Digital Commons Network^™

Rat Somatic Genome Editing Enables Er+ Breast Cancer Modeling, Wen Bu, Tobie Lee, Meenakshi Anurag, Yunfeng Ding, Ruixin Xu, Lillian He, Alexandria Z Bu, Chandandeep Nagi, Carolina Gutierrez, Susan Hilsenbeck, Chonghui Cheng, Bing Zhang, Shixia Huang, Jianming Xu, C Kent Osborne, Arun Sreekumar, Eric Chang, Chad J Creighton, Xiang Zhang, Yi Li

Faculty, Staff and Students Publications

Genetically engineered mouse models have advanced cancer research but often fail to capture key features of certain human tumors. Rats, with distinct physiology and tumor biology, offer a powerful alternative, yet their use has been constrained by technical barriers to genome editing. Here, we report efficient somatic genome editing in rats, enabling both Indel and substitution mutations. We then apply this approach to model estrogen receptor (ER)-positive breast cancer, which accounts for ~70% of human cases but remains poorly represented in mice. The resulting rat tumors reproduce hallmarks of human ER+ breast cancer, including ductal histology, hormone responsiveness, and immune-microenvironmental …

Seeing Google At 25, Paul A. Soukup S.J.

Communication Research Trends

Seeing Google at 25

1. History . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

A. Fits and starts to dominating the world . . . . . 5

2. Google in the Eyes of Scholars: Google Services 8

A. Digital library . . . . . . . . . . . . . . . . . . . . . . . . . 8

B. Google Earth and Google Maps . …

Managing Digital Visibility, Ben Medeiros

Communication Research Trends

No abstract provided.

Toward An Understanding Of Tax Complexity, Daniel Schaffa

Florida Tax Review

The study of tax complexity has reached consensus on two things. First, complexity pervades the U.S. tax system. And second, it is not always clear what tax complexity means. Indeed, it is common practice for tax complexity scholarship to note the absence of a universal tax complexity definition and then conduct its inquiry without one. A universal definition of tax complexity has proven elusive because tax complexity means many different (although often related) things. This has made the tax policy analysis of complexity challenging. As an alternative to a definition, this Article proposes a framework with four elements for considering …

Do Tax Judges Favor The Tax Authority?, Orli Oren-Kolbinger

Florida Tax Review

Judges and judicial systems have become more specialized in response to increasing legal complexity. While the theoretical literature has discussed judicial specialization extensively, deliberating its pros and cons and its implications—arguably an appealing background for empirical investigation—few empirical studies have attempted to quantify the relationship between judicial specialization and case outcomes. This Article fills that lacuna. It analyzes a hand-coded dataset of tax cases in which rulings were made by both specialized tax judges and generalist judges in Israeli District Courts. Its main finding is that specialized tax judges are more inclined than generalist judges toward the Tax Authority. It …

Ai And The Regulation Of Tax Return Preparers, Linda Galler, Jay A. Soled

Florida Tax Review

Tax return preparers play a pivotal role for millions of taxpayers, and their number ranges in the hundreds of thousands. Despite preparers’ importance in the tax return submission process and their numerical size, they are largely unregulated. Because of this lack of oversight, a significant number of tax return preparers put their own financial interests and those of their clients ahead of the government’s financial interests.

In the past, there have been calls for increased regulatory oversight to keep wayward practitioners’ actions in check. Therefore, a decade and a half ago, Congress, in conjunction with the Treasury Department, mandated that …

Capitalizing Carbon: The Taxation Of Carbon Credits In Voluntary Carbon Markets, Levi Loveless

Florida Tax Review

This Article explores the evolving intersection of carbon offset credits, U.S. federal tax law and clean energy tax incentives, emphasizing the complexities faced by businesses in navigating these areas. As carbon offset credits gain prominence in corporate sustainability strategies, their tax treatment remains ambiguous, with companies encountering varying interpretations under sections 162 and 263.

