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Layout Of Basic Research Based On Think Tank Double Helix Methodology, Jinbo Wan, Jian Jiao, Peng Du

Bulletin of Chinese Academy of Sciences (Chinese Version)

The layout of basic research is a typical multi-stakeholder and multi-disciplinary comprehensive policy research, which is suitable to be guided by the think tank double helix methodology. Firstly, the study summarizes the "organization" and theoretical understanding of basic research layout. Secondly, based on MIPS logical hierarchy method and DIIS process fusion method, the study analyzes the fusion mechanism of "discipline layout" and "task layout" of basic research. Finally, the study puts forward the promotion strategies and measures of the future basic research layout from four aspects:system layout, discipline layout, task layout, and international layout.

Impact And Enlightenment Of Eu’S “Industry 5.0” To High-Quality Development Of China’S Manufacturing—Research On Application Of Think Tank Double Helix Methodology, Lu Zhao, Dawei Song, Feng Zhang, Jiaofeng Pan

Bulletin of Chinese Academy of Sciences (Chinese Version)

The world is experiencing a great change with the combined impact of the COVID-19 pandemic. In the post-epidemic era, the world's major economies have begun to plan their strategic adjustments, economic revival and transformation. Industry 5.0, as the EU's new strategy to plan the "New Industrial Revolution" and promote industrial transformation in Europe, has raised wide attentions in the world and has become a hotspot of think tank research. Guided by the think tank double helix methodology, this study constructed a cognitive framework to study industrial strategy and its related complex system issues such as international relations, science and technology …

Ndls Communicator: Week Of 06.20.22, Notre Dame Law School

NDLS Communicator

The Latest News

• Religious Liberty Clinic files amicus brief supporting school choice in Kentucky
• Research Program on Law and Market Behavior and University of Lucerne to host Graduate Academy for Law and Economics
• Professor Richard Garnett co-authors book analyzing Supreme Court cases on religious freedom
• Religious Liberty Clinic files amicus brief with Religious Freedom Institute to protect the rights of prisoners
• Diane Desierto's article, "The Human Right to Food, Freedom from Hunger, and SDG 2: Global Food Crisis and Starvation Tactics from the Russian Invasion of Ukraine," was featured in EJLI Talk!
• Lloyd Mayer was interviewed by Marketplace in “What …

Microbiome Assembly In Thawing Permafrost And Its Feedbacks To Climate, Jessica G. Ernakovich, Robyn A. Barbato, Virginia I. Ritch, Christina Schadel, Rebecca E. Hewitt, Stacey J. Doherty, Emily D. Whalen, Benjamin Abbott, Jiri Barta, Christina Biasi, Chris L. Chabot, Jenni Hultman, Christian Knoblauch, Maggie C. Y. Lau Vetter, Mary-Cathrine Leewis, Susanne Liebner, Rachel Mackelprang, Tullis C. Onstott, Andreas Richter, Ursel M. E. Schutte, Henri M. P. Siljanen, Neslihan Tas, Ina Timling, Tatiana A. Vishnivetskaya, Mark P. Waldrop, Matthias Winkel

Faculty Publications

The physical and chemical changes that accompany permafrost thaw directly influence the microbial communities that mediate the decomposition of formerly frozen organic matter, leading to uncertainty in permafrost–climate feedbacks. Although changes to microbial metabolism and community structure are documented following thaw, the generality of post-thaw assembly patterns across permafrost soils of the world remains uncertain, limiting our ability to predict biogeochemistry and microbial community responses to climate change. Based on our review of the Arctic microbiome, permafrost microbiology, and community ecology, we propose that Assembly Theory provides a framework to better understand thaw-mediated microbiome changes and the implications for community …

Preliminary Study Of Shape-Memory Alloy Torsional Tubes As Thermal Management Actuators Under Non-Ideal Conditions, Paula Sanjuan Espejo, Samuel Desloover, Devon Hardy, Mark Ricklick, Frederick Calkin, David Foutch

Publications

Shape-memory alloys (SMAs) have been used in many engineering applications because of their shape-memory effect and pseudoelasticity. SMA behavior is well understood under steady and constant temperature and loading conditions, whereas transient and non-ideal conditions effects should be further investigated. In this research, SMA torque tubes are studied for use in thermal management applications as self-regulated actuators responding to a process fluid with changes in temperature, with the goal of improved system efficiency by keeping components at an optimal temperature. When utilized in a thermal management configuration, it is likely that the SMA’s thermal environment will be different than that …

