Digital Commons Network^™

Helicobacter Pylori And Cancer: What's The Link?, Elettra Merola, Giovanni Mario Pes, David Yates Graham, Maria Pina Dore

Faculty, Staff and Students Publications

Helicobacter pylori (H. pylori) is a human bacterial pathogen that causes one of the most common chronic bacterial infections worldwide. The microorganism has been classified by the International Agency for Research on Cancer as a Group I carcinogen. While the etiological link to gastric cancer is well established, the precise molecular and cellular mechanisms driving this transformation are highly complex and incompletely understood. Fundamentally, the infection results from the chronic presence of acute on chronic gastric mucosal inflammation. H. pylori pathogenicity is increased by bacterial virulence factors including the cytotoxin-associated gene A (CagA) and Vacuolating cytotoxin A (VacA) …

Hypothyroidism Is Associated With Higher Healthcare Utilisation And Higher Need For Blood Transfusion After Primary Total Knee Arthroplasty (Tka) In Patients With Osteoarthritis: A National Inpatient Sample Analysis, Sumanth R Chandrupatla, Kranti C Rumalla, Jasvinder A Singh

Faculty, Staff and Students Publications

Purpose: To examine the association of hypothyroidism with primary total knee arthroplasty (TKA) outcomes in adults with primary underlying diagnosis of osteoarthritis (OA).

Methods: We identified a prospective cohort of patients in the 2016-2020 national inpatient sample (NIS) that received primary TKA with an underlying diagnosis of OA, identified using International Classification of Diseases, Tenth Revision, Common Modification (ICD-10-CM) and Procedure Coding System (ICD-10-PCS) codes in the primary procedure and diagnosis positions, respectively. We performed multivariable-adjusted regression analyses for healthcare utilisation (length of hospital stay, hospital charges and discharge destination) and clinical outcomes (blood transfusion; prosthetic fracture, dislocation or infection; …

A Taxonomy And Empirical Evaluation Of Webassembly Runtimes For Performance And Energy Across Machine Learning And Arithmetic Workloads, Sallar Khan, Tania Malik, Khalid Hasanov

Research Outputs: 2025-Present

WebAssembly (Wasm) has emerged as a lightweight, portable, and secure execution environment beyond the browser, with growing adoption in data-intensive, machine learning, and performance-sensitive workloads. However, the runtime ecosystem remains fragmented, and a systems-level understanding of how runtime design affects performance and energy efficiency is still lacking. This paper makes two contributions. First, it presents a taxonomy of modern WebAssembly runtimes that classifies the runtime landscape by execution model, compilation strategy, integration style, and systemslevel capabilities. Second, it provides an empirical evaluation of 13WASI-compatible runtimes and a native baseline across eight benchmarks, namely, four machine learning workloads (Logistic Regression, K-Means, …

Ai For Prognosis Among People Living With Hiv: Protocol For A Systematic Review And Meta-Analysis, Degninou Yehadji, Markus Hofmann, Petros Isaakidis, Smaila Alidou, Olushina Ayo Junior Ale, Kofivi Mawouko Yena, Kodjo Guidigan, Geraldine Gray, Nadjime Pindra, Gayo Diallo

Research Outputs: 2025-Present

Background: Advanced HIV disease remains a major global health concern, with nearly 40.8 million people living with HIV as of 2024. Antiretroviral therapy has improved outcomes, but its success depends on timely intervention, adherence, and retention in care. AI, including machine learning and deep learning, offers promising tools for prognostic modeling that could support clinical decision-making and personalized treatment. Existing syntheses, however, have been largely narrative and have not systematically evaluated the performance, risk of bias, reporting quality, or clinical readiness of AI-based prognostic models, leaving a critical gap in understanding their validity and applicability. Objective: This study aims to …

Discipline With Due Process: Constitutional Safeguards For Student Speech After Plaintiff A, Sarah Stich

Missouri Law Review

When fifteen-year-old Louie posted a TikTok video criticizing his school’s disciplinary policies from his bedroom, he faced a month-long suspension despite having no notice of which policies he had violated. Across the country, Kaitlin shared a Snapchat criticizing her chemistry teacher with friends at a local coffee shop and faced expulsion with minimal opportunity to explain the context. In both cases, students received limited procedural protections before suffering severe academic consequences.

