Digital Commons Network^™

Conserved And Divergent Gene Regulatory Programs Of The Mammalian Neocortex, Nathan R Zemke, Daofeng Li, Xiaoyu Zhuo, Vincent Xu, Ting Wang, Et Al.

2020-Current year OA Pubs

Divergence of cis-regulatory elements drives species-specific traits

Multi-Ancestry Genome-Wide Association Study Of Cannabis Use Disorder Yields Insight Into Disease Biology And Public Health Implications, Daniel F Levey, Emma C Johnson, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities. Here we performed a genome-wide association study of CanUD in the Million Veteran Program (MVP), followed by meta-analysis in 1,054,365 individuals (n

Single-Cell Analysis Of Chromatin Accessibility In The Adult Mouse Brain, Songpeng Zu, Yang Eric Li, Et Al.

2020-Current year OA Pubs

Recent advances in single-cell technologies have led to the discovery of thousands of brain cell types; however, our understanding of the gene regulatory programs in these cell types is far from complete

Programmable And Reversible Integrin-Mediated Cell Adhesion Reveals Hysteresis In Actin Kinetics That Alters Subsequent Mechanotransduction, Zheng Zhang, Guy M Genin, Et Al.

2020-Current year OA Pubs

Dynamically evolving adhesions between cells and extracellular matrix (ECM) transmit time-varying signals that control cytoskeletal dynamics and cell fate. Dynamic cell adhesion and ECM stiffness regulate cellular mechanosensing cooperatively, but it has not previously been possible to characterize their individual effects because of challenges with controlling these factors independently. Therefore, a DNA-driven molecular system is developed wherein the integrin-binding ligand RGD can be reversibly presented and removed to achieve cyclic cell attachment/detachment on substrates of defined stiffness. Using this culture system, it is discovered that cyclic adhesion accelerates F-actin kinetics and nuclear mechanosensing in human mesenchymal stem cells (hMSCs), with …

Trpv4 Differentially Controls Inflammatory Cytokine Networks During Static And Dynamic Compression Of The Intervertebral Disc, Garrett W D Easson, Alireza Savadipour, Christian Gonzalez, Farshid Guilak, Simon Y Tang

2020-Current year OA Pubs

BACKGROUND: The ion channel transient receptor potential vanilloid 4 (TRPV4) critically transduces mechanical forces in the IVD, and its inhibition can prevent IVD degeneration due to static overloading. However, it remains unknown whether different modes of loading signals through TRPV4 to regulate the expression of inflammatory cytokines. We hypothesized that TRPV4 signaling is essential during static and dynamic loading to mediate homeostasis and mechanotransduction.

METHODS: Mouse functional spine units were isolated and either cyclically compressed for 5 days (1 Hz, 1 h, 10% strain) or statically compressed (24 h, 0.2 MPa). Conditioned media were monitored at 6 h, 24 h, …

Longitudinal Lipidomic Profiles During Pregnancy And Associations With Neonatal Anthropometry: Findings From A Multiracial Cohort, Yiqing Song, Ruijin Lu, Guoqi Yu, Mohammad L Rahman, Liwei Chen, Yeiyi Zhu, Michael Y Tsai, Oliver Fiehn, Zhen Chen, Cuilin Zhang

2020-Current year OA Pubs

BACKGROUND: Maternal lipidomic profiling offers promise for characterizing lipid metabolites during pregnancy, but longitudinal data are limited. This study aimed to examine associations of longitudinal lipidomic profiles during pregnancy with multiple neonatal anthropometry using data from a multiracial cohort.

