Digital Commons Network^™

Figo Position Statement: Gamete Donations, Laurie Henry, Aris Antsaklis, Dov Feldberg, Jaideep Malhotra, Suchitra Pandit, Carlos Salazar, Alex Vidaeff, Rafal Zadykowicz, M Louise Hull, Nikhil Purandare

Faculty, Staff and Students Publications

Gamete donation has become a crucial part of Assisted Reproductive Technologies (ARTs), providing hope to individuals, including those who may have no other option for parenthood. This process comes with a wide range of ethical, medical, and legal challenges that need to be carefully addressed to protect the well-being and rights of all parties involved: donors, recipients, and offspring. Navigating these complexities requires strict ethical standards, robust regulatory frameworks, and international collaboration. By standardizing these, the field of gamete donation can continue to develop while ensuring that all parties are well informed and safeguarded. This paper explores the ethical concerns …

Microbial Biosensor For Sensing And Treatment Of Intestinal Inflammation, Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V Douglas, Walter J Chazin, Eric P Skaar, Jeffrey J Tabor, Robert A Britton

Faculty, Staff and Students Publications

Synthetic biology has enabled the development of biosensors to detect intestinal inflammation, yet few target the clinically validated biomarker of intestinal inflammation calprotectin with both diagnostic and therapeutic capabilities. Here, an optimized calprotectin biosensor is presented that leverages a zinc uptake regulator (Zur) controlled promoter coupled with a memory circuit to detect and record intestinal inflammation in vivo. The level of biosensor activation strongly correlates with calprotectin levels in the colon of two independent mouse models of colitis. Coupling of the biosensor with the production of the anti-inflammatory cytokine IL10 allowed for the resolution of chemically induced colitis, demonstrating the …

Cytokine Release Syndrome And Neurotoxicity Following Cd19 Car-T In B-Cell Lymphoma, Roni Shouval, Christopher Strouse, Soyoung Kim, Temitope Oloyede, Sairah Ahmed, Farrukh T Awan, Danny Luan, Veronika Bachanova, Talha Badar, Merav Bar, Pere Barba, Amer M Beitinjaneh, Amanda Cashen, Bhagirathbhai Dholaria, Mahmoud Elsawy, Siddhartha Ganguly, Praveen Ramakrishnan Geethakumari, Uri Greenbaum, Hamza Hashmi, Laquisa C Hill, Michael D Jain, Tania Jain, Partow Kebriaei, Adam S Kittai, Frederick L Locke, Premal D Lulla, Elena Mead, Joseph P Mcguirk, Alberto Mussetti, Taiga Nishihori, Amanda L Olson, Martina Pennisi, Miguel-Angel Perales, Peter A Riedell, Wael Saber, Abu-Sayeef Mirza, Margarida Magalhaes-Silverman, Elizabeth J Shpall, Mohamed Sorror, Kitsada Wudhikarn, Cameron J Turtle, Amy Moskop, Marcelo C Pasquini

Faculty, Staff and Students Publications

Chimeric antigen receptor T cell (CAR-T) therapy is an effective treatment for relapsed-refractory large B-cell lymphoma (LBCL). However, toxicities, particularly cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), remain significant concerns. Analyze temporal trends, risk factors, and associations between these toxicities and their severity. In this registry study by the Center for International Blood and Marrow Transplant Research, we studied CRS and ICANS in 1916 LBCL patients treated with commercial CAR-T therapies (axicabtagene ciloleucel 74.9%, tisagenlecleucel 25.1%) between 2018 and 2020. Outcomes include development of CRS/ICANS, timing and severity according to ASTC grading, overall survival (OS). Risk …

