Digital Commons Network^™

Reform Vs Revolution: Revisiting Original Institutionalist’S Axiology, Jacob Powell

Working Papers

No abstract provided.

Edwena Leite V. School District Of Philadelphia

2025 Decisions

USDC for the Eastern District of Pennsylvania

Investigating The Consequences Of Conjugated And Secreted Isg15 On Coronavirus Pathogenesis, Mudassir Syed Ali

Dissertations

Coronaviruses have evolved a breadth of mechanisms to antagonize host innate immune responses. One widely studied mechanism is the ability to deconjugate ISG15 from target proteins in a process called deISGylation, which is catalyzed by the papain-like protease (PLP) domain of viral non-structural protein (nsp) 3. Since PLP activity is required for viral replication, it has been challenging to generate an infectious virus with a PLP that maintains protease activity but has lost deISGylase activity. In this study, we generated a chimeric MHV-A59 with its PLP2 domain replaced with that of the human coronavirus HKU1, which has been documented to …

Emerging Therapeutic Potential Of Fisetin For Nephrotoxicity, Kidney Injury, And Nephropathy: A Systematic Review, Saeed Mohajeri, Alizamen Salehifard Jouneghani, Saeid Heidari-Soureshjani, Catherine M.T. Sherwin, Faramarz Beigi

Pediatrics Faculty Publications

INTRODUCTION/OBJECTIVE: Kidney diseases cause high morbidity and mortality worldwide. This study investigated the mechanistic effects of Fisetin (FIS) on nephrotoxicity, kidney injury, and nephropathy induced by drugs, toxic chemicals, diabetes, lupus, diet, ureteral obstruction, and ischemic situations.

METHODS: To identify pertinent articles published before Oct 1, 2024, a comprehensive electronic search was performed across several databases, including MEDLINE/PubMed, Embase, Cochrane Library, Web of Science, and Scopus. After establishing clear inclusion and exclusion criteria, studies that met the research objectives were selected. Data were extracted and analyzed, documenting study characteristics, methodologies, and biological mechanisms.

RESULTS: Antioxidant benefits were evident with increased …

Cardiac-Derived Fibroblast Growth Factor 23 Contributes To Physiologic And Pathologic Cardiac Remodeling, Isaac Daniel Campos

All ETDs from UAB

Chronic Kidney Disease (CKD) is a global health risk that increases patients’ risk for premature mortality and is accompanied by pathologic cardiac hypertrophy and fibrosis. Declining kidney function results in elevations of serum phosphate and Fibroblast Growth Factor (FGF) 23, a bone-derived phosphaturic hormone. Hyperphosphatemia and elevated FGF23 are associated with cardiovascular mortality in CKD. FGF23 can directly target cardiac myocytes via FGF Receptor (FGFR) 4 and induce cardiac hypertrophy and blocking FGFR4 signaling in CKD models reduces cardiac hypertrophy, but not fibrosis. FGF23 elevations are also observed following exercise and during pregnancy, two scenarios of physiologic hypertrophy not associated …

Functional Resilience Of Healthcare In The Critical Juncture Of The Covid-19 Pandemic, Avner Kronisch, Christian Bongiorno, Kerane Smith, John Baker

Working Papers Series

This paper offers a comparative analysis of eight national healthcare systems—spanning democracies, autocracies, and various institutional models—to evaluate resilience during the COVID-19 pandemic. Drawing on Shvetsova et al.’s framework of informational and authority redundancies, and Parker & Klein’s “choke point” theory of healthcare rationing, we examine how institutional structure shaped pandemic response, system adaptability, and continuity of non-COVID services. Using indicators like life expectancy, under-five mortality, hospital capacity, cancer survival, and excess mortality, we explore how systems absorbed shock and maintained essential care. We find that decentralized and polycentric governance structures, when paired with coordination and resource adequacy, enhanced resilience—exemplified …

Institutional Change In Healthcare As Brought About By The Critical Juncture Of The Covid-19 Pandemic, Olga Shvetsova

Working Papers Series

This introduction to the 2025 capstone symposium lays the conceptual groundwork for a new approach to analyzing institutional change in healthcare systems triggered by the COVID-19 pandemic. Departing from conventional legal-institutional perspectives, it extends the decision space framework developed by Bossert (1998) to capture both formal authority and the de-facto responsibilities exercised by public and non-public actors. By disaggregating health responsibilities across levels of government and sectors—public, private, and hybrid—and operationalizing these as quantifiable indicators over time, the framework allows for real-time and comparative assessment of institutional transformation. The pandemic is treated as a critical juncture that exposed and reconfigured …

Nazor V. Sydney Sol Group, Ltd.

