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Dietary Inflammatory Index Score And Its Association With Body Mass Index, Body Fat Percentage, Body Fat Mass, And Lipid Profile In Patients With Multiple Sclerosis, Seda Kaya, Zeynep Uzdi̇l, Ni̇ti̇n Shi̇vappa, James R. Hebert, Pinar Sökülmez Kaya, Murat Terzi̇ Oct 2023

Dietary Inflammatory Index Score And Its Association With Body Mass Index, Body Fat Percentage, Body Fat Mass, And Lipid Profile In Patients With Multiple Sclerosis, Seda Kaya, Zeynep Uzdi̇l, Ni̇ti̇n Shi̇vappa, James R. Hebert, Pinar Sökülmez Kaya, Murat Terzi̇

Turkish Journal of Medical Sciences

Background/aim: Multiple sclerosis (MS) may cause modifications in body composition, particularly for body fat associated with obesity and some biochemical parameters such as lipid profiles. We investigated whether there is a link between the inflammatory contents of diets and body composition and lipid profiles in patients with MS. Materials and methods: This was a cross-sectional study that included 85 MS patients. The study data of the patients were collected in the Neurology Clinic of Ondokuz Mayıs University?s Health Practice and Research Center. The data included demographic characteristics; anthropometric measurements such as body weight, height, body mass index, waist circumference, hip …


Effects Of Vitrification Solution Supplemented With Platelet-Rich Plasma In Rat Ovarian Tissue Cryopreservation, Ayli̇n Gökhan, Türker Çavuşoğlu, Kubi̇lay Doğan Kiliç, Cansin Şi̇ri̇n, Canberk Tomruk, Gürkan Yi̇ği̇ttürk, Oytun Erbaş, Eser Sözmen, Meral Baka Oct 2023

Effects Of Vitrification Solution Supplemented With Platelet-Rich Plasma In Rat Ovarian Tissue Cryopreservation, Ayli̇n Gökhan, Türker Çavuşoğlu, Kubi̇lay Doğan Kiliç, Cansin Şi̇ri̇n, Canberk Tomruk, Gürkan Yi̇ği̇ttürk, Oytun Erbaş, Eser Sözmen, Meral Baka

Turkish Journal of Medical Sciences

Background/aim: The subject of this study was to investigate the utility of platelet-rich plasma (PRP) in the cryopreservation process to reduce cryodamage and increase tissue viability. Materials and methods: Twenty-one female Wistar rats were randomly allocated to three groups. In Group 1 (G1), rats were not subjected to vitrification (n = 7). Group 2 (G2) was the vitrification group in which PRP was added to the basic vitrification solution (n = 7). Group 3 (G3) was the vitrification group in which fetal bovine serum was added to the basic vitrification solution (n = 7). Warmed tissues were evaluated with histochemical …


Evaluation Of Vitamin D Levels And Biochemical Markers In Infants Diagnosed With Laryngomalacia, Nagi̇han Bi̇lal, Ömer Faruk Çinar, Sevcan İpek, Muhammed Seyi̇thanoğlu, Adem Doğaner, Muhammed Gazi̇ Yildiz Oct 2023

Evaluation Of Vitamin D Levels And Biochemical Markers In Infants Diagnosed With Laryngomalacia, Nagi̇han Bi̇lal, Ömer Faruk Çinar, Sevcan İpek, Muhammed Seyi̇thanoğlu, Adem Doğaner, Muhammed Gazi̇ Yildiz

Turkish Journal of Medical Sciences

Background/aim: The pathology of laryngomalacia is still not clear. The aim of this study was to investigate the relationship between vitamin D levels and laryngomalacia, and to evaluate vitamin D levels according to the classification of laryngomalacia. Materials and methods: This retrospective study was conducted in the Kahramanmaraş Sütçü İmam University Medicine Faculty?s Otorhinolaryngology Clinic between June 2014 and January 2021. Laryngomalacia was classified. Laboratory tests for all patients included calcium (Ca), phosphorus (P), parathormone (PTH), blood urea nitrogen (BUN), creatinine (Cre), alanine transaminase (ALT), and 25-hydroxy vitamin D (25-OH-D). Results: Evaluations were performed for 64 infants with laryngomalacia, including …


October 26, 2023, James Madison University Oct 2023

October 26, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.


