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The Echo: December 4, 2023, Taylor University

2023-2024 (Volume 111)

No abstract provided.

Jun Upregulation Drives Aberrant Transposable Element Mobilization, Associated Innate Immune Response, And Impaired Neurogenesis In Alzheimer’S Disease, Chiara Scopa, Samantha Barnada, Maria Cicardi, Mo Singer, Davide Trotti, Marco Trizzino

Farber Institute for Neuroscience Faculty Papers

Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of Alzheimer's disease (AD). Mobilization of transposable elements (TEs) in heterochromatic regions was recently reported in AD, but the underlying mechanisms are still underappreciated. Combining functional genomics with the differentiation of familial and sporadic AD patient derived-iPSCs into hippocampal progenitors, CA3 neurons, and cerebral organoids, we found that the upregulation of the AP-1 subunit, c-Jun, triggers decondensation of genomic regions containing TEs. This leads to the cytoplasmic accumulation of HERVK-derived RNA-DNA hybrids, the activation of the cGAS-STING cascade, and increased levels of cleaved caspase-3, suggesting the initiation of programmed cell death …

Diaryl Oxazoles As Cleavable Linkers For Drug Discovery Platforms, Elizabeth Taggart

Honors Theses

Within the field of medicine and pharmacology, discovering small molecule or biologic based molecules with therapeutic potential is a difficult task. Current methods involve individually screening hundreds of compounds on a potential target biomolecule, and recent technologies have explored peptide encoded libraries (PELs) as a means of making this screening process more high-throughput. These libraries produce a large number of small molecule drug candidates each conjugated to a unique peptide fragment, functioning as a barcode. Analysis of PELs requires the capture of hit small molecules and the subsequent release of their peptide tags; however, current approaches are limited in their …

Structural Basis Of Gating In Msl Channels, Jingying Zhang

Arts & Sciences Graduate Student Theses and Dissertations

All living organisms experience exogenous and endogenous mechanical stress that are fundamental to their growth, survival, and development. A prominent strategy to manage these stresses and ensure efficient physiological responses is through mechanosensitive (MS) ion channels by transforming mechanical forces into electrochemical signaling. However, given their structural diversity and the inherent challenges of applying membrane tension during structural study, how MS channels sense mechanical force and transit into different functional states remain unclear. MSL channels in plants, members of the mechanosensitive ion channel of small conductance (MscS) superfamily, provide a compelling avenue for studying the structural basis for gating of …

From Chinese Language To Female - Him, Humans And Us, Dandong Ouyang

Theses

To establish a new sense of ownership of the female figure in my studio practice, this thesis investigates the unspoken secondary existence of women implied in the structural systems of both language and portraiture.

Microwave-Photonic Vernier Effect Enabled High-Sensitivity Fiber Bragg Grating Sensors For Point-Wise And Quasi-Distributed Sensing, Chen Zhu, Osamah Alsalman, Jie Huang

Electrical and Computer Engineering Faculty Research & Creative Works

This paper reports a sensitivity-improved fiber Bragg grating (FBG) sensor system based on microwave-photonic interferometry and the Vernier effect. an incoherent microwave photonics system based on a broadband light source is employed to interrogate the FBG sensor using the wavelength-to-delay mapping technique combined with interferometry. Specifically, the sensing FBG together with a reference FBG is used to construct a microwave photonics Michelson interferometer (MI). Changes in the Bragg wavelength of the sensing FBG subject to external perturbations are encoded into the spectral shifts of the microwave interferogram of the MI. a virtual interferometer is then generated from the sensing MI …

Platinum Measurements In Dulbecco’S Phosphate-Buffered Saline Are Lower Than In Plasma And Can Be Sampled With Ultrafiltration Probes In Vitro, Marije Risselada, Robyn Mccain

Purdue University Libraries Open Access Publishing Fund

OBJECTIVE

To compare the influence of fluid on carboplatin elution, and assess the feasibility of ultrafiltration (UF) probe sampling

SAMPLE

20 samples of 5 mg carboplatin in 1.0 mL 30% poloxamer 407 eluting in Dulbecco’s phosphate-buffered saline (DPBS) or canine plasma and 6 samples of UF probe sampling in 0.01 mg/mL carboplatin in DPBS or plasma.

