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The Truth About The Truth, Chester Gary Dds, Jd

The New York State Dental Journal

Dentists and patients must question the authority and motivation of purveyors of oral health information

N Y State Dent J June-July 2022

The New York State Dental Journal

In the June-July 2022 issue, the reader will find the following feature articles:

• The Challenges are Many, but There’s Reason for Optimism
• Medication-Related Osteonecrosis of the Jaw: Important Clinical Considerations
• Retained Third Molars Protect Against Fractures of Mandibular Condylar Region
• Patient Recall in the Informed-Consent Process
• Clinical Report on Restoration of Patient with Immediate Loaded Maxillary Restoration Supported by Zygomatic/Endosseous Implants and Mandibular Prothesis Utilizing Three-implant Solution

This issue includes regular columns with regional news impacting the New York membership including: editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

The Politics Of Institutional Reform: Vulnerability And Bureaucratic Independence In Asian Agriculture, Jacob Ricks

Research Collection School of Social Sciences

Although effective bureaucracies are seen as key for service provision in developing states, we still have limited explanations for their emergence. I argue getting these institutions right is a political, rather than technical, challenge based on a set of theoretical predictions for reform outcomes acknowledging the interaction between a state’s political vulnerability and degree of bureaucratic independence. I apply these predictions to a controlled comparison of irrigation sector reforms in three Asian countries. The results demonstrate that the success of institutional reforms necessary to implement policies is contingent on both the degree of vulnerability experienced as well as the extent …

Cucurbitacin B: A Potential Natural Agent For Targeting Tumor Immune Cell Population, Emmanuel Anning

Theses and Dissertations

Immune checkpoint blockade (PD1, PDL-1 and CTLA-4) immunotherapies have emerged as the breakthrough in cancer treatment. However, some malignancies show marginal response. One factor that influences the efficacy of immunotherapy is the development of immunosuppressive tumor microenvironment (TME), caused by infiltration of myeloid derived suppressor cells (MDSCs) and tumor associated macrophages (TAM) into the tumor, facilitating metastatic tumor growth and immunotherapy resistance. We have identified Cucurbitacin B (Cuc. B), a potent small molecule that targets TAM and MDSCs and inhibits Stat3, CSF-1R, and PI3Kγ signaling axis at lower doses compared to the pharmacological inhibitor of PI3Kγ (IPI-549). IL-4 polarization of …

Anticancer Potential Of Hesperidin Against Hep-2 Laryngeal Carcinoma Cell Line In Comparison To Doxorubicin, Sara Abdelwahed, Nadia Fathy Hassabou, Mai Abd Elhalim Hamouda

Dentistry

No abstract provided.

Tfeb Induces Mitochondrial Itaconate Synthesis To Suppress Bacterial Growth In Macrophages, Ev-Marie Schuster, Maximilian W Epple, Katharina M Glaser, Michael Mihlan, Kerstin Lucht, Julia A Zimmermann, Anna Bremser, Aikaterini Polyzou, Nadine Obier, Nina Cabezas-Wallscheid, Eirini Trompouki, Andrea Ballabio, Jörg Vogel, Joerg M Buescher, Alexander J Westermann, Angelika S Rambold

Duncan NRI Faculty and Staff Publications

Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator for phago-lysosome-mitochondria crosstalk in macrophages. By combining cellular imaging and metabolic profiling, we find that TFEB activation, in response to bacterial stimuli, promotes the transcription of aconitate decarboxylase (Acod1, Irg1) and synthesis of its product itaconate, a mitochondrial metabolite with antimicrobial activity. Activation of the TFEB-Irg1-itaconate signalling axis reduces the survival of the intravacuolar pathogen Salmonella enterica serovar Typhimurium. TFEB-driven …

The Property Law Of Tokens, Juliet M. Moringiello, Christopher K. Odinet

Faculty Scholarship

Non-fungible tokens—or NFTs, as they are better known—have taken the world by storm. The idea behind an NFT is that by owning a certain thing (specifically, a digital token that is tracked on a blockchain), one can hold property rights in something else (either a real or intangible asset). In the early part of 2021, NFTs for items ranging from a gif of a pop-tart cat with a rainbow tail, to Twitter CEO Jack Dorsey’s first tweet, to a New York Times column (about NFTs!) have sold for millions of dollars over the internet. Promoters assert that NFTs are the …