Bringing Technological Transparency To Tenebrous Markets: The Case For Using Blockchain To Validate Carbon Credit Trading Markets, Gary E. Marchant, Zachary Cooper, Philip Gough-Stone

Natural Resources Journal

Carbon reductions have become a priority as companies and other entities emitting greenhouse gases seek to comply with regulatory requirements and commit to voluntary goals that are consistent with their sustainability pledges. These carbon reductions are accounted for by carbon credits, which are tradeable units of carbon reduction that can be used to comply with regulatory or voluntary carbon reduction credits. Many companies are making such carbon reduction promises, and are frequently relying on credits generated by non-traditional mitigation sources such as agriculture or forestry to achieve those reductions and credits. However, the credibility and reliance on such carbon credit …

To Infinity And Beyond: Shifting The Space Regulatory Framework To Create Conservation-Minded Expansion, Brandon M.G. Dekema

Natural Resources Journal

The early days of American expansion were categorized by policies that emphasized resource extraction and utilization. In turn, these policies created major conflicts with overuse, ownership, and rehabilitation−, many of which continue to this day. Now, the United States has begun to shift its focus to the next untapped frontier: outer space. As resource extraction in space grows more feasible, the United States has begun to shape a regulatory framework. In doing so, the United States is copying early American resource policy, leaving open the same gaps for conflicts arising from overuse, ownership disputes, and restoration. This paper analyzes historical …

Book Review: The Development Of The Law Of The Sea Convention: The Role Of International Courts And Tribunals, Kalista Wilson

Natural Resources Journal

No abstract provided.

Homotopic Contralesional Excitation Suppresses Spontaneous Circuit Repair And Global Network Reconnections Following Ischemic Stroke, Annie R Bice, Qingli Xiao, Justin Kong, Ping Yan, Zachary Pollack Rosenthal, Andrew W Kraft, Karen P Smith, Tadeusz Wieloch, Jin-Moo Lee, Joseph P Culver, Adam Q Bauer

2020-Current year OA Pubs

Understanding circuit-level manipulations that affect the brain's capacity for plasticity will inform the design of targeted interventions that enhance recovery after stroke. Following stroke, increased contralesional activity (e.g. use of the unaffected limb) can negatively influence recovery, but it is unknown which specific neural connections exert this influence, and to what extent increased contralesional activity affects systems- and molecular-level biomarkers of recovery. Here, we combine optogenetic photostimulation with optical intrinsic signal imaging to examine how contralesional excitatory activity affects cortical remodeling after stroke in mice. Following photothrombosis of left primary somatosensory forepaw (S1FP) cortex, mice either recovered spontaneously or received …

Dynamic Prototype Convolution Network For Few-Shot Semantic Segmentation, Jie Liu, Yanqi Bao, Guo-Sen Xie, Huan Xiong, Jan-Jakob Sonke, Efstratios Gavves

Machine Learning Faculty Publications

The key challenge for few-shot semantic segmentation (FSS) is how to tailor a desirable interaction among sup-port and query features and/or their prototypes, under the episodic training scenario. Most existing FSS methods im-plement such support/query interactions by solely leveraging plain operations - e.g., cosine similarity and feature concatenation - for segmenting the query objects. How-ever, these interaction approaches usually cannot well capture the intrinsic object details in the query images that are widely encountered in FSS, e.g., if the query object to be segmented has holes and slots, inaccurate segmentation al-most always happens. To this end, we propose a dynamic …

Promoting Cancer Health Equity: A Qualitative Study Of Mentee And Mentor Perspectives Of A Training Program For Underrepresented Scholars In Cancer Health Disparities, Anastasia Rogova, Isabel Martinez Leal, Maggie Britton, Shine Chang, Kamisha H Escoto, Crystal Roberson, Lorraine R Reitzel

Faculty, Staff and Student Publications

Racial and ethnic minorities, and women, experience stark disparities in cancer risk behaviors and mortality rates, yet often remain underrepresented in scientific research positions. We conducted an exploratory, qualitative study to examine the value of mentored research experience as part of an NCI-funded research training program designed to increase the representation of minority and women scientists in cancer disparities research. Using individual interviews, we explored 16 mentees' and 7 mentors' program experiences and perspectives to identify the most effective strategies to build strong mentoring relationships that could ultimately contribute to increased representation in health disparities research. Two expert analysts employed …

