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Articles 34261 - 34290 of 1195152
Full-Text Articles in Entire DC Network
Culture Bears The Way, While Technology Facilitates Action: Research Of The Adoption Willingness Of Aigc In Academic Writing Among Young Scholars, Jiangfeng Liu, Zihui Wang, Zhiwei Hu, Lei Pei
Culture Bears The Way, While Technology Facilitates Action: Research Of The Adoption Willingness Of Aigc In Academic Writing Among Young Scholars, Jiangfeng Liu, Zihui Wang, Zhiwei Hu, Lei Pei
Journal of Scientific Information Research
[Purpose/significance] Clarifying the influencing factors of young scholars' willingness to use AIGC and its path of action,then making effective enhancement strategies,would help to further expand the application of AIGC in academic writing.
[Method/process] This paper combs through the studies on AIGC information behavior, and identifies TOE(Technology-Organization-Envifonment,TOE) theory and research life cycle theory as the base theory. Semi-structured interviews were conducted for procedural grounded theory coding. Then, a questionnaire survey and qualitative comparative analysis using fuzzy sets were conducted to obtain the influencing factors grouping path.
[Result/conclusion] Five factors, induding content quality, system quality, perceived risk, expectation confirmation, and group norms, …
Earnings Management In Borsa Istanbul During Seasoned Equity Offerings, Mahmoud Ashour, Asuman Atik
Earnings Management In Borsa Istanbul During Seasoned Equity Offerings, Mahmoud Ashour, Asuman Atik
The Indonesian Capital Market Review
To increase share prices during the issuance of seasoned equity shares, firms may be motivated to boost earnings through earnings management, particularly just before the offering. This study examines the earnings management practices of non-financial firms listed in Borsa Istanbul and surrounding seasoned equity offerings. Using the cross-sectional Modified Jones and Roychowdhury (2006) models, both accrual-based and real earnings management practices were analyzed from 2005 to 2018. The sample consists of 120 rights offerings within the research period. The results indicate that firms listed on Borsa Istanbul did not engage in earnings management the year before the offering. Instead, earnings …
Genu Valgum Relation With Sociodemographic Factors In A Sample Of Iraqi Children Attending Sadr Al Qanat Center For Prosthetics And Orthotics, Abdulnasser Mohammed, Faiq Gorial
Genu Valgum Relation With Sociodemographic Factors In A Sample Of Iraqi Children Attending Sadr Al Qanat Center For Prosthetics And Orthotics, Abdulnasser Mohammed, Faiq Gorial
Iraqi Postgraduate Medical Journal
Background: Genu valgum is a deformity resulting from the separation of ankles, when the medial faces of the knees are in contact while the person is in anatomical position, the patella and the hallux turning to the anterior direction.Aim: To evaluate the features of genu valgum and associated sociodemographic factors in children.Patients and methods: A cross-sectional study was conducted at Sader Al-Qanat Center for Prosthetics and Orthotics, a tertiary referral center in Baghdad/Iraq during the period from January to December 2022. A convenient sampling method was adopted to enrol 60 patients aged 2-14 years with genu valgum who attained the …
Effect Of Ramadan Fasting On Lipid Profile And Bmi Among A Group Of Healthy Adult People In Mosul City/ Iraq, Safana Mohammed, Manal Rasheed
Effect Of Ramadan Fasting On Lipid Profile And Bmi Among A Group Of Healthy Adult People In Mosul City/ Iraq, Safana Mohammed, Manal Rasheed
Iraqi Postgraduate Medical Journal
Background :- There is increasing interest regarding the health implications of Ramadan fasting in the recent years. Many reports indicate that fasting during the holy month of Ramadan results in reduced body weight and improved metabolic parameters like lipid profile in healthy individuals . Aim of the study :- To study the effect of fasting during the holy month of Ramadan on serum lipid profile and BMI in healthy adult volunteers. Subjects and methods :- prospective cohort study was done including a total of 50 healthy volunteers. Venous blood samples were taken from volunteer, 1week before Ramadan, and , in …
The Immunological Benefits Of Breast Feeding (Review Article), Ahmed Al-Harbi, Asmaa Shetawi
The Immunological Benefits Of Breast Feeding (Review Article), Ahmed Al-Harbi, Asmaa Shetawi
Iraqi Postgraduate Medical Journal