All Decisions

In this loft tenant action, the court modified the lower court's order, reinstating claims for rent overcharge, unjust enrichment, and breach of warranty of habitability. The court held that court-ordered use and occupancy payments are not "voluntarily paid" rent under MDL § 302(b), allowing these claims to proceed in a related action. The court also reinstated a claim for accounting of the security deposit and attorneys' fees, finding the landlord failed to prove non-commingling. However, claims for harassment, retaliatory eviction, and constructive eviction were dismissed.

Universal Underwriters Insurance Co V. John Swenson

2025 Decisions

USDC for the Middle District of Pennsylvania

In Re: Aaron Mazie

2025 Decisions

USDC for the District of New Jersey

Usa V. Barron Thomas

2025 Decisions

USDC for the Middle District of Pennsylvania

S. M. V. Freehold Regional High Sch Dist Board Of Education

2025 Decisions

USDC for the District of New Jersey

The (Dis)Continuity Of Meaning In John Dewey’S Experience And Nature, Harrison S. Jackson

Center for Dewey Studies Essay Award

Experience and Nature proposes a naturalistic empiricism emphasizing continuity. This paper will argue that this continuity is threatened by Dewey’s anthropocentric in its account of meaning, which is only found in humans but is necessary for the perception of objects, communication, and social existence. Given contemporary research in ethology, Dewey’s denotative method requires a modification of this account. I will propose Merleau-Ponty’s notion of sense or the neuroscientific theory of enactivism as supplements preserving embodiment and social communication while being more continuous. Finally, I examine some recent applications of Dewey’s naturalism and show how they modify this account of meaning.

Systems And Methods For Providing Active Contraction Properties Of The Myocardium Using Limited Clinical Metrics, Igor Nobrega, Wenbin Mao

USF Patents

A deep learning model can be used for the identification of active contraction properties of the myocardium using limited clinical methods. A method for identifying the active contraction properties can include inputting a plurality of clinical metrics into a deep learning model. The method can further include inputting a representation of a cardiac cycle through a pressure volume-loop into the deep learning model. The deep learning model can include a first process layer with a first intermediate output and a second process layer that receives the first intermediate output as a first intermediate input. The method can further include outputting …

Adoption, Friendships, And Social Skills, Alexis M. Chelle

Sociology Undergraduate Senior Theses

Adoption functions as both an identity status and a source of unique social benefits and challenges for teenagers, informing their experience of friendship. While prior research primarily focuses on individual outcomes and difficulties that adoptees face, such as trauma-related disorders and social skill deficits, it often overlooks how adoptees and their parents perceive these impacts on peer relationships. This study draws on twenty-one in-depth interviews with adoptees ages thirteen to twenty-one and their adoptive parents to explore the role that adoption and adverse childhood experiences have on an adopted teen’s experience of friendships. Findings reveal that despite facing significant social …

Current Issues In Oral Health: Introduction To The Special Issue, Nejat Düzgüneş

Pacific Faculty Work

No abstract provided.

Unframing Spatial Presence And Resonating Aesthetic Presence : A “Continuous Interaction” Of Visitor Engagement With Chinese Art, Yi Zhu

Lingnan Theses (MPhil & PhD)

Digital technologies, as a prevalent method of display in museums, has been widely used in the presentation and creation of Chinese art, such as software, hardware, and interactive installations in exhibitions. According to Peng Feng (2022), digital technologies can effectively disseminate Chinese classical artworks while enriching visitors’ experience, enhancing their perceptions of aesthetic concepts and facilitating their understanding of the artworks. However, current studies are primarily focused on the social and cultural background information conveyed by the objects, rather than the visitor experiences in the process of interaction with the artworks. Digital technologies can engage visitors through active interaction with …

Interrogating The Dispersal Process And Relevant Genes In Vibrio Fischeri, Jeremy Esin

Dissertations

Biofilms are aggregates of bacteria encased in a matrix that shields bacteria from environmental hazards. These structures are formed in response to cues from the environment and drive colonization of new niches. Biofilms can be both beneficial and detrimental. Largely, research focuses on biofilms that have negative outcomes in clinical, environmental, and economical settings. However, the value of beneficial biofilms is recognized and studied. The marine bacterium Vibrio fischeri is part of a model system for studying symbiotic biofilms in a eukaryotic host. V. fischeri produces a transient biofilm at the surface of a specialized light organ and then disperses …

Comparing Emotional Facial Expressions Produced During Personal Narrative Discourse By People With And Without Aphasia, Chloe K. Houghton

