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“Have You Ever Dreamed Of A Better Version Of Yourself?”: A Psychoanalysis Of Representations Of Women Across Age In Horror Films, Weston Blu Stogner Dec 2025

“Have You Ever Dreamed Of A Better Version Of Yourself?”: A Psychoanalysis Of Representations Of Women Across Age In Horror Films, Weston Blu Stogner

Open Access Theses & Dissertations

The purpose of this study was to examine representations of older and younger women in four horror films: The Leech Woman (1960), The Shining (1980), The Witch (2015), and The Substance (2024). Regarding horror film narratives, research suggests aged women are often depicted as wicked and lacking mental faculties, while young women with idealized and privileged body types are often fetishized. According to Creed (2023), these harmful, oppressive depictions are informed by male anxieties about women in patriarchy. When women are presented as monstrous (i.e., the monstrous-feminine) in horror films, they symbolize these anxieties. Therefore, all four films selected for …


Hubert-Based Models And Evaluation Strategies For Pragmatically-Faithful Speech To Speech Translation, Javier Vazquez Dec 2025

Hubert-Based Models And Evaluation Strategies For Pragmatically-Faithful Speech To Speech Translation, Javier Vazquez

Open Access Theses & Dissertations

Pragmatic fidelity in speech-to-speech translation (S2ST) has largely been understudied, leading to communication tools inadequate to support non-superficial dialog. We aim to improve pragmatic faithfulness in English-Spanish translation through the development of machine learning models that are able to predict a corresponding pragmatic representation in the other language. To evaluate performance, we developed a pipeline that utilizes a recently-developed pragmatic similarity evaluation metric to compare models. Further, we developed models that exploit HuBERT features as these have been found suitable for various prosody and pragmatics related tasks. Our models outperformed human and state-of-the-art predictions, albeit the methodology being limited to …


The Identity Navigation Challenge, Arielle Badger Newman, Mauricio Mercado, Ashley Gomez, Rosalinda Maury Dec 2025

The Identity Navigation Challenge, Arielle Badger Newman, Mauricio Mercado, Ashley Gomez, Rosalinda Maury

The Lender Center for Social Justice

While veteran status should serve as a credential that opens doors for entrepreneurs, our research reveals a troubling reality: underrepresented racial minority (URM) veteran entrepreneurs must perform complex "identity work" to navigate bias in funding and support systems. Through interviews with 76 veteran entrepreneurs, we discovered the Intersectional Legitimacy Work Model, a three-phase process showing how entrepreneurs strategically manage their race, gender, and veteran identities when seeking resources. Black and Latino veteran entrepreneurs report having to prove they are the "right kind" of veteran, often downplaying or emphasizing aspects of their identity depending on their audience. This creates an exhausting …


Dialogue And Storytelling To Bridge The Civil-Military Gap On Campus—And Beyond: Resources And Recommendations, Corri Zoli, Linda Euto Dec 2025

Dialogue And Storytelling To Bridge The Civil-Military Gap On Campus—And Beyond: Resources And Recommendations, Corri Zoli, Linda Euto

The Lender Center for Social Justice

This brief presents key applied insights from innovative approaches to bridge the gap on college campuses between student veterans and nonveterans. The brief provides a model for using dialogue and storytelling as powerful pedagogical and research tools to share insights with students and the broader public about public national service, the distinctive contributions of U.S. military service members, and the transition needs of military students in higher education.


