Digital Commons Network^™

Franklin Park: Forgotten Gem Of The Emerald Necklace, Thomas Aversa

Bird Observer

No abstract provided.

Book Review: Peterson Field Guide To Birds Of Britain And Europe And Birds Of Europe With North Africa And The Middle East By Roger Tory Peterson, Mark Lynch

Bird Observer

No abstract provided.

Contents, Bird Observer

Bird Observer

No abstract provided.

Water Quality And Road Salt In New Jersey, Deborah Kratzer

Sustainability Seminar Series

Water quality monitoring data show a long-term trend of increasing chloride and total dissolved solids (TDS) concentrations in NJ surface waters and increasing exceedances of standards for aquatic life and drinking water. In this presentation, Debbie Kratzer will review the data linking road salt use with these trends, sustainability of winter deicing practices, and approaches to reverse these negative water quality trends.

Analyzing The Shark Paleoecology Of Coastal Georgia From The Miocene And Pliocene Epochs, Joshua Lee Clark, Benjamin Angalet

Georgia Journal of Science

The field of shark paleoecology often yields indecisive conclusions based on the limited fossilization of their anatomical structures, with the exception of their teeth. The majority of the Atlantic coast has been studied regarding the presence of certain prehistoric shark species from the Miocene, Pliocene, and Pleistocene epochs. However, information pertaining to the Georgia coast and understanding its potential community structure is relatively understudied. This study was conducted in which thousands of fossil shark specimens and subsequent marine fauna were collected from dredge spoils created by the US Army Corps of Engineers (USACE): Savannah District. A total of 5,127 fossil …

Volatiles And Interspecific Competition, Stephen T. Trumbo

EEB Articles

No abstract provided.

On Some Teratological Scorpions In The Natural History Museum, London And Checklist Of The Scorpiological Literature On Morphological Anomalies (Arachnida: Scorpiones), Danniella Sherwood, Luis F. De Armas

Euscorpius

Whilst undertaking curation in the collections of the Natural History Museum, London, the senior author came across a jar of scorpions marked ‘scorpions with curled feet’. Further investigation showed this jar was full of scorpions with teratological anatomy. We hereby document and illustrate all of the specimens and discuss their respective anomalies. Furthermore, a comprehensive checklist of the literature on anomalies in scorpions, including giving the life stage and sex where known, is compiled for the benefit of future workers.

Sovereign Lands, Brent D. Chicken, Amanda J. Dick

Oil and Gas, Natural Resources, and Energy Journal

No abstract provided.

Cas Connections- 2023-2024 Fall/Winter Term, Dean's Office

CAS Connections

No abstract provided.

Ada News - 12/11/2023, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Utah Statesman, December 11, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Draheim, Marilyn Oral History Interview, Doris Meyer

Emeriti Society Oral History Collection

Associate Professor of Education and Assistant Dean of Education (1986-2019). Topics include: Educational Background; Director of The Academic Skills Center; ASC's Programs, Curriculum and Instruction Department Chair and Selected Grants/Programs with Districts and Teacher Preparation, Committee Service; Changes at the University; Commission on Teacher Credentialing, Backgrounds of Students Over Several Years of Teaching/Administration, Selected Programs: Reentry Adults Bachelor's Degree (Ed Pro2); Ed.D Program for Shanghai Normal University, Tianhua College's Faculty

On Liberty: From Due Process To Equal Protection—Dobbs’ Impact On The Transgender Community, Emily Kaufman

University of Miami Race & Social Justice Law Review

Liberty has been a bedrock principle of American democracy from the time of our nation’s founding and is the norm that charters our nation’s existence. Liberty was the motivation driving the colonists’ rebellion against tyranny in order to establish a nation that would preserve liberty, at all costs. The preamble of the Constitution explicitly classifies every subsequent article’s purpose, to secure the blessings of liberty.

This note will touch on the concepts of personal liberty in the context of abortion in the landmark case Dobbs v. Jackson Women’s Health Org, and the implications of this case on the transgender community. …

Advanced Separations And Mass Spectrometry Data Acquisition Strategies To Improve Sensitivity And Throughput In Single-Cell Proteomics, Thy Truong

Theses and Dissertations

Single Cell Proteomics (SCP) is an emerging discipline that contributes to a deeper understanding of individual cells' essential components. In biological systems, individual cells exhibit remarkable diversity, showcasing distinct proteomic profiles and functions. Mass Spectrometry (MS)-based techniques have become essential tools for exploring the proteomes of single cells with remarkable precision. While traditional bulk proteomics methods have been invaluable in revealing the overall protein composition of biological samples, they fall short in capturing the subtle nuances and heterogeneity among individual cells in a population. This limitation emphasizes the need for more targeted and detailed analyses to uncover the protein makeup …