Performance Of Stool Xpert Mtb/Rif Ultra For Detection Of Mycobacterium Tuberculosis Among Adults Living With Hiv: A Multicentre, Prospective Diagnostic Study, George W Kasule, Sabine Hermans, Sozinho Acacio, Alexander Kay, Joachim Kikoyo Nsubuga, Carlos Fernández-Escobar, Nosisa Shiba, Lucia Carratalá-Castro, Derrick Semugenze, Patricia Mwachan, Shilzia Munguambe, Joanna Ehrlich, Elisa Lopez-Varela, Andrew R Dinardo, Frank Cobelens, Christoph Lange, Moses Joloba, Anna M Mandalakas, Willy Ssengooba, Alberto L García-Basteiro

Faculty, Staff and Students Publications

Background: When people living with HIV develop pulmonary tuberculosis, it often manifests without detectable acid-fast bacilli on sputum microscopy. We aimed to assess the diagnostic accuracy of stool Xpert MTB/RIF Ultra (hereafter, Ultra) for Mycobacterium tuberculosis detection among adults with HIV.

Methods: This multicentre, prospective diagnostic accuracy study was done in outpatient and inpatient health centres in Eswatini, Mozambique, and Uganda. We enrolled adults aged 15 years and older with HIV with presumptive tuberculosis. We evaluated the diagnostic accuracy of stool Ultra using the simple one-step processing method against a composite microbiological reference standard (CMRS) including three WHO-recommended tuberculosis diagnostic …

A Hypomorphic Model Of Cps1 Deficiency For Investigating The Effects Of Hyperammonemia On The Developing Nervous System, Stuti Bakshi, Taryn Diep, Brandon J Willis, Rachel Reyes, Grace F Wu, Georgios Makris, Martin Poms, Isabel Day, Qin Sun, Irina Zhuravka, Lindsay Lueptow, Michelle Tang, Gareth A Cromie, Aimée M Dudley, Johannes Häberle, Gerald S Lipshutz

Faculty, Staff and Students Publications

Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a rare metabolic disorder that, in neonatal onset, is typically characterized by severe life-threatening and neurologically injuring hyperammonemic episodes with high unmet patient need. Patients that retain limited enzyme activity may present later in life with less severe hyperammonemia. CPS1 drives the first step in the urea cycle, the pathway terrestrial mammals utilize to metabolize nitrogen. In order to probe the effect of hyperammonemia on the developing nervous system and explore new therapies, a murine Cps1 exon 3-4 mutant was previously generated. However, these mice die within 24 h of birth, limiting study …

Role Of Kctd13 In Modulating Ar And Sox9 Expression In Different Penile Cell Populations, Carolina J Jorgez, Ahmed Chahdi, Hunter Flores, Marisol O'Neill, Abhishek Seth

Faculty, Staff and Students Publications

Objective: Micropenis is a condition with significant physical and psychological implications caused mainly by decreased androgen action in penile development. Kctd13-knockout (Kctd13-KO) mice have micropenis, cryptorchidism, and fertility defects because of reduced levels of androgen receptor (AR) and SOX9. We hypothesized that normalizing the levels of AR and SOX9 in the Kctd13-KO penis could help us to understand the mechanism of action of these signaling pathways on penile development.

Methods: We generated transgenic mice lacking Kctd13 and conditionally expressing AR in the urethral mesenchyme after Cre activation with Twist2cre (Kctd13-KO; AR-CMV; Twist2cre; herein called AR+), and Sox9 in the urethral …

Catching Up To Technology: Mediation’S Role In The Era Of Driverless Cars, Kaitlyn Puyear

Journal of Dispute Resolution

An autonomous vehicle (AV), also known as a driverless or self-driving car, is a vehicle that can operate itself and perform necessary functions without human intervention. Autonomous vehicles have been under development since the midtwentieth century and operate with the use of cameras and radar systems to acquire information about road conditions—allowing them to choose the easiest path of travel.

