Digital Commons Network^™

Combinatorial Gli Activity Directs Immune Infiltration And Tumor Growth In Pancreatic Cancer, Michael K. Scales, Ashley Velez-Delgado, Nina G. Steele, Hannah E. Schrader, Anna M. Stabnick, Wei Yan, Nayanna M. Mercado Soto, Zeribe C. Nwosu, Craig Johnson, Yaqing Zhang, Daniel J. Salas-Escabillas, Rosa E. Menjivar, H. Carlo Maurer, Howard C. Crawford, Filip Bednar, Kenneth P. Olive, Marina Pasca Di Magliano, Benjamin L. Allen

Surgery Articles

Proper Hedgehog (HH) signaling is essential for embryonic development, while aberrant HH signaling drives pediatric and adult cancers. HH signaling is frequently dysregulated in pancreatic cancer, yet its role remains controversial, with both tumor-promoting and tumor-restraining functions reported. Notably, the GLI family of HH transcription factors (GLI1, GLI2, GLI3), remain largely unexplored in pancreatic cancer. We therefore investigated the individual and combined contributions of GLI1-3 to pancreatic cancer progression. At pre-cancerous stages, fibroblast-specific Gli2/Gli3 deletion decreases immunosuppressive macrophage infiltration and promotes T cell infiltration. Strikingly, combined loss of Gli1/Gli2/Gli3 promotes macrophage infiltration, indicating that subtle changes in Gli expression differentially …

Lessons Learned: Michael Silva, Mercedes Cardona

Documents

Recommended Citation: Cardona, Mercedes (2022) "Lessons Learned: Michael Silva," Journal of Financial Crises: Vol. 4 : Iss. 2, 2031-2035.

July 2022 Louisiana Bar Exam, Louisiana Supreme Court Committee On Bar Admissions

Louisiana Bar Exams

No abstract provided.

Comment: Understanding Xenophobia As Intersectional Discrimination, Shreya Atrey

Washington and Lee Law Review

This Comment examines the nature of xenophobia and why it seems to fall through the cracks of international human rights law, especially as a form of racial discrimination under the International Convention on the Elimination of All Forms of Racial Discrimination. It considers an understanding of xenophobia as a sui generis case of intersectional discrimination because it has to do with racial grounds but also perhaps other grounds (such as nationality, religion, language, culture, and class), which makes it difficult to disentangle the basis of xenophobic discrimination as based on strictly racial grounds alone.

Rurality As An Intersecting Axis Of Inequality In The Work Of The U.N. Treaty Bodies, Amanda Lyons

Washington and Lee Law Review

Rurality intersects with other identities, power dynamics, and structural inequalities—including those related to gender, race, disability, and age—to create unique patterns of human rights deprivations, violations, and challenges in rural spaces. Therefore, accurately assessing human rights and duties in rural spaces requires attention to the dynamics of rurality in a particular context, the unique nature of diverse rural identities and livelihoods, the systemic forces operating in and on those spaces, and the intersections with other forms of structural discrimination and inequality.

Although much of the work of the U.N. treaty bodies has in fact addressed human rights situations in rural …

Sexual Violence, Intangible Harm, And The Promise Of Transformative Remedies, Jill C. Engle

Washington and Lee Law Review

This Article describes alternative remedies that survivors of sexual violence can access inside and outside the legal system. It describes the leading restorative justice approaches and recommends one of the newest and most innovative of those—“transformative justice”—to heal the intangible harms of sexual violence. The Article also discusses the intersectional effects of sexual violence on women of color and their communities. It explains the importance of transformative justice’s intersectional approach to redress sexual violence. Transformative justice offers community-based, victim-centric methods that cultivate deep, lasting healing for sexual violence survivors and their communities, with genuine accountability for those who have caused …

Mass Arbitration 2.0, Andrew B. Nissensohn

Washington and Lee Law Review

Over the past four decades, corporate interests, in concert with the Supreme Court, have surgically dismantled the American civil litigation system. Enacted nearly a century ago, the Federal Arbitration Act (FAA) was once a procedural law mandating that federal courts enforce arbitration agreements between sophisticated parties with equal bargaining power. Through death by a thousand cuts, corporate interests shielded themselves from nearly all methods of en masse dispute resolution. These interests weaponized the FAA into a “one size fits all” means to compel potential litigants with unequal bargaining power into arbitration. The so-called “Arbitration Revolution” is the subject of much …