Breast feeding (BF) provides infants with the most suitable nutrients from birth tell weaning. The major part of mother breast milk (MBM) is water in which the other components dissolve. These components include nutrients and immune factors. The concentration of these components varies by time after delivery. Breast milk even provides infants with various types of bacterial species that contribute for development of infant microbiota.Components that are regarded important for shaping of infant immune response include different factors. MBM contains oligosaccharides which are associated with guts defenses, cytokines that participate in inflammation and immune cells activation, immunoglobulins that arm infant’s …
Towards Efficient Privacy-Preserving Deep Learning: He-Friendly Structures, Flexible Pruning, He-Efficient Architectures, And Secure Transformer Token Drop, Yifei Cai
Electrical & Computer Engineering Theses & Dissertations
Deep learning (DL) has become a powerful tool for solving complex problems, but developing DL models typically requires vast datasets, high computational resources, and expert knowledge—barriers that limit accessibility. Machine Learning as a Service (MLaaS) addresses this challenge by allowing resource-rich providers to deliver pre-trained DL models as services. However, privacy concerns arise: clients hesitate to share sensitive data, while providers protect their proprietary models. To address this, privacy-preserving MLaaS integrates cryptographic techniques into DL computations, as seen in frameworks like Cryptonets, SecureML, GAZELLE, CrypTFlow2, Cheetah, and BOLT. Among them, Homomorphic Encryption (HE) enables computation on encrypted data but remains …
Germination Time: Impact On Nutritional, Thermal, And Paste Properties Of Red Rice, Thauana Heberie, Lucas Avila Do Nascimento, Ya-Jane Wang, Rosana Colussi, Jaqueline Ferreira De Souza, Andre Ricardo Fajardo, Marcia Foster Mesko
Germination Time: Impact On Nutritional, Thermal, And Paste Properties Of Red Rice, Thauana Heberie, Lucas Avila Do Nascimento, Ya-Jane Wang, Rosana Colussi, Jaqueline Ferreira De Souza, Andre Ricardo Fajardo, Marcia Foster Mesko
Food Science Faculty Publications and Presentations
BACKGROUNDThe study investigates how varying germination times affect the nutritional, thermal, and pasting properties of red rice. Germination was conducted over 32 h, with aliquots collected every 2 h starting from 18 h for property evaluation.RESULTSAt all evaluated germination times, the red rice samples exhibited low to intermediate amylose levels, while resistant starch content remained relatively constant (approximately 15-20%). Structural changes in the starch were observed: the peak viscosity decreased, maximum gelatinization of the granules occurred at 76 degrees C, and spectroscopic bands characteristic of this polysaccharide were detected at 3400 cm-1 (O-H stretching) and within the 1150-1000 cm-1 range …
Superhypersoft Set-Based Evaluation Of Teaching Quality In Ideological And Political Courses In Colleges And Universities In The New Era, Ningning Wang, Zheng Zhao
Superhypersoft Set-Based Evaluation Of Teaching Quality In Ideological And Political Courses In Colleges And Universities In The New Era, Ningning Wang, Zheng Zhao
Neutrosophic Sets and Systems
No abstract provided.
Neutrosophic Sets And Systems, Vol. 85,2025, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez
Neutrosophic Sets And Systems, Vol. 85,2025, Florentin Smarandache, Mohamed Abdel-Basset, Maikel. Leyva Vazquez
Neutrosophic Sets and Systems
No abstract provided.
Evidence-Based Shared Agendas For Scholarship On Teaching With Primary Sources: Reflections On A Bibliometric Analysis, Jen Hoyer, Anne Bahde
Evidence-Based Shared Agendas For Scholarship On Teaching With Primary Sources: Reflections On A Bibliometric Analysis, Jen Hoyer, Anne Bahde
Publications and Research
This article explores how scholarship about teaching with primary sources (TPS) has evolved over time and what future directions past work might suggests. Using bibliometric analysis and visualization tools, we examined how TPS work has grown; what fields and disciplines focus on this work; key themes and issues; and what scholarship has been influential to the field. These insights led to reflections on disconnects across the field, considerations for publishing about TPS, and the potential of pedagogical standards and guidelines. Finally, this article concludes with recommendations on how this analysis points to possibilities for shared education, space, conversation, and products.