Endogenous Processes Underlying Clock-Like Mutational Signatures, Teresa Druck, Rami I Aqeilan, C Marcelo Aldaz, Nicola Zanesi, Kay Huebner

Faculty, Staff and Student Publications

Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging and present in normal tissues. SBS1 results from cytosine demethylation, whereas SBS5 and SBS40 arise from unknown endogenous mechanisms. We hypothesized that loss of fragile‐site genes drives these two signatures. FHIT, located at FRA3B, is frequently deleted in cancers, and Fhit‐deficient mouse tissues exhibit a mutation profile resembling human SBS5. Data mining of …

Blood Flow Regulates Metabolism In Hematopoietic Development, Pamela L Wenzel

Faculty, Staff and Student Publications

Blood flow modifies oxygen availability and biomechanical forces within the vasculature of the embryo as the hematopoietic system develops. The aorta-gonad-mesonephros (AGM) envelops the largest artery in the body and is a critical site for the emergence of hematopoietic stem cells (HSCs). Herein, I discuss the role of hypoxia-inducible factors (HIFs) and force as determinants of metabolism and fate determination. To address the effects of blood flow on hematopoietic development, I employ mouse embryo models and biomimetic culture. Real-time cell metabolic analyses show that oxygen consumption rates (OCR) and extracellular acidification rates (ECAR) are altered by flow in cultures of …

Host Modulation Therapy In Periodontitis: From Established Therapies To Emerging Technologies, Aonjittra Phanrungsuwan, Jiaqi Huang, Neeraja Dharmaraj, Alejandra Cobos Perez, Omid Veiseh, Simon Young, Chun-Teh Lee

Faculty, Staff and Student Publications

Periodontitis is a biofilm-induced chronic inflammatory disease, characterized by gingival inflammation and alveolar bone loss. According to a national survey, approximately half of the U.S. adults are affected by periodontal disease. To effectively prevent and treat periodontitis, it is essential to address its underlying causes. The primary etiological factors include polymicrobial synergy and dysbiosis of the oral microbiota, and a dysregulated immune response. The standard therapeutic approach, mechanical removal of biofilm through debridement, sometimes demonstrates limited efficacy, particularly in cases of severe periodontitis, which may require adjunctive or additional therapy. Emerging evidence indicates that periodontal tissue destruction is initiated by …

Serum Protein Signatures For Breast Cancer Detection In Treatment-Naïve African American Women Using Integrated Proteomics And Pattern Analysis, Padma Tadi Uppala, Elmer Rivera, Hyun J. Kwon, Sharon S. Lum

Faculty Publications

Breast cancer is the leading cause of cancer-related mortality in African American (AA) women. In this study we evaluated the serum proteomic profile of AA women with breast cancer using an integrated proteomic framework with multivariate pattern analysis. Using 2D-DIGE, thousands of serum protein spots were detected across 33 gels; 46 spots met criteria for presence, statistical significance, and differential expression. Proteins from the spots were identified by MALDI-TOF/TOF and matched in curated databases, highlighting serum biomarkers including ceruloplasmin, alpha-2-macroglobulin, complement component C3 and C6, alpha-1-antitrypsin, alpha-1B-glycoprotein, alpha-2-HS-glycoprotein and haptoglobin-related protein. LC-MS/MS analysis revealed 163 differentiating peptides after imputing and …

Prophetic Preaching As A Tool For Social Justice, Trevor A. O'Reggio

Faculty Publications

No abstract provided.

Ideology And Law In Tension: The Macedonian Socialist Model Of Secularism And Its Constitutional Legacy, Aleksandar Spasenovski

Occasional Papers on Religion in Eastern Europe

This article examines the constitutional and ideological foundations of church–state relations in socialist Macedonia (1945–1990), situating them within the broader framework of socialist Yugoslavia. It argues that the Macedonian model of secularism was shaped by a structural tension between Marxist atheism as an official ideological doctrine and formal constitutional guarantees of freedom of religion. While constitutional texts affirmed separation and religious liberty, statutory regulation and political practice constrained the public role of religion and marginalized religious communities within the socialist legal order.