Divergent Responses Of Branched-Chain And Straight-Chain Lipid Membranes To Butanol Stress Revealed By All-Atom Molecular Dynamics Simulations, Joshua Olaf Aggrey Dec 2025

Divergent Responses Of Branched-Chain And Straight-Chain Lipid Membranes To Butanol Stress Revealed By All-Atom Molecular Dynamics Simulations, Joshua Olaf Aggrey

Electronic Theses and Dissertations

Membrane integrity under chemical stress is critical to cellular survival and industrial microbial bioproduction, yet the molecular basis of bilayer resilience remains poorly understood. Using all-atom molecular dynamics simulation, we compare the effect of increasing concentrations of 1‑butanol on membranes composed of straight-chain (1,2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) and branched-chain (1-anteiso-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, APPC) lipids, which differ in the point of attachment of a single methyl group. In the absence of butanol, both membranes exhibit well-ordered architectures consistent with experimental benchmarks; however, under increasing solvent stress, their behaviors diverge markedly. DPPC membranes display gradual thinning, modest area per lipid …


Exploring The Use Of Culturally And Linguistically Responsive Practices Within The Multi-Tiered System Of Support (Mtss) Framework When Supporting Students With Disabilities At A Dual Language Immersion School, Sylvia Simmons Dec 2025

Exploring The Use Of Culturally And Linguistically Responsive Practices Within The Multi-Tiered System Of Support (Mtss) Framework When Supporting Students With Disabilities At A Dual Language Immersion School, Sylvia Simmons

Dissertations

The integration of culturally and linguistically responsive practices (CLRP) within the Multi-Tiered System of Support (MTSS) framework has been recognized as a promising method for improving learning opportunities for diverse students. However, little to no research has been conducted on the intersection of CLRP within the MTSS framework to support students with disabilities in dual language immersion schools (DLI). This lack of research has posed challenges for educators seeking effective strategies to support diverse learners with disabilities in such settings. Therefore, the purposes of this qualitative case study were to (a) explore how a dual language immersion school utilizes the …


Civics Teachers’ Perceptions Of Disciplinary Literacy Strategies That Use Primary Sources: A Case Study, Whitney Williams Dec 2025

Civics Teachers’ Perceptions Of Disciplinary Literacy Strategies That Use Primary Sources: A Case Study, Whitney Williams

Dissertations

This study has been designed as a case study to examine teachers’ perceptions of document-based strategies when combined with primary sources as pedagogical tools. The participants were ninth grade civics teachers. Semi-structured interviews, focused observations, and artifact collection were the sources of collected data. As the researcher, my constructivism guided this study through the lens of Albert Bandura’s social cognitive theory (SCT). Therefore, the participants’ perception will be interpreted through SCT concepts such as personal influences, behavioral influences, and environmental influences. Findings show a handful of disciplinary literacy strategies that occurred most often across all participants. Teachers valued an emphasis …


Detection Of Phase-Binning And Interpolation Artifacts In 4-Dimensional Computed Tomography Imaging Using Deep Learning And Rule-Based Approaches, Jorge Cisneros, Nathan H. Feldt, Yevgeniy Vinogradskiy, Richard Castillo, Edward Castillo Dec 2025

Detection Of Phase-Binning And Interpolation Artifacts In 4-Dimensional Computed Tomography Imaging Using Deep Learning And Rule-Based Approaches, Jorge Cisneros, Nathan H. Feldt, Yevgeniy Vinogradskiy, Richard Castillo, Edward Castillo

Department of Radiation Oncology Faculty Papers

BACKGROUND: Four-dimensional computed tomography (4DCT) imaging is a crucial component to lung cancer radiotherapy planning and enables CT-ventilation-based functional avoidance planning to mitigate radiation toxicity. However, 4DCT scans are frequently impaired by acquisition artifacts that corrupt downstream analyses that depend on lung segmentation and deformable image registration, such as CT-ventilation and dose accumulation.

PURPOSE: This study develops 3D deep learning models to identify phase-binning artifacts at the voxel level and a heuristic, rule-based method to identify interpolation slices within 4DCT images.

