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Clarifying Parens Patriae, James G. Dwyer May 2025

Clarifying Parens Patriae, James G. Dwyer

Faculty Publications

Throughout the Anglo-American legal world, the state claims an authority, termed parens patriae, to exert control over the lives of nonautonomous persons in ways it does not presume to control autonomous persons. Philosophers have given little attention to when and how that authority should be exercised, yet there is disagreement or confusion about this among courts and legal scholars. This article examines how parens patriae differs from other government roles, identifies which conceptions of the parens patriae role are coherent, and then presents a normative case for adopting a conception of the role as that of fiduciary for nonautonomous …


Fpso Motion In Synthetic Environments: Stereo-Driven Deep Learning For Wavefield Reconstruction, Motion Analysis, And Mooring System Assessment, Omar Jebari May 2025

Fpso Motion In Synthetic Environments: Stereo-Driven Deep Learning For Wavefield Reconstruction, Motion Analysis, And Mooring System Assessment, Omar Jebari

Theses and Dissertations

This dissertation presents an integrated synthetic environment for simulating the motion and monitoring the integrity of a moored Floating Production Storage and Offloading (FPSO) vessel. The central hypothesis is that synthetic data-driven approaches can (1) accurately estimate spatio-temporal wave fields, (2) predict vessel motion, and (3) monitor the integrity of the mooring system—using stereo imagery of the wave field and structure motion, both of which can be acquired in real time. The first study develops a synthetic framework for estimating spatial wave fields using stereo images captured by dual cameras mounted on a moving FPSO. Dynamic sea states and vessel …


Towards Visual Inertial Navigation With Fixed Tetrahedral Targets, Joao Leonardo Silva Cotta May 2025

Towards Visual Inertial Navigation With Fixed Tetrahedral Targets, Joao Leonardo Silva Cotta

Theses and Dissertations

This dissertation presents a robust method for 6DoF position estimation under impaired visual conditions utilizing a minimum 4-point Perspective-n-Point (P4P) solver designed for tetrahedral targets. Using SO(3) × R 3 instead of SE(3), the method uses a Lie group-based formulation to discriminate between rotation and translation, thereby enabling computationally efficient, resource-conscious op- optimization while preserving correct geometric behavior. Designed using the contemporary C++17 library ShomerTarget, the solver is analytically formulated and assessed under pragmatic robotic conditions. Particularly in low-light and high-dynamic environments, experiments on embedded systems, UAVs, and NASA’s Astrobee show that the proposed solver attains enhanced accuracy compared to …


Analytics Insights From Text: Machine Learning, Ai, And Sentiment Analysis On Beige Books, Charlie Smith May 2025

Analytics Insights From Text: Machine Learning, Ai, And Sentiment Analysis On Beige Books, Charlie Smith

Graduate Theses and Dissertations (2019 - present)

Business analytics is about drawing actionable insights from data. These distinct but connected essays represent a novel approach to explore how natural language processing (NLP) advances and machine learning can transform unstructured text data into actionable conclusions. Essay 1 provides a broad framework. Essay 2 strengthens the sentiment analysis with the most recent artificial intelligence methodologies for capturing nuanced sentiment in complex texts. Essay 3 applies those insights to forecast recessions using topics that can be readily interpreted and applied.

The research demonstrates how these methodologies can be applied to enhance understanding of the same dataset, Beige Books. Published by …


Investigating Business Cybersecurity Vulnerability And Development Of An Application For Security Awareness Training Platform For Small And Medium-Sized Enterprises, Baijun (Jack Skywalker) Jiang May 2025

Investigating Business Cybersecurity Vulnerability And Development Of An Application For Security Awareness Training Platform For Small And Medium-Sized Enterprises, Baijun (Jack Skywalker) Jiang