By analyzing ideological premises, constitutional provisions, and legislative instruments, the article identifies the defining paradox of the Yugoslav …

Theological Foundations And Regional Adaptation Of Jihadist Ideology In Russia: Case Of The North Caucasus, Tilekkabyl Amangeldi, Gulzhan Rasheva

Occasional Papers on Religion in Eastern Europe

The growth of jihadist movements in the post-Soviet space has generated significant scholarly interest in the ideological and theological mechanisms that sustain militant mobilization. Russia, particularly the North Caucasus, represents an important regional context where global jihadist doctrines intersect with local political conflicts and historical narratives of resistance. This article examines the theological foundations of Russian jihadist movements in order to understand how militant actors reinterpret Islamic doctrines to legitimize violence and construct ideological authority. The study aims to analyze the key theological concepts that shape jihadist discourse in Russia and to explore how global Salafi-jihadist ideology has been adapted …

The Symbolic Language Of Militarized Orthodoxy In Patriarchal Sermons, Architecture, And Pseudo-Historical Memory, Oleksandr Lukyanenko

Occasional Papers on Religion in Eastern Europe

The article is devoted to a comprehensive cultural and religious analysis of the processes of militarization of religious worldview in modern Russia using the example of public speeches of Patriarch Kirill of Moscow, as well as the symbolic space of the Main Temple of the Armed Forces of the Russian Federation. Particular attention is paid to the study of the mechanisms of sacralization of war through the integration of historical memory, Orthodox rhetoric and the state ideology of the “Russian world”. The study analyzes the peculiarities of the interpretation of World War II as the sacred foundation of modern Russian …

Imperial Islam And Colonial Control: The Orenburg Muslim Spiritual Assembly As A Mediator Of Russian Rule In The Kazakh Frontier, Zharas Akhan

Occasional Papers on Religion in Eastern Europe

Examination of the strategic role of the Orenburg Muslim Spiritual Assembly (OMSA) as a pivotal instrument of imperial governance in the Kazakh Steppe during the late eighteenth and nineteenth centuries. The study investigates how the Russian Tsarist administration instrumentalized Islamic institutions to exercise political control and facilitate the integration of nomadic Kazakh society into the imperial hierarchy. Drawing on extensive archival evidence, the author analyzes the institutional evolution of the Muftiate, its involvement in diplomatic and intelligence operations, and the intermediary agency of Tatar mullahs who bridged the gap between the Kazakh aristocracy and the Russian bureaucracy. The paper identifies …

The Reformation And The Formation Of A Ukrainian Model Of Theological Education: From The Ostroh Academy To The Present, Vitalii Leonidovich Khromets Dr.

Occasional Papers on Religion in Eastern Europe

The article traces the institutional history of theological education in Ukraine from the Ostroh Academy (1576) to the present, proposing a typological framework of four models. The Ostroh Academy is interpreted as a proto-university synthesising Orthodox confessional formation, humanist learning, and civic responsibility. The Kyiv-Mohyla Academy (1632/1701) is read as a paradoxical Counter-Reformation continuation of the same logic, appropriating the Jesuit collegium model as an instrument of resistance to Polonisation and Latinisation. The eighteenth-century network of collegia — Chernihiv, Pereiaslav-Khmelnytsky, Kharkiv, and the Poltava Slavonic Seminary — is treated as a mature networked form integrating theological education with Pietist influences …

Religious Norms In The Mechanisms Of Legal Regulation Of Freedom Of Conscience In Modern States, Mykola Lahodych

Occasional Papers on Religion in Eastern Europe

This article is devoted to role of religious norms in the legal regulation of freedom of conscience, with a special focus on the institutional interaction in modern democratic societies between religious organizations and the state, particularly in Central and Eastern Europe. The extant scholarly literature has addressed first and foremost the constitutional guarantees of religious freedom and church autonomy. However, less attention has been devoted to the institutional mechanisms through which religious norms operate within public administration. The study utilizes comparative legal analysis, institutional analysis, discourse analysis of official church documents and qualitative analysis of 28 judicial and institutional cases …

The Bureaucratization Of Faith: Appointed Clerics And The Limits Of Tsarist Administrative Control In The Kazakh Steppe, Zharas Akhan, Kanat Uskembaev

Occasional Papers on Religion in Eastern Europe

This article explores the religious policy of the Russian Empire in the Kazakh Steppe during the nineteenth and early twentieth centuries, focusing on the state's institutional efforts to co-opt and instrumentalize the Islamic clergy for colonial governance. Drawing on administrative and archival data, the study examines how Tsarist authorities leveraged imperial religious frameworks to deploy state-appointed Tatar mullahs into Kazakh society and formalize the middle-tier religious office of the akhund. Taking the Bukei Horde under Jangir Khan as a critical case study, the author illustrates how religious titles were integrated into the imperial bureaucratic apparatus to enforce political loyalty and …

