Digital Commons Network^™

Crypto Exchanges In Market Regulation, Yesha Yadav

Vanderbilt Law Review

The cryptocurrency market has proven notoriously challenging to regulate despite a decade during which it has gained in economic size, sophistication, and cultural impact. Even as repeated crises have left ordinary savers wiped out, regulation has shown itself to be woefully absent as a means of mitigating risks ex ante or helping cover the cost of damage ex post. This Article looks to break this deadlock by proposing a tried-and-tested solution: It argues that regulators should task crypto exchanges with providing oversight as self-regulatory organizations of the crypto market in which they play an anchoring role. It offers three supporting …

A Direct Path Should Be Easy To Follow: Reframing The “Direct Effect” Test For Jurisdictional Immunity Under The Foreign Sovereign Immunities Act, Greggory Cashmark

Vanderbilt Law Review

As sovereign nations become more involved in international commercial dealings, it becomes more important to establish a reliable and stable framework for resolving disputes with foreign sovereigns. The FSIA is the result of a long historical trend towards establishing that framework. While the FSIA is a step in the right direction, there are a number of interpretive questions regarding where it places the boundaries of a court's jurisdiction over foreign sovereign activity. While these questions remain open and while courts continue to find reasons to keep them open, they undermine the principal purpose of the FSIA: predictability. There is no …

Presidential Immunity: Before And After Trump, Thomas P. Schmidt

Vanderbilt Law Review

'All the officers of government," the Supreme Court said long ago, "from the highest to the lowest, are creatures of the law, and are bound to obey it." Despite that ringing and categorical language, however, the Court has held that the President-the "highest" and most powerful of all government officers-is "immune" from judicial oversight in several respects. Indeed, when the Court held last Term that former presidents are presumptively immune from criminal prosecution for officials acts, the dissenters warned: '`n every use of official power, the President is now a king above the law."

This Article unpacks the various presidential …

Voxvista: Enhancing Screen Reading Experience For Online User Comments, Yash Prakash, Akshay Kolgar Nayak, Mohammed Shoaib Alyaan, Sampath Jayarathna, Hae-Na Lee, Vikas Ashok

Computer Science Faculty Publications

Online discussions have become integral to how people exchange ideas, form opinions, and participate in collective deliberation. While sighted users can comfortably engage with online discussions, blind users who are dependent on screen readers are forced to listen to long threads narrated in a single, monotonic voice that lacks prosodic variation, rhythm, or emotion. This robotic auditory experience not only deteriorates the user engagement with the content but also increases cognitive strain, by making it difficult to remain attentive and discern meaning beyond literal words. In an interview study, most blind participants reported that monotonous narration hindered their ability to …

Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez

Computer Science Faculty Publications

The Marshall–Olkin family of distributions has gained increasing attention in fields such as reliability engineering, survival analysis, financial risk modeling, and actuarial science because of its flexibility in modeling dependence among events and its wide range of extensions. Despite its growing relevance, a systematic understanding of how research on Marshall–Olkin models has evolved over time is still limited. This study addresses this gap by combining bibliometric techniques with topic modeling to analyze the structure and evolution of the scientific literature on Marshall–Olkin models. The analysis includes all 266 peer-reviewed publications on Marshall–Olkin models indexed in Scopus between 1981 and 2025. …

The Deregulation Of Cancer, Daniel G. Aaron

Utah Law Faculty Scholarship

Fifty years ago, the U.S. embarked on a radical new path. Under pressure from the environmental movement, Congress passed an array of statutes aimed at regulating carcinogens out of our world. This regulatory experiment sprawled from air and water to food and consumer products.

Legal scholars have paid scant attention to this wave of cancer regulation despite its size and importance and the public’s apparent interest in avoiding carcinogens. But there is a growing literature finding flaws with individual regimes within the framework, such as the Clean Air Act, the Toxic Substances Control Act, and the Tobacco Control Act. In …

The Crisis In U.S. Cancer Care: Law, Markets, And Privatization, Daniel G. Aaron

Utah Law Faculty Scholarship

Cancer is surging among youth and young adults in the U.S., yet instead of public regulation addressing its root causes, we have outsourced the management of cancer to the private sector.  A suite of laws, embodying faith that corporations will cure cancer, has subsidized the cancer biomedical enterprise and transformed quasi-public institutions into marketized, profit-seeking entities.  These changes, across patent law, healthcare law, innovation law, and Food and Drug Administration (FDA) law, have privatized cancer. 