Senior Honors Theses

Small and medium-sized enterprises (SMEs) are increasingly becoming prime targets for cybercriminals due to their limited IT expertise, inadequate cybersecurity investment, and insufficient security awareness training. The increasing sophistication of social engineering attacks are rendering traditional security awareness programs obsolete, as they fail to effectively promote behavior change. The proposed solution develops a software-based security awareness training program that integrates interactive activities, realistic scenarios, and gamified learning methods to engage employees and facilitate long-term behavioral change towards security awareness. Future research should focus on evaluating the effectiveness of the proposed training program in real-world scenarios to measure its impact on …


Mechanisms Of Behavioral Change In Hosts Of Toxoplasma Gondii: A Review, Olivia Grimsley May 2025

Mechanisms Of Behavioral Change In Hosts Of Toxoplasma Gondii: A Review, Olivia Grimsley

Senior Honors Theses

The parasite Toxoplasma gondii is a highly ubiquitous parasite that latently infects an estimated 33% percent of the global population. Toxoplasmosis is of obvious clinical significance due to the extremely high risks to the unborn who contract it congenitally. Less attention has been given to a more subtle aspect of latent infection, which is the behavioral alterations that are commonly experienced by those who contract the parasite. Infected individuals commonly display a variety of altered behaviors, such as increased aggression and risk-seeking behaviors, depression, higher tendency towards suicide and self-directed violence, a loss of fear response, and a greatly increased …


U.S. Tax Treatment Of Crypto Assets, Kylie May Schmitt May 2025

U.S. Tax Treatment Of Crypto Assets, Kylie May Schmitt

Senior Honors Theses

Disagreements exist surrounding the proper definition and tax treatment of cryptocurrency. The IRS views crypto assets as a type of intangible property, and most guidance regarding how to include income or loss from cryptocurrency on the relevant tax forms stems from this classification. Crypto asset transactions create either ordinary or capital income or loss, depending on the taxpayer’s reason for holding the assets. This requires keeping track of the cryptocurrency’s fair market value at the time of receipt and disposition. While researchers have not reached a unanimous conclusion, most identify problems with this treatment and instead propose alternative methods, such …


Earth As Archive: An Interdisciplinary Approach To Possibility And Understanding, Alissa Petrizzo May 2025

Earth As Archive: An Interdisciplinary Approach To Possibility And Understanding, Alissa Petrizzo

Honors College Theses

This thesis takes the reader on a journey through the process of literary analysis to uncover new considerations of our past, present, and future. Living in the climate crisis, we are in dire need of the humanistic presence within solution-making conversations. I introduce scholarly voices from anthropologists, environmental scientists, and novelists before diving into Pitchaya Sudbanthad's novel Bangkok Wakes to Rain. While you hear my voice throughout the journey, I exist more so as a tour guide, helping you along the way to new possibilities of understanding. We dig up and analyze evidence of the Earth as an archive …


Breaking The Chains: Challenging Antiblackness In Social Work Education And Practice: A Qualitative Study, Brandon Rothschild May 2025

Breaking The Chains: Challenging Antiblackness In Social Work Education And Practice: A Qualitative Study, Brandon Rothschild

PhD of Social Work

This dissertation critically examines the pervasive effects of anti-Blackness within social work education, focusing on how these experiences influence the development of Black identity among social work faculty. Situated within a historical context of systemic exclusion, marginalization, and racial discrimination, the study investigates the strategies employed by Black social work educators to navigate and construct their professional identities. The central research question explores how anti-Blackness within social work members. The study's findings are organized into five key themes: recognition of systemic racism, challenging dominant narratives, amplifying counter-narratives, intersectionality and complex identities, and advocacy for systemic change. These themes highlight the …


Evidence For Distal Bolide Impact And Tsunami Deposits In The Upper Atlantic Coastal Plain Of Moore County (North Carolina, Usa) Generated By The Eocene Chesapeake Bay Bolide Impact, G. Robert Ganis, Ralph H. Willoughby, David J. Cicimurri, G. Richard Whittecar, Steven J. Hageman May 2025