Daily Religious Life Of Muslims In Kazakhstan And Central Asia During The Soviet Period: Controlled Institutions, Unofficial Islam, And Atheist Policy, Adiyet Kairken, Kuralay Aubakirova

Occasional Papers on Religion in Eastern Europe

The core focus of this study is the dialectic between the anti-religious policies enforced by the Soviet totalitarian regime in Central Asia and Kazakhstan and the resilience of Muslim communities in preserving their spiritual and cultural identity. This article provides a comprehensive analysis of the daily religious lives of Muslims under Soviet rule, examining the constraints placed on religious obligations and the functions of state-controlled religious institutions. The research investigates the mechanisms of the state apparatus, including atheist propaganda techniques, educational campaigns targeting the youth, and the role of official religious directorates. Furthermore, the study identifies the significance of underground …

Simulation In Occupational Therapy Graduate Programs, Donna Walls, Lillie Thomas, Melinda A. Underwood, Kendall Davis

Journal of Occupational Therapy Education

The purpose of this study was to identify the use of simulation in occupational therapy graduate programs. A national survey was analyzed from participants who were faculty members of graduate programs in the United States. The survey questions focused on the characteristics of the simulated experiences, student skills addressed, faculty collaboration efforts, and the debriefing process. Over 1,750 emails were sent to faculty of accredited graduate occupational therapy programs and yielded a response rate of approximately 9.5% from faculty of 80+ programs in 31 states that were included in the responses. Survey data were analyzed with cross-tabulation and statistical analyses, …

Scholarship Of Knowledge Discovery In Occupational Therapy Practice Model (Spot-M), Nicole R. Quint, Penelope Cleveland

Journal of Occupational Therapy Education

The Scholarship of Knowledge Discovery in Occupational Therapy Practice model guides occupational therapists, especially those with professional doctorates, in conducting practice scholarship and informing capstone projects. This model shifts the capstone from an academic experience to meaningful practice scholarship, like the dissertation’s role in scientific inquiry. The model highlights collaboration across research, practice, and education, while describing the practice scholars’ unique contributions. As evidence-based practice, implementation science, and healthcare complexity evolve, the importance of practice scholars has grown. The expertise of occupational therapists as practice scholars is pivotal for translating research findings into real-world, often unpredictable contexts; and practice scholarship …

Disability Accommodation Implementation Within Occupational Therapy Academia: A National Descriptive Survey On Knowledge, Training, And Attitudes, Nicole Pawek, Julie Olson Rand, Rebecca Ozelie, Hannah Y. Oldenburg

Journal of Occupational Therapy Education

Occupational therapy and occupational therapy assistant programs are accredited health professional programs that have, anecdotally, seen an increase in requested disability accommodations among students over the last decade. There is limited knowledge regarding faculty preparedness, available resources, and attitudes related to implementing accommodations in accredited occupational therapy and occupational therapy assistant programs located in the United States. Researchers aimed to describe faculty knowledge and experience with disability accommodation implementation, as well as identify available training and resources related to accommodation implementation and faculty attitudes toward the accommodation implementation process. Researchers used the Checklist for Reporting Results of Internet E-Surveys (CHERRIES) …

Artificial Intelligence: Current Uses In Occupational Therapy Education, Breanna Chycinski, Rebecca Tauber, Brina Crown, Caitlin Noble, Meredith Murphy

Journal of Occupational Therapy Education

Although artificial intelligence (AI) may be an advantageous tool to enhance learning, its societal impacts are still widely unexplored. This study examined how AI is utilized in occupational therapy master’s and doctoral educational programs by faculty and students, while also investigating how such programs are preparing students to employ AI in ethical and beneficial ways. Through the lens of the Person-Environment-Occupation (PEO) Model, this paper examined relationships among occupational therapy students, faculty, their educational environments, and AI. An online survey was distributed to faculty at accredited occupational therapy programs across the United States. Questions included topics such as classroom practices, …

Moringa Oleifera As An Immunomodulator, Noha Swilam, Khaled A. Nematallah, Omayma Eldahshan'

