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Proteomics And Machine Learning For Pulmonary Embolism Risk With Protein Markers, Yaa Amankwah Awuah

Electronic Theses and Dissertations

This thesis investigates protein markers linked to pulmonary embolism risk using proteomics and statistical methods, employing unsupervised and supervised machine learning techniques. The research analyzes existing datasets, identifies significant features, and observes gender differences through MANOVA. Principal Component Analysis reduces variables from 378 to 59, and Random Forest achieves 70% accuracy. These findings contribute to our understanding of pulmonary embolism and may lead to diagnostic biomarkers. MANOVA reveals significant gender differences, and applying proteomics holds promise for clinical practice and research.

The Impact Of Aces On College Students And Their Major Choice, Britten Harrison

Electronic Theses and Dissertations

Research examining Adverse Childhood Experiences (ACEs) has mostly focused on the long-term effects of these experiences on adult mental and physical health. Less attention has been focused on the impact of ACEs on college student satisfaction, dropout rates, and major choice. The overarching questions for the current study sought to further research by (1) assessing if there is a relationship between the ACE scores of college students and their mental and physical health, (2) if ACEs play a role in student satisfaction or desire to drop out, and (3) determining if there is a connection between students with high ACE …

Investigating The Role Of Maternal Adiposity On Human Breast Milk And Preterm Infant Stool Short Chain Fatty Acid And Microbiome Profiles, Kristy L. Thomas

Electronic Theses and Dissertations

Preterm birth is the number one cause of death in neonates, accounting for 35% of neonatal mortality. The preterm birth rate in the U.S. in 2021 was 10.5%, disproportionally affected by race and ethnicity. Obese women have an increased risk of preterm pregnancy, and if delivered before 37 weeks of gestation, the offspring have higher rates of complications that extend from the neonatal period into life-long metabolic and immune adverse outcomes. In the early months after delivery, preterm infants have higher rates of adverse health outcomes than term infants, including infections, extrauterine growth restrictions, respiratory, metabolic, and neurological complications, necrotizing …

E-Cigarettes: What Is The Relationship Between E-Cigarette Usage And Periodontal Disease?, Deborah Rose

Electronic Theses and Dissertations

The dental community has a broad understanding of how traditional combustible cigarettes affect the oral cavity of the dental patient but there is little research available on the effects that e-cigarettes have on the patient’s dental health. Vaping products have been marketed as a healthier option over traditional combustible cigarettes. Since they were first introduced in 2003, very little research has been performed to understand their dental implications. This project was executed to investigate the chemicals associated with these vaping products and how they possibly contribute to the progression of periodontal disease. This research project was conducted with the contribution …

Mechanical Properties Of Natural Osmia Lignaria Silk And Recombinant Expression Of The Silk Proteins, Jackson Morley

Undergraduate Honors Capstone Projects

The use of petroleum-based plastic and the subsequent waste has led researchers to explore alternatives in the form of biopolymers. Spider silk and hagfish intermediate filaments show the potential to be advantageously utilized in textile and biomedical industries. Bee silk is a sparsely studied biopolymer that has shown potential to be added to these other impressive biopolymers. Osmia lignaria, is a solitary bee native to the western United States. Silk from these bees can be isolated while the larvae are spinning their silk. The silk from these bees has been mechanically tested for strength, stress, strain, and elasticity. Cocoon …

Examining Factors Among People With Opioid Use Disorder And Comorbid Mental Health Disorders, Tori Denae Livingston

Theses and Dissertations

Opioid use disorder (OUD) affects over two million Americans, and over 42,000 Americans perished of opioid overdoses in 2016 (Volkow et al., 2019). During the initial years of the opioid crisis, overdose deaths were primarily attributed to prescription analgesics, heroin, and synthetic opioids. However, it was illicit prescription opioid painkiller use that ranked highest in terms of fatalities (Volkow et al., 2019). The increasing prevalence of opioid use among individuals with mental health disorders is in stark contrast to the ongoing opioid crisis (Prince, 2019). Additionally, there is evidence that individuals undergoing substance use treatment and concurrently suffering from a …