Evidence For Distal Bolide Impact And Tsunami Deposits In The Upper Atlantic Coastal Plain Of Moore County (North Carolina, Usa) Generated By The Eocene Chesapeake Bay Bolide Impact, G. Robert Ganis, Ralph H. Willoughby, David J. Cicimurri, G. Richard Whittecar, Steven J. Hageman

OES Faculty Publications

Beds interpreted as Eocene bolide-generated impact and tsunami deposits occur at Paint Hill in the Upper Atlantic Coastal Plain of Moore County, North Carolina, USA. These strata, herein named the Mount Helicon Formation, consist of four distinct beds comprising about one meter of total section. Bed 1 (the basal bed) is approximately 43 cm thick and consists of sandy carbonaceous clay with carbon glass and rock fragments and contains 14-18 parts per billion (ppb) iridium (interpreted as bolide impact ejecta). Bed 2 is approximately 9 cm thick and consists of non-cohesive silt-size particles and loosely bound sand-size accretionary lapilli-like masses …


Support Effects On Fe- Or Cu-Promoted Ni Catalysts Used In The Catalytic Deoxygenation Of Tristearin To Fuel-Like Hydrocarbons, Great C. Umenweke, Robert Pace, Thomas Récalt, Olivier Heintz, Gilles Caboche, Eduardo Santillan-Jimenez May 2025

Support Effects On Fe- Or Cu-Promoted Ni Catalysts Used In The Catalytic Deoxygenation Of Tristearin To Fuel-Like Hydrocarbons, Great C. Umenweke, Robert Pace, Thomas Récalt, Olivier Heintz, Gilles Caboche, Eduardo Santillan-Jimenez

Chemistry Faculty Publications

Previous studies have shown that fats, oils, and greases (FOG) can be deoxygenated to fuel-like hydrocarbons over inexpensive alumina-supported Ni catalysts promoted with Cu or Fe to afford excellent yields of renewable diesel (RD). In this study, supports other than alumina—namely, SiO2-Al2O3, Ce0.8Pr0.2O2, and ZrO2—were investigated to develop catalysts showing improved RD yields and resistance to coke-induced deactivation relative to Al2O3-supported catalysts. Results showed that catalysts supported on Ce0.8Pr0.2O2 and ZrO2 outperformed SiO2-Al2 …


The Effect Of Employment Shocks On Earnings: Evidence From The Covid-19 Pandemic, Giovanny A. Martinez Rodriguez May 2025

The Effect Of Employment Shocks On Earnings: Evidence From The Covid-19 Pandemic, Giovanny A. Martinez Rodriguez

Economics Honors Projects

Economic research has documented significant short, medium, and long-term labor market consequences following recessions (Goodman & Mance, 2011; Yagan, 2017; Farber, 2011). The Covid-19 recession triggered an unprecedented economic downturn, disproportionately impacting employment in industries with high concentrations of low-income and female workers. In this paper, I leverage the substantial spatial variation in employment shocks to examine their effects on earnings and employment outcomes in both the short and medium terms. I find remarkably stable trends in earnings and employment when comparing counties experiencing high employment shocks with those that did not. Although these results differ from previous recessions, they …


Co-Designing Manufacturing Systems For Robustness And Resilience: A Decision-Based Design Perspective, Mathew Baby May 2025

Co-Designing Manufacturing Systems For Robustness And Resilience: A Decision-Based Design Perspective, Mathew Baby

Theses and Dissertations

Manufacturing systems (MSs) comprise various stakeholders associated with the manufacture and supply of products required by customers and are interrelated by the flow of materials and information. The interrelated stakeholders make system-specific decisions and stakeholder-specific decisions across multiple levels of a decision hierarchy to satisfy many conflicting system-specific and stakeholder-specific requirements that define system and stakeholder performances. Given the stakeholder interrelations and conflicting nature of system-specific and stakeholder-specific requirements, system and stakeholder performances are correlated and conflicting.

