Digital Commons Network^™

Rigorous Computation Of The Evans Function, Devin Mcghie

Theses and Dissertations

We develop computer-assisted methods of proof for rigorous computation of the Evans function in order to prove stability of traveling waves. We use the parameterization method, series solutions, and the Newton-Kantorovich Theorem to obtain precise, rigorous error bounds for the numerical solution of the ODE used in the construction of the Evans function. We demonstrate these methods on a scalar reaction-diffusion model and on the Gray-Scott model.

Ivermectin: Covid-19 "Miracle Cure?": A Case Study On Public Health Communication To Combat Disinformation, Ashley Dittmar

Honors Theses

Communicating accurate health information to the public has always been a vital role of public health professionals. This role became especially prominent in light of the COVID-19 pandemic, when public health professionals had the challenge of sharing up-to-date information about a novel coronavirus while other messages about the virus - both true and false - were being spread by other entities. This paper focuses on one case of intentionally incorrect information (disinformation) that was spread during the COVID-19 pandemic, purporting anti-parasitic drug ivermectin as a “miracle cure” for COVID-19. This case study is analyzed through the lens of the Media …

The Public Trust Doctrine: Roman Law Roots And Future In Environmental Litigation, Phoebe Liccardo

Honors Theses

The public trust is an ancient and enduring legal doctrine. With roots in Roman law, the public trust persists through English law, and into the United States. Scholars and jurists in the field of Roman and environmental law do not all agree on the history and continuity of the public trust doctrine (PTD). There are those who argue the Roman law introducing a public trust did not assert the same protections present in the doctrine today. Conversely, there are those who believe the Roman law did enshrine similar protections, and further, that it calls for an expansion of PTD in …

Database Of Video Games And Their Therapeutic Properties, Tyler Brinkman

Student Capstone Papers

There are reported to be 2.96 billion video game players in the world as of 2021 and this number is expected to grow to 3.32 billion by the year 2024. Of that total, 215.5 million video game players live in the United States with a reported average age of 33 years old. Thousands of commercial video games are released every year. There is evidence to support video game technology use as therapeutic media however it predominately utilizes outdated technology or technology designed for a specific purpose also called “serious games.” The problem is that OT practitioners are unaware of the …

The Cowl - V. 87 N. 16 - April 20, 2023

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 16 - April 20, 2023. 24 pages.

West 173rd Realty Llc V. Lambert

All Decisions

No abstract provided.

Rutledge Apts. Llc V. Rodriguez

All Decisions

ERAP Case.

The Colby Echo (2023-04-20), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly during the academic year, 1898-present.

The Role Of Interleukin-15 In The Development And Treatment Of Hematological Malignancies, Paola Sindaco, Hritisha Pandey, Colleen Isabelle, Nitin Chakravarti, Jonathan Edward Brammer, Pierluigi Porcu, Anjali Mishra

Kimmel Cancer Center Faculty Papers

Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.

Faculty Senate Meeting Minutes April 20, 2023, University Of Rhode Island Faculty Senate

Faculty Senate Meeting Minutes

No abstract provided.

Faculty Senate Meeting Agenda April 20, 2023, University Of Rhode Island Faculty Senate

Faculty Senate Meeting Agendas

No abstract provided.

Montana Kaimin, April 20, 2023, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Law School News: Joyce And Bill Cummings Of Cummings Foundation To Deliver Keynote Address At Rwu Commencement 4-20-2023, Jill Rodrigues

Life of the Law School (1993- )

No abstract provided.

The Legacy Of Colonization And Civil Societies In South Africa, Erika Frydenlund, Melissa Miller-Felton, Bolu Ayankojo

Modeling, Simulation and Visualization Student Capstone Conference

This research analyzes the unique ways that civil societies operate in Sub-Saharan Africa in the context of post-apartheid Cape Town, South Africa. Decades after the demise of apartheid, remnants of inequality remain without the promise of actionable change. We used a computational modeling approach to understand the dynamics of migrants in the receiving community as derived from qualitative interviews conducted with 24 stakeholders in Cape Town, South Africa between 2020 and 2021. Our findings show that the presence of NGOs can promote access to resources and reduce xenophobia if they can have the right influence on government policies.