Postoperative Discharge Destination Impacts 30-Day Outcomes: A National Surgical Quality Improvement Program Multi-Specialty Surgical Cohort Analysis, Carlos Riveros, Sanjana Ranganathan, Yash Shah, Emily Huang, Jiaqiong Xu, Michael Geng, Zachary Melchiode, Siqi Hu, Brian Miles, Nestor Esnaola, Dharam Kaushik, Angela Jerath, Christopher Wallis, Raj Satkunasivam Oct 2023

Postoperative Discharge Destination Impacts 30-Day Outcomes: A National Surgical Quality Improvement Program Multi-Specialty Surgical Cohort Analysis, Carlos Riveros, Sanjana Ranganathan, Yash Shah, Emily Huang, Jiaqiong Xu, Michael Geng, Zachary Melchiode, Siqi Hu, Brian Miles, Nestor Esnaola, Dharam Kaushik, Angela Jerath, Christopher Wallis, Raj Satkunasivam

Student Papers, Posters & Projects

Surgical patients can be discharged to a variety of facilities which vary widely in intensity of care. Postoperative readmissions have been found to be more strongly associated with post-discharge events than pre-discharge complications, indicating the importance of discharge destination. We sought to evaluate the association between discharge destination and 30-day outcomes. A retrospective cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database. Patients were dichotomized based on discharge destination: home versus non-home. The main outcome of interest was 30-day unplanned readmission. The secondary outcomes included post-discharge pulmonary, infectious, thromboembolic, and bleeding complications, …


Rna-Based Translation Activators For Targeted Gene Upregulation, Yang Cao, Huachun Liu, Shannon S Lu, Krysten A Jones, Anitha P Govind, Okunola Jeyifous, Christine Q Simmons, Negar Tabatabaei, William N Green, Jimmy L Holder, Soroush Tahmasebi, Alfred L George, Bryan C Dickinson Oct 2023

Rna-Based Translation Activators For Targeted Gene Upregulation, Yang Cao, Huachun Liu, Shannon S Lu, Krysten A Jones, Anitha P Govind, Okunola Jeyifous, Christine Q Simmons, Negar Tabatabaei, William N Green, Jimmy L Holder, Soroush Tahmasebi, Alfred L George, Bryan C Dickinson

Duncan NRI Faculty and Staff Publications

Technologies capable of programmable translation activation offer strategies to develop therapeutics for diseases caused by insufficient gene expression. Here, we present "translation-activating RNAs" (taRNAs), a bifunctional RNA-based molecular technology that binds to a specific mRNA of interest and directly upregulates its translation. taRNAs are constructed from a variety of viral or mammalian RNA internal ribosome entry sites (IRESs) and upregulate translation for a suite of target mRNAs. We minimize the taRNA scaffold to 94 nucleotides, identify two translation initiation factor proteins responsible for taRNA activity, and validate the technology by amplifying SYNGAP1 expression, a haploinsufficiency disease target, in patient-derived cells. …


Study Abroad, Open-Source Laboratories, And Citizen Science, Brandon Winters Oct 2023

Study Abroad, Open-Source Laboratories, And Citizen Science, Brandon Winters

Day of Scholarship

For over 30 years, students and faculty from Bethel University, St. Paul have been traveling to the Amazon rainforest of Ecuador each January. In the course titled, Ecology in the Tropics: Natural History & Future Prospects- Ecuador & the Galapagos Islands students spend three weeks engaging in ecological, cultural, and research-focused activities while also observing and discussing the various impacts of human occupation on the natural environment. The need for cheap and portable laboratory equipment for these research activities along with the growing popularity of open-source equipment development and the growth of relationships with local communities have given rise to …


The Future-War Literature Of The Reagan Era—Winning World War Iii In Fiction, Nicholas Evan Sarantakes Oct 2023

The Future-War Literature Of The Reagan Era—Winning World War Iii In Fiction, Nicholas Evan Sarantakes

Naval War College Review

During the Reagan era, fiction about a hypothetical World War III was generally popular among the book-buying public, but a few authors actually influenced national-security matters by shining a light on particular topics, forcing discussions on particular issues, and giving ideas to those in power.