METHODS: We measured untargeted plasma lipidome profiles among 321 pregnant women from the NICHD Fetal Growth Study-Singletons using plasma samples collected longitudinally during four study visits at gestational weeks (GW) 10-14, 15-26, 23-31, and 33-39, respectively. We evaluated individual lipidomic metabolites at each study visit in association with neonatal anthropometry. We also evaluated the associations longitudinally by constructing lipid networks using …

The Effect Of Nitroglycerin In Testicular Histopathology, Reproductive Hormones And Testicular Oxidative Stress In Adolescent Rats, Volkan Koşal, Çağlar Okulmuş, Yılmaz Koçak, Ömer Faruk Keleş, Nesrin Ceylan, Yıldıray Başbuğan

Mansoura Veterinary Medical Journal

Background: Nitroglycerin (NTG) exerts a vasodilation effect by acting on vascular smooth muscles. The exact impact of vasodilation on the testes is not fully understood. Objectives: This study aimed to investigate the effects of NTG on the testes before the onset of spermatogenesis and reproductive activity in adolescent rats. Methods: An Average of 45 days male Albino Wistar rats were used. Two groups were formed: an adolescent control group and an adolescent NTG group (10 mg/kg, 5 d). Results: At the end of the study, testicular oxidative stress (malondialdehyde /MDA, catalase/ CAT, advanced oxidation protein products /AOPP, and nitric oxide/ …

Gr-406 Federated Learning In Cardiac Diagnostics: Balancing Predictive Accuracy With Data Privacy In Heart Sound Classification, Sricharan Donkada

C-Day Computing Showcase

Cardiovascular diseases account for nearly a third of global deaths, posing a challenge that machine learning can help address. However, data privacy concerns hinder the direct application of conventional machine learning in this sensitive area. This paper explores Federated Learning (FL) as a decentralized strategy to mitigate these concerns by allowing for local data processing. FL's design ensures that only processed updates, not raw data, are shared with a central server, maintaining individual privacy. Our research assesses FL's practicality and effectiveness in predicting heart disease while adhering to ethical and legal norms. We build upon previous studies, such as Wanyong …

Gr-504 Synthetic Dna Sequence Generation And Classification For Species Discrimination, Nishat Tasnim

C-Day Computing Showcase

The two main goals of this research are to apply machine learning models in computational biology to classify DNA sequences from different species and to create synthetic DNA sequences using GANs. Generative Adversarial Networks (GANs) synthesize DNA sequences while preserving key characteristics like sequence length and GC content. The dataset is enhanced by these artificial sequences, which makes classification jobs better. The classification accuracy of black rat and human genome sequences is evaluated using machine learning models, including Random Forest, SVM, and Logistic Regression. Notably, when trained with synthetic data, all models perform better.

Lung Dosimetry Model Of Inhaled 222rn For Workers At Selected Building Material Factories In Erbil City, Iraq, Sardar Qader Othman, Ali Hassan Ahmed, Sarbaz Ibrahim Mohammed

Polytechnic Journal

Radon gas can cause lung harm, leading to extensive research on the biological effects of radon exposure in human lungs under various environmental conditions. The study estimates radon progeny doses for workers in Erbil city's building materials industries, focusing on alpha particle energy deposition, particle clearance, and lung deposition. Using a home condition of 1 Bq.m-3, radon progeny particle-absorbed doses in the trachea, bronchi, bronchioles, alveolar-interstitial sections, and lungs were determined in the first scenario. The 1 Bq.m-3 is replaced with the radon level for each factory to prepare its atmosphere in the second scenario. For the first scenario, the …

Medical School Watercooler Newsletter - November 30, 2023, Lindsey Lyle

Watercooler Newsletter

This is the November 30, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Pediatric interventional radiologist joins radiology faculty
• USA researchers identify potential biomarkers for detection and treatment of triple-negative breast cancer
• Now accepting nominations for USA Medical Alumni Awards
• Register now: Tools for Teaching in Medical Education
• Center for Healthy Communities to host community health worker forum

The Black Garden, Madalene Klocke

Theses

“The Black Garden” is a novel-length fantasy fiction work. It follows the narrative of Ryan, an 18-year-old girl, who has great expectations for what her first year at university will hold. Her entire world view is tilted when she attends a party with her new roommate, Blair, and wakes up in an unfamiliar place. Ryan must fight to keep her sanity as she is thrust into the world of faeries, witches, and far worse creatures than she could have ever imagined: including her parents.