The analysis in Part II suggests that carbon offset credit purchases are likely to be generally capitalized, subject to rare exceptions. This conclusion is drawn from notable legal precedents, including Welch v. Helvering, Jenkins v. Commissioner and INDOPCO v. Commissioner. These cases provide insight …

Contextual Analysis Of Physical-Tactical Match Performance Demands In Elite U21 Soccer Players, Craig Davies, Christian Vassallo, Ben Ryan, Piotr Zmijewski, Rafael Oliveria, José E. Teixeira, Alexandre Moreira, Ryland Morgans

Baltic Journal of Health and Physical Activity

Background: Soccer matches include physical and tactical factors, yet limited research has integrated physical-tactical variables involving U21 soccer players. This study examined how different phases of play influence physical intensity in elite U21 soccer players. Materials and Methods: Twelve professional development league matches involving 29 male U21 soccer players (106 observations) were analysed. Players wore 10 Hz GPS units to derive relative (m/min) physical metrics during six phases of play. Phases and positions were compared using repeated‑measures ANOVA and one‑way ANOVA. Results: Players covered significantly greater high-speed running per minute (HSR/min) during the final third compared to build-up (p …

Development And Validation Of An Analytical Method For Determination Of Bongkrekic Acid In Biofluids For Toxin Monitoring, Ying-Tzu Shieh, Te-I Weng, Ju-Yu Chen, I-Ting Wang, Kevin Shu-Leung Lai, Chia-Mo Lin, Chu-Yun Teng, Guan-Yuan Chen

Journal of Food and Drug Analysis

Bongkrekic acid (BKA) poisoning is a severe foodborne illness with a high mortality rate. This study aimed to identifyBKA in postmortem tissues from poisoning victims in Taiwan and to develop a reliable analytical method for detectingBKA in biofluids to aid clinical diagnosis and treatment. BKA was identified in postmortem samples using high-reso-lution mass spectrometry (HRMS) and confirmed with an independent ultrahigh-performance liquid chromatographycoupled with tandem mass spectrometry (UHPLC-MS/MS) method. To meet clinical needs, a UHPLC-MS/MS methodwas developed and validated for BKA detection in plasma and urine. Method optimization included adjustments to ionsource conditions for multiple reaction monitoring (MRM) transitions and …

The Economic Burden Of Covid-19 In A Region With Stringent Response Measures: A Case Study Of Taiwan, Elise Chia-Hui Tan, Fei-Yuan Hsiao, Ming-Chin Yang

Journal of Food and Drug Analysis

The COVID-19 pandemic has imposed a significant economic burden globally, particularly in regions with stringentresponse measures. This study aimed to assess the economic impact of COVID-19 in Taiwan, focusing on both directand indirect costs. A cost-of-illness analysis was conducted, utilizing data from the Taiwan Centers for Disease Control(CDC), national databases, epidemiological studies, and economic surveys. The analysis included both direct costs (e.g.,hospital admissions, outpatient care) and indirect costs (e.g., productivity losses due to long COVID, absenteeism, caregiving duties). The study encompassed Taiwan's population of 23.2 million, with particular attention to age-specific impacts on economic outcomes. The total economic burden of …

Community Defining Archives: A Comparative View Of Community Archives Definitions, Britney Bibeault

Journal of Contemporary Archival Studies

Defining community archives has been described as difficult in academic literature because of the wide range of activities the organizations do and who they represent, leading to a lack of an agreed-upon definition in the field. Until now, a comparison between how community archivists describe themselves and academic definitions of community archiving has not been undertaken. This paper explores the definitions of community archives given by practitioners in their digital community archives and compares them with academic literature. Using both qualitative thematic coding and quantitative word frequency counts, this study found Flinn (2007) and Flinn et al. (2009) definitions are …

Comparative Analysis Of Life Cycle Assessment Of Traditional And Contemporary Timber Buildings, Sadık Akşar, Gökçe Tuna

Journal of Sustainable Construction Materials and Technologies

Wood has long been used as a primary building material, but with the Industrial Revolution and the spread of multi-story structures, its structural limitations became evident. In the 21st century, engineered timber products have reintroduced wood as a sustainable alternative, offering advantages such as lightness, rapid assembly, and recyclability. At the same time, buildings are responsible for significant environmental impacts, making assessment methods essential. Life Cycle Assessment (LCA) is one of the most widely used tools for evaluating these impacts across all stages of a building’s life cycle. This study applies LCA to timber construction systems, focusing on both traditional …