METHODS: We introduce a generator that systematically inserts synthetic phase-binning and interpolation artifacts into any artifact-free breathing phase obtained …


A Strategic Audit Of Live Nation Entertainment: Industry Position, Competitive Dynamics, And Long-Term Growth Outlook, William H. Wooden Iv, Owen B. Crone, Reece L. Flores, Grace A. Schaefer, Eric M. Jacob, Sydney A. Beck Dec 2025

A Strategic Audit Of Live Nation Entertainment: Industry Position, Competitive Dynamics, And Long-Term Growth Outlook, William H. Wooden Iv, Owen B. Crone, Reece L. Flores, Grace A. Schaefer, Eric M. Jacob, Sydney A. Beck

Honors Program: Senior Projects (Public)

Live Nation Entertainment is the dominant global leader in the concert and live events industry, supported by a vertically integrated model that spans artist management, concert promotion, venue operations, ticketing, and sponsorship. This strategic audit evaluates Live Nation’s internal strengths, external threats, competitive position, corporate governance, and long-term strategic prospects based on comprehensive analysis of company reports, industry dynamics, and market trends. Live Nation benefits from unmatched scale, global venue ownership, exclusive artist relationships, and the substantial network effects generated by Ticketmaster, which collectively create high barriers to entry and sustained competitive advantage. The audit also examines significant challenges such …


From Winans To Wallahee: Treaties, The Washington State Supreme Court, And The Pursuit Of A More Just Rule Of Law, Monte Mills Dec 2025

From Winans To Wallahee: Treaties, The Washington State Supreme Court, And The Pursuit Of A More Just Rule Of Law, Monte Mills

Washington Law Review

The relationship between the United States federal government, the states, and Native Nations has long been at the core of federal Indian law. From the earliest decades of its jurisprudence, for example, the United States Supreme Court struggled in its efforts to analyze and define the rights, authorities, and interactions of Native Nations within and in relation to the evolving structure of constitutional federalism. Treaties between the United States and Native Nations were central to those decisions and provided a necessary, constitutional check against state interests intent on eliminating sovereign Native Nations. Those constitutional and structural implications thus go well …


Who Counts As A "Reasonable Employee"? The Third Circuit's Bungling Of Section 8(A)(1) Violations, Ben Milstein Dec 2025

Who Counts As A "Reasonable Employee"? The Third Circuit's Bungling Of Section 8(A)(1) Violations, Ben Milstein

Washington Law Review

The National Labor Relations Act (NLRA) protects private employees’ right to unionize and collectively bargain with their employers. Section 7 of the NLRA guarantees employees the right to self-organize labor unions, while section 8 outlines numerous unfair labor practices. Specifically, section 8(a)(1) bans employer interference, coercion, or restraint of any section 7 rights. In a 2022 case, FDRLST Media v. NLRB, the Third Circuit Court of Appeals reversed a National Labor Relations Board (NLRB) finding that FDRLST Media’s executive officer’s tweet constituted a section 8(a)(1) violation. This Comment examines the history of section 8(a)(1) violations, specifically discussing the widely …


The Reasonability Rule For Medical Damages In Tort: In Defense Of Chargemaster Recovery, Avery E. Tunstill Dec 2025

The Reasonability Rule For Medical Damages In Tort: In Defense Of Chargemaster Recovery, Avery E. Tunstill

Washington Law Review

In a personal injury suit, Washington law requires the plaintiff to prove that their medical costs are reasonable to recover damages for those costs. Tort reform proponents attempt to use this reasonability rule to limit tort damages awards. They argue that a plaintiff should only recover a portion of a hospital’s bill because most people do not pay a hospital’s sticker price—or the “chargemaster rate”—for medical care. Some reformers argue that recovery rates should instead be based on a set figure. Others argue in favor of eliminating the collateral source rule, which prohibits juries from reducing tort damages awards in …


Collective Action Under Repressive Conditions: Integration Of Individual, Group, And Structural Level Research, Recommendations, And Reflections, Arin H. Ayanian, Aya Adra, Fouad Bou Zeineddine, Rim Saab, Johanna Vollhardt, Nicole Tausch Dec 2025