In the Industry 5.0 era, there is an increased emphasis on the creation and equitable distribution of value among all the stakeholders in …


Offering A Manufacturing Curriculum Online To Rural Schools: The Case Of The Nimm Project, Raymond A. Dixon, Farjahan Shawon May 2025

Offering A Manufacturing Curriculum Online To Rural Schools: The Case Of The Nimm Project, Raymond A. Dixon, Farjahan Shawon

Journal of Research in Technical Careers

This case study examined the extent to which the two implemented manufacturing pathways of the NIMM project successfully facilitated access and engaged high school students from rural regions in two manufacturing curricula. The program consisted of two tracks or career pathways for manufacturing technicians: Mechanical CADD technician and Electro-Mechanical technician. The Mechanical CADD program was delivered online, and the Electro-Mechanical program was delivered online and through a summer skills academy. Findings include, students showed less preference for CTE manufacturing courses in an online asynchronous format, CTE instructors need to be trained to teach online, proper IT infrastructure is needed for …


Here Be Dragons: The Barriers Of Korean American Female Leaders In Secondary Schools, Joyce A. Kim May 2025

Here Be Dragons: The Barriers Of Korean American Female Leaders In Secondary Schools, Joyce A. Kim

Dissertations

In K-12 public schools, there is a shortage of Korean American women in school leadership roles at the secondary level. This phenomenological study explores the contributing factors to this lack of representation, how institutions can recruit and retain Korean American female leaders, and how school systems can better support them. This study examines the leadership experiences of eight Korean American women. It utilizes the socio-political contexts of Korean patriarchy, the Model Minority Myth, and mentorship to help frame the problem of existing barriers. This study explores the following questions: What factors hinder Korean American women in school leadership? What structural …


An International Prosecutor As U.S. Special Counsel, Cody Corliss May 2025

An International Prosecutor As U.S. Special Counsel, Cody Corliss

Utah Law Review

The appointment of Jack Smith to investigate then-former President Donald Trump brought to the fore the essential qualities for special counsels who act when a conflict of interest precludes investigation by the Department of Justice. Most attention on Smith centered on his domestic work and its correlation with a special counsel’s responsibilities. That emphasis, however, obscured the most salient line on his resume: international investigator and prosecutor. The conclusion of Smith’s tenure as special counsel following the election of Donald Trump to a second term as president provides an opportunity to consider the skills and qualifications that matter most in …


Sometimes Is Not Enough: A Legislative Solution To The Failures Of The Federal Government In Compensating Civilians Harmed By U.S. Military Action, Olivia Mcquarrie May 2025

Sometimes Is Not Enough: A Legislative Solution To The Failures Of The Federal Government In Compensating Civilians Harmed By U.S. Military Action, Olivia Mcquarrie

Utah Law Review

The United States has a large military presence abroad. With that presence has come instances of human rights abuses. This Note highlights the issues of civilian deaths and poisoning at the hands of the U.S. military, focusing specifically on the U.S.’s Middle Eastern theater of operations. It advocates for a comprehensive statutory scheme that requires uniform compensation to civilians while also requiring public disclosures to ensure government accountability. Previous research has focused on the cause of the U.S. military’s human rights violations abroad and methods of addressing physical and environmental harms separately. This Note proposes an approach that encompasses both …


Building Educator Sel Capacity To Support Disruptive Student Behavior, Kendall Eshenfelder Fenton May 2025

Building Educator Sel Capacity To Support Disruptive Student Behavior, Kendall Eshenfelder Fenton

Doctor of Education (Ed.D.)

