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Family Caregivers: From Invisible To Visible Within The Healthcare Continuum, Tara Anglim

Theses & Dissertations

As the United States' aging population rapidly grows, the prevalence of adults with chronic illness or disabilities who require intermittent or long-term caregiving from family members also increases. Despite the prevalence of caregiving, the role of the family caregiver is a label that lacks a clear description, definition, or societal understanding. The inability to identify family caregivers creates negative ramifications, including diminished recognition and support throughout the healthcare continuum. Drawing from caregiver identity theory, this qualitative phenomenological study aimed to describe the experiences of family caregivers to promote a deeper understanding of how they became aware of their caregiver identity …

Decreasing The Risk For Type Ii Diabetes After Gestational Diabetes: An Integrative Review, Tara Call, Melissa Field

Master of Science in Nursing Final Projects

Abstract

Aim: This integrative review aimed to review studies on the risk of developing type II diabetes (T2DM) after a diagnosis of gestational diabetes mellitus (GDM) and available programs to mitigate this risk. The research question that guided this review was: For women diagnosed with gestational diabetes, what programs are available to decrease risk factors for developing T2DM later in life?

Background: Women who experience GDM have an increased risk of developing T2DM at a rate of eight times higher than those with no history of GDM (Song et al., 2017). The risk for T2DM after a diagnosis of GDM …

Cortisol And Epinephrine Alter The Adipose Functions And The Mobilization Of Pcbs In Adipose Tissue Slices From Elephant Seal, Laura Pirard, Jane I. Khudyakov, Daniel E. Crocker, Liesbeth Van Hassel, Georges Scholl, Gauthier Eppe, Melissa M. Page, Jean-François Rees, Donald R. Smith, Cathy Debier

Pacific Faculty Work

Marine mammals are exposed to increasing intensities of anthropogenic stressors such as acoustic disturbance and contaminants. Correlative studies have suggested concerning shifts in behavioral and physiological status of stress-exposed individuals, which could alter the health and survival of marine mammal populations. However, functional studies of the effects of multiple stressors on marine mammals are lacking. To fill in this gap, we recently developed an ex vivo approach of precision-cut adipose tissue slices (PCATS) to study the impact of stressors on the function of an essential endocrine organ: the adipose tissue. In the present study, we investigated the impact of hormones …

In Yellow: A Solo Poem-Play, Emily Kitchens

Faculty Articles

“In Yellow” was developed in the INKubator residency at Art House Productions (Jersey City, NJ) in 2019 with the following blurb:

In Yellow is a solo poem-play about a relationship between a young woman and a ceramic doll her grandmother made that she has just accidentally broken. It is about grief. It is about breaking out of generationally instilled feminine values. It is about the color yellow. It’s all true.

“In Yellow” is an experiment of a poem and play for one voice. I was in New York City for about 10 years, before that The Bay Area, but am …

A Qualitative Phenomenological Study Of History Doctoral Candidates' Experiences With Technology And Information Overload, Roger A. White

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to describe the experiences of history doctoral candidates at Liefrig University with technology and information overload. The theory guiding this study was Sweller’s cognitive load theory, as it explains the characteristics of the information received using technology and the effect of exposure to varying levels of data. The study advances the understanding of the influence of technology on online students and their experiences with information overload. The participants consisted of history doctoral candidates completing their studies through a private online higher education institution in a Southeastern state. The three data collection methods …

Groove Comes To The Cumberlands: The Importance Of Percussion Education In Appalachia, Timothy Adam Hopper

Doctoral Dissertations and Projects

The purpose of this qualitative ethnographic study is to determine the effects and influences of percussion ensemble literature in underprivileged secondary schools in the Appalachian region of eastern Kentucky. This study was conducted within the framework of psychologist Yuri Bronfenbrenner’s ecological theory of development. The aim was to research the importance of percussion pedagogy on the global musical knowledge and cultural understandings of high school music students and their communities from underprivileged schools in eastern Kentucky. The study sought to determine how percussion students, non-percussion students, and non-music students conceptualized these diverse and modern pieces of percussion literature. The study …

Improving Diversity And Inclusion Increasing Multiethnic Presence Within Religious Organizations, Marquita Nicole Davie