The United Methodist Tradition: Religious Beliefs And Health Care Decisions, 2002, Edwin R. Dubose Oct 2023

The United Methodist Tradition: Religious Beliefs And Health Care Decisions, 2002, Edwin R. Dubose

Historical Documents - Combined

Chicago, IL: Park Ridge Center for the Study of Health, Faith, and Ethics published this handbook on United Methodist tradition as part of a series entitled "Religious Traditions and Healthcare Decisions". Sections include:

  • The Individual and the Patient-Caregiver Relationship, p. 2
  • Family, Sexuality, and Procreation, p. 3
  • Genetics, p. 4
  • Organ and Tissue Transplantation, p. 5
  • Mental Health, p. 6
  • Medical Experimentation and Research, p. 6
  • Death and Dying, p. 6
  • Special Concerns, p. 8


The Presbyterian Church (Usa) Tradition: Religious Beliefs And Health Care Decisions, 2002, Abigail Rian Evans Oct 2023

The Presbyterian Church (Usa) Tradition: Religious Beliefs And Health Care Decisions, 2002, Abigail Rian Evans

Historical Documents - Combined

Chicago, IL: Park Ridge Center for the Study of Health, Faith, and Ethics published this handbook on Prebysterian traditions as part of a series entitled "Religious Traditions and Healthcare Decisions". Sections include Buddhism and:

  • The Individual and the Patient-Caregiver Relationship, p. 4
  • Family, Sexuality, and Procreation, p. 5
  • Genetics, p. 7
  • Organ and Tissue Transplantation, p. 8
  • Mental Health, p. 8
  • Medical Experimentation and Research, p. 8
  • Death and Dying, p. 10
  • Special Concerns, p. 11


Making Your Spring Break Sustainable: Can Tourism Be A Driver For Positive Environmental Change?, Katherine Ort Oct 2023

Making Your Spring Break Sustainable: Can Tourism Be A Driver For Positive Environmental Change?, Katherine Ort

Journal of Maya Heritage

The Riviera Maya has undergone rapid development in the last few decades due to increased demand for tourism, putting pressure on surrounding ecosystems and cultural sites. As demand for tourism shows no signs of decreasing, there is an ever-increasing need for effective management solutions. The town of Puerto Morelos is striving to forward sustainable tourism based on its natural and cultural assets. As a new municipality, it has the chance to shape policy from a relatively blank canvas. This study involved collecting data about the different perspectives of key stakeholders through qualitative interviews and surveys to understand if the views …


Freshwater Macroinvertebrate Communities In Baldwin County, Georgia, Heath Michael Ghioto, Michelle K. Murdock, Nadya S. Gutierrez, Kristine N. White Ph.D. Oct 2023

Freshwater Macroinvertebrate Communities In Baldwin County, Georgia, Heath Michael Ghioto, Michelle K. Murdock, Nadya S. Gutierrez, Kristine N. White Ph.D.

Georgia Journal of Science

Freshwater ecosystems are critical habitats for maintaining biodiversity, often providing refuge for organisms especially in urban settings. Baldwin County, GA is home to many freshwater lakes that are part of the Oconee River watershed. Despite ongoing water quality monitoring, aquatic macroinvertebrates are under studied in the area. Aquatic macroinvertebrate diversity of one forested and one residential lake in Milledgeville, GA was documented for the first time. Despite low sample size, community composition was significantly different between lakes, with 27 families in Lake Laurel (forested), 44 families in Lake Oliver Hardy (residential), and only 19 families collected from both lakes. Seasonal …


An Investigation Of Mitigation Measures On The Spread Of Covid-19 In A College Classroom Using Agent-Based Modeling, Saharsh Talwar, Anne E. Yust Oct 2023

An Investigation Of Mitigation Measures On The Spread Of Covid-19 In A College Classroom Using Agent-Based Modeling, Saharsh Talwar, Anne E. Yust

Spora: A Journal of Biomathematics

In this manuscript, we describe the process of using agent-based modeling in NetLogo to create a simulation of COVID-19 spread in a traditional college classroom. The model allows for an evaluation of different preventative measures implemented by the University of Pittsburgh, including the cohort classroom attendance model, mask and vaccine mandates, contact tracing, and classroom sanitation. Through the use of the model's interactive interface, the impact of adjusting specific measures by the institution could be visualized, providing a valuable tool for combating diseases that spread through droplet transmission.