A Signature Of Five 7-Methylguanosine-Related Genes Is A Prognostic Marker For Lung Squamous Cell Carcinoma., Wensheng Liu, Ying Wang, Paola Ulivi, Simona Tavolari, Syed A A Rizvi, Enrico Capobianco, Alfons Navarro, Yongjun Zhang

Faculty Research 2023

Background: N7-methylguanosine (m7G) is an important posttranscriptional modification affecting mRNA and tRNA functions and stability. The genes regulating the m7G process have been previously found involved in the carcinogenesis process. We aimed to analyze the role of m7G-related genes as potential prognostic markers for lung squamous cell carcinoma (LSCC).

Methods: Twenty-nine m7G-related genes were selected for the analysis in the LSCC cohort of the Cancer Genome Atlas (TCGA). Univariate, multivariate, and Kaplan-Meier analyses were used to evaluate the predictive value of risk model developed with m7G signature for overall survival (OS). The Gene Ontology (GO) and Kyoto Encyclopedia of Genes …

What’S In A Word? A Study Of Emotional Valence, Trisha Patel, Cameron Smith, Olivia Williams, Raul Rodriguez-Calva

Science University Research Symposium (SURS)

Cognitive stress affects humans mentally and physically, and specifically may impact emotional recognition. Previous studies have focused on the perceived emotional valence of nouns vs. adjectives and the emotional recognition of photographs. While this has led to the creation of an emotional valence database, there has yet to be a study to explore how stress can change perceived emotional valence. Using data from the Affective Norms for English Words (ANEW), the Portland Arithmetic Stress Test (PAST), and the Montreal Imaging Stress Task (MIST), a study was created to explore how participants emotional valence of words would change after being placed …

Trehalose Enhances Mitochondria Deficits In Human Npc1 Mutant Fibroblasts But Disrupts Mouse Purkinje Cell Dendritic Growth Ex Vivo., Collin M Macleod, Fawad A K Yousufzai, Liam T Spencer, Sarah Kim, Lucianne A Rivera-Rosario, Zerian D Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Soto

College of Science & Mathematics Departmental Research

Lysosomes play important roles in catabolism, nutrient sensing, metabolic signaling, and homeostasis. NPC1 deficiency disrupts lysosomal function by inducing cholesterol accumulation that leads to early neurodegeneration in Niemann-Pick type C (NPC) disease. Mitochondria pathology and deficits in NPC1 deficient cells are associated with impaired lysosomal proteolysis and metabolic signaling. It is thought that activation of the transcription factor TFEB, an inducer of lysosome biogenesis, restores lysosomal-autophagy activity in lysosomal storage disorders. Here, we investigated the effect of trehalose, a TFEB activator, in the mitochondria pathology of NPC1 mutant fibroblasts in vitro and in mouse developmental Purkinje cells ex vivo. We …

Curriculum Subcommittee Agenda December 7, 2023, Utah State University

Educational Policies Committee

• Program Proposals
• Semester Course Approval Reviews
• Other Business
• Adjourn

Novel Tri-Biopolymer Thin Film With Superior Antimicrobial Efficacy, Ashraf Al-Goraee, Ali Alshami, Abdulrahman Al-Shami, Jason Power, Jadyn Guidinger, Christopher Buelke, Musabbir Jahan Talukder, Xiaodong Hou

Chemical Engineering Faculty Publications

This work reports a novel synthesis, characterization, and performance of antimicrobial polymeric thin films utilizing unreported ternary blend of Chitosan, PLA, and PCL. For binary systems, the selection of matching polymers has improved the material’s structures and properties; however, the transition to using a ternary system is not well-established yet. The ability to homogeneously blend 3 biopolymers would expand the potential to prepare new materials with tailored properties. Herein, unary, binary, and ternary films were produced by physical blending using the casting and solvent evaporation method. The films were then characterized using different techniques for comparing the properties of 3 …

