Antagonism Between Prdm16 And Smad4 Specifies The Trajectory And Progression Of Pancreatic Cancer, Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allan Austin Bryan, Ting-Xuan Lu, Mohammed S. Razzaque

School of Medicine Publications

The transcription factor Prdm16 functions as a potent suppressor of transforming growth factor-beta (TGF-β) signaling, whose inactivation is deemed essential to the progression of pancreatic ductal adenocarcinoma (PDAC). Using the KrasG12D-based mouse model of human PDAC, we surprisingly found that ablating Prdm16 did not block but instead accelerated PDAC formation and progression, suggesting that Prdm16 might function as a tumor suppressor in this malignancy. Subsequent genetic experiments showed that ablating Prdm16 along with Smad4 resulted in a shift from a well-differentiated and confined neoplasm to a highly aggressive and metastatic disease, which was associated with a striking deviation in the …

Applicability Of A Flood Forecasting System For Nebraska Watersheds, Sinan Rasiya Koya, Nicolas Velasquez Giron, Marcela Rojas, Ricardo Mantilla, Kirk Harvey, Daniel Ceynar, Felipe Quintero, Witold F. Krajewski, Tirthankar Roy

Department of Civil and Environmental Engineering: Faculty Publications

Accurate and timely flood prediction can reduce the risk of flooding, bolster preparedness, and help build resilience. In this study, we have developed a flood forecasting system prototype and checked its potential for carrying out operational flood forecasting in the state of Nebraska. This system builds upon some of the core components of the Iowa Flood Information System (IFIS), which is a state-of-the-art platform widely recognized around the world. We implemented our platform on a pilot basin in Nebraska (Elkhorn River basin) by installing eight stream sensors and setting up the hydrologic model component of IFIS, i.e., the Hillslope Link …

Diego Beekman Mutual Housing Association, Hdfc V. Lee

All Decisions

ERAP Case.

Impact Of Climate Risk On Long-Term Core Activity Management In The Power Sector, Dariusz Michalski, Paweł Hawranek

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

The global economy faces the challenges of climate change that generates the climate risk, which essentially affects the operational activity of power companies. The power sector is both, one of the most important greenhouse gases emitters, and an industry especially exposed to widely perceived climate risk. Changes in the natural environment cause negative impacts on the energy infrastructure (physical risk), while regulatory changes and society sentiments (transition risk) reshape the conditions of operational profitability of power companies. These phenomena, currently accelerating changes in the global economy, persuaded the authors to undertake a study on necessary changes in the core activities …

A Qualitative Approach Examining The Effects Of Universal Design For Learning For Students With Intellectual Disabilities In Kenya, Molly Mckinnon

Dissertations, Theses, and Projects

This research aims to explore the Universal Design for Learning framework looking at multiple means of representation, multiple means of expression, and multiple means of engagement and how it can support students with intellectual disabilities within the country of Kenya. Using the Structural-Functional theory, this collective case study was designed to look at schools located throughout Kenya putting an emphasis on adaptations to an environment, integration into the community, and shared values and beliefs focused on student education. Three sub-questions will be used to support data analysis focused on the pillars of Universal Design for Learning. How does the Universal …

Donations With Strings Attached: Experience Of Academic Libraries In South-West Nigeria, Olutoyin Olukemi Oso Mrs

Library Philosophy and Practice (e-journal)

This study investigated the experience of academic libraries on handling of book donations and gifts with strings or conditions attached. This study adopted the descriptive survey research design. The study population consisted of eighteen (18) academic libraries from public and private universities in South-West, Nigeria. Purposive sampling techniques was adopted to select librarians who are in charge of Collection Development of their respective libraries. Descriptive statistics involving frequency and percentage distribution were used for data analysis. The findings of the study revealed that individuals 13(72.2%) are the major source of donations with strings attached and further revealed that 6(33.3%) indicated …

Svip Dependent Tubular Lysosomal Restoration: A New Direction In Vcp Diseases, Ankita Basu

