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Lipid Deposition In Beef Cattle, Kyra L. Elliott May 2026

Lipid Deposition In Beef Cattle, Kyra L. Elliott

Department of Animal Science: Dissertations, Theses, and Student Research

Both the amount and types of lipid deposition in beef cattle are key determinants of carcass value and meat quality. Amounts of intramuscular, subcutaneous, and visceral fat influence carcass grading outcomes, palatability, and composition traits that are important to beef producers as well as consumers. The objectives of this thesis were to: 1) compare beef grading camera estimates of intramuscular fat to amounts of chemically extractable lipid, 2) characterize the lipidomes of beef intramuscular fat, subcutaneous fat, and lean muscle using shotgun lipidomics, and 3) identify and characterize a novel genetic variant in cattle that may have important implications for …


The "Evil Forest" As Threshold: A Computational Eco-Feminist Study Of The Forest In Nigerian Fantasy, Cynthia O. Mbagwu May 2026

The "Evil Forest" As Threshold: A Computational Eco-Feminist Study Of The Forest In Nigerian Fantasy, Cynthia O. Mbagwu

Department of English: Dissertations, Theses, and Student Research

This study examines the representation of the “evil forest” in Nnedi Okorafor’s Zahrah the Windseeker and Ukamaka Olisakwe’s Don’t Answer When They Call Your Name, arguing that the forest functions as a liminal threshold that catalyses female transformation. Combining close reading with computational tools like TF-IDF keyword extraction in Ruby and sentiment analysis using VADER, the project investigates how pre-colonial and colonial connotations of the “evil forest” are re-imagined in contemporary Nigerian fantasy fiction. By segmenting each narrative into pre-liminal, liminal, and post-liminal phases, the study tracks shifts in sentiment toward the forest and correlates them with thematic developments …


Factors Affecting The Efficacy Of Free Choice Vitamin & Mineral Supplementation Programs, Tanner K. Wansing May 2026

Factors Affecting The Efficacy Of Free Choice Vitamin & Mineral Supplementation Programs, Tanner K. Wansing

Department of Animal Science: Dissertations, Theses, and Student Research

While free choice vitamin and mineral supplements are widely used within the cow/calf sector, large knowledge gaps exist around the proper management of those supplements. This thesis discusses two factors affecting the efficacy of supplementation. The first interest was the stability of vitamin A when stored with a common free choice mineral supplement. This research addressed a critical data gap by generating information on vitamin A stability within the beef industry, as current data are predominantly based in the swine industry. Vitamin A was discovered to be stable until 4 months of storage regardless of storage conditions, whereas after 4 …


Cytoplasmic Shift Of Interferon Regulatory Factors Co‐Evolved With Jawed Vertebrate Innate Immunity, Vanessa M. Hubing May 2026

Cytoplasmic Shift Of Interferon Regulatory Factors Co‐Evolved With Jawed Vertebrate Innate Immunity, Vanessa M. Hubing

Honors Program: Senior Projects (Public)

The emergence of jaws in early vertebrates introduced a novel feeding apparatus and powerful oral defenses, but it also increased the risk of physical injury and pathogen exposure. Interferon regulatory factors (IRFs) play critical roles in orches-trating innate immunity and inflammation in response to invading microbes and tissue damage, with their subcellular local-ization being essential to some IRFs' function. Our results indicate that IRF members underwent independent expansion and diversification in two distinct vertebrate lineages: jawed and jawless vertebrates. The jawed vertebrate-specific factor, IRF5, has maintained conserved nuclear export sequences throughout evolution, while newly diversified IRF members in jawed verte-brates …


Transforming Theory Into Action: Feminist Frameworks In Reproductive Justice Organizing, Ella R. Mitchell May 2026

Transforming Theory Into Action: Feminist Frameworks In Reproductive Justice Organizing, Ella R. Mitchell

Honors Program: Senior Projects (Public)

This honors thesis examines how feminist theoretical frameworks can be translated into practical strategies for reproductive justice organizing. Grounded in a reproductive justice framework and drawing on three key feminist frameworks, intersectional feminism, queer feminist theory, and feminist ethics of care, this paper explores how each provides critical tools for understanding and responding to reproductive oppression. Intersectional feminism illuminates how overlapping systems of inequality structure reproductive experiences and political marginalization. Queer feminist theory challenges heteronormative assumptions about family, gender, and reproduction, expanding reproductive justice discourse to include LGBTQ+ communities and diverse forms of kinship. Feminist ethics of care emphasizes relational …