Outcome Predictors In Catheter Interventions For Severe Right Ventricular Outflow Tract Obstructions, Sonia A. El-Saiedi, Wael A. Attia, Ashraf Abdelrahim, Baher M. Hanna

Journal of the Saudi Heart Association

Introduction & Aim of Work: Transcatheter treatment for critical pulmonary stenosis and membranous pulmonary atresia has become the gold standard of care in many centers. We aimed at evaluating the predictors of outcome in interventions for treatment of duct-dependent right ventricular outflow tract obstruction with intact interventricular septum. Subjects & Methods: 68 cases with pulmonary atresia with intact interventricular septum (PA/IVS) and 50 cases with critical pulmonary stenosis (CPS), all younger than 3 months of age, were operated during the period of 10 years; excluding patients with tricuspid valve annulus Z-score smaller than -4, evidence of right ventricular-dependent coronary circulation …

Effect Of A Vegetable Oil-Based Regenerant On Performance Of Aged Asphalt, Chang Runtian, Wang Wei, Fan Changcuan, Pei Qiang

Journal of China & Foreign Highway

In this paper, a hot regenerant ZZ-1 for asphalt pavement was formulated by compounding waste vegetable oil as the main raw material with aromatic oil and a small amount of additives. The laboratory conducted a comparative test on the Fourier transform infrared spectra, thermal stability, and regeneration effect on short-term aged asphalt between the self-made regenerant and the other two commercially purchased regenerants. The results show that the indicators such as the flash point, mass loss before and after aging, and viscosity ratio of the self-made regenerant all meet the specification requirements, and the regeneration effect is better than the …

Aspartyl Protease Inhibitors As Anti-Filarial Drugs, Liana Beld, Hyeim Jung, Christina A Bulman, Bruce A Rosa, Peter U Fischer, James W Janetka, Sara Lustigman, Judy A Sakanari, Makedonka Mitreva

2020-Current year OA Pubs

The current treatments for lymphatic filariasis and onchocerciasis do not effectively kill the adult parasitic nematodes, allowing these chronic and debilitating diseases to persist in millions of people. Thus, the discovery of new drugs with macrofilaricidal potential to treat these filarial diseases is critical. To facilitate this need, we first investigated the effects of three aspartyl protease inhibitors (APIs) that are FDA-approved as HIV antiretroviral drugs on the adult filarial nematode,

Anxiety Symptoms Among Extension Professionals' During The Covid-19 Pandemic With The Gad-2, Glenn D. Israel, Colleen E. Gariton, Harsha E. James

Journal of Rural Social Sciences

According to the National Institute of Mental Health, anxiety disorders are a common mental health disorder but often remain undetected and undertreated. During the COVID-19 pandemic, Extension professionals have worked hard to address emerging issues that communities face, possibly impacting the amount of anxiety they experience. This study determined the prevalence of anxiety symptoms among Extension professionals in the United States. Participants from 24 states completed a survey containing the Generalized Anxiety Disorder 2-item (GAD-2) screener. Almost one-quarter of Extension professionals had a GAD-2 score greater than three, an indicator of anxiety with a possibility of generalized anxiety disorder, which …

Comprehensive Local Injury Surveillance For Pediatric Fatal And Nonfatal Firearm Injury Prevention Planning, Bindi Naik-Mathuria, Ned Levine, Cary Cain, Abiodun O. Oluyomi, Mike Henson-Garcia, Lisa Pompeii

Journal of Applied Research on Children: Informing Policy for Children at Risk

Injury by firearm is now the leading cause of death in children in the U.S.. Effective injury prevention requires first defining the problem and identifying risk and protective factors before implementing prevention strategies. There is no comprehensive source available to define firearm injuries, especially at the local level. We propose a local firearm injury surveillance model based on the socio-ecological injury prevention framework that combines injury data from health care, law enforcement, county services, and census data that can help to guide targeted firearm injury prevention interventions.