An Ace2 Decamer Viral Trap As A Durable Intervention Solution For Current And Future Sars-Cov, Hailong Guo, Bomsoo Cho, Paul R Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W Botten, Stephen F Carroll, Bruce A Keyt, Andrew W Womack, William R Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W Shiver, Tong-Ming Fu

Faculty, Staff and Student Publications

The capacity of SARS-CoV-2 to evolve poses challenges to conventional prevention and treatment options such as vaccination and monoclonal antibodies, as they rely on viral receptor binding domain (RBD) sequences from previous strains. Additionally, animal CoVs, especially those of the SARS family, are now appreciated as a constant pandemic threat. We present here a new antiviral approach featuring inhalation delivery of a recombinant viral trap composed of ten copies of angiotensin-converting enzyme 2 (ACE2) fused to the IgM Fc. This ACE2 decamer viral trap is designed to inhibit SARS-CoV-2 entry function, regardless of viral RBD sequence variations as shown by …

Explainable Artificial Intelligence: Approaching It From The Lowest Level, Ralf P. Riedel

Graduate Theses and Dissertations (2019 - present)

The increasing complexity of artificial intelligence models has given rise to extensive work toward understanding the inner workings of neural networks. Much of that work, however, has focused on manipulating input data feeding the network to assess their affects on network output or pruning model components after the often-extensive time-consuming training. It is postulated in this study that understanding of neural network can benefit from model structure simplification. In turn, it is shown that model simplification can benefit from investigating network node, the most fundamental unit of neural networks, evolving trends during training. Whereas studies on simplification of model structure …

Impact Of Using Gagne’S Nine Events Of Instruction On Student’S Academic Achievement And Satisfaction In An Online English Course For French Speakers, Yara Olive Paterne Loua

Graduate Theses and Dissertations (2019 - present)

This dissertation explored the effect of Gagne's nine events of instruction on student academic achievement and satisfaction during an online English class for French speakers. A group of 30 Facebook users from French-speaking countries in North and Sub-Saharan Africa participated in the research. They were divided randomly into two groups: one receiving traditional instruction through an asynchronous online lecture with PowerPoint presentation, and the other using instruction utilizing Gagne's nine events of instruction integrated with an LMS designed for this purpose. This mixed methods study explored several hypotheses related to academic achievement and satisfaction in the two groups. While the …

Unlocking The Mysteries Of Opportunism: Neuroendocrine Insights From An Aseasonal Breeder (Taeniopygia Guttata), Jessica A. Moodie

Graduate Theses and Dissertations (2019 - present)

The regulation of reproductive physiology in animals is mediated by the Hypothalamus-Pituitary-Gonad (HPG) axis. In seasonal breeders, a conserved reciprocal switching of deiodinase enzymes alters thyroid hormone signaling, which controls HPG activity. This study tested the hypothesis that neural regulation of the HPG axis as described in seasonal systems is conserved and repurposed to respond to other cues in aseasonal species. Using water deprivation and nest restriction in the opportunistic Zebra Finch, we were able to create a breeding group and non-breeding group, confirmed by egg laying and changes in ovarian anatomy. Breeding females had clear follicular hierarchy, increased ovary …

Interactions Between Sediment Mechanical Structure And Infaunal Community Structure Following Physical Disturbance, William Cyrus Roger Clemo

Graduate Theses and Dissertations (2019 - present)

Shallow, river-influenced coastal sediments are important for global carbon storage and nutrient cycling and provide a habitat for diverse communities of invertebrates (infauna). Elevated bed shear stress from extreme storms can resuspend, transport, and deposit sediments, disrupting the cohesive structure of muds, and sorting and depositing sand eroded from beaches. These physical disruptions can also resuspend or smother infauna, decreasing abundances and changing community structure. Infaunal activities such as burrowing, tube construction, and feeding can impact sediment structure and stability. However, little is known about how physical disturbance impacts short and long-term sediment habitat suitability and whether disturbance-tolerant infauna influence …

Gravel Conveyance System: An Evaluation On E. Coli Removal Capabilities, Madison Grace

Graduate Theses and Dissertations (2019 - present)