Kimball Hall, 1970: Collective Organizing Through Print Production, Jen Hoyer
Kimball Hall, 1970: Collective Organizing Through Print Production, Jen Hoyer
Publications and Research
This article examines the May 1970 occupation of Kimball Hall, a university administrative building at New York University, and specifically of its basement printshop. The group that came together in this space referred to itself as the Kimball Commune; they used university equipment and resources to print material in support of the strike and related movements, and they invited students, activists, and the general public to come into the printshop and produce material with them. I demonstrate how the Kimball Commune provides a concrete example of how a collaborative radical printing project isn’t just about creating alternative media. It also …
Advanced Study Of Nickel-Titanium Alloy: Effects Of Point Defects On Mechanical And Thermodynamic Properties, Diego Armando Juarez Rosales
Advanced Study Of Nickel-Titanium Alloy: Effects Of Point Defects On Mechanical And Thermodynamic Properties, Diego Armando Juarez Rosales
Open Access Theses & Dissertations
High-throughput first-principles calculations of point defects are emerging as a powerful tool to accelerate materials discovery in applications [1]. Substitutional, antisite, and vacancy defects can play an important role in the mechanical and thermal properties of intermetallic alloys [2]. In this present work I compute the thermal and mechanical properties of shape-memory alloy nickel-titaniun (NiTi) in the B19â?? martensitic and B2 austenitic phases from molecular dynamics (MD), using a second nearest neighbor (2NN) modified embedded atom method (MEAM) [3] classical potential in the temperature range from 200K to 600K and composition range from 45 atomic percent to 55 atomic percent …
Spiritual Practices In Survivor Care: A Qualitative Analysis Of Christian Faith-Based Shelters And Survivor Well-Being, Jeanne L. Allert
Spiritual Practices In Survivor Care: A Qualitative Analysis Of Christian Faith-Based Shelters And Survivor Well-Being, Jeanne L. Allert
Dignity: A Journal of Analysis of Exploitation and Violence
Christian faith-based organizations constituted a significant proportion of shelter programs for survivors of sex trafficking in the United States, with an estimated 63% identifying as Christian-affiliated (Institute for Survivor Care, 2024). Despite their prevalence, such programs often elicited skepticism due to the rise of secularism (Pew Research, 2022) and concerns that spiritual programming might retraumatize survivors (Ahrens et al., 2010; Hodge, 2020). However, Ahrens et al. (2010) and Hodge (2020) also found that religious practices can be helpful. This qualitative study employed a trauma-informed, descriptive survey design to explore the experiences of 158 trafficking survivors, who had either resided in …
Redundant Functions Of Mir156-Targeted Squamosa Promoter Binding Protein-Like Transcription Factors In Promoting Cauline Leaf Identity, Darren Manuela, Liren Du, Qi Zhang, Yifei Liao, Tieqiang Hu, Jim P. Fouracre, Mingli Xu
Redundant Functions Of Mir156-Targeted Squamosa Promoter Binding Protein-Like Transcription Factors In Promoting Cauline Leaf Identity, Darren Manuela, Liren Du, Qi Zhang, Yifei Liao, Tieqiang Hu, Jim P. Fouracre, Mingli Xu
Faculty Publications
No abstract provided.
Against The Phrase "Aggressive Care", Trevor M Bibler
Against The Phrase "Aggressive Care", Trevor M Bibler
Center for Medical Ethics and Health Policy Staff Publications
Language is the primary technology clinical ethicists use as they offer guidance about norms. Like any other piece of technology, to use the technology well requires attention, intention, skill, and knowledge. Word choice becomes a matter of professional practice. The Brief Report offers clinical ethicists several reasons for rejecting the phrase "aggressive care." Instead, ethicists should consider replacing "aggressive care" with the adjacent concept of a "recovery-focused path." The virtues of this neologism include: the opportunity to set aside the emotion of "aggression," the phrase's accuracy when capturing the intention of the patient or their representative, and an unappreciated rhetorical …
Utility Of The Us Preventive Services Task Force For Preeclampsia Risk Assessment And Aspirin Prophylaxis, Thomas F Mcelrath, Antonina I Frolova, Et Al.
