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Investigating The Link Between O-Glcnacylation And Parkin In Parkinson’S Disease, Kathryn E. Henderson Apr 2023

Investigating The Link Between O-Glcnacylation And Parkin In Parkinson’S Disease, Kathryn E. Henderson

Selected Honors Theses

Parkinson’s Disease (PD) is a devastating neurodegenerative disease (ND) that is believed to impact around 1 million Americans, from both reported and nonreported cases. It is characterized by impaired motor and cognitive functioning resulting from a host of proposed causes, including the loss of dopaminergic neurons in the substantia nigra and the more debated aggregation of proteins. The role of proteins in PD is the focus of the following proposed research, which aims to evaluate the link between O-GlcNAcylation and the phosphorylation states of protein in NDs. This link has been investigated in other NDs such as Alzheimer’s as well …

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Gonzalez V. Google: Testing The Boundaries Of Section 230, Ohona Chowdhury Apr 2023

Gonzalez V. Google: Testing The Boundaries Of Section 230, Ohona Chowdhury

UC Law SF Communications and Entertainment Journal

No abstract provided.

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Ai Ethical Compliance Is Undecidable, Lorin Brennan Apr 2023

Ai Ethical Compliance Is Undecidable, Lorin Brennan

UC Law Science and Technology Journal

One response to concerns about AI systems has been to espouse “ethical AI,” that is, to elucidate ethical norms and then impose a legal requirement that AI systems comport with these norms. But will it work? More precisely, does there exist an effective procedure by which an AI system developer, or regulator, can determine in advance whether an AI system, once put into operation, will consistently generate output that conforms to a desired ethical norm? This paper argues “no.” The Halting Problem shows that there is no algorithm that can reliably do so for all AI systems running any allowed …

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Unique Civic Education Program Aims To Teach Young People About Courts And Civility, Robin L. Rosenberg, Beth Bloom Apr 2023

Unique Civic Education Program Aims To Teach Young People About Courts And Civility, Robin L. Rosenberg, Beth Bloom

Judicature International

No abstract provided.

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Proposed Legal Reforms In Israel: Are Israel’S “Constitutional Conventions” In Jeopardy?, Peter Kahn, Dov Weissglas Apr 2023

Proposed Legal Reforms In Israel: Are Israel’S “Constitutional Conventions” In Jeopardy?, Peter Kahn, Dov Weissglas

Judicature International

No abstract provided.

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Helms School Of Government Newsletter- Spring 2023, Liberty University Apr 2023

Helms School Of Government Newsletter- Spring 2023, Liberty University

The Helms School of Government Newsletter

Helms School of Government Newsletter- Spring 2023

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2023 University Research Symposium Program Book, The Graduate School Apr 2023

2023 University Research Symposium Program Book, The Graduate School

University Research Symposium Programs

Program book for the 2023 University Research Symposium.

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Phys 213 Apr 2023

Phys 213

Department of Physics and Astronomy: Syllabi

No abstract provided.

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Phys 451/851 Apr 2023

Phys 451/851

Department of Physics and Astronomy: Syllabi

No abstract provided.

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Moved To Compassion: Envisioning Parables In The Gospel Of Luke, Patrick J. O'Kernick Apr 2023

Moved To Compassion: Envisioning Parables In The Gospel Of Luke, Patrick J. O'Kernick

Dissertations (1934 -)

The primary goal of modern parable studies seems to be objective, more or less impersonal, interpretations. The subjective experience of the reader, the ways in which real readers are active and personally engaged in their encounters with parable texts—these things have hardly been addressed. Moreover, narrow views of reception activity have yielded narrow views of the parables themselves. Why, after all, read a parable firsthand? This is the central concern of my study. From reader response criticism, education-oriented reading research, cognitive psychology, and cognitive literary studies I derive what I call an Envisionment-Development Model of Reading (EDMR). According to EDMR, …

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Book Of Abstracts, Seton Hall University Apr 2023

Book Of Abstracts, Seton Hall University

Petersheim Academic Exposition

No abstract provided.

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Joint Force Quarterly 109 (2nd Quarter, April 2023), National Defense University Press Apr 2023

Joint Force Quarterly 109 (2nd Quarter, April 2023), National Defense University Press

Joint Force Quarterly ARCHIVES

No abstract provided.

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Gold & Blue Law Edition, Spring 2023, St. Mary's University- San Antonio, Texas Apr 2023

Gold & Blue Law Edition, Spring 2023, St. Mary's University- San Antonio, Texas

Gold & Blue Law Edition

This is the Spring 2023 edition of Gold & Blue Law Edition which is St. Mary's University's official School of Law publication.

