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The Extinction Race: Techniques Of The Human In Proust, Via Houellebecq, James Dutton Jun 2022

The Extinction Race: Techniques Of The Human In Proust, Via Houellebecq, James Dutton

CLCWeb: Comparative Literature and Culture

In his article, “The Extinction Race: Techniques of the Human in Proust, via Houellebecq” James Dutton “reads” identity and race from the point of view of technics. Namely, he does so through the work of two nominally “Eurocentric” authors, Marcel Proust and Michel Houellebecq, observing how familial and racial resemblance is a living inscription of “lost time.” This inscription comes about through the technical means available to and constitutive of the categories which bind them. Thus, instead of furthering unfinishable racial distinctions which only serve to support discourses of racism, this article follows assertions made in the novels of …

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The Silmarillion By J.R.R. Tolkien And Shahnameh By Firdausi: A Sadraic Interpretation Of Free Will And Determinism, Mohsen Hanif, Masoud Tadayoni Jun 2022

The Silmarillion By J.R.R. Tolkien And Shahnameh By Firdausi: A Sadraic Interpretation Of Free Will And Determinism, Mohsen Hanif, Masoud Tadayoni

CLCWeb: Comparative Literature and Culture

Fate, doom, and free will have always proved to be controversial terms among philosophers. The chief problem is whether a deterministic power prescribes the destiny of creatures or they possess pure free will in shaping their destinies. Mulla Sadra, a 17th century Iranian philosopher, believes in a blending of determinism and free will which he develops in the terms of Qaza and Qadar respectively. He introduces a model of fate through which determinism and free will equally participate. Using the human soul as a model, Mulla Sadra points out that people meet their fate through several factors, one of which …

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Poetics Of The Crystal-Image: Dreams In Mirror And Ashes Of Time Redux, Yuh-Yi Tan Jun 2022

Poetics Of The Crystal-Image: Dreams In Mirror And Ashes Of Time Redux, Yuh-Yi Tan

CLCWeb: Comparative Literature and Culture

This paper delves into recurrent dreams and related recollections in Andrei Tarkovsky’s Mirror and Wong Kar-wai’s Ashes of Time Redux. Gilles Deleuze has called Mirror a film of “turning crystal” because it reflects the two sides of the protagonist’s relationship with his mother and ex-wife by juxtaposing them in a mysterious labyrinth of past-present-future. The crystal imaging refracts four sides of two couples by showing the bonding of the parents along with the connection to his ex-wife and son. The same structure is apparent in Ashes of Time Redux where another set of two bilateral symmetries is initiated between …

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The Turn Toward The Nonhuman In Susan Straight’S A Million Nightingales, Katarzyna E. Nowak-Mcneice Jun 2022

The Turn Toward The Nonhuman In Susan Straight’S A Million Nightingales, Katarzyna E. Nowak-Mcneice

CLCWeb: Comparative Literature and Culture

This article proposes a reading of Susan Straight’s 2006 novel A Million Nightingales in the light of critical posthumanities, focusing specifically on references to nonhuman animals. It does so in order to place Straight’s writing within the context of the recent posthumanist debate concerning the distinction between human and nonhuman animals (cf. Donna Haraway, Cary Wolfe). I claim that while addressing the “fused” discrimination (after Carol J. Adams) of sexism, racism, and speciesism, Straight’s prose can be seen as a proposition of a reconfigured subjectivity, one based on “entanglement” and “intra-action” (Karen Barad). A Million Nightingales, which – together …

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Cooling Down Transmedia Storytelling, Jan Baetens, Domingo Sánchez-Mesa Jun 2022

Cooling Down Transmedia Storytelling, Jan Baetens, Domingo Sánchez-Mesa

CLCWeb: Comparative Literature and Culture

In this article we propose a reading of “Dead End Street”, one of the most successful songs of one of the most popular British pop groups of the 60s, The Kinks. However, we will not discuss the song as such, but its remediation as a music video (a practice that did not have to wait for MTV to make its appearance in mass media culture). The analysis will briefly contextualize the group, the song and the clip, but its major objective is to use the Kinks example to open a new question in the larger debate on intermediality and transmediality …