Doctoral Dissertations and Projects

The program is committed to promoting diversity and inclusion within a religious organization by increasing the participation of individuals from various ethnic backgrounds. The validity of Dr. Martin Luther King Jr.'s statement regarding the most segregated time in Christian America being Sunday mornings will be evaluated through observation, exploration, and scholarly articles. The Fort Leonard Wood Protestant Women of the Chapel will serve as a framework for program design and implementation. The program serves to boost the presence of multiethnic members and leaders by 10% and 5%, respectively. This program will adhere to a logic model that will include five …

Program Evaluation On 4kids On Foster Parent Retention, Brittany Morton

Doctoral Dissertations and Projects

The number of children coming to the foster care system is increasing while the individuals willing to be foster parents and take these children in their care is rapidly decreasing. There are some aspects that play a crucial part in foster parents’ choice to foster children, including available resources and motivation. Research has studied why foster parents elect to foster and what leads foster parents to close their doors. For the foster care programs that provide services to foster parents, there is minimal research on foster care program evaluation regarding foster parent retention. The program evaluation aims to assess 4Kids …

K-8 Teachers' Experiences Instructing Students Diagnosed With Adhd: A Phenomenological Study, Van C. Kirchhoff

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the lived experiences of teachers who have experience working with students diagnosed with ADHD in the K-8 public school system in the Mid-Atlantic United States. The problem is that the number of students diagnosed with ADHD is rapidly increasing, and yet, educators are not being provided with the knowledge or the skills to support these students in the classroom (Dort et al., 2020). Due to the large percentage of students diagnosed with ADHD, research is needed to provide insight into what methods are being used by teachers in an inclusive classroom …

A Qualitative Descriptive Case Study Of Special Education Teachers' Experiences Utilizing Interactive Whiteboards For Students With Autism Spectrum Disorder In Elementary Self-Contained Classrooms, John P. Terrell

Doctoral Dissertations and Projects

The purpose of this qualitative descriptive case study was to describe the experiences of special education teachers who use Interactive Whiteboards (IWBs) to instruct students diagnosed with autism spectrum disorder (ASD) in elementary self-contained special education classrooms. The theoretical framework for this study includes the persuasive technology theory and the social learning theory. Ten special education teachers from two elementary schools in a suburb of north Georgia will be asked to participate in this study. Data collection included an individual interview, and participant letters, followed by a focus group. Data analysis consisted of categorical aggregation, development of naturalistic generalizations, and …

Causal Comparative Study Of Public Middle And High School English Language Arts Teachers' Usage Of Technology For Learning And Teaching, Alison Lauren Watson

Doctoral Dissertations and Projects

This quantitative casual-comparative study examines the differences between reported barriers and technology anxiety when integrating technology into teaching and learning based on years of teaching experience of public middle and high school English language arts (ELA) teachers. Despite the need for a 21st-century learning environment, there is a lack of study on the challenges of integrating technology into ELA classes in public middle and high schools and the level of teacher anxiety these teachers experience. The Kotrlik-Redmann Technology Integration Survey was used to poll 163 middle and high school ELA instructors from various school systems in the Southeast. The data …

Latina Christian Women Describe Their Religious Experience Overcoming Child Abuse Trauma In The Western United States, Norma Rosales

Doctoral Dissertations and Projects

Abstract This phenomenological study aimed to understand and discover the childhood abuse experienced by Christian Latinas in the Western United States. The theory guiding this study was Lazarus and Folkman's stress and coping theory, as it focused on the adaptation to stress as a process of interaction between individuals and stressful stimuli. This study explored issues concerning religious coping and how participants adapted and managed child abuse. Data was collected through a semi-structured interview process, whereby the discussion was recorded to ensure that all pertinent information was collected with participant consent. The interviews lasted 1–1.5 hours each, depending on the …

Effectiveness Of Post-Abortion Bible Studies On Self-Forgiveness And Depression, Karen Haaland Hubbard

Doctoral Dissertations and Projects

Pro-choice and pro-life perspectives differ regarding adverse emotional symptoms after abortion. Pro-choice researchers maintain that abortion presents no more risk of emotional distress than carrying an unplanned pregnancy to term. However, pro-life researchers discuss evidence that abortion does increase the risk of adverse emotional symptoms that persist long after the abortion. Since many women seek faith-based interventions, the purpose of the current study was to examine the effectiveness of the post-abortion Bible study, Forgiven and Set Free by Linda Cochrane, in decreasing depression and increasing self-forgiveness. The first research question was, “Does participation in a post-abortion Bible study increase post-abortive …