LSU Doctoral Dissertations

Multisystem Proteinopathy-1 (MSP-1) is a rare, autosomal dominant, degenerative disease resulting from single amino acid mis-sense mutations in the AAA+ ATPase, Valosin containing protein (VCP). Patients with VCP mutations vary widely in their pathology and clinical penetrance, making it difficult to devise effective treatment strategies. To investigate the pathology of VCP- related disease, we engineered CRISPR knock-in Drosophila models for nine MSP-1 associated VCP mutations. These mutant animals mimic human MSP-1 disease phenotypes, including progressive mobility decline and accumulation of protein aggregates, making them excellent models to study the pathology of VCP associated mutations and test potential treatment strategies. At …

Anti-Cancer Effect Of Cissus Quadrangularis On Human Glioblastoma Cells, Benxu Cheng, Yunlin Wei, Lili Guerra, Rozena Shirvani-Arani, Santiago Balderas, Laura Valdez, Andrew Tsin, Xiaoqian Fang

School of Medicine Publications

Objectives

Glioblastoma multiforme (GBM) is a common and fatal brain tumour in the central nervous system with a poor survival rate and a median survival time of 15 months only. The standard treatment is aggressive surgical resection followed by radiotherapy and chemotherapy. However, effective drugs available in chemotherapy are limited. This study was designed to evaluate, for the first time, the potential therapeutic effect of Cissus quadrangularis (CQ) in human glioblastoma cells and to investigate its possible mechanisms of action. Methods

In this study, we examined the anticancer activity of CQ in human glioblastoma U87 MG cells by cell viability …

Raising The Threshold For Trademark Infringement To Protect Free Expression, Christine Haight Farley, Lisa P. Ramsey

Scholarly Articles in Law Reviews & Journals

The First Amendment right to free speech limits the scope of rights in trademark law. Congress and the courts have devised various defenses and common law doctrines to ensure that protected speech is exempted from trademark infringement liability. These defensive trademark doctrines, however, are narrow and often vary by jurisdiction. One current example is the speech-protective test first articulated by the Second Circuit in Rogers v. Grimaldi, expanded by the Ninth Circuit, and recently restricted by the Supreme Court in Jack Daniel’s Properties v. VIP Products to uses of another’s mark within an expressive work that do not designate the …

Dysregulation And Epigenetic Reprogramming Of Nrf2 Signaling Axis Promote Acquisition Of Cisplatin Resistance And Metastasis In Head And Neck Squamous Cell Carcinoma, Abdullah A Osman, Emre Arslan, Mason Bartels, Chieko Michikawa, Antje Lindemann, Wangjie Yu, Wencai Ma, Li Shen, Jing Wang, Anand K Singh, Mitchell J Frederick, Nakia D Spencer, Jeffery Kovacs, Timothy Heffernan, William F Symmans, Kunal Rai, Jeffrey N Myers

Faculty, Staff and Student Publications

PURPOSE: Cisplatin (CDDP)-based chemotherapy is a first-line treatment for patients with advanced head and neck squamous cell carcinomas (HNSCC), despite a high rate of treatment failures, acquired resistance, and subsequent aggressive behavior. The purpose of this study was to study the mechanism of CDDP resistance and metastasis in HNSCC. We investigated the role of NRF2 pathway activation as a driven event for tumor progression and metastasis of HNSCC.

EXPERIMENTAL DESIGN: Human HNSCC cell lines that are highly resistant to CDDP were generated. Clonogenic survival assays and a mouse model of oral cancer were used to examine the impact of NRF2 …

Dna Damage Repair Kinase Dna-Pk And Cgas Synergize To Induce Cancer-Related Inflammation In Glioblastoma, Clara Taffoni, Johanna Marines, Hanane Chamma, Soumyabrata Guha, Mathilde Saccas, Ana-Luiza Chaves Valadao, Jane Jardine, Mi Kyung Park, Katarzyna Polak, Mara De Martino, Claire Vanpouille-Box, Maguy Del Rio, Celine Gongora, Julie Gavard, Nicolas Bidère, Min Sup Song, Donovan Pineau, Jean-Philippe Hugnot, Karima Kissa, Laura Fontenille, Fabien P Blanchet, Isabelle K Vila, Nadine Laguette