Collective Action Under Repressive Conditions: Integration Of Individual, Group, And Structural Level Research, Recommendations, And Reflections, Arin H. Ayanian, Aya Adra, Fouad Bou Zeineddine, Rim Saab, Johanna Vollhardt, Nicole Tausch

Psychology

Social scientific research from different traditions on collective action under repressive conditions is fragmented across different levels of analysis. The current paper takes a first step toward remedying this fragmentation by reviewing research findings on repression and collective action and organizing them into a multilevel framework. We describe the impact of repression on antecedents of collective action at the (a) individual level (including grievances, emotions, efficacy beliefs, politicized identity, and individual differences), (b) group level (including community cohesion and norms), and (c) structural level (including political opportunities and socioecological conditions). We then present an integrative summary reflecting on the broad …


The Supreme Court Of India's Use Of Inherent Power Under Article 142 Of The Constitution: An Empirical Study, M. P. Ram Mohan, Sriram Prasad, Vijay V. Venkitesh, Sai Muralidhar, Jacob P Alex Dec 2025

The Supreme Court Of India's Use Of Inherent Power Under Article 142 Of The Constitution: An Empirical Study, M. P. Ram Mohan, Sriram Prasad, Vijay V. Venkitesh, Sai Muralidhar, Jacob P Alex

National Law School of India Review

The Constitution of India under Article 142 grants the Supreme Court of India broad inherent powers to do complete justice. The contours of these inherent powers and what it means to achieve complete justice were left to the Supreme Court to determine on its own. In this paper, we empirically examine all the Supreme Court cases from its inception in 1950 till 2023 which use the term “Article 142” or “complete justice.” We found 1579 cases, which were then hand-coded for many variables such as the nature of the case, where the case was appealed from, the temporal distribution, the …


What Is The Standard Of Review For (Mixed) Constitutional Questions?, Anthony Sangiuliano, Mark Friedman Dec 2025

What Is The Standard Of Review For (Mixed) Constitutional Questions?, Anthony Sangiuliano, Mark Friedman

UBC Law Review

No abstract provided.


Essays On The Economics Of Farmland Valuation And Investment In U.S. Agriculture, Colson Tester Dec 2025

Essays On The Economics Of Farmland Valuation And Investment In U.S. Agriculture, Colson Tester

Graduate Theses and Dissertations

This dissertation presents three empirical essays that collectively advance the understanding of farmland valuation in key U.S. agricultural regions, emphasizing the critical advantages of comprehensive, transaction-based data over traditional survey methods. Farmland represents a significant portion of agricultural wealth, and its accurate valuation is crucial for farmers, investors, and policymakers, influencing everything from credit access to investment strategies. Historically, research has often relied on subjective survey data, which can suffer from biases, inaccuracies, and insufficient granularity. This dissertation addresses these limitations by leveraging extensive datasets of arm’s-length farmland transactions, offering a more precise and market-driven perspective on land values. The …


“Starlight Suite”: A Compositional Exploration Of The Argo Navis Constellations In Three Movements, Adam Miller Dec 2025

“Starlight Suite”: A Compositional Exploration Of The Argo Navis Constellations In Three Movements, Adam Miller

Student Publications

This thesis explores a compositional technique in which stellar constellations are arranged upon musical staves in a variety of iterations to create a basis from which to draw melodic, harmonic, and rhythmic material. These raw extrapolations of unaltered notes are then arranged and orchestrated into thematic music for full orchestra, centered around elements from the mythological background behind the constellations used. An accompanying analysis explains the specific applications of this technique within each movement of the work, the significance of each, and the variety of ways in which musical inspiration was drawn from the raw materials. The objective of this …


An Analysis Of Neuroidal Memory Formation Within D. Melanogaster, Jerry Chang Dec 2025