This improvement science dissertation addressed disruptive student behavior by building educators’ SEL capacity and knowledge. Specifically, the study provided classroom teachers with Tier I SEL instructional lessons and training to support managing disruptive student behaviors within the classroom. This intervention at a suburban elementary school consisted of a six-week intervention that included weekly professional learning sessions and SEL lessons to be implemented in the classroom. This action research, using a mixed methods convergent preexperimental design, included quantitative data assessing classroom teachers’ SEL knowledge and capacity. The researcher also gathered qualitative data through semi-structured interviews with participants following the completion of …


A Comprehensive Analysis Of The Production Of Biofuels From Nanno 3600 Microalgae And Algae Native To Connecticut Via Greener Alternative Extraction Solvents For Lipid Recovery, Juhkory Najar May 2025

A Comprehensive Analysis Of The Production Of Biofuels From Nanno 3600 Microalgae And Algae Native To Connecticut Via Greener Alternative Extraction Solvents For Lipid Recovery, Juhkory Najar

Master's Theses

As the world continues to evolve and expand in both technology and population, the energy demand continues to increase as well to keep up with the production of new products and higher production rates. The depletion of fossil fuels and the considerable amount of greenhouse gases from the use of nonrenewable energy sources fuel the demand for renewable energy sources. These renewable energy sources originate from a variety of places, such as wind power, hydroelectric, and solar. Biomass continues to grow in the renewable energy sector due to its versatility in high lipid content and minimal competition with other biomass …


The Rise Of Cyber Conflict As A Policy Tool: A Comparison Of The United States And The People's Republic Of China, Sophia Radzim May 2025

The Rise Of Cyber Conflict As A Policy Tool: A Comparison Of The United States And The People's Republic Of China, Sophia Radzim

Master's Theses

This thesis explores cyber incident trends and its effects on conflict resolution of interstate relationships between the U.S. and China. Key findings of this research discovered that the U.S. relies on diplomatic negotiations to resolve cyber conflicts and does not utilize an aggressive approach within the cyber domain. China, on the other hand, has aggressively expanded its cyber capabilities. They leverage cyber attacks to promote their technology, military, and economy sectors, while undermining the U.S.’ global status as a political leader and innovator. China’s dominance in cyberspace poses a great threat to the national security of the U.S. Through descriptive …


What Role Do Economic Interests Play In Improving Bilateral Relations Between Algeria And Morocco?, Sabrina Laib May 2025

What Role Do Economic Interests Play In Improving Bilateral Relations Between Algeria And Morocco?, Sabrina Laib

International Studies (MA) Theses

Tensions between Algeria and Morocco began after Algeria gained independence from France in 1962, culminating in the Sand War of 1963. Since then, various mediation efforts and economic reconciliation attempts have been initiated, but have consistently been hindered by differing stances—particularly regarding the Western Sahara conflict. I argue that economic interests, especially those in illicit trade, are impactful factors that have negatively affected the bilateral cooperation between Algeria and Morocco. To explain the factors facilitating bilateral relations, this project explores four variables: mediation attempts, regional development schemes, trade, and illicit economy. Qualitative data is used to provide historical-contextual and thematic …


A Fragile New World: An Analysis Of The History, Present, And Future Of The U.S. Global Fragility Act, Declan F. Coakley May 2025

A Fragile New World: An Analysis Of The History, Present, And Future Of The U.S. Global Fragility Act, Declan F. Coakley

International Studies (MA) Theses

In 2019, the U.S. Congress passed the Global Fragility Act with bipartisan support. (GFA). The act aimed to reform U.S. foreign aid and development, focusing on stabilization initiatives that proactively address the root causes of conflict before they escalate into full-blown violence. Despite the significant implications of the GFA for both domestic and international foreign policy, extant research examining the novel legislation remains limited and disjointed in its examination. This paper builds on previous studies by combining content analysis and qualitative interviews with a diverse group of professionals within the foreign aid sector to offer a comprehensive analysis of the …


Contracted Wars, Compromised Oversight: Private Military Companies In Iraq, Afghanistan, And The Decline Of U.S. Accountability Standards, Brianna N. Buzzell May 2025