In many rural, low-income communities such as the Black Belt of Alabama, there is a lack of wastewater infrastructure and solutions leaving homeowners non-compliant to state and federal law and with potential health risks on their property. New regulations have allowed for onsite, surface discharge for single family homes that are not connected to a centralized sewer or large flow development. These new regulations also contain strict disinfection criteria for the treated wastewater that will be discharged. A low-cost and low-maintenance treatment system that provides adequate disinfection is necessary to allow homeowners to take advantage of the new opportunity for …

Medication Use Evaluation Of Il-17 And Il-23 Inhibitors At A Large Health System., Corey Uetrecht Pharmd Candidate, Robert D. Beckett , Pharmd, Bcps, Kevin Baumgartner Pharmd, Jennifer Sposito Pharmd

Parkview Pharmacy Department

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This project evaluated the appropriateness of interleukin (IL)-17 and IL-23 inhibitor usage within Parkview Health, in both inpatient and outpatient settings.

Vozick Hans, Alexandra, Sophia Maier Garcia

Bronx Jewish History Project

Alexandra Vozick Hans was born to Canadian parents, who, upon moving to New York, lived in the Amalgamated Housing Cooperative, where she grew up. She remained in the Bronx until she graduated college in 1966. After college, she moved to Boston and became a social worker.

Hans and her family were socialists, and Hans recalls tensions between the socialists and the communists in the Amalgamated. She also recalls tensions over the issue of integration in the building: the Amalgamated was not integrated, and residents complained about the lack of integration. Overall, however, Hans looks back with great fondness on the …

Degronmd: Leveraging Evolutionary And Structural Features For Deciphering Protein-Targeted Degradation, Mutations, And Drug Response To Degrons, Haodong Xu, Ruifeng Hu, Zhongming Zhao

Faculty, Staff and Student Publications

Protein-targeted degradation is an emerging and promising therapeutic approach. The specificity of degradation and the maintenance of cellular homeostasis are determined by the interactions between E3 ubiquitin ligase and degradation signals, known as degrons. The human genome encodes over 600 E3 ligases; however, only a small number of targeted degron instances have been identified so far. In this study, we introduced DegronMD, an open knowledgebase designed for the investigation of degrons, their associated dysfunctional events, and drug responses. We revealed that degrons are evolutionarily conserved and tend to occur near the sites of protein translational modifications, particularly in the regions …

Federal District Court Rejects Challenge To Florida Ban On Transgender Girls From Competitive Girls’ Sports, Arthur S. Leonard

Other Publications

No abstract provided.

A New Method To Evaluate Pressure Distribution Using A 3d-Printed C2-C3 Cervical Spine Model With An Embedded Sensor Array, Frank Vrionis

All Publications

Cervical degenerative disc diseases such as myelopathy and radiculopathy often require conventional treatments like artificial cervical disc replacement or anterior cervical discectomy and fusion (ACDF). When designing a medical device, like the stand-alone cage, there are many design inputs to consider. However, the precise biomechanics of the force between the vertebrae and implanted devices under certain conditions require further investigation. In this study, a new method was developed to evaluate the pressure between the vertebrae and implanted devices by embedding a sensor array into a 3D-printed C2-C3 cervical spine. The 3D-printed cervical spine model was subjected to a range of …

Comprehensive, Evidence-Based, Consensus Guidelines For Prescription Of Opioids For Chronic Non-Cancer Pain From The American Society Of Interventional Pain Physicians (Asipp), Radomir Kosanovic

All Publications

Background: Opioid prescribing in the United States is decreasing, however, the opioid epidemic is continuing at an uncontrollable rate. Available data show a significant number of opioid deaths, primarily associated with illicit fentanyl use. It is interesting to also note that the data show no clear correlation between opioid prescribing (either number of prescriptions or morphine milligram equivalent [MME] per capita), opioid hospitalizations, and deaths. Furthermore, the data suggest that the 2016 guidelines from the Centers for Disease Control and Prevention (CDC) have resulted in notable problems including increased hospitalizations and mental health disorders due to the lack of appropriate …

A Muscle Exercise Research Revolution Powered By -Omics At Single Cell And Nucleus Resolution, Kevin A. Murach, Charlotte Peterson

Health, Human Performance and Recreation Faculty Publications and Presentations

In the last few years, single cell and single nucleus RNA-sequencing technologies have been leveraged in exercised adult skeletal muscle to reveal complex cell type-specific regulation of muscle plasticity. Expanding -omics technology at single cell resolution, complimented by advanced computational approaches, promise to rapidly accelerate our understanding of how exercise confers its numerous beneficial effects, paving the way for cell type-specific and targeted therapeutics to increase exercise responses during aging and in the face of chronic disease.