Lidar Buoy Detection For Autonomous Marine Vessel Using Pointnet Classification, Christopher Adolphi, Dorothy Dorie Parry, Yaohang Li, Masha Sosonkina, Ahmet Saglam, Yiannis E. Papelis

Modeling, Simulation and Visualization Student Capstone Conference

Maritime autonomy, specifically the use of autonomous and semi-autonomous maritime vessels, is a key enabling technology supporting a set of diverse and critical research areas, including coastal and environmental resilience, assessment of waterway health, ecosystem/asset monitoring and maritime port security. Critical to the safe, efficient and reliable operation of an autonomous maritime vessel is its ability to perceive on-the-fly the external environment through onboard sensors. In this paper, buoy detection for LiDAR images is explored by using several tools and techniques: machine learning methods, Unity Game Engine (herein referred to as Unity) simulation, and traditional image processing. The Unity Game …

Factors That Influence The Recruitment And Retention Of Civil Engineers, Gina Young Souriac

Theses and Dissertations

With a growing demand for civil engineers in the United States, understanding factors that influence students to choose civil engineering (CE) as a major in college, pursue an M.S. degree in CE, and persist in the CE industry can lead to valuable insights for recruitment and retention of future and current civil engineers. Additionally, understanding factors that prominently influence male and female civil engineers to persist in and depart from CE, separately, can lead to valuable insight towards improving focused recruitment and retention of both genders. This thesis includes three research studies that identify, analyze, and discuss these important factors. …

Consensus On The Ras Dimerization Hypothesis: Strong Evidence For Lipid-Mediated Clustering But Not For G-Domain-Mediated Interactions, Dhirendra K Simanshu, Mark R Philips, John F Hancock

Faculty, Staff and Student Publications

One of the open questions in RAS biology is the existence of RAS dimers and their role in RAF dimerization and activation. The idea of RAS dimers arose from the discovery that RAF kinases function as obligate dimers, which generated the hypothesis that RAF dimer formation might be nucleated by G-domain-mediated RAS dimerization. Here, we review the evidence for RAS dimerization and describe a recent discussion among RAS researchers that led to a consensus that the clustering of two or more RAS proteins is not due to the stable association of G-domains but, instead, is a consequence of RAS C-terminal …

New Physics In The Age Of Precision Cosmology, Vivian I. Sabla

Dartmouth College Ph.D Dissertations

The Lambda-cold dark matter (LCDM) model has become the standard model of cosmology because of its ability to reproduce a vast array of cosmological observations, from the earliest moments of our Universe, to the current period of accelerated expansion, which it does with great accuracy. However, the success of this model only distracts from its inherent flaws and ambiguities. LCDM is purely phenomenological, providing no physical explanation for the nature of dark matter, responsible for the formation and evolution of large-scale structure, and giving an inconclusive explanation for dark energy, which drives the current period of accelerated expansion.

Furthermore, cracks …

The Kenyon Collegian - April 20, 2023

The Kenyon Collegian

No abstract provided.

Measuring Perceived Stress Levels And Adaptive Coping Strategies In Undergraduate College Students: A Quasi-Experimental Study, Sarah Milner

Dissertations, Theses, and Projects

This study aimed to analyze changes in perceived stress and physiological variables in undergraduate students and identify preferred adaptive coping strategies utilized over one semester. Additionally, the study aimed to assess the impact of demographic factors on the students' perception of stress. A quasi-experimental study was conducted using non-random convenience sampling with 30 undergraduate students enrolled in an Introduction to Stress Management class at a small, regional institution in the upper Midwest in the fall of 2022.

Data collection included the use of the Perceived Stress Scale (i.e., PSS-10), stress physiological variables (e.g., heart rate), demographic characteristics (e.g., sex, relationship …

Breakthrough Mechanism Of “Stuck Neck” Technology: “Situation-Strategy” Asymmetric Matching Perspective, Rongjian Yu, Yaping Wang, Yizhi Zhao, Wei Bai

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the dual background of the impact of the epidemic and anti-globalization, the technical problem of “stuck neck” is a major practical problem that China urgently needs to solve. Existing researches lack a structured theoretical framework to solve the technical problem of “stuck neck”, and overlooked the analysis of the situation-dependent mechanism of “stuck neck” technologies. This study evaluates the technical situation from the two dimensions of the technical capability base and the dynamic of the technical paradigm, constructs a “stuck neck” technology cracking strategy matrix from the technical category and technology track, integrates the two categories of the technical …

Disciplinary System, Academic System And Discourse System Of Technological Sciences, Zhongkai Yang, Deming Lin, Yongxia Liang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In 1957, Tsien Hsue-shen published an article entitled “On the Technological Sciences” in Chinese Science Bulletin, which laid the foundation for the research of technological sciences in China. However, in the following 60 years, the thought of technological sciences failed to receive stable attention and support. It was not until 2021 when General Secretary Xi Jinping made another important statement at the 20th Academician Conference of the Chinese Academy of Sciences, the 15th Academician Conference of the Chinese Academy of Engineering, and the 10th National Congress of the China Association for Science and Technology that technological sciences had entered into …

Deprofessionalism At The Reference Desk: Validating Room For The New And Evolving Roles Of The Information Professional, Jameson Paul Ghalioungui

Library Philosophy and Practice (e-journal)