Contracted Wars, Compromised Oversight: Private Military Companies In Iraq, Afghanistan, And The Decline Of U.S. Accountability Standards, Brianna N. Buzzell

International Studies (MA) Theses

The Global War on Terror, beginning in 2001, started U.S. military operations in Iraq and Afghanistan, facilitating the expansion of Private Military Contractors (PMCs) through a combination of operational necessity, strategic policy decisions, and systemic oversight failures. Despite their growing role, PMCs operate in legal and oversight grey zones. Despite a growing body of work on PMC accountability, there remains little agreement on how U.S. military interventions created conditions for their proliferation. This paper examines how U.S. military operations in Iraq and Afghanistan facilitated the expansion of PMC influence, resulting in reduced oversight and accountability for both the U.S. government …


Predicting Perinatal Mood Disorders, Honey Newton May 2025

Predicting Perinatal Mood Disorders, Honey Newton

Doctor of Nursing Practice

Perinatal Mood Disorders (PMD) constitute a significant public health concern, impacting the perinatal patient and the family.

Purpose

This project describes the relationship between Adverse Childhood Experiences and Perinatal Mood Disorders including depression and anxiety.

Goals

The goals of this study were to define the perinatal population in a rural Montana clinic and describe the relationship between ACEs and PMDs to identify early intervention opportunities.

Methods

A ten-year retrospective IRB approved study described the relationship between ACE, PHQ9 and OASIS scores to determine the prevalence of PMD and connection to ACE’s in perinatal patients in rural northwest Montana. Calculations were …


A Qualitative Study Exploring Senior Leaders’ Experiences And Perceptions In Addressing Workplace Sexual Harassment In The U.S. Federal Government: A Systems Perspective, Karen Jane Dean May 2025

A Qualitative Study Exploring Senior Leaders’ Experiences And Perceptions In Addressing Workplace Sexual Harassment In The U.S. Federal Government: A Systems Perspective, Karen Jane Dean

Electronic Theses and Dissertations

Sexual harassment (SH) is a prevalent, costly, and often unreported problem in the U.S. Federal Government. Despite decades of research from multiple perspectives and recommendations to address SH, the problem persists and remains complex. While some researchers and U.S. Government agencies have called upon leaders to commit to eliminating workplace SH, others have suggested using an integrated conflict management system (ICMS) to manage the complexity, nuances, and conflicts. Even though there is a call for leadership to address SH, there is limited documentation in the literature about leaders’ experiences and perceptions in addressing the problem. Therefore, this qualitative study was …


From Interactions To Brand Value Co-Creation: How Internal And External Stakeholders Drive Consumer-Generated Branding, Vaibhav Shwetangbhai Diwanji, Juliann Cortese May 2025

From Interactions To Brand Value Co-Creation: How Internal And External Stakeholders Drive Consumer-Generated Branding, Vaibhav Shwetangbhai Diwanji, Juliann Cortese

Journal of Applied Marketing Theory

Brand value co-creation (BVCC), a key concept in service-dominant logic (SDL) and identity-based brand management approach (IBBMA), plays a critical role in branding. However, the integrated roles of internal stakeholders (e.g., brand practitioners) and external stakeholders (e.g., consumers) in this process are not fully understood. Existing research has focused on either internal or external perspectives in isolation. This study addresses this gap by exploring the concept of consumer-generated branding (CGB) through the combined lens of both internal and external brand stakeholders. The findings show that as brand value becomes more experience-driven, meaningful interactions between consumers and marketers can lead to …


A Comparative Analysis Of Advertising Appeals In Anti- Smoking Advertisements (Print And Online Display Ads) From 1990s To 2020s In The U.K, Ayomide Adebare Mr, Jill Nash Dr May 2025