Glioblastoma-Instructed Astrocytes Suppress Tumour-Specific T Cell Immunity, Camilo Faust Akl, Brian M Andersen, Zhaorong Li, Federico Giovannoni, Martin Diebold, Liliana M Sanmarco, Michael Kilian, Luca Fehrenbacher, Florian Pernin, Joseph M Rone, Hong-Gyun Lee, Gavin Piester, Jessica E Kenison, Joon-Hyuk Lee, Tomer Illouz, Carolina M Polonio, Léna Srun, Jazmin Martinez, Elizabeth N Chung, Anton Schüle, Agustin Plasencia, Lucinda Li, Kylynne Ferrara, Mercedes Lewandrowski, Craig A Strathdee, Lorena Lerner, Christophe Quéva, Iain C Clark, Benjamin Deneen, Judy Lieberman, David H Sherr, Jack P Antel, Michael A Wheeler, Keith L Ligon, E Antonio Chiocca, Marco Prinz, David A Reardon, Francisco J Quintana

Faculty, Staff and Students Publications

Glioblastoma is the most common and aggressive primary brain cancer and shows minimal response to therapies. The immunosuppressive tumour microenvironment in glioblastoma contributes to the limited therapeutic response. Astrocytes are abundant in the central nervous system and have important immunoregulatory roles. However, little is known about their role in the immune response to glioblastoma1. Here we used single-cell and bulk RNA sequencing of clinical glioblastoma samples and samples from preclinical models, multiplexed immunofluorescence, in vivo CRISPR-based cell-specific genetic perturbations and in vitro mouse and human experimental systems to address this gap in knowledge. We identified an astrocyte subset …

Against The Phrase "Aggressive Care", Trevor M Bibler

Center for Medical Ethics and Health Policy Staff Publications

Language is the primary technology clinical ethicists use as they offer guidance about norms. Like any other piece of technology, to use the technology well requires attention, intention, skill, and knowledge. Word choice becomes a matter of professional practice. The Brief Report offers clinical ethicists several reasons for rejecting the phrase "aggressive care." Instead, ethicists should consider replacing "aggressive care" with the adjacent concept of a "recovery-focused path." The virtues of this neologism include: the opportunity to set aside the emotion of "aggression," the phrase's accuracy when capturing the intention of the patient or their representative, and an unappreciated rhetorical …

A Lysosomal Surveillance Response To Stress Extends Healthspan, Terytty Yang Li, Arwen W Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J Liu, Rachel N Arey, Kimberly Morales, Raya B Liu, Wenzheng Wang, Ang Zhou, Tong-Jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H Houtkooper, Johan Auwerx

Faculty, Staff and Students Publications

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H+-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%. This longevity phenotype can be explained by an adaptive transcriptional response typified by induction of a set of transcripts involved in lysosomal function and proteolysis, which we termed the lysosomal surveillance response (LySR). LySR activation is characterized by boosted lysosomal activity …

Student Life, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Undergraduate Curriculum, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Index 2025-2026, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

2. Faculty, Saint Mary's College Of California

Faculty Handbook

No abstract provided.

2025-2026 Academic Catalog, Saint Mary's College Of California

Undergraduate Academic Catalog

No abstract provided.

Competition In The Labor Market: The Wage Effect Of Employer Concentration In China, Jianan Liu, Hongbo Cai, Carl Lin

Faculty Journal Articles

Competition in the labor market theoretically leads to higher wages, yet empirical evidence to substantiate it, particularly in developing countries, has been sparse. Our study delves into the impact of increased competition in the labor market on workers' wages using a panel dataset from Chinese industrial firms spanning 1998 to 2013. Employing OLS and IV regressions, we demonstrate that a decrease in employer concentration is significantly linked to higher wages. The elasticities of employer concentration on wages fall within the range of −0.034 and −0.107. Additionally, our findings suggest that state-owned enterprises gained the most from this upswing in competition, …

Clinically Validated Graphical Approaches Identify Hepatosplenic Multimorbidity In Individuals At Risk Of Schistosomiasis, Yin-Cong Zhi, Simon Mpooya, Narcis Kabatereine, Betty Nabatte, Christopher Opio, Narcis Kabatereine, Goylette Chami