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The View From Somewhere: Essays On Philosophy, Positionality And Power, Moya Mapps Apr 2023

The View From Somewhere: Essays On Philosophy, Positionality And Power, Moya Mapps

Yale Graduate School of Arts and Sciences Dissertations

The typical analytic philosophy paper is quite reticent about the personal, written as if its author occupied a “view from nowhere.” In a few subfields, however – feminist philosophy, philosophy of disability, critical philosophy of race – it is far more common for philosophers to write openly about how their personal experiences inform their work. In Chapter 1, “Getting Personal,” I argue that we have good reasons, both epistemic and political, to embrace these more openly personal methods of philosophical reasoning and writing. The personal is philosophical. In the remaining chapters I put theory into practice, building philosophical arguments informed …

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Stealth Dark Matter With Lattice Field Theory, Kimmy Kelly Cushman Apr 2023

Stealth Dark Matter With Lattice Field Theory, Kimmy Kelly Cushman

Yale Graduate School of Arts and Sciences Dissertations

This work presents non-perturbative lattice field theory calculations of the low-lying meson and baryon spectrum of the SU(4) gauge theory with fermion constituents in the funda-mental representation, known as stealth dark matter. This strongly coupled theory is an extension of the Standard Model, where the spin-zero baryon is the dark matter candidate. This work constitutes the first milestone in the research program to predict stealth dark matter self-interactions. The focus of this work is on reducing excited state contamination in the single baryon channel by applying the Laplacian Heaviside (LapH) method, as well as projecting the baryon operators into irreducible …

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Uncovering Novel Biological Regulators Of Ribosome Biogenesis, Carson J. Bryant Apr 2023

Uncovering Novel Biological Regulators Of Ribosome Biogenesis, Carson J. Bryant

Yale Graduate School of Arts and Sciences Dissertations

Ribosomes are the complex macromolecular machines which assemble proteins in all forms of life, and their production process is known as ribosome biogenesis (RB). In eukaryotes, RB begins in the nucleolus with the transcription of the pre-ribosomal (pre-r)RNA, which undergoes modification, processing, and assembly into mature ribosomes. Malfunctioning RB can cause severe human diseases including rare developmental disorders called ribosomopathies, as well as cancer. Therefore, better understanding of the human RB machinery and its regulation is imperative for pursuing more effective clinical diagnoses and therapies. In this dissertation, I present work which simultaneously advances the field of RB in the …

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Animation Before Anime, Jason Cody Douglass Apr 2023

Animation Before Anime, Jason Cody Douglass

Yale Graduate School of Arts and Sciences Dissertations

This dissertation asserts that animated media circulating into, within, and away from Japan during the mid-20th century stand to tell us much about how such texts shaped, and were shaped by, the cultural forces of class, gender, age, and race. The four chapters traverse intersecting, albeit disparate planes. Each uses a distinct critical lens to demonstrate how understudied archival materials can help to resolve some of the most pressing questions currently raised within animation studies. Chapter 1 focuses upon issues of socioeconomic class, forging a vital link between functional animation, such as television advertisements, and working-class animators who developed their …

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Uncovering The Function And Molecular Mechanism Of Mili In Mouse Germline Stem Cells, Yuqi Wang Apr 2023

Uncovering The Function And Molecular Mechanism Of Mili In Mouse Germline Stem Cells, Yuqi Wang

Yale Graduate School of Arts and Sciences Dissertations

Mouse germline stem cells (GSCs) play critical roles in spermatogenesis by self-renewal and differentiation into daughter spermatogonia. Like other stem cells, the proper functions of mouse GSCs are governed by a delicate regulatory network. PIWI proteins belong to the Argonaute protein family, and they act with piRNAs to control gene expression through transcriptional and post-transcriptional regulation. Extensive research has demonstrated the vital functions of PIWI proteins in germline development, stem cell maintenance, and transposon control. Despite this, the role of PIWI in mammalian GSCs remains largely unknown. MILI is one of three murine PIWI proteins. Recent study has discovered that …

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The Functional Effects Of Tree And Shrub Mycorrhizal Associations On Soil Organic Matter Dynamics In Forests, Elisabeth B. Ward Apr 2023

The Functional Effects Of Tree And Shrub Mycorrhizal Associations On Soil Organic Matter Dynamics In Forests, Elisabeth B. Ward

Yale Graduate School of Arts and Sciences Dissertations

Plant-fungal associations can strongly influence the composition, persistence, and turnover of soil organic matter in forests. The prevailing framework for understanding these relationships is through the relative abundance of tree mycorrhizal functional types, the vast majority of which associate with arbuscular (AM) and/or ectomycorrhizal (EcM) fungi. Differences in functional traits and ecosystem characteristics between AM and EcM trees have generated immense interest in assessing the ecosystem biogeochemical effects of tree mycorrhizal dominance within and among forest biomes to improve understanding of patterns in soil carbon and nitrogen pools and how they might respond to factors of global change. Yet, forests …