Faculty, Staff and Student Publications

Cytosolic DNA promotes inflammatory responses upon detection by the cyclic GMP-AMP (cGAMP) synthase (cGAS). It has been suggested that cGAS downregulation is an immune escape strategy harnessed by tumor cells. Here, we used glioblastoma cells that show undetectable cGAS levels to address if alternative DNA detection pathways can promote pro-inflammatory signaling. We show that the DNA-PK DNA repair complex (i) drives cGAS-independent IRF3-mediated type I Interferon responses and (ii) that its catalytic activity is required for cGAS-dependent cGAMP production and optimal downstream signaling. We further show that the cooperation between DNA-PK and cGAS favors the expression of chemokines that promote …

Evaluating Attitudes Toward Non-Formal Science Education Programs Among High School Science Teachers In Southeast Louisiana, Heather Egger

LSU Master's Theses

Abstract

The Louisiana Department of Education (LDOE) has begun implementing Louisiana Student Standards for Science (LSSS), as well as developing high school science certification programs. The LDOE recognizes that teaching science using three-dimensional learning methods and phenomena based inquiry learning will be a challenge that would be addressed in part by partnerships between formal science teachers and nonformal science education programs. However, limited available information on this topic shows that utilization of nonformal science education opportunities by science educators has declined and, in some instances, have been relegated to unstructured “fun” outings to reward students, often after the final quarter …

2023 April, 2; Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes; 2023 April, 2

Clickbait Compliance And Transnational Corruption, William R. Heaston

University of Dayton Law Review

In the corporate compliance and anti-corruption domains, international standard-setting is in vogue. Recent years have witnessed a flurry of new compliance standards authored by the International Organization for Standardization (ISO), the world’s leading private standard-setter. ISO claims to offer a more effective way to address transnational corruption risks and related compliance challenges, one that boasts the approval of a global committee of technical experts and enticingly purports to accord with international “best practices.” A number of companies and governments around the world have taken the bait, with many adopting or giving legal effect to ISO’s anti-bribery standard (ISO 37001) in …

Ohio’S Return To Indefinite Sentencing: Why Minor Changes Make A Major Difference, Zachary R. Kennedy

University of Dayton Law Review

No abstract provided.

Because The Internet: Why The Federal Government Cannot Regulate Online Sports Betting, Kris Milner

University of Dayton Law Review

No abstract provided.

Dissecting Sauan Sibarrung's Business Plan Credit Union, Selmita Paranoan, Made Sudarma, Roekhudin Roekhudin, Noval Adib

The Qualitative Report

This article aims to describe the accountability practiced in credit unions. This study examines formal and informal practices and underlying approaches to accountability to members. Design/methodology/approach, namely with an ethnomethodological approach, this study explores accountability of Credit Union in Indonesia, through interviews and observations with practitioners, management, government, and credit union members, as well as documentation analysis. The results of the study found that Credit Union Sauan Sibarrung prioritizes accountability to members through the actualization of the vision and mission, which is manifested concretely in the preparation of programs (business plans) in the form of mindset transformation through Education and …

Journey Of Realization And Adaptation Through Auto/Ethnography: A Shift To Transformative Educational Research, Tara Paudel, Bal Chandra Luitel, Niroj Dahal

The Qualitative Report

This reflective paper explores Tara's doctoral research journey of realization and adaptation in auto/ethnography as a transformative research methodology. While reflecting on Tara’s journey, the auto/ethnographic paper emphasizes cultural perspectives, interpreting one's own experiences, thoughts, actions, and behaviors relating to society and culture. Likewise, auto/ethnography investigates and associates an individual's confrontation within specific educational, societal, and cultural contexts. With this ethos, the paper demonstrates how Tara, a mathematics teacher and doctoral student, encountered and observed auto/ethnography and discovered it as a path to transformation as a paradigm shift in transformative educational research by connecting lives and research (Dahal et al., …