Internal Medicine, East Africa

The global burden of multimorbidity is increasing yet poorly understood, owing to insufficient methods for modelling complex systems of conditions. In particular, hepatosplenic multimorbidity has been inadequately investigated. From 17 January to 16 February 2023, we examined 3186 individuals aged 5–92 years from 52 villages across Uganda within the SchistoTrack Cohort. Point-of-care B-mode ultrasound was used to assess 45 hepatosplenic conditions within the context of schistosomiasis (Schistosoma mansoni). Three graph learning methods for representing hepatosplenic multimorbidity were compared. Thresholds for including graph edges were found using graph kernels and tested with graph neural networks to assess predictive utility for unobserved …

From Nation-Building To Collapse: Analyzing Afghanistan’S 2021 Fall And The Geopolitical Entropies Of U.S. Withdrawal, Arash Beidollahkhani, Edriss Rasa

Journal of Strategic Security

The collapse of the Afghan government in 2021 and the subsequent return of the Taliban marked a significant shift in contemporary geopolitics. This paper examines the political and social dynamics surrounding the U.S. and allied forces' withdrawal, focusing on the entropic forces that contributed to the breakdown of Afghanistan’s governance system. While Afghanistan has experienced recurrent governmental collapses, the post-2021 crisis highlights deeper structural challenges within both the geopolitical and domestic spheres. The research investigates the failure of the U.S.-backed Afghan government, established through two decades of nation-building efforts, and explores how the abrupt foreign withdrawal dismantled fragile political structures, …

Evidence-Based Shared Agendas For Scholarship On Teaching With Primary Sources: Reflections On A Bibliometric Analysis, Jen Hoyer, Anne Bahde

Publications and Research

This article explores how scholarship about teaching with primary sources (TPS) has evolved over time and what future directions past work might suggests. Using bibliometric analysis and visualization tools, we examined how TPS work has grown; what fields and disciplines focus on this work; key themes and issues; and what scholarship has been influential to the field. These insights led to reflections on disconnects across the field, considerations for publishing about TPS, and the potential of pedagogical standards and guidelines. Finally, this article concludes with recommendations on how this analysis points to possibilities for shared education, space, conversation, and products.

Kimball Hall, 1970: Collective Organizing Through Print Production, Jen Hoyer

Publications and Research

This article examines the May 1970 occupation of Kimball Hall, a university administrative building at New York University, and specifically of its basement printshop. The group that came together in this space referred to itself as the Kimball Commune; they used university equipment and resources to print material in support of the strike and related movements, and they invited students, activists, and the general public to come into the printshop and produce material with them. I demonstrate how the Kimball Commune provides a concrete example of how a collaborative radical printing project isn’t just about creating alternative media. It also …

Using Fables To Enhance Social Emotional Learning, Eric Albers

School of Education and Leadership Student Capstone Projects

The research question guiding this project is: How can we use fables to strengthen SEL connections with our students and families while enhancing the relationship between character development and life skills? The project addresses growing concerns about student anxiety, depression, and social disconnection while recognizing schools' expanding role in mental health. This work builds upon literature on home-school partnerships, bibliotherapy, and culturally responsive pedagogy, including research on fable comprehension, CASEL's SEL framework, and "funds of knowledge" that honor diverse cultural perspectives.The methodology involved developing a curriculum unit that integrates fables into the existing CharacterStrong SEL program through a Universal Design …

Beyond Language Barriers: Challenging The Equity And Validity Of English-Only Standardized Tests For English Language Learners, Courtney Pille

School of Education and Leadership Student Capstone Projects

English Language Learners represent one of the fastest-growing student populations in American schools, yet they are required to take state standardized tests designed exclusively for native English speakers. This practice creates significant validity, reliability, and equity concerns–as research demonstrates that academic English proficiency takes 4-8 years to develop while students face annual testing requirements beginning in grade 3. This capstone uses a comprehensive literature review examining standardized testing practices, English language acquisition processes, and equity challenges to answer the research question: To what extent does administering English-only standardized tests to English Language Learners (ELLs) produce valid measurements of their academic …