An Analysis Of Neuroidal Memory Formation Within D. Melanogaster, Jerry Chang

Master's Theses

The Neuroidal model poses a neurobiologically plausible theory for modeling the brain. This symbolic network has been shown to capture realistic memorization behaviors using the JOIN algorithm. The model has also been recently improved by incorporating Watts-Strogatz small-worlds within its base structure. From the efforts of neuroscience researchers, we have access to the Drosophila melanogaster (D. melanogaster) fruit fly’s connectome, which has been found to also contain small-worlds in this thesis. By synthesizing the Ocellar Ganglion (OCG) region of Drosophila, we compare a digitized version of a real-world brain with an instance of the Neuroidal model. In this thesis, we …


Development Of A Kytc Highway Geometric Design Workshop, Jill Asher, Jeff Jasper, Travis Thompson, Chris Van Dyke Dec 2025

Development Of A Kytc Highway Geometric Design Workshop, Jill Asher, Jeff Jasper, Travis Thompson, Chris Van Dyke

Kentucky Transportation Center Research Report

In-depth knowledge of geometric design principles is a prerequisite for delivering road projects that provide safe and efficient multimodal mobility for all users. Historically, Kentucky Transportation Cabinet (KYTC) early-career design staff arrived at the agency with little design experience. The agency has relied on a combination of short courses and mentorship provided by experienced personnel to bring early-career design staff up to speed on design best practices. However, this approach to training carries limitations. Employee turnover and imposing workloads make it challenging for early- and even mid-career design professionals to receive guidance from seasoned designers who have long tenures at …


From Policy To Practice: How Institutional Interpretations Of Ferpa Shape The Campus Safety Conversation, Britney Deaver Dec 2025

From Policy To Practice: How Institutional Interpretations Of Ferpa Shape The Campus Safety Conversation, Britney Deaver

Electronic Theses and Dissertations

The Family Educational Rights and Privacy Act (FERPA) is a foundational federal law designed to protect the privacy of student education records. FERPA includes exceptions—such as for health and safety emergencies—that institutions may interpret and apply in varied ways. This qualitative study explores how higher education professionals across diverse institutional contexts conceptualize and apply the health or safety exception, and how those interpretations influence campus safety practices and policy-making. Through semi-structured interviews with compliance officers and administrators, the research examines the intersection of federal policy, institutional culture, and individual judgment.

Findings reveal a range of interpretations shaped by institutional risk …


Practices To Possibility: A Narrative Inquiry Examining Practices Supporting Post-School Outcomes For Students With Disabilities, Joshua Reese Dec 2025

Practices To Possibility: A Narrative Inquiry Examining Practices Supporting Post-School Outcomes For Students With Disabilities, Joshua Reese

Electronic Theses and Dissertations

The purpose of this qualitative narrative inquiry was to examine how educators in high-performing districts that met or exceeded state targets for Individuals with Disabilities Education Act (IDEA) post-school outcomes implemented and sustained evidence-based practices to support successful transitions for students with disabilities. Despite decades of legislative mandates and educational reforms, students with disabilities continue to experience disproportionately lower rates of employment, postsecondary education, and independent living compared to their peers. This study sought to identify not only which practices are effective but also how they are operationalized and maintained within school systems.

Two Tennessee districts identified by exemplary performance …


Spatial–Temporal Evolution Of The Box Springs Plutonic Complex, Riverside, Ca, Mateo Ospino Díaz Dec 2025

Spatial–Temporal Evolution Of The Box Springs Plutonic Complex, Riverside, Ca, Mateo Ospino Díaz

Loma Linda University Electronic Theses, Dissertations & Projects

The mechanisms of pluton emplacement into continental crust have long been debated in igneous geology, with early models emphasizing forceful processes such as ballooning, later contrasted by alternative emplacement mechanisms including diapirism, incremental assembly, stoping and, emplacement by sheets and dikes. These contrasting perspectives highlight the complexity of the construction of mid-crustal intrusions and the need for case studies that integrate multiple datasets. The Box Springs Plutonic Complex (BSPC) in the northern Peninsular Ranges Batholith (PRB) preserves structural, textural, and compositional features that record its emplacement and internal construction. Although its lithology, structure, and geochemistry have been described, an integrated …