Analog Cosmology And Superfluidity In Atomic Gases And Electronic Materials, Anshuman Bhardwaj

LSU Doctoral Dissertations

We present a study of analog cosmological models in Bose-Einstein condensates (BEC) and in graphene, and superfluidity in a box-shaped traps. We start by examining the dynamics of a Bose-Einstein condensate (BEC) trapped inside an expanding toroid that can realize an analog inflationary universe. The expanding condensate forces phonons to undergo redshift and damping due to quantum pressure, owing to the thinness of the ring. We predict that such expanding BECs can exhibit spontaneous phonon creation from the vacuum state and show how it would manifest in the atom density and density correlations and discuss connections with the inflationary theory. …

Improving Teacher Intervention Decisions Using The Fraction Error Flowchart, Katherine Pettrey

LSU Doctoral Dissertations

In the U.S. the fifth-grade mathematics curriculum is largely devoted to building fraction skills, providing an essential foundation for future success in mathematics (National Mathematics Advisory Panel, 2008). Unfortunately, students in the U.S. struggle with fraction proficiency (National Assessment of Educational Progress, 2022; Organisation for Economic Co-operation and Development, 2018). Even when teachers facilitate interventions for struggling students those interventions may not be aligned with student need (Riccomini, 2005). Additionally, teachers struggle to identify research-based practices (RBPs) when presented with student data (Means et al., 2009). The purpose of this study was to create and test a flowchart that could …

Is There A Balance Between The U.S. Government Secrecy Regime And Free Speech Rights Of Government Employees?: The Legal Landscape Of The U.S. Government Control Of Information, Qinqin Wang

LSU Doctoral Dissertations

This dissertation explores the tension between the U.S. government’s control of information and government employees’ claims to free speech rights. The U.S. government prepublication review is a censorship system that requires former and current federal government employees to submit any materials intended for publication to their agencies for prior review before they attempt to make any external communication or proceed with any publications. The prepublication review regime has become an essential means by which the U.S. government controls internal information, and has long been controversial because of its censorship nature. Specifically, this dissertation focuses on legal disputes between the U.S. …

The Clash Between Luxury Brands And The Environment, Antoinette Harkness

Honors College Theses

ABSTRACT

Luxury brands are known for their high end material, craftsmanship, quality, materials, exclusive designs and high cost. Luxury attracts the eye of all consumers, especially young consumers that desire to be a true luxury consumer. As luxury companies try to appeal to the masses, with plenty of inventory but at what cost? Luxury brands are polluting our environment, as the textile and apparel industry is currently the second leading polluter in the world. Sustainable fashion is an all inclusive term describing products, processes, activities and actors aiming to achieve a carbon-neutral fashion industry, built on equality, social justice, animal …

Perceived Effects Of Theft And Mutilation On The Utilization Of Information Resources In Francis Idachaba Library, Joseph Sarwuwn Tarka University, Makurdi Nigeria, Richard Iorver Tondo Cln, Mnla, Iorfa Tsafa Cln, Trcn, Aondowase Augustine Mchihi Cln, Mnla

Library Philosophy and Practice (e-journal)

This study was designed to assess the effect of theft and mutilation on the use of information resources in Francis Sulemanu Idachaba Library University of Agriculture Makurdi, Nigeria. The study has four specific objectives with its corresponding research questions. The study used descriptive research design; the population of the study was 150 library staff. All the 150 library staff was used for the study as they were relatively small as such there were no need for sampling. A self-designed questionnaire was used as instrument for data collection. The collected data was analyzer using descriptive statistical analysis. The findings of the …

Investigating How Generation 1.5 Students Notice And Understand Direct Written Corrective Feedback (Wcf), Melissa Bustamante