The Perspectives Of Ghanaian Political Leaders And Citizens Concerning The Development And Implementation Of The Ghana Vision 2020 Development Plan, Kwame Aduhene-Kwarteng

Doctoral Dissertations and Projects

The purpose of this qualitative research case study is to collect, investigate, and assess Ghanaian citizens’ and political leaders’ perspectives and viewpoints regarding the success or failure of Ghana Vision 2020 and the challenges facing developing nations. The study used a descriptive approach to examine Ghana’s Vision 2020 and the country’s development challenges using a descriptive methodology and primary and secondary sources. The 105 participants for the study included 65 males and 40 females living in Ghana. The theoretical framework of this study are modernization, globalization, and dependency theories. To that end, the study set out to investigate the question: …

Understanding The Lived Experiences Of Undergraduate Transfer Students At Faith-Based And Religiously Affiliated Institutions: A Transcendental Phenomenological Study, Amanda Nicole Davis

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experiences of undergraduate transfer students at faith-based and religiously affiliated institutions in the United States. Thus, in order to explore this phenomenon, the central research question directing the present study was: What are the lived experiences of undergraduate transfer students at faith-based and religiously affiliated institutions in the United States? The two theories guiding this study were Astin’s theory of involvement and Tinto’s theory of engagement, as they explain the relationship between institutional fit, involvement, and feelings of belonging. This study employed a transcendental phenomenological design and included …

Motivation In Student Retention: A Phenomenology Of Non-Traditional Undergraduate Students In Online Learning, Jasmine Monique Reynolds

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenology study was to understand the experiences of non-traditional undergraduate students taking online courses at a public or a private university in Virginia. The self-determination theory, which guided this study, explained the motivated behaviors of intrinsic and extrinsic needs that affect the determination in non-traditional students completing a task. Self-determination theory provided the theoretical framework to answer the central research question for this study as well as the sub-questions: (1) What are the lived experiences of non-traditional students while taking online courses at a public or private university in Virginia? (2) What influences non-traditional students …

Resilience Through Relocation In Older Adulthood: An Interpretative Phenomenological Analysis, Holly Walker

Doctoral Dissertations and Projects

Resilience, the process and outcome of successful adaptation to a stressor, is important to maintain wellbeing through stressors such as relocation. Relocation is a common experience in late adulthood which can cause significant stress. The purpose of this study was to explore the lived experience of resilience and its relationship to strengths and resources following relocation in older adulthood. The research questions regarded participants’ description of experiencing resilience after relocation and strengths and resources that contributed to that experience. Data collection consisted of semi-structured interviews with a criterion sample of six adults aged 65 and older who had relocated within …

Sex And Violence: An Exploratory Study Of Changes In Male And Female Violent Offenders' Choices Of Weapon And Victim Over Time, Lindsey Hutton Nagle

Doctoral Dissertations and Projects

Violent offenses are part of the history of humankind, and as such, both male and female violent offenders have perpetrated these acts, often with gender differences between male and female offenders present. As more women leave the home and enter the workplace, the gap in gender roles has narrowed, so it follows that this narrowing may also be reflected in the actions of violent offenders. Although there are various explanations for the narrowing of the gender gap in crime, understanding the differences between male and female offenders can help inform gender-based interventions. To address this idea, the type of weapon …

Blood-Based Proteomic Signatures Associated With Men1-Related Duodenopancreatic Neuroendocrine Tumor Progression, Johannes F Fahrmann, Amanda R Wasylishen, Carolina R C Pieterman, Ehsan Irajizad, Jody Vykoukal, Ranran Wu, Jennifer B Dennison, Christine B Peterson, Hua Zhao, Kim-Anh Do, Daniel M Halperin, Sunita K Agarwal, Jenny E Blau, Smita Jha, Jaydira Del Rivero, Naris Nilubol, Mary F Walter, James M Welch, Lee S Weinstein, Menno R Vriens, Rachel S Van Leeuwaarde, Mark J C Van Treijen, Gerlof D Valk, Nancy D Perrier, Samir M Hanash, Hiroyuki Katayama

Faculty, Staff and Student Publications

PURPOSE: Patients with multiple endocrine neoplasia type 1 (MEN1) are predisposed to develop duodenopancreatic neuroendocrine tumors (dpNETs), and metastatic dpNET is the primary cause of disease-related mortality. Presently, there is a paucity of prognostic factors that can reliably identify patients with MEN1-related dpNETS who are at high risk of distant metastasis. In the current study, we aimed to establish novel circulating molecular protein signatures associated with disease progression.