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Extending The Frontiers Of The Detective Novel In Adaora Ulasi’S The Man From Sagamu, Onyeka Odoh Jun 2022

Extending The Frontiers Of The Detective Novel In Adaora Ulasi’S The Man From Sagamu, Onyeka Odoh

CLCWeb: Comparative Literature and Culture

Part of the beauty of detective literature is the mental engagement and psychological contest it stages between the author and the readers, as well as its fascinating probe into the nature and dynamism of crime. However, of greater import are the formulaic structural elements that define the genre—a crime, the detection of the crime, an omniscient detective who intelligently investigates the crime, and a justified resolution of all. Though the structure of Adaora Ulasi’s The Man from Sagamu does not exactly fit into the above model, it is still a detective novel. Therefore, this essay aims to propose a new …

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On-Line Influenza Virus Quantification For Viral Production Processes Thanks To Affinity-Based Surface Plasmon Resonance Biosensor, Emma Petiot, Laurent Durous, Manuel Rosa-Calatrava, Christophe A. Marquette Jun 2022

On-Line Influenza Virus Quantification For Viral Production Processes Thanks To Affinity-Based Surface Plasmon Resonance Biosensor, Emma Petiot, Laurent Durous, Manuel Rosa-Calatrava, Christophe A. Marquette

Vaccine Technology VIII

Influenza virus seasonal epidemics, associated with the constant threat of new pandemic outbreak, challenge vaccine manufacturers to develop responsive processes that can outreach the limitations of traditional egg-based technology. Recent progress made regarding cell culture bioprocesses allowed for numerous alternative strategies to developed future vaccine candidates, as for example the recombinant HA or Virus—like Particles (VLP) vaccines. However, while cell culture allows for more versatility than ovoculture, regarding process development and monitoring, these alternatives still require optimization to seriously concurrence the traditional process. To drive these developments, WHO and regulatory agencies underlined the need for developing better influenza vaccine potency …

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Optimization, Production, Purification And Characterization Of Hiv-1 Gag Vlps Functionalized With Sars-Cov-2 Spike Glycoprotein, Amau Boix-Besora, Elianet Lorenzo, Jesus Lavado-Garcia, Francesc Gòdia, Laura Cervera Jun 2022

Optimization, Production, Purification And Characterization Of Hiv-1 Gag Vlps Functionalized With Sars-Cov-2 Spike Glycoprotein, Amau Boix-Besora, Elianet Lorenzo, Jesus Lavado-Garcia, Francesc Gòdia, Laura Cervera

Vaccine Technology VIII

Virus-like particles (VLPs) constitute a promising approach for recombinant vaccine development. They are robust, safe, versatile and high immunogenic supra-molecular structures that closely mimic the native conformation of the viruses without carrying its genetic material. HIV-1 Gag VLPs share similar characteristics with wild type Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, making them a suitable platform to express the Spike membrane protein to generate a potential vaccine candidate for COVID-19. This work proposes a methodology for the generation of SARS-CoV-2 VLPs by its co-expression with HIV-1 Gag protein by transient transfection of HEK 293 cultures. We first evaluated the …

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Multivalent Influenza Vaccine Production In Hek-293 Cells In Response To Pandemic Threats, Amine Kamen, Cécile Toussaint, Omar Farnos, David Sharon, Alina Venereo-Sanchez, Irene González-Domínguez, Alice Bernier, Xingge Xu, Hanan Chaabane Jun 2022

Multivalent Influenza Vaccine Production In Hek-293 Cells In Response To Pandemic Threats, Amine Kamen, Cécile Toussaint, Omar Farnos, David Sharon, Alina Venereo-Sanchez, Irene González-Domínguez, Alice Bernier, Xingge Xu, Hanan Chaabane

Vaccine Technology VIII

Influenza virus infects millions of people every year worldwide, with elderly and very young people among the most critically affected. Strains that constitute a pandemic threat are characterized by the severity of the clinical manifestations and mortality rates and tend to require the urgent production of hundreds of millions of vaccine doses in very short periods of time. There is an evident need to develop new generations of influenza vaccines based on robust production systems such as mammalian or insect cell cultures. These systems may allow, in contrast to production in embryonated chicken eggs, a faster response capacity, a superior …