Working With A Different Drummer: Transgender Or Gender Creative Children And Their Families, Deborah E. Grayson

Faculty and Staff Publications & Presentations

COURSE OVERVIEW

This experiential workshop will demonstrate how the expressive art therapies will accelerate the expression of our true selves in the LGBTQ+ community and assist their families in overcoming shame and resistance and aids in healing when it comes to grieving, understanding identity and fostering lasting relationships. We will explore current challenges as well as past and current successes.

Learning Objectives

1. Demonstrate how the expressive art therapies can accelerate the expression of the true self, assists families in overcoming shame and resistance, and aids in the healing process when it comes to grieving, understanding identity and fostering lasting relationships. …

Bringing Predictability To The Chaos Of Punitive Damages, W. Kip Viscusi, Benjamin J. Mcmichael

Vanderbilt Law School Faculty Publications

Punitive damages remain unique in the American legal system. Awarded in the civil context with none of the protections offered in criminal law, courts levy punitive damages to punish and deter. The Supreme Court of the United States has clearly stated that courts may only seek to achieve these two goals when imposing punitive damages. A closer reading of the Court's punitive damages jurisprudence, however, reveals another goal that has largely been ignored: predictability. Unlike punishment and deterrence, predictability is not a purpose for which to award punitive damages. Instead, the Court requires that, when awarded, the level of punitive …

Without Accommodation, Jennifer B. Shinall

Vanderbilt Law School Faculty Publications

Under the Americans with Disabilities Act (ADA), workers with disabilities have the legal right to reasonable workplace accommodations provided by employers. Because this legal right is unique to disabled workers, these workers could, in theory, enjoy greater access to the types of accommodations that are desirable to all workers including the ability to work from home, to work flexible hours, and to take leave. This Article compares access to these accommodations, which have become increasingly desirable during the COVID-19 pandemic, between disabled workers and nondisabled workers. Using 2017-2018 data from the American Time Use Survey's Leave and Job Flexibilities Module, …

Using Learning Progressions To Enhance Student Outcomes And Performance, Andrea Werner

Master's Theses & Capstone Projects

Learning discrepancies are difficult for students to recover from. In earlier years, rote memorization, drill-and-practice, and whole-group instruction have proven little success. Students continually lack proficiency and have minimal gain year after year. More recently, small groups and interventions have made improvements on student proficiency, but they still struggle to increase overall student achievement. Research suggests learning progressions as a dynamic, individualized approach to increase not only academic achievement, but also depth of knowledge and student efficacy. Learning progressions allow for flexibility in levels of learning, the content taught, and how a student grasps information. Then learning progressions promote rigorous …

Improving School Culture Through Crucial Conversations Among Staff Members, Melissa Tuzzio

Master's Theses & Capstone Projects

This school improvement plan aims to improve school culture through crucial converstaions among staff. School culture is the set of norms, values, and beliefs that make up what a school believes in, which affects multiple areas of a school, including student success, teacher retention, and job satisfaction. Crucial conversations are discussions between two or more people who hold opposing opinions about high-stakes issues and where emotions run strong. The plan addresses ways to strengthen a school's culture, beginning at the administrative and teacher leadership level, using book studies. In addition, a literature review was conducted to support the plan and …

Comparing The Effects Of Phonics Instruction Provided To Students With Disabilities, Ashley Rohlf

Master's Theses & Capstone Projects

Special education teachers work each day to implement effective curricula to help students with disabilities receiving special education services reach grade-level standards. Recent research supports the need for implementing a comprehensive reading program that includes phonics instruction. With numerous curricula available, this action research seeks to inform educators of two methods of instruction that have a heavy phonics component that leads to growth in student reading skills. Two methods were evaluated: one method used multiple curricula to target all areas of a comprehensive reading program while the other method used a single curriculum that targeted all of the same areas. …