EXPERIMENTAL DESIGN: Mass spectrometry-based proteomic profiling was conducted on plasmas procured through an international collaboration between MD Anderson Cancer Center, the National Institutes of Health, and the University Medical Center Utrecht from …

Cohen, Ruthie, Sophia Maier Garcia

Bronx Jewish History Project

Ruthie Cohen is a second generation American, with her paternal grandparents immigrating from Poland. When she was born, her family lived at 2805 Sedgwick Avenue, but moved nearby to another two-family home at 2805 Webb Avenue. She remembers how her immediate neighborhood and school was predominantly Jewish, but Italians and Irish also lived nearby and attended parochial schools. Cohen felt very little antisemitism from them. She was the youngest of four children in a relatively observant family.

Cohen’s father was a teacher who was very involved in the larger community, and education and tolerance were important values in her family. …

Embryological Basis Of Polydactyly In 56 Years Old Male Patient, Sarayu M

Digital Journal of Clinical Medicine

Polydactyly is a common congenital hand deformity. The limb buds are the precursor structures of the limbs. Their formation begins in the 4th week, with the activation of mesenchymal cells in the somatic layer of lateral plate mesoderm. As mesenchyme cells enter the limb region, they secrete factors that induce the overlying ectoderm to form a structure called the apical ectodermal ridge (AER). Polydactyly is the congenital deformities which is seen in 1000 births. To observe and study the various type of polydactyly in relation to the preaxial polydactyly and postaxial polydactyly with other classification. So, thumb polydactyly is a …

Allogeneic Hematopoietic Cell Transplantation For Blastic Plasmacytoid Dendritic Cell Neoplasm: A Cibmtr Analysis, Hemant S. Murthy, Mei-Jie Zhang, Karen Chen, Sairah Ahmed, Uday Deotare, Siddhartha Ganguly, Ankit Kansagra, Fotios V. Michelis, Taiga Nishihori, Mrinal Patnaik, Muhammad Bilal Abid, Mahmoud Aljurf, Yasuyuki Arai, Ulrike Bacher, Talha Badar, Sherif M. Badawy, Karen Ballen, Minoo Battiwalla, Amer Beitinjaneh, Nelli Bejanyan, Vijaya Raj Bhatt, Valerie I. Brown, Rodrigo Martino, Jean-Yves Cahn, Paul Castillo, Jan Cerny, Saurabh Chhabra, Edward Copelan, Andrew Daly, Bhagirathbhai Dholaria, Miguel Angel Diaz Perez, César O. Freytes, Michael R. Grunwald, Shahrukh Hashmi, Gerhard C. Hildebrandt, Omer Jamy, Jacinth Joseph, Christopher G. Kanakry, Nandita Khera, Maxwell M. Krem, Yachiyo Kuwatsuka, Hillard M. Lazarus, Lazaros J. Lekakis, Hongtao Liu, Dipenkumar Modi, Pashna N. Munshi, Alberto Mussetti, Neil D. Palmisiano, Sagar S. Patel, David A. Rizzieri, Sachiko Seo, Mithun Vinod Shah, Akshay Sharma, Melhm Sohl, Scott R. Solomon, Matthew Ulrickson, Celalettin Ustun, Marjolein Van Der Poel, Leo F. Verdonck, John L. Wagner, Trent Wang, Baldeep Wirk, Amer Zeidan, Mark Litzow, Partow Kebriaei, Christopher S. Hourigan, Daniel J. Weisdorf, Wael Saber, Mohamed A. Kharfan-Dabaja