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Multimodal Chromatography Combining Steric Exclusion And Cation Exchange As An Intermediate Downstream Step To Purify Yellow Fever Virus-Like Particles, Túlio M. Lima, Ricardo A. Medronho, Leda R. Castilho Jun 2022

Multimodal Chromatography Combining Steric Exclusion And Cation Exchange As An Intermediate Downstream Step To Purify Yellow Fever Virus-Like Particles, Túlio M. Lima, Ricardo A. Medronho, Leda R. Castilho

Vaccine Technology VIII

Yellow fever (YF) is an hemorrhagic viral disease transmitted by infected mosquitoes, which is endemic in many African and Central/South American countries. The severe symptoms and the high mortality rate of the disease can have devastating effects in case an outbreak occurs in an area where the population is non-vaccinated. Before the current YF vaccine became available, outbreaks in cities like Barcelona (Spain) and Philadelphia (USA) led to the death of approximately 10% of the population. Recent outbreaks have shown that YF continues to be a major public health threat due to production capability issues and shortage of vaccine stockpiles, …

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Rotavirus Vp6 Nanotubes Show An Antigen Form-Dependent Adjuvant Activity: Zika Virus Envelope Protein Monomer Vs Zika Virus-Like Particles, Arturo Liñan, Ana Ruth Pastor, Selene J. Uribe-Romero, Mabel Rodriguez, Octavio T. Ramirez, Laura A. Palomares Jun 2022

Rotavirus Vp6 Nanotubes Show An Antigen Form-Dependent Adjuvant Activity: Zika Virus Envelope Protein Monomer Vs Zika Virus-Like Particles, Arturo Liñan, Ana Ruth Pastor, Selene J. Uribe-Romero, Mabel Rodriguez, Octavio T. Ramirez, Laura A. Palomares

Vaccine Technology VIII

The structural protein of rotavirus (RV) VP6 can self-assemble into tubular polymeric structures under specific conditions of pH and ionic strength when expressed in recombinant systems. Previous studies have shown that RV VP6 nanotubes (VP6NT) have an adjuvant effect on the immunogenicity of norovirus virus-like particles (VLPs) in mice (Blazevic et al., 2011; Malm et al., 2016). The present study focused on the determination of adjuvant activity of VP6NT on the immunogenicity of monomers of the viral envelope (E) protein or of Zika virus (ZikV) VLPs. ZikV infection can cause congenital malformations in fetuses and the Guillain-Barré syndrome in adults, …

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Protein Design And Immunogenic Analysis Of Covid-19 Vaccine Candidates Based On Rbd/Trimeric-Spike Antigens And Chimeric Vlps Antigens, Claudio Prieto, Ernesto Garay, Javier Villarraza, Antonela Fuselli, Agustina Gugliotta, Celeste Rodríguez, Victoria Gastaldi, Natalia Ceaglio, Diego Fontana Jun 2022

Protein Design And Immunogenic Analysis Of Covid-19 Vaccine Candidates Based On Rbd/Trimeric-Spike Antigens And Chimeric Vlps Antigens, Claudio Prieto, Ernesto Garay, Javier Villarraza, Antonela Fuselli, Agustina Gugliotta, Celeste Rodríguez, Victoria Gastaldi, Natalia Ceaglio, Diego Fontana

Vaccine Technology VIII

Spike glycoprotein (S) and its Receptor Binding Domain region (RBD) are the main targets of neutralizing antibodies during an infection with SARS-CoV-2, the etiologic agent of COVID-19 pandemic viral disease. Thus, they are the chosen antigens for the development of diagnostic kits and vaccines candidates. Furthermore, Virus-like Particles (VLPs) constitute potent immunogens that have been engineered to obtain vaccine candidates through expression of SARS-CoV-2 S, M, E and N proteins. Although it might be a challenging platform, as multiple proteins must be expressed in order to assure VLP budding, they are able to induce stronger immune responses than soluble antigens …

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Divergent Evolution Of Extreme Production Of Variant Plant Monounsaturated Fatty Acids, Lu Gan, Kiyoul Park, Jin Chai, Evan M. Updike, Hyojin Kim, Adam Voshall, Sairam Behera, Xiao-Hong Yu, Yuanheng Cai, Chunyu Zhang, Mark A. Wilson, Jeffrey P. Mower, Etsuko Moriyama, Chi Zhang, Sireewan Kaewsuwan, Qun Liu, John Shanklin, Edgar B. Cahoon Jun 2022