Liquid Power: Myths, Realities, And Policy Responses To Wall Street's Takeover Of Water Markets, Vanessa Casado-Pérez

Faculty Scholarship

In Don Quixote, there is a moment when all the knightly novels are thrown into the fire for their fantastical depictions of chivalry. Yet one book is spared: Tirant lo Blanc. It is saved because, unlike the others, it portrays knights who die in their beds-offering a more realistic depiction of medieval battles. Similarly, Liquid Asset stands out as the book that should be preserved from the extensive body of scholarship on water markets. Many works in this field are influenced by ideological biases that shape their analyses. In contrast, Buzz Thompson's books provides the nuance and balance often lacking …

Introduction To Leadership Concepts Handbook, Seth D. Kastle, Lori E. Kniffin, Brett Whitaker, Justin Greenleaf, Brent Goertzen, Donnette Noble, Tamas Kowalik

Leadership Open Educational Resources

This handbook was developed through a collaborative effort between a team of faculty members and AI tools. While AI assisted in drafting and organizing content, faculty members provided the scholarly direction, curated all academic references, and shaped the narrative to meet the needs of introductory undergraduate learners. Every section has been carefully reviewed and vetted to ensure both accuracy and academic integrity. The purpose of this text is to offer a clear, concise, and accessible resource that summarizes essential concepts without requiring students to purchase a textbook.

A Wearable-Based Approach To Spinal Posture Tracking And Assessment, Sydney Marie Sherman, Noah Jeffery

Biomedical Engineering: Graduate Reports and Projects

This paper describes the design, manufacturing, and testing of a novel spinal posture tracking wearable device with embedded sensors. Currently on the market, most of the spinal posture tracking devices only focus on one segment of the spine and therefore do not track the entirety of human posture. The objective for this project was to create a wearable device in the form of a “smart shirt” that offers insights into posture trends throughout the day by tracking the entire spine. To begin the project, multiple designs were developed for the sensor array and wearable materials. These concepts were compared against …

Interview Of Naomi Cahn, June Carbone & Nancy Levit, Naomi Cahn, June Carbone, Nancy Levit, Claire Hill, Matthew T. Bodie

Minnesota Journal of Law & Inequality

No abstract provided.

Conferences, Lightbulbs, And Gender, June Carbone

Minnesota Journal of Law & Inequality

No abstract provided.

An Economic, Psychological, And Linguistic Explanation Of (Some Reasons) Why Women Don’T Get A Fair Shake, Claire A. Hill

Minnesota Journal of Law & Inequality

No abstract provided.

The Impact Of Instructional School Design: The 6–12 School Model As A Strategic Response To Increase Black Boys Self-Efficacy, Xavier E. Edwards

Education Doctoral

This dissertation investigated the impact of the 6–12 instructional school design on the self-efficacy of Black boys, utilizing the theoretical frameworks of Bandura's self-efficacy model and Yosso's community cultural wealth model. The research explored how this specialized school structure supports Black boys' academic achievement, aspirations, and resilience—addressing longstanding disparities in educational and social outcomes. Through qualitative interviews with Black male alumni of 6–12 school models, the study identified factors within the design that positively influence self-efficacy both within and beyond the classroom. Findings indicated that sustained relationships with supportive teachers, a keen sense of brotherhood among peers, and consistent engagement …

Book Review: Into The Void: Special Operations Forces After The War On Terror, Eric Robinson

Parameters Bookshelf – Online Book Reviews

Editors: James D. Kiras and Martijn Kitzen

Reviewed by Eric Robinson, special operations researcher, RAND Corporation

Edited by James D. Kiras and Martijn Kitzen, Into the Void: Special Operations Forces after the War on Terror, looks at what is unique about the special operations forces' enterprise, explores how the organization must evolve, as well as a range of new operational concepts that could benefit SOF. Contributors include academics and practitioners from several backgrounds and countries.