Theses and Dissertations

This study investigated the differences in emotional facial expressivity between people with aphasia (PWA) and control participants during emotional discourse tasks. Participants consisted of 26 PWA and 26 control participants from Aphasia Talk Bank who retold a stroke or illness story and an important life event story, totaling 104 video files. Undergraduate research assistants were trained to code emotional facial expressions according to valence, intensity, and duration utilizing a modified Facial Expression Coding System (FACES; Kring & Sloan, 1991). Dependent variables included positive frequency, negative frequency, positive intensity, and negative intensity. Results from this study demonstrate that female participants used …

Time-Driven Activity-Based Costing For Cervical Myelopathy Surgery: A Step Towards Total Episode Costs, Kavantissa M. Keppetipola, Adam Leibold, Jay Trivedi, Ashmal Sami, Advith Sarikonda, D. Mitchell Self, Emily L. Isch, Steven R. Glener, Srinivas Prasad, Jack Jallo, Joshua E. Pelta-Heller, James Harrop, Alex R. Vaccaro, Ahilan Sivaganesan

Department of Neurosurgery Faculty Papers

INTRODUCTION: Time-driven activity-based costing (TDABC) is a highly accurate method for determining the true cost of delivering a healthcare service. However, TDABC is most often applied to a singular phase of care such as an outpatient visit or a surgical event. Here we broaden the scope by using TDABC to estimate the costs of surgically treating cervical myelopathy - from the moment of surgical scheduling until post-operative hospital discharge.

METHODS: In a single-center retrospective study at a large tertiary academic institution, TDABC was employed to measure pre-operative, intra-operative, and post-operative (inpatient) costs for 63 patients undergoing elective surgery for cervical …

Level Of Service Criteria For Urban Arterials With Heterogeneous And Undisciplined Traffic Streams, Afzal Ahmed, Farah Khan, Syed Faraz Abbas Rizvi, Fatma Outay, Muhammad Faiq Ahmed, Muhammad Adnan

All Works

Accurate evaluation of the prevailing traffic operations plays an important part in developing sustainable transport systems. This research examines the suitability of the level of service (LOS) criteria developed by the Indian and United States (US) Highway Capacity Manuals (HCM) for heterogeneous and undisciplined traffic streams and proposes new criteria using a data-driven approach. Traffic data were collected from a selected major arterial in Karachi, and fundamental diagrams were developed using these data. These fundamental diagrams and field-collected data were analyzed using the K-mean clustering approach to examine the actual traffic states at various LOS bands used in practice. Associating …

Maternal Loss Of Mouse Nlrp2 Alters The Transcriptome And Dna Methylome In Gv Oocytes And Impairs Zygotic Genome Activation In Embryos, Zahra Anvar, Michael D Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K To, Daniel C Kraushaar, Ying-Wooi Wan, Michael C Mari, Simon Andrews, Gavin Kelsey, Ignatia B Van Den Veyver

Center for Medical Ethics and Health Policy Staff Publications

Background: NLRP2 is a subcortical maternal complex (SCMC) protein of mammalian oocytes and preimplantation embryos. SCMC proteins are encoded by maternal effect genes and play a pivotal role in the maternal-to-zygotic transition (MZT), early embryogenesis, and epigenetic (re)programming. Maternal inactivation of genes encoding SCMC proteins has been linked to infertility and subfertility in mice and humans, but the underlying molecular mechanisms for the diverse functions of SCMC proteins, and specifically the role of NLRP2, are incompletely understood.

Results: We profiled the DNA methylome of pre-ovulatory germinal-vesicle (GV) oocytes from Nlrp2-null, heterozygous (Het), and wild-type (WT) female mice and assessed the …

Race, Reflection And Resistance: An Autoethnographic Journey In Social Studies Curriculum Development, Jesse Nicholas Hendryx-Dobson

Dissertations and Theses

The purpose of this qualitative, self- study, autoethnography is to explore my instructional practices, strategies and decision making as I navigate my attempts to build a more anti-racist, racial justice social studies curriculum in a predominantly white school environment. Critical Race Theory as well as racial literacy provided me with a conceptual framework, but also with the language I need to articulate the research problem and my findings. Three research questions guided how I collected and analyzed my data: 1) How do I plan social studies lessons that address the topic of race/racism? 2) How can I use social studies …

Restoration Of The Tumor Suppressor Function Of Y220c-Mutant P53 By Rezatapopt, A Small-Molecule Reactivator, Anna M Puzio-Kuter, Lizhong Xu, Mary Kate Mcbrayer, Romyr Dominique, Hongju H Li, Bruce J Fahr, Alyssa M Brown, Amy E Wiebesiek, Brandon M Russo, Chris L Mulligan, Hong Yang, Josh Battaglia, Kimberly A Robell, Dafydd H Thomas, Kuo-Sen Huang, Alexander Solovyov, Benjamin D Greenbaum, Jonathan D Oliner, Thomas W Davis, Melissa L Dumble, Melissa L Johnson, Shunbin Xiong, Peirong Yang, Guillermina Lozano, Marc M Fellous, Binh T Vu, Alison M Schram, Arnold J Levine, Masha V Poyurovsky