2023 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Diane Highland Oct 2023

2023 Celebration Of Scholarship, Creativity, And Engagement, Todd Bruns, Diane Highland

Programs

Annually, Eastern Illinois University honors faculty achievements in the areas of research, creativity, and engagement. This year, the list of faculty accomplishments is again truly impressive, reflective of an engaged faculty committed to excellence and the ongoing pursuit and creation of knowledge. A number of these accomplishments occurred in collaboration with our students, who serve as co-authors, research assistants and partners in bringing these activities to fruition. Indeed, in some cases these professional ambitions transpired over the course of many years, and are a testament to persistence and tenacity--ensuring that these works extend to a broader community of scholars that …


Proceedings Of The 2023 Undergraduate Research Day, Rebecca Day Babcock Dr., Mohamed Zobaa Oct 2023

Proceedings Of The 2023 Undergraduate Research Day, Rebecca Day Babcock Dr., Mohamed Zobaa

UTPB Student Research Day 2026

No abstract provided.


Uab Biology Ph.D. Student Selected As 2024 John Knauss Marine Policy Fellow, Micah Hardge Oct 2023

Uab Biology Ph.D. Student Selected As 2024 John Knauss Marine Policy Fellow, Micah Hardge

Browse All News

No abstract provided.


Alterations In Brain Activity Induced By Transcranial Magnetic Stimulation And Their Relation To Decision Making, Lexie Lawson, Stephanie Spivak, Heather Webber, Saeed Yasin, Briana Goncalves, Olivia Tarrio, Sydney Ash, Maria Ferrol, Athenia Ibragimov, Alejandro Gili Olivares, Julian Paul Keenan Oct 2023

Alterations In Brain Activity Induced By Transcranial Magnetic Stimulation And Their Relation To Decision Making, Lexie Lawson, Stephanie Spivak, Heather Webber, Saeed Yasin, Briana Goncalves, Olivia Tarrio, Sydney Ash, Maria Ferrol, Athenia Ibragimov, Alejandro Gili Olivares, Julian Paul Keenan

Department of Biology Faculty Scholarship and Creative Works

Understanding the intricate dynamics between conscious choice and neural processes is crucial for unraveling the complexity of human decision-making. This study investigates the effects of inhibitory Transcranial Magnetic Stimulation (TMS) on choice bias, shedding light on the malleability of cognitive-motor functions involved in decisions. While reaction times remained unaffected, inhibitory TMS to either the left or right motor cortex led to a significant bias in screen side preference during a choice task. These findings suggest that our cognitive-motor processes underlying decision-making can be unconsciously influenced by TMS. Furthermore, analysis of choice attribution categories revealed individual variability, emphasizing the complex nature …


Statistical And Machine Learning Approaches To Describe Factors Affecting Preweaning Mortality Of Piglets, Md Towfiqur Rahman, Tami M. Brown-Brandl, Gary A. Rohrer, Sudhendu R. Sharma, Vamsi Manthena, Yeyin Shi Oct 2023

Statistical And Machine Learning Approaches To Describe Factors Affecting Preweaning Mortality Of Piglets, Md Towfiqur Rahman, Tami M. Brown-Brandl, Gary A. Rohrer, Sudhendu R. Sharma, Vamsi Manthena, Yeyin Shi

Department of Agricultural and Biological Systems Engineering: Faculty Publications

High preweaning mortality (PWM) rates for piglets are a significant concern for the worldwide pork industries, causing economic loss and well-being issues. This study focused on identifying the factors affecting PWM, overlays, and predicting PWM using historical production data with statistical and machine learning models. Data were collected from 1,982 litters from the United States Meat Animal Research Center, Nebraska, over the years 2016 to 2021. Sows were housed in a farrowing building with three rooms, each with 20 farrowing crates, and taken care of by well-trained animal caretakers. A generalized linear model was used to analyze the various sow, …


The Rattler (Volume 112, Issue 4), St. Mary's University Oct 2023

The Rattler (Volume 112, Issue 4), St. Mary's University

The Rattler (Previous issues)

Founded in 1919, The Rattler is the student voice of St. Mary’s University in San Antonio, Texas. The newspaper documents campus life, academic and social issues, student opinion, and local and national events as they relate to the University community. Content typically includes news articles, editorial commentary, arts and culture coverage, sports reporting, and advertisements.


The Lumberjack, October 25, 2023 Oct 2023

The Lumberjack, October 25, 2023

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.