Targeting Ribosome Biogenesis For Pancreatic Cancer Treatment, Carlos Perez Iii

Theses and Dissertations

Pancreatic cancer (PanCa) is one of the leading causes of cancer-related death in the United States. Currently, PanCa is one of the recalcitrant cancers that has very limited therapeutic options available for its treatment. The current standard care of PanCa is gemcitabine (GEM) alone or in combination with FOLFIRINOX, nab-paclitaxel, erlotinib, or 5-FU PanCa, which often show poor response. Therefore, new treatment strategies are required for the prevention and treatment of cancer. Ribosome biogenesis process is dysregulated in most of the cancer types of results in production of more ribosomes and synthesis of oncoproteins which lead to the induction, progression, …

Mratbn72: Familiar And Unfamiliar Features Of A New Rat Genome Reference Assembly, Tristan V De Jong, Hao Chen, Wesley A Brashear, Kelli J Kochan, Andrew E Hillhouse, Yaming Zhu, Isha S Dhande, Elizabeth A Hudson, Mary H Sumlut, Melissa L Smith, Theodore S Kalbfleisch, Peter A Doris

The Brown Foundation: Institute of Molecular Medicine

Rat genomic tools have been slower to emerge than for those of humans and mice and have remained less thorough and comprehensive. The arrival of a new and improved rat reference genome, mRatBN7.2, in late 2020 is a welcome event. This assembly, like predecessor rat reference assemblies, is derived from an inbred Brown Norway rat. In this "user" survey we hope to provide other users of this assembly some insight into its characteristics and some assessment of its improvements as well as a few caveats that arise from the unique aspects of this assembly. mRatBN7.2 was generated by the Wellcome …

Sped 874: Language Arts And Literacy For Students Who Are Deaf/Hard Of Hearing, Anne E. Thomas

UNL Faculty Course Portfolios

This portfolio documents the process I used to critically analyze the structure, teaching methods, assessment, and students learning in SPED 874 Language Arts and Literacy for Children who are Dear/Hard of Hearing. This is a course that students in the Deaf Education Program at the University of Nebraska-Lincoln (UNL) take while pursuing a master’s degree and/or graduate endorsement in Deaf Education. This portfolio documents how I aligned the course objectives, content, and activities to the Council for Exceptional Children - Initial Specialty Set for Teachers of the Deaf/Hard of Hearing (CEC-DHH). I share the results of one method I use …

On The Superiority Of Divine Legislation Theory To Divine Command Theory, Mark C. Murphy

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Nathan L. King, The Excellent Mind: Intellectual Virtues For Everyday Life, Sabrina B. Little

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Otulin's Novel Regulatory Mechanisms In Genotoxic And Inflammatory Nf-Kb Signaling, Mingqi Li

Theses and Dissertations (ETD)

Triple negative breast cancer (TNBC) is aggressive but cannot be treated with hormone therapy or molecular therapy due to the lack of a target. Chemotherapy is a systemic treatment that works by attacking rapidly growing cells, which is initially more effective for TNBC patients than those individuals with the hormone receptor-positive breast cancer. However, patients with TNBC tend to develop resistance to chemo drugs, called chemoresistance. After years of effort, the signaling pathways involved in TNBC chemoresistance are gradually revealed, including the nuclear factor-kappa B (NF-kB) pathway. Transcription factor NF-kB is widely involved in cancer development and progression, and its …

Wetlands As Social Ecological Systems, And Relationality In The Policy Domain, Pierre Horwitz

Research outputs 2022 to 2026

A wetland policy perspective based on social ecological systems accepts that wetlands are part of landwaterscapes, that people are part of wetland ecosystems, and that the health of wetlands and the health of people are interdependent, evidence of the close, reciprocal and indivisible relationships between nature and culture. These relationships are storied and place-based, associated with place attachment, and are representations of relational values. They are most easily located wherever and whenever Indigenous and local peoples’ knowledge and interests are at play in wetland settings. Legal and administrative processes that recognise Chthonic law and rights for wetlands will elevate relational …

The Coming Connected-Products Liability Revolution, Robert S. Peck

UC Law Journal

Technological innovation begets legal revolution. And tort law, as a creature of the common law, makes the most profound doctrinal leaps and does so more rapidly than any other area of law when technology changes our everyday lives to create new wrongs and demand remedies. History demonstrates tort’s unique ability to respond to the newest technologies, as it did with the appearance of railroads and later automobiles.