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Identifying The Role And Mechanism By Which Gdf15 And Fgf21 Regulate Glucose Homeostasis, Zongyu Li Apr 2023

Identifying The Role And Mechanism By Which Gdf15 And Fgf21 Regulate Glucose Homeostasis, Zongyu Li

Yale Graduate School of Arts and Sciences Dissertations

As a highly utilized substrate in most cells of the body, glucose homeostasis is strictly regulated by a variety of mechanisms. Under physiological conditions, blood glucose is sophisticatedly maintained by temporal coordination of whole-body glucose uptake, absorption from the digestive system, and endogenous glucose production from the liver and kidney. However, the factors and mechanisms by which plasma glucose is regulated under pathological conditions are not clearly understood. In this Ph.D. thesis, we interrogated the role of two cytokines, Growth Differentiation Factor 15 (GDF15) and fibroblast growth factor-21 (FGF-21), in regulating glucose output under extreme metabolic stress. By employing two …

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Apoptosis Recognition Receptors Regulate Skin Tissue Repair In Mice, Olivia Justynski Apr 2023

Apoptosis Recognition Receptors Regulate Skin Tissue Repair In Mice, Olivia Justynski

Yale Graduate School of Arts and Sciences Dissertations

The skin is an essential barrier against the outside world, and must withstand constant exposure to damage from the environment. When this barrier is broken, it must be repaired quickly and effectively in order to prevent infection and restore function. The skin’s ability to heal wounds is vital for human health, and insufficient wound treatment is a major clinical problem, contributing to decreased quality of life and increased healthcare costs for many patients due to chronic or non-healing wounds. The complex process of wound healing involves the coordination of many cell types and signals, which were here investigated using single-cell …

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Classical Sociological Theory Before The 'Fathers': The Radical Materialism Of Miss Harriet Martineau, Elexis Ellis Apr 2023

Classical Sociological Theory Before The 'Fathers': The Radical Materialism Of Miss Harriet Martineau, Elexis Ellis

Yale Graduate School of Arts and Sciences Dissertations

Harriet Martineau was a radical materialist in several respects. Taking the (Baconian) scientific method—avoiding confirmation bias by “bringing together an accumulation of facts previous to the formation of a theory”—to its radical conclusion by extending it to mental phenomena, her (wholly neurophysiological) anti-dualist ontology of human consciousness demolished the division between mental and natural philosophy, the special spiritual status of humans among animals, a clear distinction between thought and perception, & etc. Because it revealed humans—and the mental/physical activity thereof—to be wholly material, and therefore subject to observable laws of nature as any other physical phenomenon, it also made human/social …

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Diversity And Distribution Of Herbaceous Plants Along A Tropical Rainfall Gradient In Western Ghats, India, Harikrishnan Venugopalan Nair Radhamoni Apr 2023

Diversity And Distribution Of Herbaceous Plants Along A Tropical Rainfall Gradient In Western Ghats, India, Harikrishnan Venugopalan Nair Radhamoni

Yale Graduate School of Arts and Sciences Dissertations

Tropical forests hold most of the vascular plant life on earth. Much of our understanding on the diversity patterns and drivers of plants in tropical forests is based on studies on trees, which form only a quarter of the plant diversity in these forests. Over 40% of plant diversity in some tropical forests is comprised of understory herbaceous angiosperms (herbs). Despite such high species richness, and their critical role in the functioning of forest ecosystems, our knowledge on the diversity patterns and drivers of herbs is poor, compared to trees. This knowledge gap not only precludes any claim on a …

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Pulmonary Delivery Of Mrna Therapeutics, Alexandra Ahova Suberi Apr 2023

Pulmonary Delivery Of Mrna Therapeutics, Alexandra Ahova Suberi

Yale Graduate School of Arts and Sciences Dissertations

Advances in mRNA sequence design and chemical modifications have brought us to theprecipice of translating mRNA therapeutics to treat and cure innumerable human diseases. However, targeting mRNA delivery to relevant tissues remains a major obstacle in the clinical translation of mRNA therapeutics. Topical delivery of mRNA to the respiratory mucosa is an attractive strategy for treating pulmonary disorders. Despite significant interest, there are no approved delivery vehicles capable of efficiently and safely transfecting lung cells with mRNA. In this work, we created a polymer delivery vehicle for mRNA encapsulation and airway delivery. We employed a screening approach to formulate polyplexes …

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A Diagrammatic Method To Compute The Effective Hamiltonian Of Driven Nonlinear Oscillators, Xu Xiao Apr 2023

A Diagrammatic Method To Compute The Effective Hamiltonian Of Driven Nonlinear Oscillators, Xu Xiao