Quantum Computing And Resilient Design Perspectives For Cybersecurity Of Feedback Systems, Keshav Kasturi Rangan, Jihan Abou Halloun, Henrique Oyama, Samantha Cherney, Ilham Azali Assoumani, Nazir Jairazbhoy, Helen Durand, Simon Ka Ng

Chemical Engineering and Materials Science Faculty Research Publications

Cybersecurity of control systems is an important issue in next-generation manufac- turing that can impact both operational objectives (safety and performance) as well as process designs (via hazard analysis). Cyberattacks differ from faults in that they can be coordinated efforts to exploit system vulnerabilities to create otherwise unlikely hazard scenarios. Because coordination and targeted process manipulation can be characteristics of attacks, some of the tactics previously analyzed in our group from a control system cybersecurity perspective have incorporated randomness to attempt to thwart attacks. The underlying assumption for the generation of this randomness has been that it can be achieved …

Happy Juneteenth!, Office Of Marketing And Communications

Newsroom

Governors State University Office of Institutional Advancement is proud to join the nation in celebrating Juneteenth this Sunday, honoring the day freedom reached the last enslaved African Americans.

Marcella Dos Santos V. Attorney General United States

2022 Decisions

Agency

Yanilda Toro V. N.J. State Courts Judge

2022 Decisions

USDC for the District of New Jersey

Investigating Roles Of 2 Novel Eklf Targets Involved In Erythropoiesis, Rose M. Gott

ETD Archive

Erythrocytes are primarily comprised of the oxygen carrying protein hemoglobin. Genetic mutations causing defects in the proper synthesis of hemoglobin result in various anemias. It is during the last phases of terminal erythroid differentiation that hemoglobin levels rise, making it a focus for therapeutic research. Fetal hemoglobin is comprised of ⍺-globin and gamma globin, then after a change in gene expression called hemoglobin switching which takes place after birth, adult hemoglobin is comprised of ⍺-globin and beta globin. We investigated hemoglobin switching and erythroid terminal differentiation by focusing on the master erythroid transcription factor Erythroid Krüppel-like Factor (EKLF). Data led …

Exploring The Metabolic Landscape Of Pancreatic Ductal Adenocarcinoma Cells Using Genome-Scale Metabolic Modeling, Mohammad Mazharul Islam, Andrea Goertzen, Pankaj K. Singh, Rajib Saha

Department of Chemical and Biomolecular Engineering: Faculty Publications

Pancreatic ductal adenocarcinoma (PDAC) is a major research focus because of its poor therapy response and dismal prognosis. PDAC cells adapt their metabolism to the surrounding environment, often relying on diverse nutrient sources. Because traditional experimental techniques appear exhaustive to find a viable therapeutic strategy, a highly curated and omics-informed PDAC genome-scale metabolic model was reconstructed using patient-specific transcriptomics data. From the model-predictions, several new metabolic functions were explored as potential therapeutic targets in addition to the known metabolic hallmarks of PDAC. Significant downregulation in the peroxisomal beta oxidation pathway, flux modulation in the carnitine shuttle system, and upregulation in …

Literacy Identity And Motherhood: Implications Of Hermans' Dialogical Self Theory, Chelsea J. Ames

Theses and Dissertations

This multiple case study shows how motherhood works with and against two women's literacy identities, as interpreted through the theoretical lens of Herman's Dialogical Self Theory. The evidence of this is shown in the tension between their roles as mothers and their personal roles as readers and writers. In many ways, taking on a reader or writer role meant to deny other roles for these women, showing the clash between efforts to consolidate multiple I-positions. While their meta-positions helped them recognize the discrepancies in their I-positions, there was little evidence of mediating third positions to negotiate their roles. This descriptive …

"Newstead And I Stand Or Fall Together": Memorial Ecology And Multispecies Agency In Byron's Early Poetry, Taylore Ann Wintch

Theses and Dissertations

Scholars studying memory, literary tourism, and Byron all note the cooperation between author and audience at work in memorials--be it in terms of speech and response, hospitality and reception, or memory and forgetting. None, however, address the environment at Newstead as an agentic being involved with Byron's memorial legacy. Byron acknowledged multispecies beings as important actors in his eventual legacy. Through some of his early poems, we see the land under and around Newstead Abbey, as well as its nonhuman life, exercising agency and affecting Byron's memory. I limit my analysis to Byron's early poetry partly to trace how a …

Medford: A Human And Machine Readable Metadata Markup Language, Polina Shpilker, John Freeman, Hailey Mckelvie, Jill Ashey, Jay-Miguel Fonticella, Hollie Putnam, Jane Greenberg, Lenore J. Cowen, Alva Couch, Noah M. Daniels