METHODS

Carboplatin-gel specimens in dialysis tubing (12- to 14-kDa pores) were placed in 100 mL of DPBS or canine plasma (37 °C and 600 rpm stirring) in a nonlidded and lidded experiment. Samples were collected in decreasing frequency for 96 hours. The 0.01-mg/mL carboplatin …

Organ-Specific Characteristics Govern The Relationship Between Histone Code Dynamics And Transcriptional Reprogramming During Nitrogen Response In Tomato, Russell Julian, Ryan M. Patrick, Ying Li

Purdue University Libraries Open Access Publishing Fund

Environmental stimuli trigger rapid transcriptional reprogramming of gene networks. These responses occur in the context of the local chromatin landscape, but the contribution of organ-specific dynamic chromatin modifications in responses to external signals remains largely unexplored. We treated tomato seedlings with a supply of nitrate and measured the genome-wide changes of four histone marks, the permissive marks H3K27ac, H3K4me3, and H3K36me3 and repressive mark H3K27me3, in shoots and roots separately, as well as H3K9me2 in shoots. Dynamic and organ-specific histone acetylation and methylation were observed at functionally relevant gene loci. Integration of transcriptomic and epigenomic datasets generated from the same …

Economic Governance And Violence: A Cross-National Analysis, Steven Mccain

Theses and Dissertations

Understanding how economic governance influences routine activities is crucial within the field of criminology to better understand how grounds for violence emerge. Literature of cross-national studies concerning the effects of economic governance has recently developed to study its relationship with violence, specifically homicide. However, there is a deficit of frameworks related to criminological theory in this literature. Using a routine activity framework, the current dissertation seeks understand how different degrees of economic governance in general and, more specifically, the five areas of economic governance – size of government, legal system and property rights, sound money, freedom to international trade, and …

Identifying The Drivers Of Pollen Limitation In Apples (Malus Domestica) Within The Urban Orchards Of St. Louis, Mo, Jordan Hathaway

Theses

The human population is projected to continue growing throughout the remainder of the 21st century. Thus, agricultural production will need to increase drastically in order to ensure global food security. Management strategies aimed at enhancing crop pollination by promoting pollinator diversity have shown potential as an environmentally sustainable method of increasing yields. Optimizing the design and implementation of these strategies will require us to expand our understanding of the processes which influence crop pollen limitation. In this study, we examined pollen limitation in self-incompatible apple trees (Malus domestica) within urban orchards located in St. Louis, MO. In our first field …

Tropikong Americano, Allan Punzalan Isaac

Katipunan

Sinusuri ng American Tropics ang teoretiko at historikong muhon ng terminong ito sa mga araling postkolonyal, Americano, Asyano Americano, at pampanitikan. Nagpepresenta ang “tropikong Americano” buhat sa imperyal na pagnanasa at pantasyang Americano ng iba pang mukha ng kultural na harayang Asyano Americano upang madesentro ang imigrasyon at eksklusyon bilang pangunahing tuon ng pagbubuong panlahi ng Asyano Americano. Kung mahalagang bahagi ng mga identidad na Asyano Americano ang imperyalismong kultural at ekonomikong Americano bilang “pagbubuong panlipunan” sa mga ito, para hiramin na rin ang pagtukoy nina Omi at Winant hinggil sa lahi at pagsasalahi, paano hinuhubog ng pagnanasang imperyal na …

Phi-1, An Endogenous Inhibitor Protein For Protein Phosphatase-1 And A Pan-Cancer Marker, Regulates Raf-1 Proteostasis, Jason Kirkbride, Garbo Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto

Kimmel Cancer Center Faculty Papers

Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases. Cellular Raf-1 activity is intricately regulated through pathways involving the binding of regulatory proteins, direct phosphorylation, and the ubiquitin-proteasome axis. In this study, we demonstrate that PHI-1, an endogenous inhibitor of protein phosphatase-1 (PP1), plays a pivotal role in modulating Raf-1 proteostasis within cells. Knocking down endogenous PHI-1 in HEK293 cells using siRNA resulted in increased cell proliferation and reduced apoptosis. This heightened cell proliferation was accompanied by a 15-fold increase in ERK1/2 phosphorylation. Importantly, the observed …