Emergency Lending By The Federal Reserve, Kathryn Judge, Richard Clarida Dec 2025

Emergency Lending By The Federal Reserve, Kathryn Judge, Richard Clarida

Faculty Scholarship

The Federal Reserve established an array of innovative emergency lending facilities during the Great Financial Crisis and expanded the scope of its emergency lending yet further in response to the Covid-19 pandemic. This Article provides a retrospective of how the Federal Reserve used its emergency lending authority across these two episodes, identifying patterns and revealing some differences. It sheds light on the conditions that enabled the Federal Reserve to establish the facilities that it did, including the roles played by Congress and Treasury in providing the equity funding that made certain facilities possible. It shows how in each episode, the …


Slaughter, Parsons, And The Original Meaning Of A Term Of Years, Jane Manners, Lev Menand Dec 2025

Slaughter, Parsons, And The Original Meaning Of A Term Of Years, Jane Manners, Lev Menand

Faculty Scholarship

This term the Supreme Court is hearing argument in two major cases regarding the law of federal offices. One — Trump v. Slaughter — may strip Congress of the power to place any restrictions on the President’s ability to remove administrators at will. Another — Trump v. Cook — will address how such restrictions work, assuming that the President has to follow them.


(R2130) Cusum-Test For Unconditional Variance Change Detection In Bilinear Garch Models, Edoh Katchekpele, Abdou Kâ Diongue, Ben Célestin Kouassi Dec 2025

(R2130) Cusum-Test For Unconditional Variance Change Detection In Bilinear Garch Models, Edoh Katchekpele, Abdou Kâ Diongue, Ben Célestin Kouassi

Applications and Applied Mathematics: An International Journal (AAM)

We examine CUSUM-type test for detecting changes in unconditional variance within Bilinear GARCH models. We derive the asymptotic distribution of the test statistic under both null and alternative hypotheses and assess test effectiveness in identifying single structural breaks. Simulation studies support our theoretical results and demonstrate the practical utility of the test.


Judge Platt Potter: Politics And Principle In Interbranch Conflict, Aaron-Andrew P. Bruhl Dec 2025

Judge Platt Potter: Politics And Principle In Interbranch Conflict, Aaron-Andrew P. Bruhl

Faculty Publications

During the previous Congress, some commentators called on the Senate Judiciary Committee, then controlled by Democrats and chaired by Senator Dick Durbin of Illinois, to demand the testimony of Supreme Court Justices Clarence Thomas and Samuel Alito over allegations of ethical breaches, securing their presence by subpoena if necessary. The Committee did not subpoena the Justices, with Durbin citing the likely lack of sufficient votes and worrying that the Senate would not be able to enforce the subpoenas anyway. During the same Congress, Durbin asked Chief Justice Roberts to testify about judicial ethics, an invitation that Roberts declined.

These incidents …


Rethinking Juror Impartiality, Anna Offit Dec 2025

Rethinking Juror Impartiality, Anna Offit

Faculty Publications

Jury impartiality in the contemporary court often justifies the perpetuation of exclusionary selection practices that make juries more—not less—biased. This Article calls for a rethinking of this important but flawed concept. Constitutional interpretations and conceptions of “impartiality” frame it as a transient orientation toward particular evidence or parties. Yet, during voir dire, the prevailing conception of jury impartiality is that it is an immutable character trait that must be discovered—if not created—by professional legal actors. What voir dire creates is not an impartial jury, but precisely the opposite: a venire shaped by the strategic biases of lawyers.