Utility Of The Us Preventive Services Task Force For Preeclampsia Risk Assessment And Aspirin Prophylaxis, Thomas F Mcelrath, Antonina I Frolova, Et Al.
2020-Current year OA Pubs
IMPORTANCE: The US Preventive Services Task Force (USPSTF) guidelines on preeclampsia risk assessment and aspirin prophylaxis (AP) have not been evaluated for clinical utility.
OBJECTIVE: To evaluate which characteristics in the USPSTF guidelines identify risk status and the association of preeclampsia risk with AP recommendations.
DESIGN, SETTING, AND PARTICIPANTS: This observational cohort study enrolled from July 2020 to March 2023 with data analysis performed from October to December 2024. Enrollment occurred at 11 centers throughout the US or via direct-to-participant recruitment. Pregnant participants aged 18 years or older with a singleton pregnancy less than 22 weeks' gestation were selected via …
Bispecific Antibodies In Follicular Lymphoma, Imran A. Nizamuddin, Nancy L. Bartlett
Bispecific Antibodies In Follicular Lymphoma, Imran A. Nizamuddin, Nancy L. Bartlett
2020-Current year OA Pubs
Bispecific antibodies, specifically anti-CD20 T-cell engaging constructs, are poised to alter the treatment paradigm for multiple B-cell malignancies, including follicular lymphoma. Two CD20xCD3 bispecific antibodies, mosunetuzumab and epcoritamab, are now approved in the United States for third-line or later treatment of follicular lymphoma. A third agent, odronextamab, remains under review by regulatory agencies. In pivotal phase II trials, these bispecific antibodies demonstrated overall response rates of approximately 80%, with complete response rates of 60-70%, the majority of which have been durable at 2 years. Important safety signals included risk of infections, neutropenia, and cytokine release syndrome, which occurred in approximately …
Robust Photogrammetric Scalp Morphology Estimation For Functional Optical Neuroimaging, Abigail L Magee, Calamity Svoboda, Tessa G George, Alvin A Agato, Edward J Richter, Joseph P Culver, Adam T Eggebrecht
Robust Photogrammetric Scalp Morphology Estimation For Functional Optical Neuroimaging, Abigail L Magee, Calamity Svoboda, Tessa G George, Alvin A Agato, Edward J Richter, Joseph P Culver, Adam T Eggebrecht
2020-Current year OA Pubs
SIGNIFICANCE: Optical functional neuroimaging relies upon accurate anatomical models to provide optimal data registration and image reconstruction.
AIM: We establish and validate a robust photogrammetric algorithm for scalp morphology that utilizes 3-dimensional (3D) imaging with a photogrammetric cap to provide individualized scalp morphology estimation through hair in the absence of magnetic resonance imaging (MRI).
APPROACH: The scalp morphology estimation uses a flexible, neoprene cap and 3D-printed photogrammetric modules with fiducials. We create a sparse scalp sampling and align the MNI152 atlas to generate the scalp morphology estimation. We used the international 10 to 20 electroencephalogram positions for alignment and calculated …
The Impact Of Diabetes And Metabolic Syndrome Burden On Pain, Neuropathy Severity And Fiber Type, Long Davalos, Brian C Callaghan, Lavanya Muthukumar, Simone Thomas, Evan L Reynolds, A Gordon Smith, J Robinson Singleton, Ahmet Höke, Senda Ajroud-Driss, Mazen M Dimachkie, Stefanie Geisler, David M Simpson, Pnrr Study Group, Amro M Stino
The Impact Of Diabetes And Metabolic Syndrome Burden On Pain, Neuropathy Severity And Fiber Type, Long Davalos, Brian C Callaghan, Lavanya Muthukumar, Simone Thomas, Evan L Reynolds, A Gordon Smith, J Robinson Singleton, Ahmet Höke, Senda Ajroud-Driss, Mazen M Dimachkie, Stefanie Geisler, David M Simpson, Pnrr Study Group, Amro M Stino
2020-Current year OA Pubs
OBJECTIVE: Determine the association between diabetes and metabolic syndrome (MetS) burden (number of MetS criteria fulfilled) and pain, neuropathy severity, and fiber type involvement in individuals with established polyneuropathy.