Piano Composition And The Role Of Women In Nineteenth Century Europe, Khang Nguyen May 2026

Piano Composition And The Role Of Women In Nineteenth Century Europe, Khang Nguyen

Honors Program: Senior Projects (Public)

In the nineteenth century, women underwent a social transition, slowly obtaining more employment and educational opportunities. The lives of women piano composers were similar, with their status as women affecting their compositional careers. This thesis explores the connection between piano composition and the role of women in the nineteenth century, with a focus on Western Europe. A brief history of Europe in the nineteenth century will be given, followed by an overview on how music and the music industry were gendered at the time. Then, the lives of Clara Schumann, Fanny Hensel, and Agathe Backer Grøndahl will be analyzed as …


The Consumptive Female Ideal: The Case Study Of “Snow White”, Nayla G. Torres Ruiz May 2026

The Consumptive Female Ideal: The Case Study Of “Snow White”, Nayla G. Torres Ruiz

Honors Program: Senior Projects (Public)

Tuberculosis (TB), also known as “consumption” or “phthisis,” was one of the most pervasive and culturally significant diseases of the eighteenth and nineteenth centuries. Despite its high mortality rate—claiming more lives than cholera and smallpox combined—TB was widely romanticized in art, literature, and popular culture, particularly as a feminine disease associated with beauty, purity, fragility, and moral virtue. The physical traits of consumption—pale skin, rosy cheeks, red lips, glassy eyes, and a slender, delicate frame—became an ideal of female beauty, one that many women sought to emulate through restrictive diets, toxic cosmetics, and evolving fashion trends, such as increasingly tight …


Killing The Hot Vampire: Gender, Camp, And The Stakes Of Desire In Nineteenth-Century Vampire Fiction, Ella G. Kehr May 2026

Killing The Hot Vampire: Gender, Camp, And The Stakes Of Desire In Nineteenth-Century Vampire Fiction, Ella G. Kehr

Department of English: Dissertations, Theses, and Student Research

This thesis examines the representation and destruction of the Hot Vampire in nineteenth-century vampire fiction, focusing on Dracula (1897), Carmilla (1872), and The Blood of the Vampire (1897). It argues that these texts construct the female vampire as a figure of excessive sexuality, independence, and deviance which causes both societal (patriarchal) and narrative disruption. In the male-authored texts, the construction of the Hot Vampire is exaggerated beyond the neat bounds of gothic excess and monster theory. The destruction of these vampires also follows this unbound extravagance. The Hot Vampire’s death becomes the ritualized restoration of patriarchal order, which is often …


Kroc Ipj Border Fellows Report 2024 — English, Rebeca Cázares Adame May 2026

Kroc Ipj Border Fellows Report 2024 — English, Rebeca Cázares Adame

Kroc IPJ Research and Resources

The Kroc Border Fellows Program brings together change agents from academia, civil society, the public sector, and the private sector to build a more inclusive and peaceful Mexico-U.S. border region through action-oriented research and meaningful community partnerships.

The non-residential fellowship spans 10 months and provides financial and technical support for Fellow-designed and -implemented projects. This model reflects a core belief that those closest to border communities' challenges are best positioned to develop effective solutions — and that lasting change must be built on existing community assets and strengths.

Throughout the fellowship, cohort members meet regularly to foster collaboration, mutual learning, …


Understanding The Equestrian Learner: A Sociomaterial Analysis Of Equestrian Learners, Anna Lloyd May 2026

Understanding The Equestrian Learner: A Sociomaterial Analysis Of Equestrian Learners, Anna Lloyd

All Graduate Theses and Dissertations, Fall 2023 to Present

Limited research has been done on equestrian riders actively participating in training programs. To better understand these equestrians, this study examined how elements in their learning environments influenced their learning. Data was collected through interviews with two active, competing adult female members of the United States Hunter Jumper Association. Key findings from analyzing these equestrians’ relationships with different elements in their learning environment include the finding that equestrians shift between viewing horses as material objects or social partners, depending on the context. It was also seen that an equestrian’s skill is not dependent solely on the rider, but is influenced …


Investigating Utah's Watershed Restoration Initiative: A Qualitative Case Study Of A State-Managed Collaborative Platform, Casey Trout May 2026