The market failures I describe in U.S. cancer care raise larger questions about who we entrust with managing critical social problems.  This Article provides theoretical …

Prickle4 Drives Microenvironmental Remodeling And Resistance To Parp Inhibition In Idh-Mutant Glioma, Ju Yang, Hua Yang, Yifan Yuan, Chenyang Zhang, Ziwei Fu, Yanyan Chen, Yinghong Xiong, Shuyu Chen, Kexin Ling, Ying Liu, Jason T Huse, Bo Chen, Timothy A Chan, Zengxin Qi, Zhao Zhang, Xiuping Liu, Yuxiang Wang

Faculty, Staff and Student Publications

Mutations in isocitrate dehydrogenase (IDH) genes sensitize gliomas to PARP inhibition (PARPi) by inducing epigenetic reprogramming of DNA damage repair circuits. However, tumors treated with PARPi eventually relapse despite initial responsiveness. In this study, it is demonstrated that the anti-angiogenic agent lenvatinib synergizes effectively with PARPi, resulting in substantial tumor regression and significantly extended survival. Genomic analysis of tumors reveals that PARPi induces widespread transcriptomic changes that are predominantly pro-inflammatory, thereby promoting tumor angiogenesis. Prickle4, a planar cell polarity protein, is identified as a critical mediator of PARPi-induced neovascularization. Targeting Prickle4 effectively overcomes PARPi resistance in these tumors. Collectively, these …

Clinical And Molecular Characteristics Of Patients With Young-Onset And Average-Onset Pancreatic Adenocarcinoma, Adriana C Gamboa, Kever A Lewis, Laura R Prakash, Zhouxuan Li, Wei Qiao, Dan Zhao, Mark W Hurd, Mahmoud Yousef, Naruhiko Ikoma, Michael P Kim, Jeffrey E Lee, Jessica E Maxwell, Ching-Wei D Tzeng, Matthew H G Katz, Rebecca A Snyder

Faculty, Staff and Student Publications

Purpose: The incidence of young-onset pancreatic cancer (YO-PC) has risen over the past two decades, yet its molecular characteristics and long-term outcomes remain poorly defined.

Methods: We retrospectively evaluated patients with PC treated at a tertiary referral center from 2016 to 2022 who had available molecular data. Patients were classified as YO-PC (≤50 years) or average-onset PC (AO-PC, >50 years). A subset analysis examined outcomes in those who underwent curative-intent pancreatectomy. Primary end points included overall survival (OS) and recurrence-free survival (RFS).

Results: Among 511 patients, 10.9% had YO-PC (n = 56; median age 44 years). Patients with YO-PC more …

Engineering Mutation Clones In Mammalian Cells With Crispr/Cas9, Zijun Huo, Jian Tu, Rachel Shoemaker, Dung-Fang Lee, Ruiying Zhao

Faculty, Staff and Student Publications

CRISPR, Clustered Regularly Interspaced Short Palindromic Repeat, as a powerful genome engineering system, has been widely accepted and employed in gene editing of a vast range of cell types. Compared to zinc finger nucleases (ZFNs) or transcription activator-like effector nucleases (TALENs), CRISPR shows a less complicated process and higher efficiency. With the development of different CRISPR systems, it can be used not only to knock out a gene but also to make precise modifications, activate or repress target genes with epigenetic modifications, and even for genome wide screening. Here we will describe the procedure of generating a stable cell line …

Inclusive Psychology Pedagogy Is Linked To Increased Belonging And Reduced Prejudice Toward Consensually Non-Monogamous Relationships, Rose Bern, Rachel Dinero, Kate Linenbach, Amy Moors

Psychology Faculty Articles and Research

Students enrolled in an elective psychology course entitled Relationship Science, which emphasized inclusive curricula focused on relationship diversity, completed pre- and postcourse assessments of attitudes toward consensually nonmonogamous (CNM) relationships, relationship skills (e.g., constructive communication), and classroom belonging. Given the established literature on lesbian, gay, bisexual, transgender, queer+-inclusive pedagogy, attitudes toward lesbian, gay, bisexual, transgender, queer+ individuals were also measured. Comparisons of pre- and postcourse assessments revealed significant reductions in stigma toward individuals engaged in CNM, alongside increased acceptance of CNM relationships more broadly. Students also reported increases in relationship skills and classroom belonging over the course of the …

When We Don’T Get Community Right In Restorative Justice Spaces: Cancel Culture And Failure To Transform, Aparna Polavarapu