Sustainable Paving Block Development: Utilizing Rejected Coal As Filler And Assessing Its Impact On Paving Block’S Properties, Siti Nikmatin, Allen Kurniawan, Heriansyah Putra, Rima Fitria Adiati, Riawan Ma’Ruf, Dwi Arso Yedi Irwanto

Journal of Sustainable Construction Materials and Technologies

This study investigated the potential use of rejected coal as a fine aggregate filler in paving block production. Comprehensive characterization of the rejected coal was conducted, including toxicity, physical, chemical, and mineralogical analyses of the coal. The results showed that the rejected coal met environmental safety standards (TCLP) and had suitable properties as an aggregate. Paving blocks were produced by incorporating different proportions of rejected coal fillers and were tested for compressive strength, water absorption, and density. The optimal mix with 35% rejected coal filler as a replacement of stone ash achieved a compressive strength of 14.61 MPa, water absorption …

Facebook Decision Enables Irs To Seek - Cwi Enforcement Against Meta, Stephen L. Curtis, Reuven S. Avi-Yonah, David G. Chamberlain

Law & Economics Working Papers

In this report, the authors explain how the Tax Court's recent decision in the Facebook transfer pricing case - although widely viewed as a victory for the taxpayer, Meta Platforms Inc.- could instead be a Pyrrhic victory because it enables the IRS to pursue a potentially substantial periodic adjustment against the company. The views expressed in this report are solely the authors' and do not necessarily reflect those of any other person or institution.

Amro Elkabany V. Louis Shapiro

2025 Decisions

USDC for the District of New Jersey

Jose Cruces Cabrera V. Attorney General United States Of America

2025 Decisions

Agency

Jamal Ali V. District Attorney Philadelphia

2025 Decisions

USDC for the Eastern District of Pennsylvania

Harlem Restoration Hdfc V. Brewer

All Decisions

In this nonpayment case, the court granted a tenant's motion for partial summary judgment on a harassment counterclaim. The judge found that the landlord's repeated failure to correct hazardous violations created a **rebuttable presumption of harassment** under NYC Admin. Code § 27-2004. Since the landlord failed to rebut this presumption, the court awarded the tenant **statutory damages** of $1,000, and imposed a civil penalty of $2,000 payable to HPD. The court also issued a Class "C" harassment violation against the landlord, but the case remains pending for a final determination on the remaining claims.

Hamlet Garcia, Ii V. Angelica Cruz

2025 Decisions

USDC for the Eastern District of Pennsylvania

Christian Akhatsegbe V. Warden Allenwood Fci

2025 Decisions

USDC for the Middle District of Pennsylvania

Usa V. Daniel Gatson

2025 Decisions

USDC for the District of New Jersey

Ronald Koons V. Attorney General New Jersey

2025 Decisions

USDC for the District of New Jersey

Daily Eastern News: September 17, 2025, Eastern Illinois University

Daily Eastern News: 2025-2026

No abstract provided.

Salvage Therapies For First Relapse Of Shh Medulloblastoma In Early Childhood., Craig Erker, Martin Mynarek, Marie Simbozel, Brandon T. Craig, Virginia L. Harrod, Andrea M. Cappellano, Kenneth J. Cohen, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Lorena Baroni, Ralph Salloum, Ashley S. Margol, George Michaiel, Dolly Aguilera, Claire M. Mazewski, Cassie N. Kline, Jonathan L. Finlay, Mohamed S. Abdelbaki, Jeffrey C. Murray, Kathleen Dorris, Bruce Crooks, Kevin Ginn, Nisreen Amayiri, Stephan Tippelt, Gudrun Fleischhack, Svenja Tonn, Nicolas U. Gerber, Alvaro Lassaletta, Jordan R. Hansford, Sara Khan, Stephen W. Gilheeney, Lindsey M. Hoffman, Michal Zapotocky, Valérie Larouche, Shafqat Shah, Vijay Ramaswamy, Amar Gajjar, Sébastien Perreault, Sabine Mueller, Juliette Hukin, Sylvia Cheng, Zhihong J. Wang, Kara Matheson, Simon Bailey, Eric Bouffet, Steven C. Clifford, Giles Robinson, Christelle Dufour, Stefan Rutkowski, Lucie Lafay-Cousin