Investigating Utah's Watershed Restoration Initiative: A Qualitative Case Study Of A State-Managed Collaborative Platform, Casey Trout

All Graduate Theses and Dissertations, Fall 2023 to Present

Collaboration is necessary to address complex, cross-jurisdictional natural resource problems. To better understand the benefits and drawbacks of innovative collaborative structures, this research examined the Utah Watershed Restoration Initiative (WRI). WRI is a state-managed program in Utah that implements cross-boundary habitat restoration projects. Local, state, and federal government agencies as well as non-profit organizations convene on five regional teams to design and evaluate projects. Project partners are engaged at a local level while most program administration occurs at the state level. A case study of WRI was conducted, making use of interviews with 33 participants, document review, and field observations. …


The Dark Side Of Sport: Exploring Conceptualizations And Operationalizations Of Authority Figure-Athlete Abuse, Katherine Nicole Alexander May 2026

The Dark Side Of Sport: Exploring Conceptualizations And Operationalizations Of Authority Figure-Athlete Abuse, Katherine Nicole Alexander

All Graduate Theses and Dissertations, Fall 2023 to Present

Although sport can be a fun and positive environment, it can also be a unique and common setting for athlete abuse. Coaches and other authority figures can serve in positive and negative caregiving roles, and many athletes report experiencing at least one form of abuse perpetrated by these important authorities during their sporting careers. We have less research on experiences of abuse in athletes from the United States. The current dissertation was designed to explore ways to more effectively and accurately define and measure athlete abuse perpetrated by authorities and coaches among adults in the United States. Given that there …


Effects Of Mineral Supplementation On Ovine Performance, Forage Selectivity, And Rangeland Utilization In Southern Utah, Ryan A. Spurling May 2026

Effects Of Mineral Supplementation On Ovine Performance, Forage Selectivity, And Rangeland Utilization In Southern Utah, Ryan A. Spurling

All Graduate Theses and Dissertations, Fall 2023 to Present

Sheep producers in the Intermountain West region of the US rely on productive rangeland ecosystems that vary widely in forage composition and nutrient availability. As such, supplementation is often necessary to offset dietary deficiencies. Soils and forages grown on rangelands are known to be highly variable in mineral content. Even so, a third to half of the producers in the Intermountain West choose not to provide a complete mineral supplement. Rangeland environments are often characterized by rugged geographical features that make optimal supplement placement difficult. New advances in technology have allowed us to measure individual animal intake on rangelands via …


The Impact Of Parental Infidelity During Childhood On Emerging Adult Relationships, Rachel Anderson May 2026

The Impact Of Parental Infidelity During Childhood On Emerging Adult Relationships, Rachel Anderson

All Graduate Theses and Dissertations, Fall 2023 to Present

In this master’s thesis, I collected and analayzed data from 429 participants, 78 of whom reported having experience with parental infidelity, namely having at least one parent be sexually unfaithful to the other. The purpose of this study was to better understand the long-term impacts of experiencing parental infidelity during childhood. Participants with and without experience of parental infidelity were invited to complete an online questionnaire about potential experiences with parental infidelity, emotional well-being, attachment security in adult romantic relationships, couple satisfaction with current romantic partner, and attitudes (permissive versus accepting) towards potentially unfaithful behaviors of infidelity and pornography. I …


Domestic Cow Of Plenty: Gender And Womanhood In The Bhāgavata Purāṇa, Harshika Ajay Gupta May 2026

Domestic Cow Of Plenty: Gender And Womanhood In The Bhāgavata Purāṇa, Harshika Ajay Gupta

All Graduate Theses and Dissertations, Fall 2023 to Present

This thesis examines gender and womanhood in the Bhāgavata Purāṇa (Bhāgavata), a Sanskrit text from the 10th century CE that holds an important theological and cultural position in contemporary Hindu traditions. It decodes the Bhāgavata’s unique perspectives on the following: (1) gender, sex, sexuality, and reproduction, (2) women’s social normativity, and (3) women’s personhood and agency. This thesis argues that the Bhāgavata contains a unique theorization of gender and sex as well as a positive valuation of femininity, and that it imbues its narratives with practical resources and actions to recognize and expand the agentive capacity of women.