Relativistic Ultrafast Electron Diffraction At High Repetition Rates, K. M. Siddiqui, D. B. Durham, F. Cropp, F. Ji, S. Paiagua, C. Ophus, N. C. Andresen, L. Jin, J. Wu, S. Wang, X. Zhang, W. You, M. Murnane, Martin Centurion, X. Wang, D. S. Slaughter, R. A. Kaindl, P. Musumeci, A. M. Minor, D. Filippetto

Department of Physics and Astronomy: Faculty Publications

The ability to resolve the dynamics of matter on its native temporal and spatial scales constitutes a key challenge and convergent theme across chemistry, biology, and materials science. The last couple of decades have witnessed ultrafast electron diffraction (UED) emerge as one of the forefront techniques with the sensitivity to resolve atomic motions. Increasingly sophisticated UED instruments are being developed that are aimed at increasing the beam brightness in order to observe structural signatures, but so far they have been limited to low average current beams. Here, we present the technical design and capabilities of the HiRES (High Repetition-rate Electron …

Two New Phreatic Snails (Mollusca, Caenogastropoda, Cochliopidae) From The Edwards And Edwards-Trinity Aquifers, Texas, Kathryn E. Perez, Yamileth Guerrero, Roel Castañeda, Peter H. Diaz, Randy Gibson, Benjamin F. Schwartz, Benjamin T. Hutchins

School of Integrative Biological & Chemical Sciences Faculty Publications

The Edwards and Edwards-Trinity Aquifers of Texas have diverse stygofauna, including fifteen species of snails found in phreatic and hyporheic habitats. These species have the hallmarks of adaptation to subterranean environments including extremely small body size and the loss of pigmentation and eyes. Here we use an integrative taxonomic approach, using shell, radula, and anatomical features as well as mitochondrial and nuclear DNA data, to circumscribe a new genus and two new cavesnail species from Central Texas. Vitropyrgus lillianae gen. et sp. nov. is described from Comal Springs (Comal County) and Fessenden Springs (Kerr County) and distinguished by a glassy, …

Duchenne Muscular Dystrophy: Age, Disease Stage, And Patient-Reported Quality Of Life, Sheila Jagers

Walden Dissertations and Doctoral Studies

No abstract provided.

Strategies Managers Use To Motivate Millennials, Talena Lynn Edwards

Walden Dissertations and Doctoral Studies

No abstract provided.

Intouch Week Of December 4, 2023, New York Medical College

InTouch

• Get to Know Dr. Schluger, the New SOM Dean
• NYMC Celebrates Faculty Authorship at 30th Annual Recognition
• NYMC's Giving Tuesday Success Fuels Clinical Skills and Simulation Center Expansion
• Students Shine at 2023 Multidisciplinary Community Outreach
• NYMC Looks at the Future of the Life Sciences at the Innovation in Research Conference
• Study Finds Racial Disparities in Postoperative Outcomes for Cervical Stenosis

Chimes: December 4, 2023, Calvin University

Chimes

Calvin building projects abound: where's the money coming from? by Savannah Shustack & Grace Buller

Campus leadership works to implement safety measures by Ashley Hamons

Fall sports wrap up as winter sports hit the ground running by Dillion Baumchen

KIM gives students real-world experience in investment management by Ethan Meyers

Calvin enters partnership to encourage civic engagement among students by Savannah Shustack

Calvin Alumni gives an on-campus talk about his experience at an aerospace startup by Jacob Westra

When cherished beliefs are challenged: Calvin students wrestle with hard questions by Nolan Cowan & Ethan Meyers

Q&A with Calvin's Career Center …

A Quest For An Integrated Management System Of Children Following A Drowning Incident: A Review Of The Literature., S Rossaouw, Carin Maree, Jos M. Latour