A Constructivist Grounded Theory Study Of Airfield Lighting Maintenance Management Strategy, David A. Burgess

Doctoral Dissertations and Master's Theses

Asset management programs can keep senior airport managers informed of the performance and life-cycle costs of assets critical to airport operations. With this information, managers can adjust operations and maintenance to minimize costs without sacrificing service quality. However, program implementation is costly and time-consuming. In addition to management and information technology changes, the individual maintenance shops must also develop and incorporate new data collection processes into their everyday workflow. Knowledgeable and experienced maintenance managers must evaluate the data, consider alternatives, and find strategies to reduce costs without negative impact. Unfortunately, such managers are rare for highly specialized assets like airfield …

Effect Of Spray Rails On Takeoff Performance Of Amphibian Aircraft, Soham Bahulekar

Doctoral Dissertations and Master's Theses

Amphibian aircraft have seen a rise in popularity in the recreational and utility sectors due to their ability to take off and land on both land and water, thus serving a myriad of purposes such as aerobatics, surveillance, and firefighting. The design of such seaplanes requires to be both aerodynamically and hydrodynamically efficient, especially during the takeoff phase. In the past, naval architects have implemented ways to make boats, yachts, and large ships more efficient; one of them being the addition of chine strips and spray rails on the hull. This thesis study explores the possibility of implementing spray rails …

Gender Norms And Gendered Traits, Rowan Bell

Dissertations - ALL

Gender oppression is sustained in part through enforcement of and compliance with gender norms. Understanding how they work is therefore salient to the goal of gender liberation.According to the category-based view, which is common in analytic feminist philosophy, gender norms are assigned to individuals based on their assigned gender category, such as woman or man. I argue that this is insufficient, because it ignores the experiences of those who are marginalized or excluded from those categories. On a category-based view, individual responsiveness to gender norms will track gender category assignment; only individuals assigned the category woman will be responsive to …

Policing The Project: Crime, Carcerality, And Chicago Public Housing, Madeleine Rose Hamlinn

Dissertations - ALL

This project examines how Chicago's public housing was policed from 1937 to 2000, when the city announced plans to redevelop public housing into privately-owned mixed-income communities under the Plan for Transformation. Drawing upon interviews, historical newspapers, and archival records, it centrally argues that policing contributed to making public housing into a carceral space: one that resembled the prison in design and management and also funneled residents into the criminal-legal system. Writing against popular narratives of public housing as an inherent site of crime and violence, this project instead positions the police—and, by extension, the state—as a central contributor to violence …

New Solid Polymer Electrolytes For Lithium, Sodium, And Calcium-Based Batteries, Francielli Silva Genier

Dissertations - ALL

The establishment of sustainable energy sources highly depends on efficient storage devices to guarantee a consistent power supply. The growing demand for lithium-ion batteries (LIBs) for this purpose, combined with concerns about lithium availability, has motivated the search for viable storage alternatives, such as sodium and calcium. While several studies have investigated different lithium-free liquid electrolytes, the transport of these alternative ions in their polymer counterparts remains understudied. The advantages of solid polymer electrolytes include the possibility of higher energy density in solid-state devices and the elimination of safety concerns associated with liquid electrolytes, such as flammability, leakage, and dendrite …

Ultrametric Diffusion, Rugged Energy Landscapes And Transition Networks, Wilson A. Zuniga-Galindo

School of Mathematical & Statistical Sciences Faculty Publications

In this article we introduce the ultrametric networks which are p-adic continuous analogues of the standard Markov state models constructed using master equations. A p-adic transition network (or an ultrametric network) is a model of a complex system consisting of a hierarchical energy landscape, a Markov process on the energy landscape, and a master equation. We focus on networks where the transition rates between two different basins are constant functions, and the jumping process inside of each basin is controlled by a p-adic radial function. We solve explicitly the Cauchy problem for the master equation attached to this type of …

