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Ligand-Activated Egfr/Mapk Signaling But Not Pi3k, Are Key Resistance Mechanisms To Egfr-Therapy In Colorectal Cancer, Xueping Qu, Habib Hamidi, Radia M Johnson, Ethan S Sokol, Eva Lin, Cathy Eng, Tae Won Kim, Johanna Bendell, Smruthy Sivakumar, Benjamin Kaplan, Felipe De Sousa E Melo, Andrew Mancini, Matthew Wongchenko, Yi Shi, David Shames, Yibing Yan, Fortunato Ciardiello, Carlos Bais May 2025

Ligand-Activated Egfr/Mapk Signaling But Not Pi3k, Are Key Resistance Mechanisms To Egfr-Therapy In Colorectal Cancer, Xueping Qu, Habib Hamidi, Radia M Johnson, Ethan S Sokol, Eva Lin, Cathy Eng, Tae Won Kim, Johanna Bendell, Smruthy Sivakumar, Benjamin Kaplan, Felipe De Sousa E Melo, Andrew Mancini, Matthew Wongchenko, Yi Shi, David Shames, Yibing Yan, Fortunato Ciardiello, Carlos Bais

Faculty, Staff and Student Publications

Understanding mechanisms of resistance to active therapies is crucial for developing more effective treatments. Here, we investigate resistance to anti-EGFR and anti-VEGF plus chemotherapy treatment in colorectal cancer (CRC) patients from the IMblaze370 trial (NCT02788279). While anti-VEGF does not select for secondary mutations, anti-EGFR leads to simultaneous mutations in EGFR and MAPK, but not PI3K pathway genes. Notably, we observe frequent acquired mutations in the EGFR extracellular but not intracellular domain and that patients with higher baseline expression of EGFR-ligands are prone to acquire resistant mutations. This data reveals a ligand-activated EGFR/MAPK-signaling dependency in CRC. We also observe enrichment for …

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Architecture Of Pseudomonas Aeruginosa Glutamyl-Trna Synthetase Defines A Subfamily Of Dimeric Class Ib Aminoacyl-Trna Synthetases, Michael K. Fenwick, Stephen J. Mayclin, Steve Seibold, Amy E. Derocher, Sandhya Subramanian, Isabelle Q. Phan, David M. Dranow, Donald D. Lorimer, Ariel B. Abramov, James M. Bullard May 2025

Architecture Of Pseudomonas Aeruginosa Glutamyl-Trna Synthetase Defines A Subfamily Of Dimeric Class Ib Aminoacyl-Trna Synthetases, Michael K. Fenwick, Stephen J. Mayclin, Steve Seibold, Amy E. Derocher, Sandhya Subramanian, Isabelle Q. Phan, David M. Dranow, Donald D. Lorimer, Ariel B. Abramov, James M. Bullard

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

The aminoacyl-tRNA synthetases (AaRSs) are an ancient family of structurally diverse enzymes that are divided into two major classes. The functionalities of most AaRSs are inextricably linked to their oligomeric states. While GluRSs were previously classified as monomers, the current investigation reveals that the form expressed in Pseudomonas aeruginosa is a rotationally pseudosymmetrical homodimer featuring intersubunit tRNA binding sites. Both subunits display a highly bent, “pipe strap” conformation, with the anticodon binding domain directed toward the active site. The tRNA binding sites are similar in shape to those of the monomeric GluRSs, but are formed through an approximately 180-degree rotation …

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Exploring The International Terminology Associated With Nurses Caring For Neonates, Infants, Children, Young People And Their Families., Matt Carey, Jane Coad, Imelda Coyne, Suja Somanadhan, Sarah Neill May 2025

Exploring The International Terminology Associated With Nurses Caring For Neonates, Infants, Children, Young People And Their Families., Matt Carey, Jane Coad, Imelda Coyne, Suja Somanadhan, Sarah Neill

School of Nursing and Midwifery

The terminology used for Registered Nurses specializing in caring for neonates, infants, children, young people (CYP), and their families varies globally. While many countries’ nursing students qualify as “Registered Nurses” upon completion of undergraduate education, specialist titles like “Children’s Nurses” in the United Kingdom or “Pediatric Nurses” in Italy denote expertise in CYP care. In countries like the United States and Canada, neonatal and pediatric nursing specialization typically requires postgraduate study. However, there is limited evidence on the range of international terms for nurses in this field. This expert opinion paper presents the results from a scoping survey designed to …

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217 E. 93 Llc V. Edwards May 2025