A Comparative Analysis Of Advertising Appeals In Anti- Smoking Advertisements (Print And Online Display Ads) From 1990s To 2020s In The U.K, Ayomide Adebare Mr, Jill Nash Dr

Journal of Applied Marketing Theory

This study provides a comparative analysis of advertising appeals in static anti-smoking advertisements in the U.K. from the 1990s to the 2020s, using quantitative content analysis. The research evaluates print and online display advertisements, focusing on the prevalence of rational (gain-framed and statistical) and emotional (fear and guilt) appeals. The study investigates shifts in appeal usage over time and the broader societal and regulatory influences driving these changes. Findings indicate a strategic shift in public health messaging, moving from fear-based appeals in the 1990s to increased reliance on gain-framed appeals by the 2020s. This study enhances academic understanding of how …


Optimizing Case Management Manuals: A Ryan White Quality Improvement Project For Northwest Missouri, Megan Mcbane May 2025

Optimizing Case Management Manuals: A Ryan White Quality Improvement Project For Northwest Missouri, Megan Mcbane

Capstone Experience: Master of Public Health

The Ryan White HIV/AIDS Act, established in 1990, has played a critical role in providing essential services for individuals living with HIV, including medication access, adherence support, health coverage, housing, and transportation. In rural Missouri, particularly in the northwest region, HIV case management under the Ryan White program is guided by four separate manuals, creating inefficiencies and burdens for case managers. This paper presents a process evaluation plan utilizing the Plan-Do-Study-Act (PDSA) framework to address these challenges and improve service delivery. The aim of this quality improvement project is to enhance the efficiency and effectiveness of HIV case management in …


Is Diabetes A Predictor Of A Diagnosis Of Hypertension In The Population Of 32- To 70-Year-Olds In A Cohort Study? A Multivariate Logistic Regression Analysis Of A Subset Of Data Obtained From The Framingham Study, Walter Marquez-Lavenant May 2025

Is Diabetes A Predictor Of A Diagnosis Of Hypertension In The Population Of 32- To 70-Year-Olds In A Cohort Study? A Multivariate Logistic Regression Analysis Of A Subset Of Data Obtained From The Framingham Study, Walter Marquez-Lavenant

Capstone Experience: Master of Public Health

Objective: Assess the independent role of diabetes on hypertension using logistic regression, while adjusting for covariates such as age, sex, BMI

Methods: A subset of data from the Framingham Cohort study, with 5,209 participants and collected across three periods from 1956 to 1968, was analyzed. The dataset includes laboratory, clinic, questionnaire, and event data from 4,434 individuals and was analyzed using SAS software for logistic regression.

Results:In the adjusted model, diabetes was not associated with hypertension (aOR:1.1, 95% CI:0.67-1.81, p=0.7). Females had 26% higher odds of hypertension than males (aOR=1.26, 95%CI:1.09-1.25, p=0.00). Participants aged 51 or older (aOR=2.86, 95%CI:2.37-2.47, …


A Biomarker Signature-Guided Clinical Trial Design For Precision Medicine, Yuan Li, Dejian Lai, Ruosha Li, Han Chen, Xuelin Huang, Jing Ning May 2025

A Biomarker Signature-Guided Clinical Trial Design For Precision Medicine, Yuan Li, Dejian Lai, Ruosha Li, Han Chen, Xuelin Huang, Jing Ning

Faculty, Staff and Student Publications

Targeted cancer therapies aim to effectively treat patients with specific biomarker profiles. Nevertheless, these therapies may not always precisely hit their intended targets, leading to uncertainty about the specific subset of patients who will benefit. To address this uncertainty, the identification of sensitive patient subsets in clinical trials becomes crucial. Our proposed phase IIB/III clinical trial design seeks to pinpoint a biomarker signature with precision, ensuring the accurate identification of patients who will respond to a specific treatment. This approach allows for the selective enrollment of sensitive patients to maximize benefits for trial participants. We incorporate Bayesian methodology to facilitate …