Faculty, Staff and Student Publications

Restoration of the tumor suppressor function of tumor-associated p53 mutants, including the Y220C substitution, has posed a significant challenge for therapeutic discovery. In this study, we describe rezatapopt (PC14586), part of a series of compounds designed to reactivate the p53 Y220C mutant. These compounds restore p53 tumor suppressor function by correcting its conformation and enabling it to bind DNA and activate downstream target genes, thus inducing antiproliferative changes in tumor cells. Our findings are supported by biochemical and structural analysis, in vitro and in vivo transcriptomics, and functional data, revealing the recovery of multiple aspects of the wild-type p53 program. …

Verifiable Summarization Of Electronic Health Records Using Large Language Models To Support Chart Review, Ritchie Verma, Emily Alsentzer, Zachary Strasser, Leslie Chang, Kirollos Roman, Esteban Gershanik, Camellia Hernandez, Miguel Linares, Jorge Rodriguez, Durga Thakral, Ozan Unlu, Jacqueline You, Li Zhou, David Bates

Faculty, Staff and Students Publications

Information overload in electronic health records (EHRs) hampers clinicians' ability to efficiently extract and synthesize critical information from a patient's longitudinal health record, leading to increased cognitive burden and delays in care. This study explores the potential of large language models (LLMs) to address this challenge by generating problem-based admission summaries for patients admitted with heart failure, a leading cause of hospitalization worldwide. We developed an extract-then-abstract approach guided by disease-specific "summary bundles" to generate summaries of longitudinal clinical notes that prioritize clinically relevant information. Through a mixed-methods evaluation using real-world clinical notes, we compared physicians' ability to answer patient-specific …

Tumor Microenvironment Governs The Prognostic Landscape Of Immunotherapy For Head And Neck Squamous Cell Carcinoma: A Computational Model-Guided Analysis, Priyan Bhattacharya, Alban J Linnenbach, Andrew P. South, Ubaldo E. Martinez-Outshoorn, Joseph M. Curry, Jennifer M. Johnson, Larry A. Harshyne, Mỹ G. Mahoney, Adam J. Luginbuhl, Rajanikanth Vadigepalli

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

Immune checkpoint inhibition (ICI) has emerged as a critical treatment strategy for squamous cell carcinoma of the head and neck (HNSCC) that halts the immune escape of the tumor cells. Increasing evidence suggests that the onset, progression, and lack of/no response of HNSCC to ICI are emergent properties arising from the interactions within the tumor microenvironment (TME). Deciphering how the diversity of cellular and molecular interactions leads to distinct HNSCC TME subtypes subsequently governing the ICI response remains largely unexplored. We developed a cellular-molecular model of the HNSCC TME that incorporates multiple cell types, cellular states, and transitions, and molecularly …

A Century Of Servant Leadership: Jimmy Carter, Jeffrey H. Coats

Servant Leadership: Theory & Practice

This paper describes the servant leadership characteristics of Jimmy and Rosalyn Carter.

Maghrebi Identity & Integration In France: Colonial Legacies And Contemporary Realities, Mariam Gohar

SUURJ: Seattle University Undergraduate Research Journal

Historical ties between France and the Maghreb continue to shape and inform the experiences of the Maghrebi population in contemporary French society. There is an extensive Maghrebi population in France as a result of France’s colonial history in the region and subsequent migration. The Maghrebi populations face structural and social barriers in French society, including employment and education disparities, spatial segregation, and social Otherization. Maghrebi communities are only one example of France’s structural discrimination against non-European populations. This work aims to unpack the historical, political, and economic factors that resulted in French colonization of the Maghreb and relate these to …

Reframing Fat: Identifying Compulsory Thinness And The Role Of Discourse And Media In Its Perpetuation, Anabella Vucci

SUURJ: Seattle University Undergraduate Research Journal

Drawing on Judith Butler’s framework of compulsory heterosexuality, as well as Robert McRuer’s use of this framework in his own theory of compulsory able-bodiedness, this paper critiques the notion that thinness is merely a beauty standard. Rather, this paper argues that thinness is a marker of superiority that requires the subordination of fat individuals and is upheld by the historically informed, albeit fabricated, narrative that being thin is right. This paper asserts that thinness is compulsory—required from all bodies that are held to an unattainable standard of perfect thinness. Further, this paper examines the role that media play in the …

Speech By Hh The Aga Khan At The Inauguration Of The Aga Khan University's Faculty Of Health Sciences And Of The Aga Khan University Hospital, Karachi

Inaugural addresses and related documents

No abstract provided.