217 E. 93 Llc V. Edwards

All Decisions

In a post-stipulation holdover for lease expiration, the tenant moved to stay execution of a warrant of eviction beyond the stipulated vacate date. The landlord opposed, arguing that RPAPL §753 imposed a one-year time bar on such relief. The court analyzed the statutory tension between RPAPL §§749(3), 753, and CPLR §2201, concluding that §749(3) governs post-issuance stays and lacks a temporal limit. It exercised discretion to extend the eviction stay until June 17, 2025, citing the tenant's health, minor children with educational needs, and lack of prejudice to the landlord. The decision clarifies that courts retain discretion under RPAPL §749(3) …

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Restoring Context: Interdisciplinary Approaches To Art Conservation And Registration Challenges In Rural Museums, Jade Karas '25 May 2025

Restoring Context: Interdisciplinary Approaches To Art Conservation And Registration Challenges In Rural Museums, Jade Karas '25

Senior Scholarly and Creative Symposium

A prevalent issue for museums in rural areas is a lack of reliable registration methods. This occurs for a number of reasons whether it be a lack of resources (human, financial, spacial, etc.) or the erosion of knowledge overtime due to cultural reliance on generational knowledge. Additionally, different registrars often develop new methods for inventory without leaving behind instructions, leading subsequent registrars to devise their own methods. These gaps in the registration process frequently result in “registration problems”, objects that don’t get properly inventoried and thus have little to no context for their origins. This thesis aims to fill in …

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Development And Evaluation Of A Multiple Sclerosis-Related Suffering Index, Carolyn A. Wilder, Jennifer Gravesa, Salem O. Dehomb, Amanda L. Goodinga, Elizabeth J. Taylor May 2025

Development And Evaluation Of A Multiple Sclerosis-Related Suffering Index, Carolyn A. Wilder, Jennifer Gravesa, Salem O. Dehomb, Amanda L. Goodinga, Elizabeth J. Taylor

Dissertations

Multiple sclerosis (MS) is a chronic, progressive neurological disease characterized by complex physical, psychological, and emotional challenges that profoundly impact patients’ quality of life. Despite advances in symptom management, the multifaceted suffering experienced by individuals with MS remains inadequately measured, understood, and addressed. This study aimed to develop and validate the Wilder Multiple Sclerosis Suffering Index (WMSSI), a novel tool designed to quantitatively measure the unique dimensions of suffering in this population.

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The Tax Adviser, Volume 16, Number 9, September 1985, American Institute Of Certified Public Accountants May 2025

The Tax Adviser, Volume 16, Number 9, September 1985, American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

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Tax Trends, Nicholas J. Fiore May 2025

Tax Trends, Nicholas J. Fiore

Tax Adviser

No abstract provided.

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Prepaid Feed Deductions Although, Kent N. Schneider, Ted D. Englebrecht May 2025

Prepaid Feed Deductions Although, Kent N. Schneider, Ted D. Englebrecht

Tax Adviser

No abstract provided.

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Dra’S Effect On The Taxation Of Partners And Partnerships, Donald M. Slattery, Ruth H. Bullard May 2025

Dra’S Effect On The Taxation Of Partners And Partnerships, Donald M. Slattery, Ruth H. Bullard

Tax Adviser

No abstract provided.

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Tax Clinic, John L. Norman Jr. May 2025

Tax Clinic, John L. Norman Jr.

Tax Adviser

No abstract provided.

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New Sec. 280f Restricts Tax Benefits For Microcomputers, Lawrence H. Hammer, Kevin E. Murphy May 2025

New Sec. 280f Restricts Tax Benefits For Microcomputers, Lawrence H. Hammer, Kevin E. Murphy

Tax Adviser

No abstract provided.

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Substantiation And Valuation For Autos After Contemporaneous Requirement Repeal, Thomas J. Feichter, Lisa L. Graves May 2025

Substantiation And Valuation For Autos After Contemporaneous Requirement Repeal, Thomas J. Feichter, Lisa L. Graves

Tax Adviser

No abstract provided.

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Just War, Pacifism, And Inevitability Of Conflict: Tolkien’S Changing Attitudes To War, Alexander Retakh May 2025

Just War, Pacifism, And Inevitability Of Conflict: Tolkien’S Changing Attitudes To War, Alexander Retakh

Journal of Tolkien Research

Tolkien’s approach to war is often considered through the lens of “just war” theory. Its main principles are the necessity of a just cause for war, proper conduct in battle, and the use of proper weapons; if possible, war should be avoided. The Lord of the Rings suggests an ethical framework inspired by this theory; however, the earlier Legendarium is more accepting of military conflicts and their harsh reality. Tolkien's attitude to war appears to shift in the mid-late 1930s, the time of intense debates about just war and pacifism among British Catholics. This paper discusses the evolution of his …