Yale Graduate School of Arts and Sciences Dissertations

The question answered in this thesis is whether it is possible to construct a rigorous and efficient perturbation method to obtain the effective static Hamiltonian of a nonlinear oscillator driven by a time-dependent oscillatory force. We present in this dissertation such a method, based on Feynman-like diagram. The pictorial structure associated with each diagram corresponds directly to a Hamiltonian term, the prefactor of which involves a simple counting of topologically equivalent diagrams. We also leverage the algorithmic simplicity of our scheme in a readily available computer program that generates the effective Hamiltonian to arbitrary order. At the heart of our …

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Mechanistic Insights Into Protein-Mediated Lipid Transfer, Zhouping Hong Apr 2023

Mechanistic Insights Into Protein-Mediated Lipid Transfer, Zhouping Hong

Yale Graduate School of Arts and Sciences Dissertations

In eukaryotes, most lipids are synthesized in the endoplasmic reticulum (ER) and then redistributed from there to other organelles, each of which has a distinct membrane lipid composition. We have long known that lipids can be trafficked between organelles by vesicles. More recently, it has become clear that there is another major means of lipid redistribution mediated by lipid transport proteins (LTPs) that localize to so-called membrane contact sites (MCSs), where two organelles come into close apposition. LTPs have a hydrophobic cavity to solubilize the lipid fatty acyl tail. They work as either shuttles that ferry 1-2 lipid molecules at …

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Integrative Analysis Of Bulk And Single Cell Rna-Seq Modalities In The C. Elegans Nervous System, Alec Barrett Apr 2023

Integrative Analysis Of Bulk And Single Cell Rna-Seq Modalities In The C. Elegans Nervous System, Alec Barrett

Yale Graduate School of Arts and Sciences Dissertations

Nervous systems are complex networks, which requires a diverse set of neurons to detect, process, learn from, and respond to external stimuli. This neuronal diversity is directly tied to diversity of gene expression networks across the nervous system. Here I present my work, as part of the CeNGEN consortium, mapping gene expression across the entire nervous system in the hermaphroditic nematode C. elegans. I outline a strategy for sequencing RNA from individual neurons using bulk RNA-seq after cell sorting, and demonstrate a species-specific reagent for ribosomal depletion for ultra-low input RNA-seq library preparation. I describe a collaborative effort to sequence …

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Characterizing Reactive Uptake At The Air-Water Interface Of Sea Spray Aerosols Using Cryogenic Ion Spectroscopy, Santino James Stropoli Apr 2023

Characterizing Reactive Uptake At The Air-Water Interface Of Sea Spray Aerosols Using Cryogenic Ion Spectroscopy, Santino James Stropoli

Yale Graduate School of Arts and Sciences Dissertations

Sea Spray Aerosols (SSA) generated from ocean wave breaking constitute one the largest sources atmospheric particulate matter, and can exhibit enormous diversity in their chemical composition. Heterogenous reactions occurring at the air-water interface of these SSA particles are thought to play a key role in the regulation of gas-phase oxidants and greenhouse gases in the troposphere and thus have broad implications for global climate. Unfortunately, the underlying chemical physics associated with interfacial reactivity is poorly understood and large uncertainties in the mechanisms, relative product yields, and kinetics of the processes occurring on SSA surfaces remain. In this dissertation, SSA reactivity …

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Observing, Controlling, And Planning Compliant Robot Manipulation, Andrew Morgan Apr 2023

Observing, Controlling, And Planning Compliant Robot Manipulation, Andrew Morgan

Yale Graduate School of Arts and Sciences Dissertations

In-hand manipulation is a complicated process—it requires a group of individual manipulators to work in proper unison with one another, modulating forces on an object while making and breaking contact. Traditional approaches to realizing such capabilities have been through the use of overly-complex, anthropomorphic, and thus expensive, robot hands equipped with a vast array of sensors, which are often noisy and can in turn lead to task failure. Mechanically compliant end effectors, on the other hand, have shown to be beneficial to robot manipulation, particularly for grasping, as they are able to "absorb the slack” in any modeling, sensing, or …

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The Avant-Garde Of Feeling: Queer Love And Modernism, Michael Abraham Apr 2023

The Avant-Garde Of Feeling: Queer Love And Modernism, Michael Abraham

Yale Graduate School of Arts and Sciences Dissertations

This dissertation reads the lives and works of Gertrude Stein, Alice B. Toklas, H.D., Bryher, and Langston Hughes to understand love’s potential for queer flourishing for American subjects in the pre-Stonewall era. Through readings of literature that run the gamut of genre from memoirs to poetry, novels to cookbooks, it teases out what love means to each of these authors and explores their orientations toward cisheteronormative constructions of kinship in twentieth-century America and Europe, while they resist, recontextualize, and sometimes capitulate to the complex of forces that constitutes normativity. The last three decades have generated manifold theorizations of queer desire, …

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