The colloquially named reference desk at public libraries is the quintessential meeting point between patron and librarian. In fact, the desk “remains a tangible symbol of [the librarian’s] mission and work” (Johnson, 2019, p. 92). However, many researchers have questioned the purpose and value of the desk in the “changing reference landscape” (Cassell and Hiremath, 2018, p. 3). The purpose of this paper, therefore, is to explore this changing reference landscape more in depth, what reference services really are, and to reiterate the distinction between a professional librarian (or information professional) and a paraprofessional. A small amount of research serves …

Circadian Clock Control Of Mrtf/Srf Pathway Suppresses Beige Adipocyte Thermogenic Recruitment, Xuekai Xiong, Weini Li, Ruya Liu, Pradip Saha, Vijay Yechoor, Ke Ma

Faculty, Staff and Students Publications

The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor (MRTF)/serum response factor (SRF) activity. Circadian clock confers temporal control in adipogenic differentiation, while the actin cytoskeleton-MRTF/SRF signaling transduces extracellular physical niche cues. Here, we define a novel circadian transcriptional control involved in actin cytoskeleton-MRTF/SRF signaling cascade that modulates beige fat thermogenic function. Key components of actin dynamic-MRTF/SRF pathway display circadian regulation in beige fat depot. The core clock regulator, brain and muscle arnt-like 1 (Bmal1), exerts direct transcriptional control of genes within the actin dynamic-MRTF/SRF cascade that impacts actin …

Cerebral Oximetry Monitoring In Extremely Preterm Infants, Mathias L Hansen, Zachary Vesoulis, Et Al.

2020-Current year OA Pubs

BACKGROUND: The use of cerebral oximetry monitoring in the care of extremely preterm infants is increasing. However, evidence that its use improves clinical outcomes is lacking.

METHODS: In this randomized, phase 3 trial conducted at 70 sites in 17 countries, we assigned extremely preterm infants (gestational age, <28 weeks), within 6 hours after birth, to receive treatment guided by cerebral oximetry monitoring for the first 72 hours after birth or to receive usual care. The primary outcome was a composite of death or severe brain injury on cerebral ultrasonography at 36 weeks' postmenstrual age. Serious adverse events that were assessed were death, severe brain injury, bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, and late-onset sepsis.

RESULTS: A total of 1601 infants underwent randomization and 1579 (98.6%) were evaluated for the primary outcome. At 36 weeks' postmenstrual age, death or severe brain injury had occurred in 272 of 772 infants (35.2%) in the cerebral oximetry group, as compared with 274 of 807 infants (34.0%) in the usual-care group (relative …

Mutational Analysis Of Anesthetic Binding Sites And Their Effects On Gabaa Receptor Activation And Modulation By Positive Allosteric Modulators Of The Α7 Nicotinic Receptor, Spencer R Pierce, Allison L Germann, Sophia Q Xu, Saumith L Menon, Marcelo O Ortells, Hugo R Arias, Gustav Akk

2020-Current year OA Pubs

The positive allosteric modulators (PAMs) of the α7 nicotinic receptor

April 20, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Legal Scholars Weigh In On The Lasting Significance Of Dominion V. Fox, Samantha Barbas, Martin Garbus, Lyrissa Lidsky, Timothy Zick, Sandra Baron

Popular Media

No abstract provided.

Ppgpp And Rna-Polymerase Backtracking Guide Antibiotic-Induced Mutable Gambler Cells, Yin Zhai, P J Minnick, John P Pribis, Libertad Garcia-Villada, P J Hastings, Christophe Herman, Susan M Rosenberg

Faculty, Staff and Students Publications

Antibiotic resistance is a global health threat and often results from new mutations. Antibiotics can induce mutations via mechanisms activated by stress responses, which both reveal environmental cues of mutagenesis and are weak links in mutagenesis networks. Network inhibition could slow the evolution of resistance during antibiotic therapies. Despite its pivotal importance, few identities and fewer functions of stress responses in mutagenesis are clear. Here, we identify the Escherichia coli stringent starvation response in fluoroquinolone-antibiotic ciprofloxacin-induced mutagenesis. Binding of response-activator ppGpp to RNA polymerase (RNAP) at two sites leads to an antibiotic-induced mutable gambler-cell subpopulation. Each activates a stress response …

Identifying Features And Predicting Consumer Helpfulness Of Product Reviews, Triston Hudgins, Shijo Joseph, Douglas Yip, Gaston Besanson

SMU Data Science Review

Major corporations utilize data from online platforms to make user product or service recommendations. Companies like Netflix, Amazon, Yelp, and Spotify rely on purchasing trends, user reviews, and helpfulness votes to make content recommendations. This strategy can increase user engagement on a company's platform. However, misleading and/or spam reviews significantly hinder the success of these recommendation strategies. The rise of social media has made it increasingly difficult to distinguish between authentic content and advertising, leading to a burst of deceptive reviews across the marketplace. The helpfulness of the review is subjective to a voting system. As such, this study aims …