This Article offers …


Advancements In Visualization, Post-Processing And Ai-Enhanced Modeling Of Multi-Scale Micromechanics For Composite Materials, Joao Guilherme Brites Rei Dec 2025

Advancements In Visualization, Post-Processing And Ai-Enhanced Modeling Of Multi-Scale Micromechanics For Composite Materials, Joao Guilherme Brites Rei

Masters Theses

This study addresses some of the primary deficits of a localization/homogenization workflow for composite materials by focusing on the visualization and enhancement of models based on GMC and HFGMC, with emphasis on their implementation within the NASMAT ecosystem.

This thesis details the development of two dynamic, ParaView-based plugins that convert large hierarchical simulation outputs into interactive insights. While NASMATDiscreteElement systematizes RUC creation with transparent parametrization in a reproducible GUI, NASMATExplorerRUC enables the inspection of deeply nested datasets through accurate cell picking and synchronizes comparisons between parent and child views. Additionally, a shallow U-Net neural network is optimized on HFGMC data …


Assessment Of Knowledge And Attitudes Of Undergraduate Students On Trichomoniasis In Ghana, Christopher Yaw Dumevi, Ezekiel Kofi Vicar, Lorie Christla Quansah, Rhoda Oklu, Smith Joshua, Joyce Junior Asiamah, James-Paul Kretchy, George Boateng Kyei, Patience B Tetteh-Quarcoo, Nicholas T K D Dayie, Irene Ayi, Patrick F Ayeh-Kumi Dec 2025

Assessment Of Knowledge And Attitudes Of Undergraduate Students On Trichomoniasis In Ghana, Christopher Yaw Dumevi, Ezekiel Kofi Vicar, Lorie Christla Quansah, Rhoda Oklu, Smith Joshua, Joyce Junior Asiamah, James-Paul Kretchy, George Boateng Kyei, Patience B Tetteh-Quarcoo, Nicholas T K D Dayie, Irene Ayi, Patrick F Ayeh-Kumi

2020-Current year OA Pubs

BACKGROUND: Trichomoniasis is a non-viral neglected sexually transmitted disease of public health importance. Undergraduate students, often experiencing newfound freedom from family oversight, may engage in risky sexual behaviors, predisposing them to trichomoniasis and other sexually transmitted infections (STIs). This study aimed to assess the knowledge, attitudes, and practices towards trichomoniasis and associated factors among the Central University students in the Greater Accra Region of Ghana.

METHODS: An institutional cross-sectional study was conducted between March and July 2024, involving 387 undergraduate students from Central University who were selected using a simple random sampling technique. Data were collected using a structured researcher-led …


Studies On Curcumin-Glucoside In The Prevention Of Alpha-Synuclein Aggregation, Lakshmi Sowmya Emani, Jayanth K. Rao, Jagadeesha Kumar Dasappa, Marisín Pecchio, Johant Lakey-Beitia, Hansapani Rodrigo, Jessica Cruz-Mora, Priya Narayan, Nikhilesh Anand, Bharathi Gadad Dec 2025

Studies On Curcumin-Glucoside In The Prevention Of Alpha-Synuclein Aggregation, Lakshmi Sowmya Emani, Jayanth K. Rao, Jagadeesha Kumar Dasappa, Marisín Pecchio, Johant Lakey-Beitia, Hansapani Rodrigo, Jessica Cruz-Mora, Priya Narayan, Nikhilesh Anand, Bharathi Gadad

School of Medicine Publications

Background: α-synuclein (α-syn) deposition in the mid-brain region is one of the hallmark pathologies of Parkinson's disease (PD). The key steps involve the transformation of α-synuclein into a toxic oligomer and insoluble fibrillar aggregates.

Objective: To understand the role of curcumin-glucoside in the prevention of α-syn aggregation, a mechanistic approach.

Methods: In the present study, we synthesized a novel molecule, curcumin-glucoside (Curc-gluc), to improve the water solubility and partition coefficient, making the molecule with high bioavailability. The present study is focused on understanding the α-syn aggregation kinetics in the presence and absence of Curc-gluc, curcumin (Cur), copper (Cu), and iron …