Characterizing The Adolescent Male Reader: A Narrative Inquiry Into The Reading Lives Of 12th Grade Boys Enrolled In Ib Language A: Literature, Marsha French Oct 2023

Characterizing The Adolescent Male Reader: A Narrative Inquiry Into The Reading Lives Of 12th Grade Boys Enrolled In Ib Language A: Literature, Marsha French

Doctor of Education in Secondary and Middle Grades Education Dissertations

The problem this research seeks to understand is the intersection of the gender achievement gap in reading and the gendered practices of “the school” as a powerful social institution. This project draws upon the studies of the 1990s-2000s in order to discover the potential impact of the social, cultural, and political movements and shifts that began in 2017. Most earlier research into adolescent male readers was conducted from a deficit perspective. This study explores the reading lives of boys who are positioned at the end of their K-12 public schooling career and are finishing their second year in IB (International …


Knowledge Integration In Domain-Informed Machine Learning And Multi-Scale Modeling Of Nonlinear Dynamics In Complex Systems, Phat K. Huynh Oct 2023

Knowledge Integration In Domain-Informed Machine Learning And Multi-Scale Modeling Of Nonlinear Dynamics In Complex Systems, Phat K. Huynh

USF Tampa Graduate Theses and Dissertations

Nonlinear dynamical systems have been extensively used to model various phenomena in the changing world around us, especially in science and engineering fields. Thanks to breakthrough advancements in sensing technologies, an increasingly high volume of multi-modal sensor data has been collected, which enables us gain better insights into complex systems dynamics and build sophisticated data-driven machine-learning-based dynamic models without having the access to the underlying governing equations. However, integrating domain-specific knowledge in machine learning algorithms remains pivotal for various reasons: it promises enhanced predictive accuracy, better model interpretability, and increased generalizability. This dissertation delves into three core research questions, each …


Analyzing Multi-Robot Leader-Follower Formations In Obstacle-Laden Environments, Zachary J. Hinnen Oct 2023

Analyzing Multi-Robot Leader-Follower Formations In Obstacle-Laden Environments, Zachary J. Hinnen

USF Tampa Graduate Theses and Dissertations

Observations in biological formation from nature likes flocks of birds, herds of mammals and packs of wolves have inspired the innovation of robotic architectures. This thesis presents an approach that aims to use robotic systems to mimic leader-follower behaviors in the navigation and formation of sparse and dense environments. The goal of this work is to extend and further analyze the original work of Weitzenfeld et al [3] to evaluate new swarm and pack based multi-robot architectures with the inclusion of obstacle avoidance and variations in group formations. The multiple robot architecture is based off a wolf pack with a …


National Science Foundation Grant Will Help Speed Up Semiconductor Manufacturing, University Of Dayton Oct 2023

National Science Foundation Grant Will Help Speed Up Semiconductor Manufacturing, University Of Dayton

News Releases

A $390,000 National Science Foundation grant will enable the University of Dayton to purchase equipment to create semiconductor chips and devices in hours rather than weeks, and at a significantly lower cost.


Fall/Winter 2023: St. Norbert College At 125: Nurturing Legacy And Sustaining Purpose, St. Norbert College Oct 2023

Fall/Winter 2023: St. Norbert College At 125: Nurturing Legacy And Sustaining Purpose, St. Norbert College

St. Norbert College Magazine 2019-2023

St. Norbert College celebrated its 125th anniversary in October, reflecting on a history of resilience, adaptability, and enduring impact.


Diesel Tractor Fuel Efficiency And Exhaust Emissions Standards, Jerin Tekolste, Cory Walters, Michael Mccullough, Lynn Hamilton, Lia Nogueira, Roger M. Hoy Oct 2023

Diesel Tractor Fuel Efficiency And Exhaust Emissions Standards, Jerin Tekolste, Cory Walters, Michael Mccullough, Lynn Hamilton, Lia Nogueira, Roger M. Hoy

Cornhusker Economics

Diesel engine performance and costs represent crucial factors for agricultural producers while pollutants from the exhaust are largely a social concern but also important to producers. Beginning in 1970, Congress authorized the Environmental Protection Agency to regulate emissions with amendments in subsequent years (U.S. EPA, 2023). In 1996 the EPA issued strict Exhaust Emission Standards for Nonroad Compression-Ignition Engines, causing a major paradigm shift in acceptable emission levels. A primary concern coming from many manufacturers was the difficulty of designing an engine to meet these standards without compromising the engines’ power output and efficient fuel consumption (Lloyd and Cackette 2001; …


Fear Of Missing Organisms (Fomo): The Discordance Among Broad-Spectrum Empiric Antibiotic Therapy, Microbiologic Results, And Definitive Antibiotic Therapy For Diabetic Foot Infections And Lower Extremity Osteomyelitis, Morgan K. Morelli, Yanis Bitar, Michelle T. Hecker Oct 2023