For scholars …


It's Okay, I'M Fine: A Communication Approach To Masculinity, Vulnerability, And Emotional Intimacy In Male Friendships, Nathan M. Spencer May 2026

It's Okay, I'M Fine: A Communication Approach To Masculinity, Vulnerability, And Emotional Intimacy In Male Friendships, Nathan M. Spencer

All Graduate Theses and Dissertations, Fall 2023 to Present

Vulnerability is a key part of any relationship, as it allows people to feel more connected and closer to one another. However, toxic masculine norms are inhibiting men from being vulnerable in their relationships, especially in their friendships with other men. This study seeks to explore how vulnerable communication can lead to increased feelings of emotional intimacy and partner responsiveness within male friendships, even when it goes against the person’s expectations. Findings suggest that when a man is exposed to a vulnerable message, he will perceive an increase in both emotional intimacy and partner responsiveness. Another factor was that when …


The Rhythm Of Reform, Michael Waldman May 2026

The Rhythm Of Reform, Michael Waldman

Cardozo Law Review

This year, we celebrate the 250th anniversary of our independence. In January 1776, Thomas Paine published Common Sense. Paine was an immigrant who had arrived only two years before. The pamphlet went viral, a widely bootlegged bestseller with 120,000 copies sold in its first three months in print. It galvanized support for independence and argued that the collection of colonies should become a republic. Paine wrote: “[I]n America THE LAW IS KING.”

Is that still true? We are finding out.

Today our Constitution and the institutions of self-government face extraordinary pressure. In the first two months of 2026 alone, …


Saying What The Law Might Be? Courts, Geofence Warrants, And The Fourth Amendment Labyrinth, Ciara Lavin May 2026

Saying What The Law Might Be? Courts, Geofence Warrants, And The Fourth Amendment Labyrinth, Ciara Lavin

Cardozo Law Review

Since 2016, Google has received thousands of geofence warrant requests from law enforcement, requesting Google to scan through its vast database of users to identify who and what devices entered into, or exited out of, a set of coordinates in a specified period of time. Several cases began making their way through the federal courts to delineate the legality of such warrants—with challenges spanning the vast amount of data they search, their relative accuracy, and whether they comported with the Fourth Amendment. Then, in the summer of 2024, two federal appellate courts handed down decisions just weeks apart: the Fourth …


The Camus Initiative: A Multiphase, Multicentre International Collaboration To Redefine Risk Stratification, Reporting, And Grading Of Surgical Complications In Urology., Christopher Soliman, Niranjan J. Sathianathen, Niall M. Corcoran, Nathan Lawrentschuk, Patrick Y. Wuethrich, Marc A. Furrer, Paul Chung, Camus Study Group Collaborators May 2026

The Camus Initiative: A Multiphase, Multicentre International Collaboration To Redefine Risk Stratification, Reporting, And Grading Of Surgical Complications In Urology., Christopher Soliman, Niranjan J. Sathianathen, Niall M. Corcoran, Nathan Lawrentschuk, Patrick Y. Wuethrich, Marc A. Furrer, Paul Chung, Camus Study Group Collaborators

Department of Neurology Faculty Papers

Surgical complications remain a major source of preventable morbidity, mortality, and health care expenditure, but existing frameworks such as the Clavien-Dindo classification and Comprehensive Complication Index are clinician-centred and intervention-focused and fail to capture cumulative patient-centred outcomes. This protocol outlines the Complications After Major and Minor Urological Surgery (CAMUS) initiative, a global, multiphase effort to redefine complication reporting, risk stratification, and outcome measurement in urological surgery. CAMUS aims to address these limitations via an integrated, seven-arm programme combining retrospective and prospective data analysis, consensus development, and digital infrastructure design. Arm 1 has assembled a retrospective data set of 130 034 …


Faculty Memorandum Of Understanding, Sample, Oerfsj May 2026

Faculty Memorandum Of Understanding, Sample, Oerfsj

OERFSJ Templates & Resources

The memorandum of understanding between faculty and OER for Social Justice administration were designed specifically for the federally-funded grant project and underwent full institutional approval including with the Office of Research, Grants, and Sponsored Programs, human resources, and risk management. Adopters should consult with their own institutional administration before using the form. Faculty participants completed the form every year of the grant.