Divergent Evolution Of Extreme Production Of Variant Plant Monounsaturated Fatty Acids, Lu Gan, Kiyoul Park, Jin Chai, Evan M. Updike, Hyojin Kim, Adam Voshall, Sairam Behera, Xiao-Hong Yu, Yuanheng Cai, Chunyu Zhang, Mark A. Wilson, Jeffrey P. Mower, Etsuko Moriyama, Chi Zhang, Sireewan Kaewsuwan, Qun Liu, John Shanklin, Edgar B. Cahoon

Center for Plant Science Innovation: Faculty Publications

Metabolic extremes provide opportunities to understand enzymatic and metabolic plasticity and biotechnological tools for novel biomaterial production. We discovered that seed oils of many Thunbergia species contain up to 92% of the unusual monounsaturated petroselinic acid (18:1Δ6), one of the highest reported levels for a single fatty acid in plants. Supporting the biosynthetic origin of petroselinic acid, we identified a Δ6-stearoyl-acyl carrier protein (18:0-ACP) desaturase from Thunbergia laurifolia, closely related to a previously identified Δ6-palmitoyl-ACP desaturase that produces sapienic acid (16:1Δ6)- rich oils in Thunbergia alata seeds. Guided by a T. laurifolia desaturase crystal structure obtained in this study, …

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Production And Characterization Of Hepatitis B Virus-Like Particles Expressed In Hek293 And Cho-K1 Recombinant Cell Lines. Analysis Of The Humoral Immune Response, Juan Manuel Battagliotti, Diego Fontana, Marina Etcheverrigaray, Claudio Prieto Jun 2022

Production And Characterization Of Hepatitis B Virus-Like Particles Expressed In Hek293 And Cho-K1 Recombinant Cell Lines. Analysis Of The Humoral Immune Response, Juan Manuel Battagliotti, Diego Fontana, Marina Etcheverrigaray, Claudio Prieto

Vaccine Technology VIII

Hepatitis B is a life-threatening liver infection caused by the hepatitis B virus (HBV). Even today, HBV infection constitutes a global health problem, affecting more than 250 million people, and vaccination represents the most cost-effective strategy to control HBV spreading. The main antigen of the HBV its the surface antigen (HBsAg), that consists of three co-carboxyterminal envelope glycoproteins, called Large (L), Middle (M), and Small (S). Current available HBV vaccines are based on the non-glycosylated form of the S protein, expressed in yeast cells. Although efficacious and safe, about 10% of people vaccinated with this vaccine fail to mount an …

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Rational Design, Expression And Characterization Of Chimeric Rabies Vlps Displaying The Major Antigenic Site Of Foot And Mouth Disease Virus, Ernesto Garay, Diego Fontana, Lautaro Leschiutta, Ricardo Kratje, Claudio Prieto Jun 2022

Rational Design, Expression And Characterization Of Chimeric Rabies Vlps Displaying The Major Antigenic Site Of Foot And Mouth Disease Virus, Ernesto Garay, Diego Fontana, Lautaro Leschiutta, Ricardo Kratje, Claudio Prieto

Vaccine Technology VIII

Virus-like Particles (VLPs) are supramolecular arrangements of one or more viral proteins that resemble the structure of the native virus but are not infective, due the fact that they lack the viral genome. They have become very important in the field of novel recombinant vaccines, because of their biosafety and improved immunogenicity over subunit vaccines due to their particulate nature and highly repetitive epitope display. Moreover, they can elicit immune responses against heterologous antigens by the incorporation of epitopes by genic fusion to the viral proteins, constituting chimeric VLPs (cVLPs). In a previous work, by recombinant expression of the rabies …

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"The Cold War: Living Under Its Shadow" Featuring Claudia Serea, Armando F. Sanchez Productions Jun 2022

"The Cold War: Living Under Its Shadow" Featuring Claudia Serea, Armando F. Sanchez Productions

Armando F. Sanchez Productions collection

Video recording of "The Cold War: Living Under Its Shadow" featuring host Armando F. Sanchez and his guest Claudia Serea, a Romanian-born immigrant to the United States who is an author, poet, copywriter, and translator. Serea shares her personal experiences and the background of her family as they lived through the Cold War in Romania.