Fear Of Missing Organisms (Fomo): The Discordance Among Broad-Spectrum Empiric Antibiotic Therapy, Microbiologic Results, And Definitive Antibiotic Therapy For Diabetic Foot Infections And Lower Extremity Osteomyelitis, Morgan K. Morelli, Yanis Bitar, Michelle T. Hecker

Faculty Scholarship

Objective: Empiric broad-spectrum antibiotic therapy is commonly prescribed for patients hospitalized with diabetic foot infections (DFI) and lower extremity osteomyelitis (OM). The primary objective was to evaluate the concordance between empiric antibiotic therapy, microbiologic results, and definitive antibiotic therapy with a focus on methicillin-resistant Staphylococcus aureus (MRSA) and resistant gram-negative organisms. The secondary objective was to evaluate the negative predictive values (NPV) of select risk factors for MRSA and resistant gram-negative organisms for microbiologic results with these organisms. Design: Retrospective cohort study. Setting: Safety-net health system in Ohio. Patients: Adults hospitalized and receiving antibiotic therapy for DFI or lower extremity …


Discovery And Generation Mechanisms Of Epigenetic Biogenic H2S From Coal Seams In The Fukang Block, Southern Junggar Basin, China, Yan Peipei, Su Xianbo, Zou Chenglong, Zhao Weizhong, Wang Lufei, Fu Haijiao Oct 2023

Discovery And Generation Mechanisms Of Epigenetic Biogenic H2S From Coal Seams In The Fukang Block, Southern Junggar Basin, China, Yan Peipei, Su Xianbo, Zou Chenglong, Zhao Weizhong, Wang Lufei, Fu Haijiao

Coal Geology & Exploration

In the Fukang block located in the eastern part of the southern Junggar Basin, coalbed methane (CBM) from CBM wells exhibits a gradually increasing H2S concentration in the process of CBM production via water drainage, severely threatening production safety. Based on the CBM exploration and extraction data, as well as the anaerobic fermentation experiments, this study preliminarily investigated the causes of abnormal H2S concentrations during the CBM production in the Fukang block. As indicated by the gas content test in the CBM exploration stage, the original CBM showed a low H2S concentration of only …


Information Needs And Use Of E-Resources By The Govt.Nursing Students In The Digital Environment Of Bhubaneswar,Odisha: An Analysis, Payel Saha, Pushpanjali Jena Oct 2023

Information Needs And Use Of E-Resources By The Govt.Nursing Students In The Digital Environment Of Bhubaneswar,Odisha: An Analysis, Payel Saha, Pushpanjali Jena

Library Philosophy and Practice (e-journal)

Like all other academic areas, nursing education has expanded both vertically and horizontally. There is a substantial body of literature in the chosen topic area, created using both traditional and modern techniques. Additionally, the methods used to produce knowledge in this particular profession have evolved, which has affected how nursing students throughout the world search for information. The current review's objective is to examine several factors related to nursing students' use of electronic resources for information seeking that have been researched by various researchers throughout the world over a range of time periods. The paper discusses a few key elements …


Composite Biomarkers, Behavioral Symptoms, And Comorbidities In Axial Low Back Pain: A Systematic Review, Anitha Saravanan, J Bai, P Bajaj, Elizabeth Sterner, M Rajagopal, S Sanders, A Luckose, M Kushnick, A Starkweather Oct 2023

Composite Biomarkers, Behavioral Symptoms, And Comorbidities In Axial Low Back Pain: A Systematic Review, Anitha Saravanan, J Bai, P Bajaj, Elizabeth Sterner, M Rajagopal, S Sanders, A Luckose, M Kushnick, A Starkweather

Faculty Articles, Papers, and Other Scholarship

Purpose

Proinflammatory cytokines play a critical role in chronic inflammation and pain and contribute to behavioral symptoms (depressive symptoms, anxiety, fatigue, sleep disturbance) and comorbidities (diabetes, cardiac diseases, cancer). Evidence is lacking on the specific proinflammatory cytokines associated with these behavioral symptoms/comorbidities co-occurring with axial low back pain (aLBP). This review aimed to systematically analyze the following: (1) specific proinflammatory cytokines associated with aLBP in adults, (2) associations among proinflammatory cytokines and behavioral symptoms in aLBP, and (3) relationships among proinflammatory cytokines and comorbidities in aLBP, to develop a new clinical framework for future diagnostic and intervention targets for patients …