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State Right To Appeal: Has Maine Been Too Cautious?, David J. Corson May 2025

State Right To Appeal: Has Maine Been Too Cautious?, David J. Corson

Maine Law Review

The Legislature of the State of Maine recently passed an act relating to appeals by the State on questions of law in criminal cases. The Governor's approval of the act on January 29, 1968, was the culmination of some three years of research and debate. The purpose of this comment is to examine the form and scope of the act in light of the continuing controversy in other jurisdictions over the conflict of interests between the people and the accused in what may be characterized as a trend toward more comprehensive state appeal laws, to the end of concluding whether …

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How Post Is Post-Conviction Relief In Maine?, Charles L. Cragin Iii May 2025

How Post Is Post-Conviction Relief In Maine?, Charles L. Cragin Iii

Maine Law Review

In a recent case the Maine Supreme Judicial Court delineated the prerequisites for relief under Maine's post-conviction relief statute. The court declared that actual or constructive custody is necessary for relief. In Thoresen v. State, petitioner was convicted of a felony in Maine in 1959. He had been represented by retained counsel, and had elected to plead guilty to an information charging him with grand larceny. His sentence was suspended by probation and he was permitted to leave the state. Formally complying with all the regulations of his probation, he was given a total discharge in 1961. In 1967, he …

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Equal Protection As A Measure Of Competing Interests In Welfare Litigation, John G. Richardson May 2025

Equal Protection As A Measure Of Competing Interests In Welfare Litigation, John G. Richardson

Maine Law Review

Presently legal attacks on welfare programs focus upon the basic theory of the program, its definitions of need and obligation, and dissatisfaction with aspects of daily administration. Because these attacks seek to invalidate state action and federal forums are usually sought, conventional constitutional arguments of due process and equal protection are adapted to the peculiar issues posed by welfare cases. These attacks in substance allege that the state has so failed to support a needy person that its actions are fundamentally unfair and unacceptable. Equal protection has been raised often in welfare cases and some courts have granted relief based …

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Suggested Revisions In Maine's Planning And Land Use Control Enabling Legislation—Part Ii, Orlando E. Delogu May 2025

Suggested Revisions In Maine's Planning And Land Use Control Enabling Legislation—Part Ii, Orlando E. Delogu

Maine Law Review

The process which transfers land from its natural or an unintensively used agricultural state to house lots, shopping centers, or industrial sites is often referred to as land subdivision. No more long-lasting or fundamental series of changes with respect to the land can be imagined; yet the process in Maine is not only unregulated by the state and by most local levels of government, but is not at present capable of being regulated in any meaningful sense of the word. No state statutes exist which impose even the most reasonable standards, limitations, or procedural safeguards on either the process of …

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Introduction: Norms And Limits Of Fairy-Tale Transgression, Alessandro Cabiati, Lewis C. Seifert May 2025

Introduction: Norms And Limits Of Fairy-Tale Transgression, Alessandro Cabiati, Lewis C. Seifert

Marvels & Tales

No abstract provided.

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Maine's Educational Television Network: Legal Difficulties, Charles L. Cragin Iii May 2025

Maine's Educational Television Network: Legal Difficulties, Charles L. Cragin Iii

Maine Law Review

Maine's educational television network (ETV) cannot pride itself in achieving broad goals and, in fact, cannot attempt to achieve them because of legislation of questionable legal validity which has become an anachronistic barrier to innovations consistent with a keener awareness of the utility of educational television. This note focuses on the state-controlled system servicing northern Maine and points out the conflicts between the system's enabling legislation and the manner in which the system currently operates, and between the enabling legislation and federal laws and regulations. Additionally, it recommends, in a statutory format, the manner in which the system should be …

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Legislative Discouragement Of Maine's Marine Industrial Growth, John H. Pursel May 2025

Legislative Discouragement Of Maine's Marine Industrial Growth, John H. Pursel

Maine Law Review

At common law the public rights to navigation and fishing could not be alienated by the King. Dry land and the land beneath the sea could be alienated but only so long as the public rights to navigation and fishing were preserved. This common law doctrine was rejected in 1842 by the United States Supreme Court as binding precedent for limiting the alienation of the public domain by the legislatures of the various states. In Martin v. Wadell the Court reasoned that this common law principle was not applicable because the people of the United States through their act of …

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The Farm Worker: His Need For Legislation, Susan Calkins May 2025

The Farm Worker: His Need For Legislation, Susan Calkins

Maine Law Review

Of America's ignored and invisible people, the farm worker is one of the most ignored and least visible. He is hidden by the crops as he works his way down the endless rows. Far from the cities where the laws are made and the issues of the day are debated, his voice is not heard. He is vitally necessary to this well-fed nation, and yet his needs are seldom considered. The legislators have not ignored the industrial worker. They have provided him with laws insuring a minimum wage, workmen's compensation and other such benefits. The farm worker, however, is expressly …