Lost In Translation? Communicating Nutrition Science, Lindsay Yarabek Datlow

Doctor of Philosophy in Translational Health Sciences Dissertations

Diet is directly correlated with overall health; therefore, nutrition is a critical piece of the obesity-epidemic puzzle. The news media has become a primary source for nutrition information yet results from International Food Information Council surveys indicate that the majority of Americans view the nutrition news they read as inconsistent and confusing. Very recent inquiry provides empirical evidence that nutrition confusion could be fueled by media. Nutrition confusion has been causally linked to “nutrition backlash,” which is complete disregard for even the most strongly supported nutrition advice. Understanding how nutrition research is translated in the news media and the mechanisms …

Everyday State And Democracy In Africa : Ethnographic Encounters, Wale Adebanwi

Ohio University Press Open Access Books

Bottom-up case studies, drawn from the perspective of ordinary Africans’ experiences with state bureaucracies, structures, and services, reveal how citizens and states define each other.

This volume examines contemporary citizens’ everyday encounters with the state and democratic processes in Africa. The contributions reveal the intricate and complex ways in which quotidian activities and experiences—from getting an identification card (genuine or fake) to sourcing black-market commodities to dealing with unreliable waste collection—both (re)produce and (re)constitute the state and democracy. This approach from below lends gravity to the mundane and recognizes the value of conceiving state governance not in terms of its …

The Guaranteed Resolution On Effective And Adapted Terms (The Great Process): A New Hybrid Dispute Resolution Process For Guaranteeing A Solution And Resolving Disputes Efficiently, Claude Amar, Véronique Fraser

Cardozo Journal of Conflict Resolution

Over the past twenty years, innovative dispute resolution processes have emerged from practitioners who aimed to tailor them to the parties' process needs. Some of the most widely known processes include med-arb, arb-med, co-mediation with an evaluative and a non-evaluative mediator, baseball arbitration, last offer arbitration, and sealed-arbitration. The list and possible combinations are infinite, when one starts combining processes. However, such spontaneity and adaptivity sometimes result in harmful consequences. In the past, arbitral awards in numerous jurisdictions were refused to be honored on the basis that the process had infringed on fundamental procedural guarantees. For that reason, it is …

Leveraging Data Analytics To Study The Impacts Of State Budget Cuts On Public Higher Education Institutions In The United States, Praveen Kumar Guraja

All-Inclusive List of Electronic Theses and Dissertations

Public higher education in the United States (US) is funded through two primary forms: one is through state higher education appropriation funds, and the other is student financial aid that is directly given to students. Increasing postsecondary full-time equivalent (FTE) enrollment and graduation rate are becoming a crucial economic priority in the US. However, only a limited study is available about whether state investment in higher education and increasing tuition charges can impact FTE student enrollment (FTEE) and graduation rate (GR) at 4-year public universities in the US. A systematic literature review was conducted for the present research to comprehend …

Stateville Speaks - Summer 2022, Brian Dolinar

Stateville Speaks

Articles include: Surviors Tell Their Stories from Inside Logan Women's Prison, The Right to Vote Should Be Available to Everyone- Including Prisoners Like Me, HB4847 Would Give a Voice to Surviors of Gender Based Violence, Prison Guards in Ilinois Used Prison Labor to Raise Money for Golf Tournaments, Guard Found Guilty for the Killing of Larry Earvin at Western Illinois Prison, In Memoriam: Gary Koger...Lauren Stumblingbear, Panorama, Greater Later, Inside the Belly, Dear Black Youth, Announcements

Efficiency In The Upper Deschutes Basin: Understanding The Hydrosocial Implications Of Irrigation Canal Piping, Rebecca Anderson

Dissertations and Theses

In response to water scarcity, irrigation efficiency projects aim to conserve water for in-stream flow and agricultural use. Piping irrigation canals is a common irrigation efficiency method which reduces the loss of incidental recharge, resulting in trade-offs within a hydrosocial system. Few studies have focused on the consequences of canal piping and none have integrated a critical analysis of the social factors involved in deciding what constitutes 'efficient' water use. This study seeks to fill this gap by combining natural and social science to give attention to the scales and perspectives involved in irrigation efficiency canal piping and the material …