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"There Is Great And Awful Immorality In This Place": Environment, Character, And Reform In South Wales, 1847-1919, Allison Kirkpatrick Jun 2022

"There Is Great And Awful Immorality In This Place": Environment, Character, And Reform In South Wales, 1847-1919, Allison Kirkpatrick

University Honors Theses

In the second half of the nineteenth century and beginning of the twentieth, sanitarians and reformers in Britain undertook a wide range of public health campaigns aimed at improving the conditions of the industrialized urban environment. Some turned their attention to south Wales, where the coal industry had spurred rapid urban growth and transformed the region into one of Britain's industrial centers. The negative effects of this transition were most acutely felt in working-class communities in the south Wales coalfield, where a near-complete lack of urban planning had left a legacy of overcrowding, nonexistent or inadequate drainage and sewage systems, …

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Self-Perceptions Of Major Choice And Employability Skill Development In Sophomore Business Students, Melissa A. Kulp Jun 2022

Self-Perceptions Of Major Choice And Employability Skill Development In Sophomore Business Students, Melissa A. Kulp

USF Tampa Graduate Theses and Dissertations

Today’s college students expect that an outcome of a college education is to be prepared to secure a well-paying job within their field of study after graduation. Within career services offices, career preparation is typically focused on upperclassmen looking for internships and jobs, leaving sophomore students to make major and career decisions on their own. The purpose of the study is to understand what on-campus experiences sophomore business students had to aid them in their major and career path choices, how they define and interpret three employability skills, and which experiences helped them develop these three employability skills needed to …

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Inari Large-Bore Mechanical Thrombectomy In Intermediate-High Risk Submassive Pe Patients: Case Series And Literature Review, Mohammad F. Mathbout, Hussam Al Hennawi, Anwar Khedr, Medical University Of South Carolina, Thomas M. Todoran Jun 2022

Inari Large-Bore Mechanical Thrombectomy In Intermediate-High Risk Submassive Pe Patients: Case Series And Literature Review, Mohammad F. Mathbout, Hussam Al Hennawi, Anwar Khedr, Medical University Of South Carolina, Thomas M. Todoran

Abington Jefferson Health Papers

Pulmonary embolism (PE) is one of the most common causes of cardiovascular (CV) mortality worldwide. Owing to the associated morbidity and mortality with other treatment modalities, including systemic thrombolysis, a discernible change in the era of acute pulmonary embolism management has been reported. Catheter-directed thrombectomy using the FlowTriever system (Inari Medical; Irvine, CA, USA) was shown to reduce endpoints of interest in patients with acute intermediate-high risk PE and was associated with rapid hemodynamic improvement. In this report, we describe our experience with three cases of patients presenting with submassive PE, whereby immediate pulmonary artery pressure improvement was evident in …

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Othermothering By African American Women In Higher Education At Predominantly White Institutions: How The Practice Affects Their Professional And Personal Lives, Julie Collins Jun 2022

Othermothering By African American Women In Higher Education At Predominantly White Institutions: How The Practice Affects Their Professional And Personal Lives, Julie Collins

College of Education Theses and Dissertations

Many African American women who work in higher education, in non-faculty roles, incorporate a historical and cultural tradition commonly referred to as “othermothering” with higher education best practices when working with African American students. The practice of othermothering was used by enslaved African American women to assist other mothers with the care of their children and to maintain the family structure. The practice continues to this day in spaces where women are present such as neighborhoods, faith communities, community organizations and educational institutions. This research, using Black Feminist Theory as the theoretical framework, sought to study othermothering as practiced by …

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A Comparative Analysis Of Best Practices In A Facial Recognition Policy For Law Enforcement Agencies, Terry H. Smith Jun 2022

A Comparative Analysis Of Best Practices In A Facial Recognition Policy For Law Enforcement Agencies, Terry H. Smith