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood medulloblastoma (iMB) and has no standard of care at relapse. This work aimed to evaluate the post-relapse survival (PRS) and explore prognostic factors of patients with nodular desmoplastic (ND) and/or SHH iMB.

METHODS: This international retrospective study included 147 subjects diagnosed with relapsed ND/SHH iMB between 1995 and 2017, < 6 years old at original diagnosis, and treated without initial craniospinal irradiation (CSI). Univariable and multivariable Cox models with propensity score analyses were used to assess PRS for those in the curative intent cohort.

RESULTS: The 3-year PRS was 61.6% (95% confidence interval [CI], 52.2-69.6). The median age at relapse was 3.4 years (interquartile range [IQR], 2.6-4.1). Those with local relapse (40.8%) more often received salvage treatment with surgery …

Salvage Therapies For First Relapse Of Shh Medulloblastoma In Early Childhood, Craig Erker, Mohamed S Abdelbaki, Et Al.

2020-Current year OA Pubs

BACKGROUND: Sonic hedgehog (SHH) medulloblastoma is the most common molecular group of infant and early childhood medulloblastoma (iMB) and has no standard of care at relapse. This work aimed to evaluate the post-relapse survival (PRS) and explore prognostic factors of patients with nodular desmoplastic (ND) and/or SHH iMB.

METHODS: This international retrospective study included 147 subjects diagnosed with relapsed ND/SHH iMB between 1995 and 2017, < 6 years old at original diagnosis, and treated without initial craniospinal irradiation (CSI). Univariable and multivariable Cox models with propensity score analyses were used to assess PRS for those in the curative intent cohort.

RESULTS: The 3-year PRS was 61.6% (95% confidence interval [CI], 52.2-69.6). The median age at relapse was 3.4 years (interquartile range [IQR], 2.6-4.1). Those with local relapse (40.8%) more often received salvage treatment with surgery …

Empathy By Design: Rethinking Law School Engagement For Critical Thinking In The Age Of Artificial Intelligence, Jon M. Garon

St. Mary's Law Journal

No abstract provided.

The Bg News September 17, 2025, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 17, 2025. Volume 105-Issue 04.

A Time Series Analysis Of Herd Investor Behavior Using Online And Social Media Data, Michael L. Smith, Valerie Kilders, Todd Kuethe, Nicole Olynk Widmar

Department of Agricultural Economics Faculty Publications

We examine the relationship between market performance of leading cryptocurrencies (Bitcoin and Ethereum), meme-stocks (AMC, GameStop), and subjects of corporate boycotts (Bud Light) using weekly market price and volume data along with social media data of weekly mentions (which total 337 million in this dataset) and net sentiment. Using vector autoregression (VAR) time series analysis along with Granger causality testing and structural breaks, we successfully predict trade volume of these various assets using social media data and price data. We also find that closing price data and trade volume are reliable predictors of net sentiment about crypto in online and …

Drag Performers In The American North And South : Identity And Resistance, Karma Rakow

QuaesitUM

No abstract provided.

Illegal Corporate Cultures, Elise Bernlohr Maizel

Duke Law Journal

Culture is a powerful force in corporate compliance. Corporate culture shapes how employees behave, dictating whether, when, and how they follow the law. Cases arising out of cultural failures often involve public harm—plane crashes, poisoned rivers, tainted cancer drugs, and collapsed mines. Before these awful outcomes, however, the corporations that caused these harms fostered cultures that permitted the disregard of legal commands and public commitments. Managers disparaged safety regulations. Messages about profits and production drowned out messages about compliance and safety. Yet, there is a gap between all we know about the power of culture and our understanding of corporate …