“Healing Symbols For Trauma”: The Role Of Art In Healing From Psychological Trauma And Post Traumatic Stress Disorder (Ptsd) Engaging Carl Gustav Jung’S Appropriation Of The Spiritual Exercises Of St. Ignatius Of Loyola, Ricardo Sebastian Nogueiro May 2026

“Healing Symbols For Trauma”: The Role Of Art In Healing From Psychological Trauma And Post Traumatic Stress Disorder (Ptsd) Engaging Carl Gustav Jung’S Appropriation Of The Spiritual Exercises Of St. Ignatius Of Loyola, Ricardo Sebastian Nogueiro

Jesuit School of Theology Dissertations

In society individuals experience trauma at least once in their lifetime which makes the experience of trauma pervasive. This thesis explores the role that art forms play in psychological and spiritual healing from trauma and PTSD. Psychological trauma and PTSD have become more prevalent in society with reliance on largely psychological approaches to healing while neglecting the spiritual dimension. This study proposes a complementary method to Cognitive Behavioral Therapy (CBT) for psycho-spiritual healing through an integration of art, psychoanalysis, and Christian spirituality, one which restores personal agency. Engaging the trauma afflicted with art forms can serve as a medium for …


Rise Pilot Teacher Implementation, Jennifer Sdunzik May 2026

Rise Pilot Teacher Implementation, Jennifer Sdunzik

Evaluation and Learning Research Center Reports

Project RISE aims to address civic opportunity and achievement gaps faced by underserved populations by integrating engineering design thinking with civic education in US middle and high schools. The curriculum uses a focus on community-based problem-solving as a mechanism for inspiring and empowering students – particularly those from traditionally underserved backgrounds – to engage in activities aimed at addressing systemic inequities in their communities. Following a week-long professional development in the summer 2024, the participating pilot teachers were tasked with implementing lessons plans and teaching practices from the RISE curriculum and reflect upon their classroom experiences post-implementation.


Scrolling Critically: Momfluencers As Sites Of Composition, Rhetoric, And Pedagogical Insight, Sarah A. O'Neill May 2026

Scrolling Critically: Momfluencers As Sites Of Composition, Rhetoric, And Pedagogical Insight, Sarah A. O'Neill

All NMU Master's Theses

This thesis critically examines the practices of Momfluencers–social media influencers who blend maternal identity with lifestyle branding–to inform pedagogy for aspiring digital professionals, particularly college students preparing for careers in social media.

Chapter 1 establishes a theoretical framework, drawing on multimodal literacy and Mikhail Bahktin’s concept of heteroglossia to analyze how meaning is constructed across platforms. Chapter 2 investigates the rhetorical and compositional strategies Momfluencers use on platforms such as Instagram and TikTok, highlighting how authenticity, professional obligations, and audience expectations intersect with platform-specific features and algorithmic mediation. Chapter 3 presents findings from a classroom study, emphasizing the literacies required …


Tau Beta Pi Engineering Mentorship Program, Tyler Black May 2026

Tau Beta Pi Engineering Mentorship Program, Tyler Black

Undergraduate Honors Capstone Projects

The purpose of this project is to design and implement a student-led engineering mentorship program directed by the members of the Utah Gamma Chapter of Tau Beta Pi on the Utah State University (USU) Logan campus. Retention data show that many undergraduate students who start engineering programs change their degree before graduation due to academic and social challenges that may be mitigated by the support of a peer mentor. The Tau Beta Pi Engineering Mentorship Program selects and trains upperclassman mentors to effectively mentor underclassman engineering students.

The design of the mentorship program is an application of backward design, where …


Ccr5 Sulfopeptide Library And O-Glycosylated Amino Acids As Chemical Tools For Probing Chemokine Receptor Recognition, Mostafa Mohammed Mohammed Ali Eldeen May 2026

Ccr5 Sulfopeptide Library And O-Glycosylated Amino Acids As Chemical Tools For Probing Chemokine Receptor Recognition, Mostafa Mohammed Mohammed Ali Eldeen

Electronic Theses and Dissertations

Chemokine-receptor interactions play a central role in immune regulation and disease pathogenesis, particularly through CCR5, a receptor engaged by chemokines such as CCL3, CCL4, and CCL5. Post-translational modifications of the CCR5 N-terminus—including tyrosine sulfation at positions 3, 10, 14, and 15, and O-glycosylation at serine 6—critically modulate chemokine recognition and selectivity. However, the impact of specific sulfation patterns on chemokine binding and the synergistic effects of combined sulfation and glycosylation remain incompletely understood. This thesis presents a two-project chemical approach to systematically investigate CCR5 post-translational modifications. In Project 1, a comprehensive 16-member library of CCR5???? sulfopeptides representing all possible combinations …