Biological Age Mediates The Effects Of Perceived Neighborhood Problems On Heart Failure Risk Among Black Persons, Ganga Bey, James Pike, Priya Palta, Anthony Zannas, Qian Xiao, Shelly-Ann Love, Gerardo Heiss

Faculty, Staff and Student Publications

OBJECTIVE: We assessed whether biological age, measured by the epigenetic clock GrimAge, mediates the association of objective and subjective neighborhood disadvantage with incident HF among Black persons.

METHODS: Participants were 1448 self-reported Black adults (mean age (standard deviation, SD) = 64.3 (5.5)) dually enrolled in two community-based cohorts in Jackson, Mississippi, the ARIC and JHS cohorts, who were free of HF as of January 1, 2000. Incident HF events leading to hospitalization through December 31, 2017, were classified using ICD-9 discharge codes of HF. Multilevel age- and sex-adjusted Cox causal mediation models were used to examine whether biological age (at …

Alignment Between 24-H Light-Dark And Activity-Rest Rhythms Is Associated With Diabetes And Glucose Metabolism In A Nationally Representative Sample Of American Adults, Qian Xiao, John Durbin, Cici Bauer, Chris Ho Ching Yeung, Mariana G Figueiro

Faculty, Staff and Student Publications

OBJECTIVE: The alignment between environmental stimuli (e.g., dark, light) and behavior cycles (e.g., rest, activity) is an essential feature of the circadian timing system, a key contributor to metabolic health. However, no previous studies have investigated light-activity alignment in relation to glycemic control in human populations.

RESEARCH DESIGN AND METHODS: The analysis included ∼7,000 adults (aged 20-80 years) from the National Health and Nutrition Examination Survey (NHANES) (2011-2014) with actigraphy-measured, multiday, 24-h activity and light data. We used phasor analysis to derive phasor magnitude and phasor angle, which measures coupling strength and phase difference between the activity-rest and light-dark cycles, …

Effect Of Plant Genotype On Plant-Microbe Interactions And Multi-Generation Ecosystem Selection Of Microbial Communities Associated With Plant Biomass In Arabidopsis Thaliana, Nachiket Shankar

Graduate Doctoral Dissertations

The microbiome's role in shaping host phenotypes is a critical area of investigation, with implications for ecology, evolution, and host health. Dynamic plant-microbe interactions are influenced by factors like soil type, environment, and genotype. Understanding their impact on microbial communities is key for tailored plant benefits. An artificial ecosystem selection experiment was done for eight generations with Arabidopsis thaliana Ler and Cvi. This revealed distinct microbial communities shaped by genotypes and biomass treatments. Initially, environment dominated, but over time, genotype and biomass gained influence, explaining ~40% of the variation. Moreover, genotype-specific rhizobacterial associations were observed, enhancing understanding of community dynamics …

3d Printed Microdialysis-Based Microsampling Probes, Patrick Pysz

Graduate Theses and Dissertations

This work will show the development of a fully 3D printed device platform in which a complex microsampling probe geometry is fabricated in a simple two-step process. This process includes the combination of 2-photon polymerization (2PP) and masked-stereolithography (MSLA). The cutting edge neurotechnology needed to monitor brain internal communication and will require multiple sensing modalities including temperature, pressure, electrophysiological, and optogenetics. Microsampling is an integrally important function for any future biosensing device platform as it allows for chemical delivery and unparalleled specificity through offline analysis of collection samples. Stereolithography (SLA) 3D printing has emerged as a powerful fabrication method capable …

Patterns In Winter Stonefly Distribution Along A River Continuum And Land-Use Gradient In Northwest Arkansas Streams, Zachary Tipton