Assessment Of Green Spaces In Metro Nashville Public High Schools, Webster G. Andrews, Anna Lennon, Darlene Panvini

Science University Research Symposium (SURS)

Green spaces on and near school property have been correlated to student mental health and academic achievement. However, there is a gap in the literature investigating how quality and quantity of green space is related to socioeconomic status and school economic metrics in public high schools and the surrounding neighborhoods. Nashville public high schools located in higher socioeconomic areas and having greater financial resources were predicted to provide larger, higher quality green spaces. This study combined a quantitative analysis of neighborhood socioeconomic metrics, school socioeconomic metrics, and quantity of green space (assessed using iTree Canopy) with a qualitative field assessment …

Conquer And Prevail Issue 152 November 30 2023, Wofford College. Office Of Marketing And Communications

Conquer and Prevail Newsletter

No abstract provided.

Ai Assisted Workflows For Computational Electromagnetics And Antenna Design, Oameed Noakoasteen

Electrical and Computer Engineering ETDs

These days large volumes of data can be recorded and manipulated with relative ease. If valuable information can be extracted from them, these vast amounts of data can be a rich resource not just for the digital economy but also for scientific discovery and development of technology. When it comes to deriving valuable information from data, Machine Learning (ML) emerges as the key solution. To unlock the potential benefits of ML to science and technology, extensive research is needed to explore what algorithms are suitable and how they can be applied.

To shine light on various ways that ML can …

Species Richness Of Moths In Parks Surrounded By Varying Levels Of ​Urbanization Around Nashville, Tennessee, Maxwell Stone, Allie Bennett

Science University Research Symposium (SURS)

Moths can act as indicators of environmental wellness due to their pollution sensitivity and the complexity of biodiversity required to support their life cycles. Urbanization can impact the occurrence of moths in protected green spaces. Higher moth species richness was hypothesized to occur in parks surrounded by more rural areas. Three metropolitan parks were chosen in the Nashville area: downtown, within a suburban neighborhood, and in a rural area. Tree canopy cover and degree of impervious surfaces were assessed for each park and surrounding area using iTreeCanopy. Moths were attracted to a white sheet using a mercury vapor bulb, UV …

The Role Of Myc-Egr1 Pathway In Colorectal Cancer Development And Its Relationship To Wnt Signaling, Lexi Chrysochoos, Erick Spears, Emily Abdoney

Science University Research Symposium (SURS)

Lexi Chrysochoos, Emily Abdoney, and Erick Spears

The Role of MYC-EGR1 Pathway in Colorectal Cancer Development and its Relationship to Wnt Signaling

Colorectal tumors show high levels of Wnt pathway activity, most often due to an initiating mutation in critical Wnt pathway components. Wnt pathway activation leads to b-catenin-driven expression of genes that generally stimulate cell cycle progression. One such Wnt pathway target gene is MYC, a well described oncogene involved in many cancers, including colorectal. MYC is known to stimulate proliferation but in certain cellular contexts, can stimulate apoptosis by stimulating the expression of EGR1. This is termed a …

Co2 Sequestration And Temperature Modulation By Plants On Green Roofs, Matthew L. Fumarola, Clema Balire, Darlene Panvini

Science University Research Symposium (SURS)

Green roofs can play a role in CO2 absorption and temperature modulation in urban areas as a means of countering the impacts of climate change and heat effects due to urbanization. While diverse plants can be found on green roofs, the different role they play in mediating these effects is not clear. This study, using constructed polyethylene tents around plants and bare soil sites, measured atmospheric CO2, soil temperature, relative humidity and air temperature for four species of plants located on Belmont University’s green roofs. The species were Sulfur Cosmos, Yucca, Hairawn Muhly, and Goldenrod. Three species, Yucca, Hairawn Muhly …

Lionfish (Pterois Volitans) Neurocranium, Kate Heffner, Hosanna Gattle, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 30 cm total length (TL) Lionfish (Pterois volitans), collected from Second Reef on 15/10/2023 by Kate Heffner.