Department of Medical Oncology Faculty Papers

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy with a poor prognosis and considered incurable with conventional chemotherapy. Small observational studies reported allogeneic hematopoietic cell transplantation (allo-HCT) offers durable remissions in patients with BPDCN. We report an analysis of patients with BPDCN who received an allo-HCT, using data reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). We identified 164 patients with BPDCN from 78 centers who underwent allo-HCT between 2007 and 2018. The 5-year overall survival (OS), disease-free survival (DFS), relapse, and nonrelapse mortality (NRM) rates were 51.2% (95% confidence interval [CI], 42.5-59.8), …

National Legal Models To Regulate Scrubbers Washwater, Shams Al Din Al Hajjaji

Loyola of Los Angeles International and Comparative Law Review

According to the findings of this study, nations should adopt uniform regulations regarding the discharge of washwater from exhaust gas cleaning systems into their ports, territories, and Exclusive Economic Zones. Scrubbers are used by ships to reduce their emissions of greenhouse gases so they can adhere to the International Maritime Organization’s limit on the sulfur content of ship fuel. The global upper limit was 0.5% in January 2020. Scrubber washwater is discharged into the ocean by ships. Toxic substances are present in the washwater for the scrubbers. The level of washwater for the scrubbers is governed by the 2008 and …

An Open Natural Language Processing (Nlp) Framework For Ehr-Based Clinical Research: A Case Demonstration Using The National Covid Cohort Collaborative (N3c), Sijia Liu, Andrew Wen, Liwei Wang, Huan He, Sunyang Fu, Robert Miller, Andrew Williams, Daniel Harris, Ramakanth Kavuluru, Mei Liu, Noor Abu-El-Rub, Dalton Schutte, Rui Zhang, Masoud Rouhizadeh, John D Osborne, Yongqun He, Umit Topaloglu, Stephanie S Hong, Joel H Saltz, Thomas Schaffter, Emily Pfaff, Christopher G Chute, Tim Duong, Melissa A Haendel, Rafael Fuentes, Peter Szolovits, Hua Xu, Hongfang Liu

Faculty, Staff and Student Publications

Despite recent methodology advancements in clinical natural language processing (NLP), the adoption of clinical NLP models within the translational research community remains hindered by process heterogeneity and human factor variations. Concurrently, these factors also dramatically increase the difficulty in developing NLP models in multi-site settings, which is necessary for algorithm robustness and generalizability. Here, we reported on our experience developing an NLP solution for Coronavirus Disease 2019 (COVID-19) signs and symptom extraction in an open NLP framework from a subset of sites participating in the National COVID Cohort (N3C). We then empirically highlight the benefits of multi-site data for both …

Mechanisms Of Endothelial Cell Membrane Repair: Progress And Perspectives., Duoduo Zha, Shizhen Wang, Paula Monaghan-Nichols, Yisong Qian, Venkatesh Sampath, Mingui Fu

Manuscripts, Articles, Book Chapters and Other Papers

Endothelial cells are the crucial inner lining of blood vessels, which are pivotal in vascular homeostasis and integrity. However, these cells are perpetually subjected to a myriad of mechanical, chemical, and biological stresses that can compromise their plasma membranes. A sophisticated repair system involving key molecules, such as calcium, annexins, dysferlin, and MG53, is essential for maintaining endothelial viability. These components orchestrate complex mechanisms, including exocytosis and endocytosis, to repair membrane disruptions. Dysfunctions in this repair machinery, often exacerbated by aging, are linked to endothelial cell death, subsequently contributing to the onset of atherosclerosis and the progression of cardiovascular diseases …

A Correlational Study On The Influence Of Teacher-Student Relationships On Teachers’ Math Self-Efficacy And Mathematical Anxiety In Students In Lower Elementary Grades, Erica M. Bates

Doctoral Dissertations and Projects

The purpose of this quantitative, correlational study was to discover the influence of teacher-student relationships on teachers’ math self-efficacy and math anxiety in first through third-grade students. This research was significant since the results inform and guide educational training, evaluations, and classroom management. This study was composed of 13 teachers and 84 students in the first through third grade classrooms in a Mid-Atlantic State. Teachers completed two surveys: Teacher-Student Relationship Scale and the Self-Efficacy for Teacher Mathematics Instrument. Students were surveyed concerning their math anxiety using the Math Anxiety Questionnaire for Children. Data analysis was conducted by using Pearson correlation …