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

Techniques In Multi-Omics Data Integration To Develop A Novel Proteogenomics Framework For Identification Of Proteoforms, Kanishka Manna

Theses and Dissertations

Multi-omics experimental approaches are becoming a mainstream practice in systems biology underlining the need to design new integrative techniques and applications to enable the multi-scale characterization of different types of diseases for targeted therapy. Proteogenomics, a sub-field within the broad field of multi-omics incorporates techniques to integrate genomics, transcriptomics and proteomics data for efficient identification of novel proteoforms or protein isoforms. There are multitude of challenges when applying proteogenomics analyses, such as improper integration of each omics data type, missing structural annotations, inefficient identification of splice-junctions, novel genes, etc. This dissertation will outline a novel and integrative proteogenomics pipeline that …

Advanced Diffusion Mri Technique And Applications In Placenta And Brain, Zhexian Sun

McKelvey School of Engineering Graduate Student Theses & Dissertations

Among a series of contrasts of MRI, diffusion MRI (dMRI) is different from conventional MRI by its ability to capture information about the random movement of water molecules and their interaction with local tissue microstructures. This capability holds the potential to reveal intricate subvoxel microstructural information linked to pathological changes, offering potential imaging biomarkers. A higher-order diffusion analysis model helps to yield more accurate and specific parameters but requires more extensive parameter tuning and higher image quality. In this study, we firstly fine-tuned the previously developed diffusion basis spectrum imaging (DBSI) method to strike a balance between efficiency and accuracy …

Biopsychosocial Markers Of Impulsive Eating And Emotional Eating, Lucia Foster-Engen

Walden Dissertations and Doctoral Studies

No abstract provided.

Isolation And Characterization Of Nut Shell Proteins From Arachis Hypogea Linn. And Cocos Nucifera Linn. And Its Effect On Macrophage Activation To Treat Visceral Leishmaniasis, Suhatha S

Theses and Dissertations

Glycoproteins are among several immunomodulatory agents known to activate the innate immune system. Plant derived glycoproteins are a generous source of glycoproteins that could be utilized as cost effective preparations for therapeutics. Isolating glycoproteins from agricultural by- products with the intention to use them against Visceral Leishmaniasis (VL) was the focus in this doctoral study. The two nut shells, Arachis hypogea L. (Groundnut) and Cocos nucifera L. (Coconut), were used for the isolation of glycoprotein used in the study. Crude glycoproteins from the A. hypogea L. (AHP-C) were isolated and fractioned. AHP-F2 was identified as 28.37 kDa Mannose/Glucose binding lectin …

Challenging Florida’S Parental Rights In Education Act, Aka The “Don’T Say Gay” Law: Finding Equality Through Equal Protection Doctrine, Nelson Garcia

University of Miami Race & Social Justice Law Review

No abstract provided.

Investigating Telomere Lengths In Chestnut-Crowned Babblers, Gabriella Rose Beberg

Honors Thesis

Telomeres are chromosomal elements that protect and maintain genes as DNA replicates in many organisms. As individuals age and DNA replicates, telomeres often shorten; thus, telomere length often corresponds with an individual’s lifespan, and early-life decreases in telomere length can be predictive of longevity. Here, I investigated the relationship between telomere length and developmental environment in a cooperatively breeding species, the chestnut-crowned babbler (Pomatostomus ruficeps; CCB). Cooperative species are unique, as some individuals give up their own breeding opportunities to help rear the offspring of others; further, cooperative breeding systems generate considerably more variation in adult carers, which …

Interleukin-1 Induces Cfos Expression In Astrocytes In The Hippocampus Of Mice, Christopher Vargas

Harriet L Wilkes Honors College Theses

The Interleukin-1 (IL-1) cytokine is responsible for various processes within the central nervous system (CNS) relating to immune responses, sleep, and memory consolidation, however the interaction between different IL-1 responding cell types is still largely unknown. cFOS is an immediate early gene (IEG) which is typically used as a cellular activity marker. IL-1’s role in modulating neuronal activity in the CNS is still under debate. Targeted Recombination in Active Populations (TRAP) is a genetic technique to identify cell activity. This is done through a tamoxifen-inducible, Cre recombinase using the Fos promoter which reports cell activity via cFOS expression in the …

Engineering Exosomes To Specifically Target The Mitochondria Of Brain Cells, Xin Yan, Xinqian Chen, Zhiying Shan, Lanrong Bi