Neuropilin-2 Regulates Androgen-Receptor Transcriptional Activity In Advanced Prostate Cancer, Samikshan Dutta, Navatha Shree Polavaram, Ridwan Islam, Sreyashi Bhattacharya, Sanika Bodas, Thomas Mayr, Sohini Roy, Sophie Alvarez, Marieta I. Toma, Anza Darehshouri, Angelika Borkowetz, Stefanie Conrad, Susanne Fuessel, Manfred Wirth, Gustavo B. Baretton, Paramita Ghosh, Kenneth J. Pienta, David L. Klinkebiel, Surinder K. Batra, Michael H. Muders, Kaustubh Datta

Department of Agronomy and Horticulture: Faculty Publications

Aberrant transcriptional activity of androgen receptor (AR) is one of the dominant mechanisms for developing of castration-resistant prostate cancer (CRPC). Analyzing AR-transcriptional complex related to CRPC is therefore important towards understanding the mechanism of therapy-resistance. While studying its mechanism, we observed that a transmembrane protein called neuropilin-2 (NRP2) plays a contributory role in forming a novel AR-transcriptional complex containing nuclear pore proteins. Using immunogold electron microscopy, high-resolution confocal microscopy, chromatin immunoprecipitation, proteomics, and other biochemical techniques, we delineated the molecular mechanism of how a specific splice variant of NRP2 becomes sumoylated upon ligand stimulation and translocates to the inner nuclear …

Mixed Methods Action Research: How Integrating Student Response Technology And Case Studies In A Largely Populated University Course Influences Student Engagement, Feedback, And Learning, Scott L. Matteson

Theses and Dissertations

The purpose of this study was to determine if implementing student response technology (SRT) and case studies into a largely populated university undergraduate course would influence student engagement. When student engagement is influenced the potential for positive learning outcomes occurs leading to a higher likelihood of student success (Swap & Walter, 2015). Four research questions guided this study: How and to what extent does incorporating SRT and case studies in a largely populated undergraduate course at MSU influence: (1) student motivation; (2) cognitive, emotional, and behavioral engagement; (3) feedback; and (4) What are the effects of SRT and case studies …

Differentiating Pleistocene Alloformations In The South Carolina Coastal Plain Through Lithologic, Textural, Mineralogical, And Cluster Analyses, Charles Andrew Wykel

Theses and Dissertations

Currently, there is no textural or mineralogic basis for identifying and differentiating Pleistocene strand deposits in the South Carolina (SC) Lower Coastal Plain (LCP). Historically, geologic mapping of the SC coastal plain uses geomorphologic and biostratigraphic techniques for identifying and mapping LCP surficial strand deposits. While useful, both approaches have problems. The aim of this study is to develop a cost-effective approach to differentiate and identify strand deposits of different Pleistocene alloformations occurring in the SC LCP. To accomplish this task, four strand samples were taken from the Ten Mile Hill, the Ladson, and Wicomico alloformations in Horry County, SC. …

Incremental, Spaced Repetition And Studymate Flashcards: The Impact On College Student Memorization Of Measurement Conversion Standards, Patricia A. Bromer

Theses and Dissertations

The purpose of this action research was to evaluate the impact of and student perception of incremental, spaced repetition of StudyMate electronic flashcard use on memorization of measurement conversion standards for an online Mathematics in Health Sciences course. Online college classes require more self-direction and usually do not allow for partner or group work. These characteristics of online classes may hinder students’ ability to memorize crucial information, increasing their cognitive load and leading to feelings of inadequacy. This mixed methods study assessed the impact of incremental, spaced repetition of StudyMate flashcard use on college math students’ memorization of measurement conversion …

Reconceptualizing Informal Learning In An Online Learning Environment, Silvia Clark

Theses and Dissertations

In 2020, many organizations moved their formal training programs to an online learning context due to COVID-19. Informal learning, which refers to activities that are self-guided and occur independently outside of formal learning contexts has gained significant interest among researchers and practitioners in the past two decades as it has been identified as the primary type of learning in today's organizations. Despite the increasing interest in informal learning, no attempt has been made to examine and understand informal learning in an online learning environment.