Theses and Dissertations

The following research focuses on an underrepresented and understudied population in academia, Generation 1.5. Generation 1.5 encompasses a group of individuals who neither fit the categories of first-generation nor second-generation students and often feel caught between two cultures, the American culture and their family’s native culture (Serventy and Allen 1; Goldschmidt and Miller 11). These individuals are neither fully proficient in their L1 or L2 and consequently, share characteristics of L1 and traditional L2 writers (Singhal 2; Ferris 311). This research study examines how university Generation 1.5 students notice and understand direct Written Corrective Feedback (WCF) on treatable and untreatable …

Putting Math In Its Place A Review Of Cathy O’Neil’S Weapons Of Math Destruction: How Big Data Increases Inequality And Threatens Democracy, Nathalie Sinclair

The Mathematics Enthusiast

With its bright yellow cover and its ominous title, this book attracts attention. The subtitle, “How big data increases inequality and threatens democracy” signals very strongly that the “math” in question in the title is primarily that which relates to the statistical and computational means of collecting, analysing and using data. For some readers, the title might be surprising, because it challenges the typical understanding of mathematics as an objective and value-neutral discipline. Worse, it claims that mathematics is significantly involved in creating inequality and compromising democracy. If it is true, then the answer to the perennial student question, “when …

Overcoming Misconceptions About Probability A Review Of David J. Hand’S The Improbability Principle, Keith Gallagher

The Mathematics Enthusiast

Have you ever struck up a conversation with a stranger in a coffee shop and been surprised to learn that you were born in the same week, but in different years? Or maybe you have that one annoying friend who always seems to win raffles and lotteries even though you never win anything, and you just can’t figure out how they always get so lucky? Or perhaps, just for fun, you visited a psychic one day, and you were shocked by how much they were able to tell you about yourself. In The Improbability Principle, David J. Hand explains …

Remineralization Effect Of Two Types Of Varnishes On Induced Enamel Caries, Abeer Tageldin, Magda El-Malt, Sara Hashem

Al-Azhar Journal of Dentistry

Purpose: to assess the remineralization capacity of MI varnish and Bifluorid 10 varnish on induced white spot lesions in deciduous enamel, using Scanning Electron Microscope- Energy Dispersive X-ray. Materials and methods: Sixty human caries-free deciduous teeth were collected. The teeth were stored in 0.1% thymol solution. A 4*4*2 window was created on the buccal surface of each tooth using acid-resistant nail varnish. Samples were then divided into 3 groups according to the remineralizing agent used, each group containing 20 teeth. Group I was remineralized with MI varnish, group II was remineralized using Bifluorid 10 varnish, while group III was a …

Center For Health & Homeland Security Newsletter, Spring 2023

Newsletter

No abstract provided.

Words Matter: Crafting And Critiquing Rhetorically Effective Styles (Engl 002w) Syllabus, Natalie Mera Ford

Aydelotte Curricular Grants

What does it mean to write an awkward or a clear sentence? Who determines what counts as appropriate or "good" writing, and how are such notions of standardized English currently being challenged? Can a scholarly voice be an authentic personal voice, too? In this course, we will examine the grammatical building blocks of written style while scrutinizing larger cultural concerns about the effectiveness of distinct styles. While recognizing famous tenets of style in creative writing, we will primarily focus on stylistic features of academic, civic, and professional discourse. We will learn grammatical terminology and apply it in analyzing and evaluating …

History And Myths Around The Battle Of Shiloh, Trey Lowenthal

Student Scholarship

On April 6th and 7th, 1862, the deadliest battle in American history up to that time was waged, with a staggering total of twenty three thousand dead, wounded, and missing.1 Though as guns fell silent on the evening of the 7th, another battle began, the battle for the narrative. It was a battle for the truth of what happened, and it is one that is still waged to this day. Unlike the physical confrontation that took place in 1862, the lines of battle and allegiance are not so easily defined. It is a patchwork of veterans, generals, newspapers, and historians. …