Scholarly Works

This Article argues that community is a central but deeply misunderstood feature of restorative justice. Restorative justice asks us to understand harm as a break in relationship that creates obligations for the person harmed, the person who caused harm, and the community. Community is theorized to play a key role in working towards reintegration and social change, both goals of restorative justice. Yet in practice, community is often misused or underused in ways that weaken these goals. Practitioners are observing an increase in cancel culture actions by groups that claim affinity with restorative and transformative justice. However, by weaponizing the …

"Tell Me About Your Esol Experience": Exploring Language Journeys Through Shared Stories, Rocio Rivero-Gutierrez

School of Law, Humanities and Social Sciences Theses

This thesis explores the English language learning experiences of ESOL(English for Speakers of Other Languages) participants from southern Spain, examining the interplay between language acquisition, cultural adaptation, andidentity transformation. Grounded in my own ESOL journey — shaped both inSpain and through immersion in an English-speaking context — the studyinvestigates how participants assign meaning to their L2 engagement acrossdiverse social settings, and how English becomes a tool for bothcommunication and personal reinvention. The research adopts a qualitative, narrative-based methodology. The datawere generated through in-depth interviews, small group discussions, andreflective journal entries with nine adult participants, all native Spanishspeakers. Crucially, the data …

Exploring And Increasing Women’S And Girls’ Recreational Ocean Access In A Coastal Community In The Tropical Majority, Florence Barraud

School of Law, Humanities and Social Sciences Theses

Vast gender inequalities restrict women’s and girls’ access to ocean spaces, particularly in the tropical majority. Globally, 68% of women cannot swim, compared to 43% of men. In many coastal communities, women are key stewards of highly biodiverse yet vulnerable marine environments that people rely upon for food security, livelihoods, culture, and coastal protection. Being able to swim is imperative for enabling access to the dominant environment and a core recreational, educational, and economic space. This study aimed to explore and increase women’s and girls’ recreational ocean access in the Maldives, a tropical majority island nation.Utilising a pragmatic feminist approach, …

Safe Family Therapy Activities And The Emotional Well-Being Of Parents Of Autistic Children, Gamze Camci

School of Law, Humanities and Social Sciences Theses

This thesis addresses a critical gap in the existing literature on the emotional well-being of parents of autistic children by applying SAFE family therapy activities grounded in the Narrative Attachment Therapy approach through a three-cycle action research design. Stage 1 involved 3 parents as primary participants, with their children present during selected sessions. Stage 2 included 2 families; the primary focus was on 3 parents across these families. Stage 3 engaged 5 therapists. Data were collected through interviews, diaries, questionnaires and therapy recordings. Data from interviews and journals were analysed thematically, whereas questionnaires were analysed idiographically. The first and second …

Exploring The Reading Motivation And Reading Experiences Of Secondary School Students With Dyslexia In England, Ahmet Kaan Alper

School of Law, Humanities and Social Sciences Theses

This research examines how a small group of secondary school students with dyslexia in England make sense of their reading experiences and motivation to read across school, home and everyday settings. It responds to concerns that literacy policy and practice foreground accuracy, speed and comparison, leaving limited space for reading for pleasure on students’ own terms. Drawing on Michel Foucault’s concepts, the study treats dyslexia and literacy as historically and institutionally produced categories and explores how discourses, norms and accountability regimes shape what counts as legitimate reading and a motivated reader. The research is grounded in a relativist ontology and …

Social And Emotional Experiences Of Higher Education Students With Dyslexia In Türki̇Ye And England: Exploring The Effect Of Context, Levent Yigit

School of Law, Humanities and Social Sciences Theses

This research study examined the social and emotional experiences of university students with dyslexia in Türkiye and England who had received an official diagnosis at some point in their lives. Findings were compared and the differing experiences in two different countries highlighted. Six students in Türkiye and five students in England participated in the study. To produce an in-depth subjective dataset capturing life-stories, a qualitative narrative approach was adopted. Three, and for some participants four, consecutive semi-structured interviews were conducted, with at least a one-week interval between each interview. The study adopted a longitudinal approach as each interview investigated students’ …