METHODS: The Peripheral Neuropathy Research Registry was queried for individuals with type 1 and type 2 diabetes (DPN) and non-diabetic peripheral neuropathy (cryptogenic sensory polyneuropathy and prediabetes) using cross-sectional observational data. Associations between diabetes or MetS burden and pain presence (yes/no), neuropathy severity (Total Neuropathy Score reduced), and fiber type involvement (pinprick, vibration, and proprioception examination-small, large, mixed) using logistic, linear, and multinomial regression models were determined.
RESULTS: A total of …
Faculty Perceptions Of Diversity And Its Impact On Postsecondary Student Success: A Case Study In A Business School, Andrea Camargo, Harika Rao
Faculty Perceptions Of Diversity And Its Impact On Postsecondary Student Success: A Case Study In A Business School, Andrea Camargo, Harika Rao
Faculty and Staff Publications & Presentations
This case study investigates the way in faculty perceives the function of diversity in molding student success and institutional inclusiveness under a business school’s context. Conducting a mixed-methods survey of faculty, the study examines the question, does diverse faculty representation influence student retention, classroom engagement, and academic performance? Findings reveal robust agreement amongst faculty that diversity makes learning environments more inclusive, promotes student well-being and creates supportive mentor relationships with desirable influence to student persistence and success. The qualitative responses show the implication of culturally responsive teaching practices and inclusive faculty–student relationships, especially to underrepresented students. Although this assumes an …
Dna Methylation Epitypes Of Burkitt Lymphoma With Distinct Molecular And Clinical Features, Nicole Thomas, Nancy L Bartlett, Et Al.
Dna Methylation Epitypes Of Burkitt Lymphoma With Distinct Molecular And Clinical Features, Nicole Thomas, Nancy L Bartlett, Et Al.
2020-Current year OA Pubs
UNLABELLED: The genetic subtypes of Burkitt lymphoma have been defined, but the role of epigenetics remains to be comprehensively characterized. We searched genomic DNA from 218 patients across four continents for recurrent DNA methylation patterns and their associations with clinical and molecular features. We identified DNA methylation patterns that were not fully explained by the Epstein-Barr virus status or mutation status, leading to two epitypes described here as HypoBL and HyperBL. Each is characterized by distinct genomic and clinical features including global methylation, mutation burden, aberrant somatic hypermutation, and survival outcomes. Methylation, gene expression, and mutational differences between the epitypes …
Muscle Rev-Erb Controls Time-Dependent Adaptations To Chronic Exercise In Mice, Jidong Liu, Fang Xiao, Abhinav Choubey, Udhaya Kumar S, Yanxiang Wang, Sungguan Hong, Tingting Yang, Husniye Gul Otlu, Ege Sanem Oturmaz, Emanuele Loro, Yuxiang Sun, Pradip Saha, Tejvir S Khurana, Li Chen, Xinguo Hou, Zheng Sun
Muscle Rev-Erb Controls Time-Dependent Adaptations To Chronic Exercise In Mice, Jidong Liu, Fang Xiao, Abhinav Choubey, Udhaya Kumar S, Yanxiang Wang, Sungguan Hong, Tingting Yang, Husniye Gul Otlu, Ege Sanem Oturmaz, Emanuele Loro, Yuxiang Sun, Pradip Saha, Tejvir S Khurana, Li Chen, Xinguo Hou, Zheng Sun
Center on Aging Staff Publications
The best time of the day for chronic exercise training and the mechanism underlying the timing effects is unclear. Here, we show that low-intensity, low-volume treadmill training in mice before sleep yields greater benefits than after waking for muscle contractile performance and systemic glucose tolerance. Baseline muscle performance also exhibits diurnal variations, with higher strength but lower endurance before sleep than after waking. Muscle-specific knockout of circadian clock genes Rev-erbα/β (Rev-MKO) in male mice eradicates the diurnal variations in both training and baseline conditions without affecting muscle mass, mitochondrial content, food intake, or spontaneous activities. Multi-omics and metabolic measurements reveal …
Why Are Men So Obsessed With Pornography? Andrea Dworkin Was Right, Robert Jensen
Why Are Men So Obsessed With Pornography? Andrea Dworkin Was Right, Robert Jensen
Dignity: A Journal of Analysis of Exploitation and Violence
No abstract provided.