College of Education Theses and Dissertations

Facial Recognition Technology (FRT) and the plethora of applications that have adopted this technology have exploded in the last decade. Most people have probably heard about local law enforcement agencies utilizing FRT to catch criminals, locate missing persons, and provide large-scale event security. Law enforcement's use of FRT has been criticized since its implementation. Critics have lambasted FRT, citing inaccuracy of the technology; potential race, age, and gender bias; the collection and retention of images; and a lack of governing standards as to when the technology can be applied. In addition, the lack of transparency has been met with fierce …

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Institutional Effectiveness On Student Retention And Diversification For African American Female Engineering Students At Higher Educational Institutions, Robbin Parker Jun 2022

Institutional Effectiveness On Student Retention And Diversification For African American Female Engineering Students At Higher Educational Institutions, Robbin Parker

College of Education Theses and Dissertations

This quantitative research study examined higher educational institutions, specifically, Land Grant, Carnegie classification of ‘Very high research activity’, and Predominantly White Institutions in the United States. Furthermore, the evaluation analyzed HEI effectiveness in engineering programs to retain and graduate African American female students. Mainly, the research looked at retention, attainment, diversity, academic support systems, assessment, and initiatives as units of measurements to analyze the various types of support mechanisms at these institutions. The goal was to determine if these units of measurement are the necessary resources that HEI require to successfully assist, engage, and strengthen the educational attainment of African …

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The Illusion Of Progress: The Disconnect Between The Anti-Racist Values Professed In Teacher Education Programs And The White Curriculum That Negatively Impact Students Of Color, Adrienne Kay Carmona Jun 2022

The Illusion Of Progress: The Disconnect Between The Anti-Racist Values Professed In Teacher Education Programs And The White Curriculum That Negatively Impact Students Of Color, Adrienne Kay Carmona

College of Education Theses and Dissertations

Research suggests that anti-racist teaching is the solution in classrooms to give students the ability to understand the origins of racism and to give them the ability to disrupt White Supremacy culture; however, there is a limited number of studies that look at anti-racist teaching in the classroom. The obstacle and challenge is how to implement an anti-racist curriculum into the secondary education classroom. With high demands from administration, teachers have struggled to successfully reach all students of color. This purpose of this study is to investigate the connection between anti-racist training for pre-service teachers and the effectiveness of implementing …

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A Study Of Addressing Chronic Absenteeism And Truancy: The Attendance Improvement Program At Emil G. Hirsch High School (Chicago, Il), Beverly Taylor-Williams Jun 2022

A Study Of Addressing Chronic Absenteeism And Truancy: The Attendance Improvement Program At Emil G. Hirsch High School (Chicago, Il), Beverly Taylor-Williams

College of Education Theses and Dissertations

This project examines the historical barriers and challenges of chronic absenteeism and truancy and offers an intervention strategy aimed at reducing these rates at one specific school, Emil G. Hirsch High School in Chicago, IL. The detrimental effects problematic absenteeism has on individual students, schools, the Department of Education, and the community has been researched extensively. Building on this existing literature, this project explores further the mitigating factors for chronic absenteeism and truancy and proposes a new intervention strategy to increase student attendance rates. The Attendance Improvement Program was designed through this capstone project-draws on elements of social control theory …

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It’S Not Easy Being Green: An Examination Of First-Generation African American College Students’ Experiences At Predominantly White Institutions, Sabrina Marie Sanders Jun 2022

It’S Not Easy Being Green: An Examination Of First-Generation African American College Students’ Experiences At Predominantly White Institutions, Sabrina Marie Sanders

College of Education Theses and Dissertations

First-generation African American students often find it challenging transitioning from high school to college. Despite facing challenges, many of these students enroll and persist to degree attainment. The purpose of this study is to explore the lived experiences of first-generation African American college students at PWIs. This qualitative, phenomenological study utilizes the marginality and mattering theory as a lens to examine the lived experiences of first-generation African American college students who persevered from predominantly Black high schools to predominantly White institutions (PWIs). Much of the research on first-generation college students tends to focus on quantifiable data such as GPAs and …

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In The Name Of Freedom: Racist Hate Speech On Campus, Institutional Whiteness, And Neofascism, Karlee Johnson Jun 2022

In The Name Of Freedom: Racist Hate Speech On Campus, Institutional Whiteness, And Neofascism, Karlee Johnson