Graduate Theses and Dissertations

Freshwater ecosystems are facing a crisis with extinction rates of aquatic species exceeding those of their terrestrial counterparts by up to fivefold. This decline is predominantly attributed to evolving land use patterns within watersheds, leading to chemical and physical transformations in freshwater habitats. Northwest Arkansas (NWA) represents one of the fastest-growing regions in the United States, undergoing substantial shifts in land use. Consequently, the status of aquatic life in this region remains uncertain. Addressing this concern, the latest Arkansas Wildlife Action Plan emphasizes the necessity of distribution and population data to guide conservation efforts for Species of Greatest Conservation Need …

We Resist, We Heal, We Transform: Exploring Youth Of Color Journeys Towards Healing Justice In A Grassroots Organization In Urban Boston, Rhyann Leslie Robinson

Graduate Masters Theses

While many would say otherwise, the current system is not a broken one (Kaba, 2021). The colonial systems, frameworks, and theories we have in place are working exactly how they are supposed to: in favor of and in tandem with systems that seek to oppress marginalized communities. This realization calls for a shift, including shifts in research in ways that builds from below (Atallah & Dutta, 2021; Fernández, 2018; Tang-Yan, 2022). The current study aims to explicitly interrogate coloniality and colonial violence in a United States socio historical context, exploring youth of color development in conditions of adversity, looking at …

Chemistry Instructors’ Perspectives On Incorporating Climate Change Instruction In Undergraduate Chemistry Courses, Patrick Wilson

Dissertations

Education plays an important role in preparing current and future generations for the challenges ahead caused by climate change. The purpose of this dissertation was to examine the educational influence textbooks and undergraduate instructors have on their students. Three studies were carried out to explore these influences on climate change instruction. The first study looked at the extent, type, and location of climate change topics across 24 undergraduate general chemistry textbooks. Gas chemistry concepts were the most prevalent topic connected to climate change. However, the distribution of climate change related material varied considerably across books. The majority of climate change …

“Just Go For The Lie”: A Critical Autoethenographic Study Of A White Female Elementary School Principal, Christie Michelle Toliver

Dissertations

The purpose of this study was to analyze my own leadership experiences as a White cisgender female elementary school principal and how my white privilege contributed to maintaining white supremacy and systemic racism. The purpose was also to explore the impact of the evolution of my white racial frame and intentionally break my silence about white supremacy and systemic racism over the 2018–2019 school year. Critical Race Theory (CRT) and Critical White Studies (CWS) provided the framework of analysis using a narrative structure to develop four critical vignettes at the micro level of education. Qualitative data were drawn from personal …

Establishing Guidelines For Achieving Optimal Individual Posture In Hornists, Daniel Alan Nebel

Dissertations

Potentially debilitating performance-related pain (PRP) is common among professional and aspiring instrumentalists, can lead to significant loss of income, and sometimes end a career. Postural misalignments that lead to PRP can develop early in students’ training and is often successfully addressed by a music teacher recommending a change in technique. The nature of a musician’s PRP is dependent on how their instrument is held; there has never been an in-depth study of PRP specifically for hornists. This dissertation summarizes the current relevant research of PRP in musicians and hornists, conducts and analyzes a comprehensive hornist-specific health survey, seeks to identify …

Resiliency In Families Of Children With Low Vision, Deborah Lynn Mendoza

Dissertations

Resiliency is comprised of a complex interplay of risk and protective factors that change and develop over time. In the past, research focused on characteristics that allowed individuals to remain untouched by negative events around them; however, over time, this has morphed into investigating not only the characteristics individuals possess but those present within families as well. Families of children who have either a congenital or an acquired disability could face a unique set of risk factors over time that might require different protective factors to ensure they emerged from their adversity positively changed. As professionals, we have a responsibility …

Management Zone Delineation For Variable-Rate Seeding In Production Soybeans, Ujjwal Sigdel

Graduate Theses and Dissertations

Soybean seeding rate (SR) is selected according to planting date, maturity group, soil properties, and yield goal. Even though one SR is applied in most fields, site-specific adjustments with variable-rate seeding (VRS) technology can help optimize production. The project goal was to determine if VRS could be beneficial to soybean producers in Arkansas. The project objectives were to i) assess planter performance and soybean yield response to five seeding rate treatments, ii) characterize the drivers of yield variability, and iii) create a-posteriori prescription maps for VRS. Five SR treatments (185,000, 247,000, 309,000, 370,000 and 432,000 seeds ha-1) were applied using …