Assessing The Benefits Of Simulations And War Games For The Homeland Security Enterprise Workforce, David Schanzer, Daveed Gartenstein-Ross, Jessica Sperling, Victoria Lee, Elena Johanson, Eleanor Ross
Assessing The Benefits Of Simulations And War Games For The Homeland Security Enterprise Workforce, David Schanzer, Daveed Gartenstein-Ross, Jessica Sperling, Victoria Lee, Elena Johanson, Eleanor Ross
Reports, Projects, and Research
In recent years, there has been great interest across government, academia, and the private sector in experiential learning, and in particular the use of simulation and game-based methodologies. The purpose of this project is to use rigorous social science research to assess the educational value of simulation-based experiential learning and provide a replicable evaluation model that allows for validation and extension by other scholars and practitioners.
This report helps to fill the gaps in understanding the specific educational and training advantages offered by games, as well as the best practices for employing games to train or educate members of the …
Cytidine Triphosphate Specifically Modulates Parb-Mediated Dna Compaction: Insights From Single-Molecule Analysis And Parb C-Terminal Lysine Mutagenesis, Lois Akosua Serwaa
Cytidine Triphosphate Specifically Modulates Parb-Mediated Dna Compaction: Insights From Single-Molecule Analysis And Parb C-Terminal Lysine Mutagenesis, Lois Akosua Serwaa
Theses and Dissertations
ParB is a central player in bacterial chromosome segregation, and cytidine triphosphate (CTP) is known to modulate its DNA compaction activity. This study explored whether CTP’s regulatory effect is due to specific molecular interactions beyond its known CTP-binding pocket. Using single-molecule flow-stretching and TIRF microscopy, we showed that CTP significantly reduces DNA compaction by wild-type Bacillus subtilis ParB, while ATP has no effect, supporting the hypothesis that CTP acts through specific recognition rather than general charge. CTP’s modulatory effect persisted across C-terminal domain (CTD) lysine mutants. Compaction was reduced in wild-type and K255A but abolished in K252A and K259A. The …
Physical Work Environments: An Integrative Review And Agenda For Future Research, Bukky Akinsanmi Oyedeji, Yea Hee Ko, Sunkee Lee
Physical Work Environments: An Integrative Review And Agenda For Future Research, Bukky Akinsanmi Oyedeji, Yea Hee Ko, Sunkee Lee
Research Collection Lee Kong Chian School Of Business
This review examines the effect of physical work environments—the dedicated, tangible spaces where employees carry out their professional tasks—on organizational processes and outcomes. We synthesize decades of research across various disciplines using a conceptual framework that defines physical work environments along three key dimensions: ambience, spatial configuration, and aesthetics. These dimensions are analyzed for their effects on both internal stakeholders, such as employees, and external stakeholders, including clients, suppliers, and investors. Our analysis reveals two major themes in prior research: (1) task accomplishment, which focuses on how physical work environments influence physical and mental health, motivation and attitudes, as well …
Tumour And Microenvironment Crosstalk In Nsclc Progression And Response To Therapy, Zahraa Rahal, Roy El Darzi, Seyed Javad Moghaddam, Tina Cascone, Humam Kadara
Tumour And Microenvironment Crosstalk In Nsclc Progression And Response To Therapy, Zahraa Rahal, Roy El Darzi, Seyed Javad Moghaddam, Tina Cascone, Humam Kadara
Faculty, Staff and Student Publications
The treatment landscape of non-small-cell lung cancer (NSCLC) is evolving rapidly, driven by advances in the development of targeted agents and immunotherapies. Despite this progress, some patients have suboptimal responses to treatment, highlighting the need for new therapeutic strategies. In the past decade, the important role of the tumour microenvironment (TME) in NSCLC progression, metastatic dissemination and response to treatment has become increasingly evident. Understanding the complexity of the TME and its interactions with NSCLC can propel efforts to improve current treatment modalities, overcome resistance and develop new treatments, which will ultimately improve the outcomes of patients. In this Review, …