College of Education Theses and Dissertations

Administrative language surrounding racist hate speech on campus is rooted in abstract interpretations of the liberal values of freedom and equality. Consequently, these color-blind discourses remove racist hate speech from its historical context of racial violence and discrimination and view it as merely another point of view that is deserving of tolerance in the “free marketplace of ideas.” As a result, this Critical Discourse Analysis project argues that 1) the administrative discourses surrounding hate speech on campus contribute to the maintenance of institutions of higher education as white institutional spaces, and 2) they also bring institutions of higher education into …

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Implementation Of Skill-Based, Transdisciplinary Competencies And Their Influence On Teacher Practice, Thomas P. Wolfe Jun 2022

Implementation Of Skill-Based, Transdisciplinary Competencies And Their Influence On Teacher Practice, Thomas P. Wolfe

College of Education Theses and Dissertations

Competency-based education has been a growing movement in K-12 education but faces several implementation challenges. In addition, discussion in the field is lacking related to the competency-based principle: learning outcomes emphasize the authentic application of knowledge. New to the competency-based field are proficiencies called competencies, which are skill-based, transdisciplinary proficiencies that are structured across a continuum of varying performance levels. This study employed a case study methodology utilizing teacher and educational leader interviews as well as artifacts to explore the implementation of competencies in a competency-based organization and two schools that partnered with it. This study specifically investigated how competencies …

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A Phenomenological Study On African American Male Conduct Officers And Their Experiences With Code-Switching In Professional Settings, Bernard Little Jun 2022

A Phenomenological Study On African American Male Conduct Officers And Their Experiences With Code-Switching In Professional Settings, Bernard Little

College of Education Theses and Dissertations

African American male student conduct professionals consciously engage in code-switching in professional settings. Student conduct professionals hold significant responsibility within a college or university. The impact of their decisions creates immense pressure and results in lasting consequences for students involved. In this qualitative, phenomenological study the use of code-switching for six African American male conduct professionals is examined. Through semi-structured interviews, their diverse experiences are explored. Findings revealed that their use of code-switching is an intentional performance that they were taught and they use code-switching for professional survival. Findings also revealed that African American male conduct professionals weigh the risks …

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"Everything Is Political Now": Teaching Politics In The Age Of Trump, John G. Lund Jun 2022

"Everything Is Political Now": Teaching Politics In The Age Of Trump, John G. Lund

College of Education Theses and Dissertations

Many American high school government and history teachers aim to convey curriculum content without bringing in their own personal political beliefs or biases. However, in the hyperpolarized political climate of the past decade, teachers have grappled with teaching their courses when potentially controversial political or cultural issues come up in class conversations or lessons. Their teaching decisions and the classroom environment can have an impact on students’ learning, mental health, and their own views on American politics, history, and culture. This qualitative, narrative inquiry study examined ten high school teachers’ practice of teaching politics in the age of Trump. Findings …

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Antigen Glycosylation Regulates Efficacy Of Car T Cells Targeting Cd19, Amanda Heard, Jack H Landmann, Ava R Hansen, Yu-Sung Hsu, Mehmet Emrah Selli, John M Warrington, John Lattin, Jufang Chang, Helen Ha, Balraj Doray, Abby M Green, Nathan Singh, Et Al Jun 2022

Antigen Glycosylation Regulates Efficacy Of Car T Cells Targeting Cd19, Amanda Heard, Jack H Landmann, Ava R Hansen, Yu-Sung Hsu, Mehmet Emrah Selli, John M Warrington, John Lattin, Jufang Chang, Helen Ha, Balraj Doray, Abby M Green, Nathan Singh, Et Al

Open Access Publications

While chimeric antigen receptor (CAR) T cells targeting CD19 can cure a subset of patients with B cell malignancies, most patients treated will not achieve durable remission. Identification of the mechanisms leading to failure is essential to broadening the efficacy of this promising platform. Several studies have demonstrated that disruption of CD19 genes and transcripts can lead to disease relapse after initial response; however, few other tumor-intrinsic drivers of CAR T cell failure have been reported. Here we identify expression of the Golgi-resident intramembrane protease Signal peptide peptidase-like 3 (SPPL3) in malignant B cells as a potent regulator of resistance …

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