Investigation Of A Global Mouse Methylome Atlas Reveals Subtype-Specific Copy Number Alterations In Pediatric Cancer Models., Melanie Schoof, Tuyu Zheng, Martin Sill, Roland Imle, Alessia Cais, Lea Altendorf, Alicia Fürst, Nina Hofmann, Kati Ernst, Dominik Vonficht, Kenneth Chun-Ho Chan, Tim Holland-Letz, Andreas Postlmayr, Ryo Shiraishi, Wanchen Wang, Alaide Morcavallo, Michael Spohn, Carolin Göbel, Judith Niesen, Levke-Sophie Peter, Franck Bourdeaut, Zhi-Yan Han, Yanxin Pei, Najiba Murad, Fredrik J. Swartling, Jessica Taylor, Monika Yadav, Garrett R. Gibson, Richard J. Gilbertson, Matthias Dottermusch, Rajanya Roy, Kornelius Kerl, Rainer Glass, Jiying Cheng, Martin A. Horstmann, Gerrit Wolters-Eisfeld, Haotian Zhao, Dominik Sturm, Viveka Nand Yadav, Louis Chesler, Simon Haas, William A. Weiss, Paul A. Northcott, Lena M. Kutscher, Ana Guerreiro Stucklin, Olivier Ayrault, Julia E. Neumann, Daisuke Kawauchi, David T W Jones, Kristian Pajtler, Ana Banito, Stefan M. Pfister, Ulrich Schüller, Marc Zuckermann

Manuscripts, Articles, Book Chapters and Other Papers

Copy number alterations (CNAs) are hallmarks of cancer, yet investigation of their oncogenic role has been hindered by technical limitations and missing model systems. Here we generated a genome-wide DNA methylation and CNA atlas of 106 genetic mouse models across 31 pediatric tumor types, including 18 new models for pediatric glioma. We demonstrated their epigenetic resemblance to human disease counterparts and identified entity-specific patterns of immune infiltration. We discovered that mouse tumors harbor highly recurrent CNA signatures that occur distinctly based on the tumor subgroup and driving oncogene and showed that these CNAs share syntenic regions with the matching human …

Thwartings, Lee Anne Fennell

Coase-Sandor Institute for Law & Economics Research Paper Series

No abstract provided.

Bibliography On Indigenous Rights In Canada, 1995-2025, Leslie Haddock, Kent Mcneil

All Papers

No abstract provided.

The Intertemporal Law Doctrine’S Application To The Acquisition Of Colonies In The Americas, Kent Mcneil

All Papers

The intertemporal doctrine provides that international disputes have to be resolved in accordance with the international law that existed at the time the events giving rise to the dispute took place, not at the time the matter is adjudicated.1 It is thought to be impermissible to apply current standards to events that occurred in the past when different legal principles and rules were the norm. This doctrine applies as much to acquisition of colonies as to other international issues.2 So in order to determine whether a European nation acquired sovereignty over an overseas territory, it is necessary to determine and …

Nh 4-H Horse Quiz Bowl Packet, Unh Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Effects Of Density Turbulence On Helicon Wave Propagation In The Core Plasmas, Eun-Hwa Kim, Syun'ichi Shiraiwa, Seung-Hoe Ku, A. Bortolon, Masayuki Ono, Nicola Bertelli, Robert I. Pinsker

Faculty Publications

No abstract provided.

Secondhand Books Industry Between Extinction And Challenges Of The New Millennium: Insights Urban And Architectural Considerations From Al-Azbakeya Book Market., Ahmed M. Selim, Heba M. Gaber, Nehal M. Elmahdy

Mansoura Engineering Journal

At the beginning of the 21st century, the printed and secondhand book industry has faced enormous challenges, particularly after the COVID-19 pandemic, when book consumers sought to engage directly with e-books. The Azbakeya Book Market in Egypt is one of the markets that confronts this challenge, while maintaining its distinctive historical character. This study aims to rehabilitate the secondhand book market in Al-Azbakeya district as a model that simulates the potential urban and sustainable architectural design strategies for reviving this industry. The study framework was comprised into four sections. First, "desk-based research" was conducted to discuss the secondhand book industry …

A Hybrid Geoid Model For The Perlis Region, Malaysia Based On Cadastral Reference Marks And A Geometric Approach, Muhammad Aiman Haiqal Abdul Malek, Muhammad Faiz Pa’Suya, Ramazan Alpay Abbak, Ami Hassan Md Din, Noorfatekah Talib

Mansoura Engineering Journal

This study presents the development of a high-resolution local geoid model for the Perlis region, Malaysia, using a geometric approach that integrates GNSS-levelling benchmarks with Cadastral Reference Mark (CRM) data. A total of 38 GNSS-levelling benchmarks were used as reference points, while 3,725 CRMs were incorporated to significantly enhance spatial coverage for geoid modelling. Orthometric heights at the CRM points were first determined by transferring heights from the reference benchmarks using gravimetric geoid information. Subsequently, geometric geoid heights were computed from the differences between ellipsoidal and orthometric heights. Five interpolation techniques were evaluated to generate the geometric geoid surface, namely …