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Proof Of Defect In A Strict Products Liability Case, Robert F. Hanson May 2025

Proof Of Defect In A Strict Products Liability Case, Robert F. Hanson

Maine Law Review

The realization that negligence doctrines do not provide an adequate remedy for consumers injured by defective products has led many courts to adopt theories of strict liability. Justification for the strict liability doctrine rests on the judicial belief that the law should provide maximum protection for the health and safety of all consumers, and that the manufacturer is "conditionally at fault" if he does not compensate consumers injured by his defective products. Manufacturers are not held liable for all product-related harm to consumers. To recover the plaintiff must plead and prove that the product which caused the harm was defective …

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Right To Jury Trial: Lemieux V. Robbins, Stephen R. Sunenblick May 2025

Right To Jury Trial: Lemieux V. Robbins, Stephen R. Sunenblick

Maine Law Review

A sagacious English liveryman named Tobias Hobson allowed each customer to choose the horse nearest the door, thereby presenting these customers with no real alternative. The State of Maine made a like proposition in Lemieux v. Robbins by implementing a novel criminal procedure whereby a defendant has a "choice" of either accepting his district court misdemeanor conviction as final, or appealing for a de novo trial by jury in superior court and possibly being convicted of a felony for contravening the same statute under which he was originally charged. The implementation of this procedure began with a complaint filed in …

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The Administrative Discharge: Changes Needed?, Norman B. Lynch May 2025

The Administrative Discharge: Changes Needed?, Norman B. Lynch

Maine Law Review

At its annual convention in 1968 the American Bar Association adopted a resolution authorizing its Special Committee on Military Justice to urge congressional action with respect to the military administrative discharge and military due process of law. In response to this urging two bills were introduced in the 91st Congress dealing with the administrative discharge of members of the Armed Forces. One was sponsored by Congressman Charles E. Bennett, (D. Fla.). Another was introduced by Senator Sam J. Ervin, (D. N.C.). The Bennett bill proposes amendments to title 10 of the United States Code to limit the separation of members …

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Procedural Rights Of The Military Accused: Advantages Over A Civilian Defendant, Homer E. Moyer Jr. May 2025

Procedural Rights Of The Military Accused: Advantages Over A Civilian Defendant, Homer E. Moyer Jr.

Maine Law Review

The Supreme Court recently decided in O'Callahan v. Parker that the military lacks jurisdiction to try servicemen for crimes that are not "service-connected." Justice Douglas, in rendering the majority opinion, was highly critical of military justice and criminal procedures in the court-martial system, which he characterized as "a system of specialized military courts, proceeding by practices different from those obtaining in the regular courts and in general less favorable to defendants . . . . .” The opinion further added that "courts-martial as an institution are singularly inept in dealing with the nice subtleties of constitutional law . . . …

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The Civilianization Of Military Law, Edward F. Sherman May 2025

The Civilianization Of Military Law, Edward F. Sherman

Maine Law Review

Military law in the United States has always functioned as a system of jurisprudence independent of the civilian judiciary. It has its own body of substantive laws and procedures which has a different historical derivation than the civilian criminal law. The federal courts have always been reluctant to interfere with the court-martial system, as explained by the Supreme Court in 1953 in Burns v. Wilson: "Military law, like state law, is a jurisprudence which exists separate and apart from the law which governs in our federal judicial establishment. This Court has played no role in its development; we have exerted …

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An Extra-Textual Analysis: Bell V. Wilkinsburg School District, Kevin R. Brinker May 2025

An Extra-Textual Analysis: Bell V. Wilkinsburg School District, Kevin R. Brinker

Widener Commonwealth Law Review

No abstract provided.

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Distancing From Precedent & Procedures In Favor Of An Uninformed Public: A Survey Of Energy Transfer V. Friedman, Gina R. Salash May 2025

Distancing From Precedent & Procedures In Favor Of An Uninformed Public: A Survey Of Energy Transfer V. Friedman, Gina R. Salash

Widener Commonwealth Law Review

No abstract provided.

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Wise V. Huntingdon County Housing Development Corporation: The Expansion Of Pennsylvania Commonwealth Sovereign Immunity Real Estate Exception, Kendyl L. Swank May 2025

Wise V. Huntingdon County Housing Development Corporation: The Expansion Of Pennsylvania Commonwealth Sovereign Immunity Real Estate Exception, Kendyl L. Swank

Widener Commonwealth Law Review

No abstract provided.

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