A Revised Quantifier Variance And Its Implications On Vagueness, Isaac Alexander Huling May 2026

A Revised Quantifier Variance And Its Implications On Vagueness, Isaac Alexander Huling

Electronic Theses and Dissertations

This paper argues that the Special Composition Question has no substantive answer, not because compositional talk is empty but because the physical structure it tracks does not have the form that would privilege a unique answer. The argument accepts Sider’s methodological premise that the world must provide structure beyond description if ontological vocabulary is to mean anything, and deploys that apparatus against his specific application of it to composition. Constraint processes among a system’s parts – the forces and interactions that hold rigid bodies together, maintain organisms, bind solar systems – satisfy every condition Lewis required of reference magnets. They …


Murdoch's Metaphorical And Mystical Moral Metaphysics, William Jade Langley May 2026

Murdoch's Metaphorical And Mystical Moral Metaphysics, William Jade Langley

Electronic Theses and Dissertations

In this project, I explain the mysticism found in Iris Murdoch’s The Sovereignty of Good, emphasizing what the illustrative thought experiments and metaphors are meant to explain. To do this, I introduce her understanding of G. E Moore’s moral realism and compare this with how Bertrand Russell understands mystical intuition and revelation. Then, to understand how we can still do moral philosophy when morality is fundamentally mystical, I compare Murdoch’s usage of metaphor with that of Victoria Welby, who also takes metaphorical understanding to be crucial to our understanding of the world. Though Welby goes further than Murdoch in saying …


Media Framing Of Peace And Justice In Post Conflict Societies: Rwanda And Colombia In Focus, Ahmer Anwar Khan May 2026

Media Framing Of Peace And Justice In Post Conflict Societies: Rwanda And Colombia In Focus, Ahmer Anwar Khan

Electronic Theses and Dissertations

This study investigates how traditional journalism frames peace and justice in post-conflict societies, using Rwanda and Colombia as comparative case studies. It explores the role of media in shaping public discourse around transitional justice, reconciliation, and national healing. The findings indicate that Rwanda’s media adopted a justice-first framing, emphasizing accountability and moral restoration through mechanisms such as the International Criminal Tribunal for Rwanda (ICTR) and the Gacaca courts. In contrast, Colombian journalism during the 2012–2016 peace negotiations with the FARC guerrilla group prioritized peace-first framing, portraying dialogue and reintegration as essential to ending decades of violence. These divergent approaches reflect …


Secondary English Teachers’ Perceptions Regarding The Impact, If Any, Of Shifts In The Emphasis Of History Education On Students’ Comprehension Of Literature, Bailey J. Poole May 2026

Secondary English Teachers’ Perceptions Regarding The Impact, If Any, Of Shifts In The Emphasis Of History Education On Students’ Comprehension Of Literature, Bailey J. Poole

Electronic Theses and Dissertations

This qualitative study explored secondary English teachers’ perceptions of the emphasis on history education and its perceived impact on their students’ comprehension of literature. This research used an interpretivist approach and a conceptual framework shaped by schema theory and constructivism to understand whether teachers perceived a shift in the value of history education, how they described such shifts, if any, and how they responded instructionally to those shifts, if necessary.

Data was collected through six semi-structured interviews with 11th and 12th grade English Language Arts teachers from public high schools in Mississippi, each with a minimum of ten years teaching …


Establishing Caenorhabditis Elegans As A Platform For Bioaccumulation And Selectivity Screening Of Anthelmintic Compounds, Jiarui Li May 2026

Establishing Caenorhabditis Elegans As A Platform For Bioaccumulation And Selectivity Screening Of Anthelmintic Compounds, Jiarui Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

To address the cuticular barrier in anthelmintic discovery, this study establishes a bifurcated framework in Caenorhabditis elegans. First, HPLC-based quantification of 14 PIM inhibitors revealed that cuticular penetrance is primarily dictated by phylogenetic lineage (Clade V) rather than ecological niche. Specifically, C. elegans demonstrated a significant pharmacokinetic correlation with the hookworm Ancylostoma ceylanicum (Clade V) but not the whipworm Trichuris muris (Clade I), validating it as a superior surrogate model for hookworm bioaccumulation. Within this small molecule inhibitor library, SGI-12was identified as a lead candidate with superior potency against C. elegans and bioaccumulation. Second, target validation using a C. …