This dissertation provides an integrative review of prior work on formal and informal learning in online …

Using Visual Arts To Teach Beginning Literacy Skills, Stacy Phaxaysithideth

Theses and Dissertations

This study examined the effect of using visual arts to teach rhyming words and word family words. Two interventions were used, both utilizing the use of visual arts to learn both literacy skills. The interventions were then assessed with a pre- and post-test to see the if the interventions were successful. A student attitude survey was also given at the end of the study to see how the students felt about the interventions. A semi-structured interview was done at the end of the interventions as well to collect the thoughts of my co-teacher on the interventions. Lastly, my teacher observations …

Truth And Identity In Dostoevsky’S Raskolnikov And Prince Myshkin, Gwendolyn Walker

Theses and Dissertations

Situated in the context of Bakhtin’s understanding of Dostoevsky’s narrative structure, the goal of this thesis aims to analyze the ways in which Dostoevsky’s characters negotiate their identities through a dialogic process of truth-telling as it appears in two forms: an explicit expression of truth that is consciously made by a novel’s characters in earnest dialogue, and an unspoken, even unconscious expression of truth that is not openly expressed, but can be inferred from the seemingly illogical reactions and behaviors of characters in the novel. The latter form is established in terms of Freud’s discussion of the unconscious and unconscious …

A Hawaiian Heroine’S Journey: The Early Life And Career Of Dancer Jean Erdman Campbell, Diane B. Mcghee

Theses and Dissertations

This biographical study covers the early life and career of dancer, choreographer, and avant-garde theatre artist, Jean Erdman Campbell (1916-2020). Based on extensive research of historical literature and archival materials, the manuscript traces Erdman’s ancestry and follows the subject through age 32, when she became established as a star of modern dance and prepared for a world tour. The guiding question for this study was what influences shaped the life course, identity and artistry of Erdman, and how might the subject be presented as biography? The researcher examined the influences on Erdman as related to various dance traditions, especially Hawaiian …

“When You Out In Open Spaces”: Copula Absence In Afro-Texan English And The Origins And Development Debate, Brandon Davis Cooper

Theses and Dissertations

African American Vernacular English (AAVE) is perhaps the most studied variety of American English, and interest in its origins and development has raised enough questions to launch a thousand studies. Naturally, positions on AAVE’s origins and development have become increasingly nuanced since the debate’s inception. Increasingly, AAVE is treated less like a monolith, and interest in the dimensions of its regional diversity has grown. No position on AAVE’s origins and development can be taken seriously if it fails to consider its capacity for areal differentiation. Indeed, most positions on AAVE’s origins and development now strongly assert the likelihood of multiple …

Trans-Atlantic Composition: The History Of British Academic Writing, Gareth George Rees-White

Theses and Dissertations

I author a revisionary comparative history of British Academic Writing and American Composition studies. My core argument is that the Composition story has always, ultimately, been a Trans-Atlantic one. This project serves two key goals: 1) it offers a comprehensive history of UK writing education; while 2) simultaneously offering a revisionist US history that fights the claim that uniquely American exigencies led to a uniquely American education system that therefore has little to learn from other global Compositions. This project tracks the history of university level writing education in the UK from the 1200s to the modern day, and follows …

Methodological Mutability: Shifting Research In The Rhetoric Of Health And Medicine, John Schuler Benson Iii

Theses and Dissertations

The Rhetoric of Health and Medicine (RHM) is a growing body of scholarship that pulls from technical communication, rhetorical theory, and a number of other disciplines to inquire about the capacities of rhetoric at the intersection of medical practitioners and scholars, the medical humanities, and the publics they inform and treat. Among RHM scholars there is a consensus that the field’s methodological diversity is one of its greatest strengths; indeed, field leaders articulate one of RHM’s exigencies as “encouraging methodological collaboration and experimentation” (Melonçon and Scott, Methodologies 4). This dissertation takes up these calls with the introduction of shifting, a …