Diagnostic Guidance For Chronic Complex Regional Pain Syndrome Type I And Type Ii From The American Society Of Interventional Physicians (Asipp), Christopher Gharibo, Miles Day, Steve M Aydin, Alan D Kaye, Salahadin Abdi, Lisa V Doan, Kris Ferguson, Kirolos Georges, Andrew Kaufman, Nebojsa Nick Knezevic, Sean Li, Franzes A Liongson, Devi Nampiaparampil, Annu Navani, Mahendra Sanapati, Michael E Schatman, Amol Soin, Peter S Staats, Giustino Varrassi, Jing Wang, Laxmaiah Manchikanti
Diagnostic Guidance For Chronic Complex Regional Pain Syndrome Type I And Type Ii From The American Society Of Interventional Physicians (Asipp), Christopher Gharibo, Miles Day, Steve M Aydin, Alan D Kaye, Salahadin Abdi, Lisa V Doan, Kris Ferguson, Kirolos Georges, Andrew Kaufman, Nebojsa Nick Knezevic, Sean Li, Franzes A Liongson, Devi Nampiaparampil, Annu Navani, Mahendra Sanapati, Michael E Schatman, Amol Soin, Peter S Staats, Giustino Varrassi, Jing Wang, Laxmaiah Manchikanti
Faculty, Staff and Student Publications
Background: Complex Regional Pain Syndrome (CRPS) is a challenging and often disabling condition marked by persistent pain, most commonly in a limb following injury or surgery. It presents with a wide array of symptoms, including intense pain, swelling, alterations in skin color and temperature, motor dysfunction, and trophic changes such as skin and tissue atrophy. While the precise cause of CRPS is not fully understood, it is thought to stem from abnormal nervous system activity, leading to heightened pain sensitivity and inflammatory responses. A thorough understanding of CRPS is essential for accurate diagnosis, effective treatment, and enhancing patients' quality of …
Incomplete Toxicity Reporting And Use Of Toxicity-Minimizing Language In Phase Iii Oncology Trials, Avital M Miller, Adina H Passy, Alexander D Sherry, Ramez Kouzy, Joseph Abi Jaoude, Gabrielle S Kupferman, Pavlos Msaouel, Ethan B Ludmir
Incomplete Toxicity Reporting And Use Of Toxicity-Minimizing Language In Phase Iii Oncology Trials, Avital M Miller, Adina H Passy, Alexander D Sherry, Ramez Kouzy, Joseph Abi Jaoude, Gabrielle S Kupferman, Pavlos Msaouel, Ethan B Ludmir
Faculty, Staff and Student Publications
Purpose: This study aimed to determine complete toxicity reporting (CTR), and the use of subjective toxicity-minimizing language (TML) among phase III oncology trials.
Methods: Two-arm superiority-design phase III oncology trials published from 2002 to 2020 were reviewed for toxicity data. CTR was defined as reporting total adverse events (TAEs), total serious adverse events (SAEs), total deaths, and study therapy discontinuations because of toxicity. Guideline concordance was defined according to guidelines published in the BMJ (defined as reporting total SAEs, total deaths, and study therapy discontinuations because of toxicity). TML was defined as a set of terms that subjectively downplay the …
Histone Lysine Methyltransferases Mll3 And Mll4 Direct Gene Expression To Produce Platelets Efficiently, Guozhen Gao, Josimar Dornelas Moreira, Prosun Das, Kevin Lin, Kai Ge, Yue Lu
Histone Lysine Methyltransferases Mll3 And Mll4 Direct Gene Expression To Produce Platelets Efficiently, Guozhen Gao, Josimar Dornelas Moreira, Prosun Das, Kevin Lin, Kai Ge, Yue Lu
Faculty, Staff and Student Publications
Circulating blood platelets are responsible for maintaining hemostasis. They are released into blood vessels from mature megakaryocytes. Although several transcription factors have been reported to orchestrate the transcriptional programs required for platelet production, how chromatin regulators control these processes is still poorly understood. MLL3 and MLL4 are the main lysine methyltransferases responsible for the deposition of H3K4me1 histone marks at enhancers. MLL3 and MLL4 typically form complexes with other co-factors, such as PTIP. Recently, we showed that loss of PTIP leads to decreased platelet numbers in mice. Here, we find that, although MLL3/4 double deficiency does not alter megakaryopoiesis and …