School of Nursing and Midwifery

Purpose Management of children following a drowning incident is based on specific interventions which are used in the prehospital environment, the emergency department (ED) and the Paediatric Intensive Care Unit (PICU). This paper presents a review of the literature to map and describe the management and interventions used by healthcare professionals when managing a child following a drowning incident. Of specific interest was to map, synthesise and describe the management and interventions according to the different clinical domains or practice areas of healthcare professionals. Design and Methods A traditional review of the literature was performed to appraise, map and describe …

Hnf4Α Isoforms Regulate The Circadian Balance Between Carbohydrate And Lipid Metabolism In The Liver, Jonathan R Deans, Poonamjot Deol, Nina Titova, Sarah H Radi, Linh M Vuong, Jane R Evans, Songqin Pan, Johannes Fahrmann, Jun Yang, Bruce D Hammock, Oliver Fiehn, Baharan Fekry, Kristin Eckel-Mahan, Frances M Sladek

Faculty, Staff and Student Publications

Hepatocyte Nuclear Factor 4α (HNF4α), a master regulator of hepatocyte differentiation, is regulated by two promoters (P1 and P2) which drive the expression of different isoforms. P1-HNF4α is the major isoform in the adult liver while P2-HNF4α is thought to be expressed only in fetal liver and liver cancer. Here, we show that P2-HNF4α is indeed expressed in the normal adult liver at Zeitgeber time (ZT)9 and ZT21. Using exon swap mice that express only P2-HNF4α we show that this isoform orchestrates a distinct transcriptome and metabolome via unique chromatin and protein-protein interactions, including with different clock proteins at different …

Plasma Exchange Reduces Aβ Levels In Plasma And Decreases Amyloid Plaques In The Brain In A Mouse Model Of Alzheimer's Disease, Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is the most common type of dementia, characterized by the abnormal accumulation of protein aggregates in the brain, known as neurofibrillary tangles and amyloid-β (Aβ) plaques. It is believed that an imbalance between cerebral and peripheral pools of Aβ may play a relevant role in the deposition of Aβ aggregates. Therefore, in this study, we aimed to evaluate the effect of the removal of Aβ from blood plasma on the accumulation of amyloid plaques in the brain. We performed monthly plasma exchange with a 5% mouse albumin solution in the APP/PS1 mouse model from 3 to 7 …

Examining The Potential Of Vitamin C Supplementation In Tissue-Engineered Equine Superficial Digital Flexor Tendon Constructs, Michael J Mienaltowski, Mitchell Callahan, Nicole L Gonzales, Angelique Wong

Faculty, Staff and Student Publications

Because equine tendinopathies are slow to heal and often recur, therapeutic strategies are being considered that aid tendon repair. Given the success of utilizing vitamin C to promote tenogenesis in other species, we hypothesized that vitamin C supplementation would produce dose-dependent improvements in the tenogenic properties of tendon proper (TP) and peritenon (PERI) cells of the equine superficial digital flexor tendon (SDFT). Equine TP- and PERI-progenitor-cell-seeded fibrin three-dimensional constructs were supplemented with four concentrations of vitamin C. The gene expression profiles of the constructs were assessed with 3'-Tag-Seq and real-time quantitative polymerase chain reaction (RT-qPCR); collagen content and fibril ultrastructure …

Maternal Diet During Early Gestation Influences Postnatal Taste Activity-Dependent Pruning By Microglia, Chengsan Sun, Shuqiu Zheng, Justin S A Perry, Geoffrey T Norris, Mei Cheng, Fanzhen Kong, Rolf Skyberg, Jianhua Cang, Alev Erisir, Jonathan Kipnis, David L Hill

2020-Current year OA Pubs

A key process in central sensory circuit development involves activity-dependent pruning of exuberant terminals. Here, we studied gustatory terminal field maturation in the postnatal mouse nucleus of the solitary tract (NST) during normal development and in mice where their mothers were fed a low NaCl diet for a limited period soon after conception. Pruning of terminal fields of gustatory nerves in controls involved the complement system and is likely driven by NaCl-elicited taste activity. In contrast, offspring of mothers with an early dietary manipulation failed to prune gustatory terminal fields even though peripheral taste activity developed normally. The ability to …