Today, once again, we are living in an age of great technological change, ushered in by ubiquitous smart devices. Computers, connected to other computers through the Internet, populate a wide variety of everyday …

Regulating Social Media In The Free-Speech Ecosystem, Anuj C. Desai

UC Law Journal

Social media is just one part of the broader free-speech ecosystem. Social media regulation thus only regulates one part of that ecosystem. To evaluate social media regulation thus requires an understanding of the role social media itself plays—or more importantly, ought to play—in that ecosystem. We must thus first answer the following question: what institutional role should social media play in that broader free-speech ecosystem?

I argue that one framework through which to view this question—or perhaps one subset of this question—is, where should social media companies lie on what we might call the “speakerconduit continuum”? When we think about …

The Law Of Pseudonymous Litigation, Eugene Volokh

UC Law Journal

When may parties in American civil cases proceed pseudonymously? The answer turns out to be deeply unsettled. This Article aims to lay out the legal rules (such as they are) and the key policy arguments, in a way intended to be helpful to judges, lawyers, pro se litigants, and academics.

The Watts Gang Treaty: Hidden History And The Power Of Social Movements, William J. Aceves

Faculty Scholarship

On the eve of the 1992 Los Angeles uprising, a small group of gang leaders and community activists drafted an agreement to curtail violence in south Los Angeles. Several gangs in Watts accepted the truce and established a cease-fire agreement. By most accounts, the 1992 Watts Gang Treaty succeeded in reducing gang violence in Los Angeles. Local activists attributed the reduction in shootings to the Treaty. Even law enforcement officials grudgingly recognized the Treaty’s contribution to reducing gang violence and a corresponding decrease in homicides.

The origins of the Watts Gang Treaty can be traced to gang leaders recognizing that …

Accelerated Identification Of Disease-Causing Variants With Ultra-Rapid Nanopore Genome Sequencing, Dianna G Fisk, Trevor Pesout, Tanner D Jensen, Jean Monlong, Pi-Chuan Chang, Gunjan Baid, Jonathan A Bernstein, Jeffrey W Christle, Karen P Dalton, Daniel R Garalde, Megan E Grove, Joseph Guillory, Alexey Kolesnikov, Maria Nattestad, Maura R Z Ruzhnikov, Mehrzad Samadi, Ankit Sethia, Elizabeth Spiteri, Christopher J Wright, Katherine Xiong, Tong Zhu, Miten Jain, Fritz J Sedlazeck, Andrew Carroll, Benedict Paten, Euan A Ashley

Faculty, Staff and Students Publications

Whole-genome sequencing (WGS) can identify variants that cause genetic disease, but the time required for sequencing and analysis has been a barrier to its use in acutely ill patients. In the present study, we develop an approach for ultra-rapid nanopore WGS that combines an optimized sample preparation protocol, distributing sequencing over 48 flow cells, near real-time base calling and alignment, accelerated variant calling and fast variant filtration for efficient manual review. Application to two example clinical cases identified a candidate variant inprioritization, and accelerates diagnostic clinical genome sequencing twofold compared with previous approaches.

The 5th Edition Of The World Health Organization Classification Of Haematolymphoid Tumours: Myeloid And Histiocytic/Dendritic Neoplasms, Yassmine Akkari, Rita Alaggio, Jane F Apperley, Rafael Bejar, Emilio Berti, Lambert Busque, John K C Chan, Weina Chen, Xueyan Chen, Wee-Joo Chng, John K Choi, Isabel Colmenero, Sarah E Coupland, Nicholas C P Cross, Daphne De Jong, M Tarek Elghetany, Emiko Takahashi, Jean-Francois Emile, Judith Ferry, Linda Fogelstrand, Michaela Fontenay, Ulrich Germing, Sumeet Gujral, Torsten Haferlach, Claire Harrison, Jennelle C Hodge, Shimin Hu, Joop H Jansen, Rashmi Kanagal-Shamanna, Hagop M Kantarjian, Christian P Kratz, Xiao-Qiu Li, Megan S Lim, Keith Loeb, Sanam Loghavi, Andrea Marcogliese, Soheil Meshinchi, Phillip Michaels, Kikkeri N Naresh, Yasodha Natkunam, Reza Nejati, German Ott, Eric Padron, Keyur P Patel, Nikhil Patkar, Jennifer Picarsic, Uwe Platzbecker, Irene Roberts, Anna Schuh, William Sewell, Reiner Siebert, Prashant Tembhare, Jeffrey Tyner, Srdan Verstovsek, Wei Wang, Brent Wood, Wenbin Xiao, Cecilia Yeung, Andreas Hochhaus