Relationships Among Development, Growth, Body Size, Reproduction, Aging, And Longevity - Trade-Offs And Pace-Of-Life., Rong Yuan, Erin Hascup, Kevin Hascup, Andrzej Bartke

Articles

Relationships of growth, metabolism, reproduction, and body size to the biological process of aging and longevity have been studied for decades and various unifying "theories of aging" have been proposed to account for the observed associations. In general, fast development, early sexual maturation leading to early reproductive effort, as well as production of many offspring, have been linked to shorter lifespans. The relationship of adult body size to longevity includes a remarkable contrast between the positive correlation in comparisons between different species and the negative correlation seen in comparisons of individuals within the same species. We now propose that longevity …

Microscale To Mesoscale Modeling Of The Ocean Under Tropical Cyclones: Effects Of Sea Spray And Surfactants On Tropical Cyclone Intensity And Air-Sea Gas Exchange, Breanna Lynn Cain Vanderplow

All HCAS Student Capstones, Theses, and Dissertations

Tropical cyclone intensity prediction remains a challenge despite computational and observational developments because successful intensity forecasting requires implementing a multitude of atmospheric and oceanic processes. Hurricane Maria 2017 and Hurricane Dorian 2019 serve as prime examples of rapidly intensifying storms that devastated communities in the Caribbean. A lack of understanding and parameterization of crucial physics involved in tropical cyclone intensity in existing forecast models may have led to these and other forecasting errors.

Microscale physical processes at the air-sea interface are a major factor in intensification of tropical cyclones that are often unaccounted for in forecasting models since they are …

Into An Interference Zone: Childbirth And Care Among Mehinako People, Aline Regitano

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article addresses issues of care and corporeality during gestation, childbirth, the postpartum period, and childcare through a case study conducted with Mehinako people. Among this Amazonian people, care forms the person, having an elementary function in the daily construction of kinship relations through means of affection. A recent trend has caused expressive transformations in the way women experience corporeality and the making of a person: the displacement of birth from the home to hospitals, motivated by women’s fear, desire, and curiosity. In the city, Indigenous women transit through medical institutions, which I propose may be read as interference zones …

Jean E. Jackson: A Pioneering Ethnographer In The Colombian Amazon, Patience Epps, Danilo Paiva Ramos, Flora Dias Cabalzar

Tipití: Journal of the Society for the Anthropology of Lowland South America

This essay celebrates the work of Jean E. Jackson, a pioneering female ethnographer who devoted most of her fifty-year career to the Indigenous peoples of Colombia. Her research, represented in an extensive set of publications from the early 1970s to the present, engages with themes of identity, stigma, and social inequality, manifested across a range of contexts. Jackson’s ethnographic contributions include her ground-breaking early work on Indigenous Tukanoan society in the Colombian Vaupés, focusing on the practice of linguistic exogamy (obligatory marriage across language groups) among the Bará people. Later, she expanded her focus to address Indigenous experiences in the …

A Comparative Study Of Yolo Models And A Transformer-Based Yolov5 Model For Mass Detection In Mammograms, Damla Coşkun, Dervi̇ş Karaboğa, Alper Baştürk, Bahri̇ye Akay, Özkan Ufuk Nalbantoğlu, Serap Doğan, İshak Paçal, Meryem Altin Karagöz

Turkish Journal of Electrical Engineering and Computer Sciences

Breast cancer is a prevalent form of cancer across the globe, and if it is not diagnosed at an early stage it can be life-threatening. In order to aid in its diagnosis, detection, and classification, computer-aided detection (CAD) systems are employed. You Only Look Once (YOLO)-based CAD algorithms have become very popular owing to their highly accurate results for object detection tasks in recent years. Therefore, the most popular YOLO models are implemented to compare the performance in mass detection with various experiments on the INbreast dataset. In addition, a YOLO model with an integrated Swin Transformer in its backbone …

The Implementation Of Forensic Genetic Genealogy And Ethics, Nayeli Carta Ramirez

Whittier Scholars Program

No abstract provided.