Evaluating The Contamination By Indoor Dust In Dubai, Yousef Nazzal, Alina Bărbulescu, Manish Sharma, Fares Howari, Muhammad Naseem

All Works

Nowadays, people spend most of their time indoors. Despite constantly cleaning these spaces, dust apparition cannot be avoided. Since dust can contain chemical elements that negatively impact people's health, we propose the analysis of the metals from the indoor dust component collected in different locations in Dubai, UAE. Multivariate statistics (correlation matrix, clustering) and quality indicators (QI)-Igeo, PI, EF, PLI, Nemerow-were used to assess the contamination level with different metals in the dust. We proposed two new QIs (CPI and AQI) and compared the results with those provided by the most used indices-PLI and Nemerow. It is shown that high …

Rapid, High Throughput, Automated Detection Of Sars-Cov-2 Neutralizing Antibodies Against Wuhan-Wt, Delta And Omicron Ba1, Ba2 Spike Trimers, Narayanaiah Cheedarla, Hans P Verkerke, Sindhu Potlapalli, Kaleb Benjamin Mclendon, Anamika Patel, Filipp Frank, William Henry O'Sick, Suneethamma Cheedarla, Tyler Jon Baugh, Gregory L Damhorst, Huixia Wu, Daniel Graciaa, Fuad Hudaib, David N Alter, Janetta Bryksin, Eric A Ortlund, Jeanette Guarner, Sara Auld, Sarita Shah, Wilbur Lam, Dawn Mattoon, Joseph M Johnson, David H Wilson, Madhav V Dhodapkar, Sean R Stowell, Andrew S Neish, John D Roback

Faculty, Staff and Student Publications

Traditional cellular and live-virus methods for detection of SARS-CoV-2 neutralizing antibodies (nAbs) are labor- and time-intensive, and thus not suited for routine use in the clinical lab to predict vaccine efficacy and natural immune protection. Here, we report the development and validation of a rapid, high throughput method for measuring SARS-CoV-2 nAbs against native-like trimeric spike proteins. This assay uses a blockade of human angiotensin converting enzyme 2 (hACE-2) binding (BoAb) approach in an automated digital immunoassay on the Quanterix HD-X platform. BoAb assays using Wuhan-WT (vaccine strain), delta (B.1.167.2), omicron BA1 and BA2 variant viral strains showed strong correlation …

Pmca Screening Of Retropharyngeal Lymph Nodes In White-Tailed Deer And Comparisons With Elisa And Ihc, Rebeca Benavente, J Hunter Reed, Mitch Lockwood, Rodrigo Morales

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting cervids. CWD diagnosis is conducted through enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry (IHC) in retropharyngeal lymph nodes. Unfortunately, these techniques have limited sensitivity against the biomarker (CWD-prions). Two in vitro prion amplification techniques, real-time quaking-induced conversion (RT-QuIC) and protein misfolding cyclic amplification (PMCA), have shown promise in detecting CWD-prions in tissues and bodily fluids. Recent studies have demonstrated that RT-QuIC yields similar results compared to ELISA and IHC. Here, we analyzed 1003 retropharyngeal lymph nodes (RPLNs) from Texas white-tailed deer. PMCA detected CWD at a higher rate compared to ELISA/IHC, identified …

Dlx2 Promotes Osteosarcoma Epithelial-Mesenchymal Transition And Doxorubicin Resistance By Enhancing Hoxc8-Cdh2 Axis, Boya Zhang, Xinhui Du, Yichao Fan, Guoxin Qu, Lon Kai Pang, Ruiying Zhao, Weitao Yao

Faculty, Staff and Student Publications

Metastasis and doxorubicin resistance are challenges in the clinical diagnosis and treatment of osteosarcoma, the mechanisms underlying these phenomena remain unclear. In this study, we found that DLX2 is highly expressed in metastatic osteosarcoma and is closely related to clinical prognosis. Knockdown of DLX2 inhibited tumor proliferation and migration in vitro and inhibited tumor growth in vivo. Mechanistically, we found that DLX2 enhanced the repression of CDH2 transcription by binding to HOXC8, thereby promoting the epithelial-mesenchymal transition in osteosarcoma cells. Through subsequent exploration, we found that targeting DLX2/HOXC8 signaling significantly restores the sensitivity of osteosarcoma cells to doxorubicin. In …