The Effect Of Second-Order Slip In Hydromagnetic Eyring-Powell Flow: A Bvp4c Study, Ch. Maheswari, B. Naga Lakshmi, G. Dharmaiah, R. Mohana Ramana, B. Reddappa

Mansoura Engineering Journal

The steady-state Eyring–Powell boundary layer fluid flow past a moving surface is examined, considering various parameter implications. These include the wall mass transfer parameter (0.5  C   2.0), the magnetic field parameter (5  Mn 20), the velocity ratio parameter (0.1  λ1  0.7), Eyring-Powell fluid parameters (0.5 K 2 & 0.1 E 0.4), as well as the first-order velocity slip (0.1 γ 1.1) and second-order velocity slip (0.1 δ  0.4). By employing appropriate similarity transformations, the PDEs are reduced to a set of non-linear ODEs, which are subsequently solved using the bvp4c numerical technique and, an implication of key factors on shear …

Finite Element Analysis Of Multiscale Fgm Plate Using Modified Third Order Shear Deformation Theory, Ravi Kumar, Ajay Kumar

Mansoura Engineering Journal

Present paper aimed to examine the static and dynamic response of a carbon nanotube (CNT) infused multiscale functionally graded (FGM) rectangular plate structure. A third-order shear deformation theory (TSDT) based on Reddy’s formulation with enforcing negligible transverse shear stresses at the outermost surface of the plate, is used. A nine-noded isoparametric element with 13 displacement variables per node is numerically investigated for finite element analysis. Using the Halpin-Tsai and homogeneous equation the elastic behaviour of the final material is obtained. The current result is first checked against a previously published result to validate the present mathematical model. The finite element …

Optimal Design Of Concrete Canal Section For Minimizing Overall Costs Using Artificial Ecosystem Optimization, Aya M. Elkhouly, Hamdy A. El-Ghandour, Tharwat Sarhan, Mahmoud E. Abd-Elmaboud

Mansoura Engineering Journal

The optimal design of concrete-lined canals represents a critical challenge in hydraulic engineering, requiring simultaneous minimization of construction and operational costs while satisfying hydraulic performance constraints. This study presents a novel optimization framework that utilizes the Artificial Ecosystem-based Optimization (AEO) algorithm for determining optimal canal cross-sectional dimensions. The proposed methodology comprehensively considers excavation costs, lining expenses, and water losses due to seepage and evaporation while ensuring hydraulic efficiency through velocity and Froude number constraints. The AEO algorithm mimics natural ecosystem processes through production, consumption, and decomposition phases to efficiently explore the design space and converge to global optima. The framework …

Data Collection Algorithm Based On Regression Analysis, Aiming To Minimize Data Processing Delays In 6g-Enabled Iot Networks, Archana Rajendra Mane, Sachin Vasant Chaudhari

Mansoura Engineering Journal

Researchers are currently investigating 6G wireless communication technologies because they can offer ultra-low latency, high data rates, and smarter network management than 5G. IoT services have spurred the development of cutting-edge technologies such as quantum communications, terahertz (THz), and artificial intelligence (AI), all of which are expected to be included into the subsequent generation of 6G networks. This paper presents a regression-based data collection algorithm for 6G-enabled IoT networks that dynamically prioritizes data through Random Forest regression. With a Mean Absolute Error (MAE) of 0.62 ms and a Root Mean Squared Error (RMSE) of 0.83 ms, the proposed method can …

Teleoperated Mobile Robot For Pesticide Spraying And Greenhouse Navigation: Numerical Analysis, Wessam Atwa, Zakaria Ismail, Mohsen Egela, Mohamed G. Alkalla

Mansoura Engineering Journal

Pesticide spraying in greenhouses is a dangerous process as the operator should wear protective suits and masks against the chemicals, which cause skin and eye irritation, respiratory issues, and even cancer. Other severe conditions involve elevated temperature and humidity in the confined greenhouse atmosphere. Therefore, this article proposes a novel teleoperated mobile robot for pesticide spraying called AMR-BPS to address such issues. It aims to keep the human securely outside during the spraying process. AMR-BPS has a novel design incorporating many innovative mechanisms, such as an extendable spraying boom, independent control of each spraying side, adjustable nozzle angles, and 2D-LiDAR …