Pharmacy

Moringa oleifera has gained increasing attention for its diverse pharmacological properties, including its potential to modulate immune responses. This chapter explores the immunomodulatory potential of M. oleifera, exploring both its phytochemical composition and experimental evidence from in vitro and in vivo studies. Key bioactive constituents, such as flavonoids (quercetin, kaempferol, apigenin), phenolic acids (chlorogenic, ferulic, caffeic), glucosinolates (glucomoringin) and their hydrolysis product, benzyl isothiocyanate, are identified as contributors to its immune-regulating properties. It has been demonstrated that these substances affect cytokine expression, suppress pro-inflammatory mediators, increase phagocytic activity and alter lymphocyte reactions. In order to support the plant's traditional use …

Summoning Firms: Promoting Democratic Stability And Economic Prosperity In Times Of Constitutional Crisis, Jon D. Michaels

Emory Business Law Review

No abstract provided.

Illiberal Democracy, Merger Regulation, And Corporate Capture, Brian Jm Quinn

Emory Business Law Review

This Essay examines how the second Trump Administration has weaponized merger regulation and regulatory approval processes as tools of corporate capture in service of democratic backsliding toward an illiberal regime. Drawing on theoretical frameworks of competitive authoritarianism and illiberal democracy, this paper demonstrates how discretionary regulatory authority combined with weakened enforcement mechanisms creates opportunities for grand corruption that systematically undermines liberal democratic institutions.

This Essay accomplishes three primary objectives. First, it establishes the essential characteristics of illiberal regimes which maintain the facade of democratic institutions while systematically skewing the political playing field through selective enforcement and regulatory capture. Second, it …

Justice On Trial: Integrating Ethics In Law School Advocacy Courses, Veronica J. Finkelstein

Emory Business Law Review

The rule of law depends not only on legal doctrine and institutional design, but on the daily ethical choices of the lawyers who operate within the adversarial system. Trial lawyers, in particular, wield extraordinary power courtroom outcomes, yet law schools too often train future advocates to perform persuasive techniques without meaningful engagement with the ethical obligations that constrain those techniques and the lawyers who wield them. This article argues that the persistent separation between trial advocacy education and legal ethics instruction leaves law students ill-prepared for the moral complexities of litigation and threatens public confidence in the justice system.

Tracing …

Pharmaceutical-Telehealth Confederacies, Michelle Onder, Michael S. Sinha

Emory Business Law Review

Access to prescription pharmaceuticals has historically been controlled by a physician’s pen. As a result, pharmaceutical companies spend billions of dollars on advertising and promotion to mitigate this barrier: first and primarily, to physicians and other prescribers, and more recently, to the general public through direct-to-consumer advertising. The success of these promotional efforts can be seen in the greater prescribing of costly brand-name medicines, even in settings where lower-priced, comparably efficacious generic alternatives exist. Brand-name prescriptions now make up only 10% of all prescriptions written yet account for 88% of drug spending. Despite these substantial returns on investment, companies continue …

Anti-Domestic Violence In China: Re-Accessing The Public Value Of Individual Experience, Xiaoran Tang

Dartmouth College Master’s Theses

In December 2019, Kim Lee, a symbolic figure in China’s anti-domestic violence (ADV) movement, publicly stated on the Chinese social media platform Weibo that she forgave her ex-husband Li Yang, sparking widespread controversy.

Drawing on Joan W. Scott’s method of examining experience, this study analyzes Kim’s case within the broader historical development of China’s ADV movement. It traces how Kim’s personal experiences and public images were continuously constructed, interpreted, and reshaped across different stages of the movement. This study finds that Kim’s experiences became public knowledge through the social, legal, and institutional processes that framed her as a domestic violence …

An Ethnographic Study Of First-Generation Alumni At Dartmouth College: Perspectives From Alumni, Faculty, Staff, And Administrators, Brittney A. Roden

Dartmouth College Master’s Theses

First- generation college students (FGCS) often face challenges adapting to the academic and social environments of elite institutions like Dartmouth College. Lacking familial experience in higher education, they must decode unspoken institutional norms, contributing to stress, social isolation, and barriers to accessing institutional support. This study examines how FGCS experience academic pressure, social belonging, and engagement with campus systems, and how these shape their personal and professional trajectories. Drawing on participant-generated audio diary journals with alumni, qualitative interviews with faculty and staff, and a review of existing literature, this research highlights the interplay of academic stress, coping strategies, cultural capital, …

Marshall Amplification V. Xingrunshangmao, Northern District Of Illinois

Historical and Topical Legal Documents

No abstract provided.