Transient Receptor Potential Vanilloid 4-Dependent Microglial Function In Myelin Injury And Repair, Jameson P Holloman, Sophia H Dimas, Angela S Archambault, Fabia Filipello, Lixia Du, Jing Feng, Yonghui Zhao, Bryan Bollman, Laura Piccio, Andrew J Steelman, Hongzhen Hu, Gregory F Wu

2020-Current year OA Pubs

Microglia are found pathologically at all stages of multiple sclerosis (MS) lesion development and are hypothesized to contribute to both inflammatory injury and neuroprotection in the MS brain. Transient receptor potential vanilloid 4 (TRPV4) channels are widely expressed, play an important role as environmental sensors, and are involved in calcium homeostasis for a variety of cells. TRPV4 modulates myeloid cell phagocytosis in the periphery and microglial motility in the central nervous system. We hypothesized that TRPV4 deletion would alter microglia phagocytosis in vitro and lessen disease activity and demyelination in experimental autoimmune encephalitis (EAE) and cuprizone-induced demyelination. We found that …

Planty: The Fitness App With A Plant, Zixin Alice Ouyang

Theses

It is common knowledge that physical exercise has multiple physical and mental benefits, yet many often find it challenging to maintain a consistent exercise habit. How can we design a more motivating exercise experience so more people would exercise? The proposed solution is Planty, an innovative fitness app. Planty aims to change the user’s exercise habits by providing an alternative motivation behind physical exercise by locking a live plant inside a terrarium. Users can only care for the plant through the Planty app through exercise. By linking users’ behavior to the livelihood of a live plant, Planty forces its users …

Analysis Of Phlebotomy Training Implementation To Reduce Lab Errors In The Clinical Setting, Sandy King

Doctor of Nursing Practice Projects

The primary responsibility of a laboratory technician is to obtain patient blood samples through venipuncture as well as collect, transport, and store other clinical specimens. Poor blood collection can lead to erroneous and misleading results for the provider in addition to the annoyance of repeat testing for the patient. The lack of formal phlebotomy training provided to nurses could be contributing to laboratory rejections. For patients receiving lab services, how effective is an implementation of formal phlebotomy training for nurses compared to non-formal phlebotomy-trained nurses, in reducing failed lab results? The purpose and aim of this quality improvement project are …

Care Work, Jennifer Nedelsky

Articles & Book Chapters

Care is routinely provided both as a commodity (paid care) and as unpaid care, usually by women. Virtually all care is treated as of low value, and care givers, paid and unpaid, are seen as low status. This devaluing of care and those who do it make care a major part of hierarchy and inequality. I argue that the solution is not more commodification (like wages for housework), but a norm of universal, unpaid care-giving. This would be made possible by a corresponding norm of limiting paid work to 30 hours a week. Part Time for All: A Care Manifesto …

Advancing Discovery With Two New Mass Spectrometers, Beth Potier

UNH Today Archive

No abstract provided.

Lakota Ethnobotany For South Dakota Middle School Students, Mikayla .Janis, Michael. A. Little Eagle, Madhav P. Nepal

iLEARN Teaching Resources

In this engaging lesson, students use mobile apps to identify local plant species in their school yards, along nature trails, or in any designated areas on the reservation. They will document the common names and morphological characteristics of the identified plants, explore native names, and uses, as well as the roles of plants in biogeochemical cycles. This immersive experience not only deepens students’ interest in science but also allows them to understand the bigger role of plants in the natural balance, enhancing their appreciation of the deeper connections between the Lakota culture and plant species.

Perceived Effect Of Awareness And Use Of Open Access Journals By Library Users For Research Efficiency In Margaret Lawrence University, Delta State, Nigeria, Obande Bonnie Obeka

Library Philosophy and Practice (e-journal)

The purpose of the present study was to examine the Perceived effect of awareness and use of Open Access Journals by Library users for research efficiency in Margaret Lawrence University. Three hundred and twenty nine Library (329) users were selected in the study. A specifically designed questionnaire was administered to gather information about the awareness and use of open access journals by library users for research efficiency in Margaret Lawrence University. Data collected were analyzed using mean () and standard deviation (SD) to answer research questions. The Results revealed that library users of MLU are much aware of open access …