Computer Science and Statistics Faculty Publications

Reproducibility of research is essential for science. However, in the way modern computational biology research is done, it is easy to lose track of small, but extremely critical, details. Key details, such as the specific version of a software used or iteration of a genome can easily be lost in the shuffle, or perhaps not noted at all. Much work is being done on the database and storage side of things, ensuring that there exists a space to store experiment-specific details, but current mechanisms for recording details are cumbersome for scientists to use. We propose a new metadata description language, …

Evaluating The Biogeochemical Effects Of Enhanced Rock Weathering At Lawrence University, Katie Mahorney

Lawrence University Honors Projects

On geologic timescales, the weathering of silicate rocks is among the most powerful negative feedbacks controlling atmospheric CO₂. However, this process is too slow to meaningfully impact our current climate crisis. Enhanced Rock Weathering (ERW) is one of the most promising carbon capture strategies to remove anthropogenic carbon from the atmosphere. Models suggest that by crushing silicate rocks such as basalt to increase surface area, the process of rock weathering can be accelerated to sequester enough carbon to be significant on human timescales. At Lawrence University, ERW is being investigated to (1) field test the efficacy of the …

Contrasting Modes Of Mitochondrial Genome Evolution In Sister Taxa Of Wood-Eating Marine Bivalves (Teredinidae And Xylophagaidae), Yuanning Li, Marvin A. Altamia, J. Reuben Shipway, Mercer R. Brugler, Angelo Fraga Bernardino, Thaís Lima De Brito, Zhenjian Lin, Francisca Andréa Da Silva Oliveira, Paulo Sumida, Craig R. Smith, Amaro Trindade-Silva, Kenneth M. Halanych, Daniel L. Distel

School of Biological and Marine Sciences

The bivalve families Teredinidae and Xylophagaidae include voracious consumers of wood in shallow-water and deep-water marine environments, respectively. The taxa are sister clades whose members consume wood as food with the aid of intracellular cellulolytic endosymbionts housed in their gills. This combination of adaptations is found in no other group of animals and was likely present in the common ancestor of both families. Despite these commonalities, the two families have followed dramatically different evolutionary paths with respect to anatomy, life history, and distribution. Here, we present 42 new mitochondrial genome sequences from Teredinidae and Xylophagaidae and show that distinct trajectories …

Recovery Of Trembling Aspen, Tamarack, And White Spruce Seedlings From Nacl Stress Following Winter Dormancy: Implications For Increased Foliar Potassium, Necrosis, And Sodium Management As Stress Resistance Mechanisms, Nathan T. Lauer

Aspen Bibliography

Revegetation of boreal forest lands disturbed by surface mining for bitumen can be challenging due to fluctuating levels of soil NaCl and harsh winter temperatures. These stressors may hinder the growth and survival of planted tree seedlings. Two experiments were carried out to examine the processes of recovery from NaCl stress and overwintering in trembling aspen, tamarack, and white spruce seedlings. In the recovery experiment, seedlings were treated with 0, 50, or 100 mM NaCl for 60 days and then allowed to recover for 60 days. Most of the examined physiological variables (total dry weight, chlorophyll concentration, photosynthesis, and transpiration) …

International Water Quality: Global Patterns Of Water Pollutants And Pathogens, Leslie Lange

Theses and Dissertations

Water quality is an essential component of vibrant societies and ecosystems. For decades, researchers, managers, and policymakers around the world have struggled to accelerate societal progress while preserving and enhancing water quality and human health. This thesis consists of two studies that I hope will contribute to better understanding, policy, and management. In the first study, I evaluated spatial and temporal patterns in global water quality and their relationship to gross domestic product (GDP) per capita, as a metric of socioeconomic development status. Using global water quality datasets containing over 2.7 million observations, I tested the Environmental Kuznet Curve (EKC) …

Clark Memorandum: Spring 2022, J. Reuben Clark Law School, Byu Law School Alumni Association, J. Reuben Clark Law Society

The Clark Memorandum

• General Joseph Smith and His Candidacy for the Presidency of the United States
• Leadership Lessons from the Life of Dallin H. Oaks
• Flunking the Founding
• Seven Lessons from the Life of Rex Lee