Faculty, Staff and Students Publications

The upcoming 5th edition of the World Health Organization (WHO) Classification of Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in various organ systems within a single relational database. This paper summarizes the new WHO classification scheme for myeloid and histiocytic/dendritic neoplasms and provides an overview of the principles and rationale underpinning changes from the prior edition. The definition and diagnosis of disease types continues to be based on multiple clinicopathologic parameters, but with refinement of diagnostic criteria and emphasis on therapeutically and/or prognostically actionable biomarkers. While a genetic basis for defining diseases is sought …

Writing Problems And Student Retention: A Quantitative Study Into Contemplation Of Withdrawal Among Undergraduate University Students In Ireland, Irina Ruppo

Irish Journal of Academic Practice

This paper examines the results of a quantitative study of the relationship between problems with academic writing and undergraduate student retention. In spite of the evidence that writing problems may affect student attrition, problems with academic writing are not listed as a separate factor in most retention models. Consequently, academic writing is not usually singled out in interventions designed to address student attrition. However, it is possible that the absence of writing issues in retention models is due to the predominant view of writing as a single element within academic studies as opposed to a complex and multi-modal process, involving …

Embedding Anti-Racism In The Teaching, Learning And Assessment Of The Community Development And Youth Work Programme: Lessons Learned To Date., Brid Ni Chonaill, Georgina Lawlor, Noirin Macnamara, Liam Mcglynn, Garreth Smith, Sheila Coyle, Mairead Cluskey

Irish Journal of Academic Practice

The Black Lives Matter movement has placed a spotlight on racism, not just as a global phenomenon but as a feature of Irish society. Research conducted with Community Development and Youth Work students on the TU Dublin Blanchardstown campus found that some had encountered racism on placement and felt ill-equipped to deal with it. As a group of white lecturers working with diverse students, we sought and received funding to conduct a project during the academic year 2020/21 which aimed to embed anti-racism in the teaching, learning and assessment of that programme. An action-research methodology using a mixed-methods approach was …

Soil Quality Indicators And Vegetation Responses Following Ecological Restoration Thinning Of Ponderosa Pine On Three Soil Parent Material Types Under Grazing And Non-Grazing In Northern Arizona, Christopher Macdonald

Electronic Theses and Dissertations

This research was performed in a northern Arizona ponderosa pine (Pinus ponderosa P. & C., Lawson) forest. The objectives were to a) increase understanding of long-term vegetation responses to ecological restoration treatments on three soils types, with and without grazing, b) evaluate the responses soil physical, chemical, and biological properties to restoration treatments, with and without grazing, c) determine the utility of measured soil quality indicators to informing risks to sustainable soils management in southwestern ponderosa pine forests.

There were no significant differences in soil bulk density by soil type, treatment type, or grazing treatment. No significant differences …

Dividing The Blue Line: The Cultural Work Of Rural Policing In Upstate New York, Michael Branch

Dissertations - ALL

This dissertation focuses on the ways in which residents of Old Forge, New York make use of policing as a resource to structure and reproduce social and symbolic boundaries. Drawing on in-depth interviews with a combination of 40 permanent residents and second-home owners in the area, I explore how policing in this rural amenity-based tourist town is rooted in the economic and social histories of the area and how it structures access to social and moral capital for residents. I focus on how social divisions between permanent residents and second-home owners are observed and experienced by both groups and how …