship, advocacy, and ritualized care. Drawing on a thematic analysis of 18 semi-structured interviews with practicing EOLDs across the United States, this thesis examines how EOLDs conceptualize a “good death,” navigate emotionally intensive work, and sustain themselves in an unregulated and often marginal professional landscape. Situating EOLD practice within anthropological scholarship on death and dying, the study highlights the ways EOLDs challenge dominant biomedical narratives that …

Influence Of Crop Diversification On Climate Change Mitigation And Business Profitability: A Study Of The Southern Marmara Region, Türkiye, Engi̇n Tolga Önder, Nuray Demi̇r

Turkish Journal of Agriculture and Forestry

Crop diversification strategies are being put forward to mitigate the negative effects of climate change associated with greenhouse gas emissions, and thus to ensure sustainable food production that is resilient to climate change and to reduce the risks faced by producers. By diversifying their agricultural products producers can insure themselves against the risks associated with climate variations, disease, and pests, contributing to both continuous food production and income flow. The present study investigates the effect of climate change on enterprise income in the Yenişehir district of Bursa province – a region noted for its intensive production of vegetables and other …

Multidimensional Scaling (Mds) Analysis Of Fire Blight Resistance In Apple Genotypes Selected From The Eastern Black Sea Region Of Türkiye, Kubi̇lay Kurtuluş Baştaş, Hati̇ce Dumanoğlu, Veli̇ Erdoğan, Ahmet Aygün, Rabi̇a Albayrak Deli̇ali̇oğlu, Sai̇d Efe Dost, Ümi̇t Serdar, Özgün Kalkişim, Sali̇h Maden, Zahi̇de Kocabaş

Turkish Journal of Agriculture and Forestry

Erwinia amylovora is the causal agent of fire blight, which is known as one of the most destructive diseases of apple. The use of fire blight-resistant cultivars/rootstocks is one of the most effective methods available to manage this disease. We previously selected 199 local apple cultivars that showed no clearly visible symptoms of fire blight on the plants from the coastline of the eastern Black Sea Region in Türkiye. The region is characterized by the highest rainfall and humidity levels in the country. In this research, young plants of these genotypes grafted onto MM.106 rootstock were screened for fire blight …

An In Vitro Mechanistic Study Of Cholinergic-Associated Mechanisms Relevant To Masld In Hepg2 Cells, Gamze Sönmez, Müslüm Gök, Suat Sari, Ebru Bodur

Turkish Journal of Biology

Background/aim: Polyunsaturated fatty acids (PUFAs) and the hepatic cholinergic axis are critical regulators of lipid metabolism and inflammatory signaling; however, their time-dependent interplay in hepatocytes remains incompletely understood. Clarifying how n-6 and n-3 PUFAs interact with cholinergic pathways may provide mechanistic insight into metabolic dysfunction-associated steatotic liver disease (MASLD).

Materials and methods: HepG2 cells were used to examine the combined effects of butyrylcholinesterase (BChE) overexpression and PUFA exposure. Cells were treated with linoleic acid (LA; n-6) or α-linolenic acid (α-LA; n-3) for 24 or 48 h. Gene expression analyses were performed to assess pathways involved in de novo lipogenesis, β-oxidation, …