Michigan Tech Publications

Mitochondrial dysfunction is associated with various health conditions, including cardiovascular and neurodegenerative diseases. Mitochondrial-targeting therapy aims to restore or enhance mitochondrial function to treat or alleviate these conditions. Exosomes, small vesicles that cells secrete, containing a variety of biomolecules, are critical in cell-to-cell communication and have been studied as potential therapeutic agents. Exosome-based therapy has the potential to treat both cardiovascular and neurodegenerative diseases. Combining these two approaches involves using exosomes as carriers to transport mitochondrial-targeting agents to dysfunctional or damaged mitochondria within target cells. This article presents a new technique for engineering brain-derived exosomes that target mitochondria and has …

A Phase I Trial Of Bevacizumab And Temsirolimus In Combination With Valproic Acid In Advanced Solid Tumors, Blessie Elizabeth Nelson, Apostolia M Tsimberidou, Xueyao Fu, Siqing Fu, Vivek Subbiah, Anil K Sood, Jordi Rodon, Daniel D Karp, George Blumenschein, Scott Kopetz, Shubham Pant, Sarina A Piha-Paul

Faculty, Staff and Student Publications

BACKGROUND: Preclinical models suggest synergy between anti-angiogenesis therapy, mammalian target of rapamycin (mTOR), and histone deacetylase inhibitors to promote anticancer activity.

METHODS: This phase I study enrolled 47 patients between April 2012 and 2018 and determined safety, maximum tolerated dose (MTD), and dose-limiting toxicities (DLTs) when combining bevacizumab, temsirolimus, and valproic acid in patients with advanced cancer.

RESULTS: Median age of enrolled patients was 56 years. Patients were heavily pretreated with a median of 4 lines of prior therapy. Forty-five patients (95.7%) experienced one or more treatment-related adverse events (TRAEs). Grade 3 TRAEs were lymphopenia (14.9%), thrombocytopenia (8.5%), and mucositis …

Synaptic Plasticity Emulation By Natural Biomaterial Honey-Cnt-Based Memristors, Zoe Templin, Md Mehedi Hasan Tanim, Feng Zhao

Electrical and Computer Engineering Faculty Research & Creative Works

Artificial synaptic devices made from natural biomaterials capable of emulating functions of biological synapses, such as synaptic plasticity and memory functions, are desirable for the construction of brain-inspired neuromorphic computing systems. The metal/dielectric/metal device structure is analogous to the pre-synapse/synaptic cleft/post-synapse structure of the biological neuron, while using natural biomaterials promotes ecologically friendly, sustainable, renewable, and low-cost electronic devices. In this work, artificial synaptic devices made from honey mixed with carbon nanotubes, honey-carbon nanotube (CNT) memristors, were investigated. The devices emulated spike-timing-dependent plasticity, with synaptic weight as high as 500%, and demonstrated a paired-pulse facilitation gain of 800%, which is …

Synthesis Of Yaku'amide A Analogues And Progress Toward Synthesis Of Virosine A, Alexander S. Ramos

Theses and Dissertations

The first project in this dissertation endeavors to outline the total synthesis of yaku'amide A and its analogs. Yaku'amide A is a natural product comprised of dehydroamino acids, including E-dehydro isoleucine, and unprecedented Z-dehydro isoleucine. These amino acids present a significant challenge to their synthesis owing to their unsymmetrical nature. To simplify the synthesis process, we synthesized analogs by substituting the E and Z dehydroamino acids with symmetrical subunits. This substitution facilitated the synthesis process and enabled us to obtain a similar three-dimensional structure to that of the natural product. Furthermore, biological testing of the simplified analogs revealed potency similar …

Impact Of Irrigation On Vulnerability Of Winter Wheat Under Extreme Climate Change Scenario: A Case Study Of North China Plain, Yulian Gao, Lin Wang, Yaojie Yue

Department of Agricultural and Biological Systems Engineering: Faculty Publications

An inadequate understanding of the impacts of adaptation countermeasures tends to exaggerate the adverse e􀀀ects of climate change on agricultural systems. Motivated by proposing reasonable climate change adaptation countermeasures, the present study applied the EPIC model to quantify the impacts of climate change and irrigation changes with future socioeconomic development on agricultural production. Winter wheat yield losses using dynamic irrigation parameters in the North China Plain (NCP) from 2010 to 2099 under a scenario coupling climate change and future socioeconomic development (RCP8.5-SSP3), and those under an extreme climate change scenario (RCP8.5), were simulated. Results show that EPIC model demonstrates superior …

Contextualizing Singlehood Among Young Adults: Exploring The Meanings And Perceived Reasons For Being Single, Jonathon J. Beckmeyer, Tyler B. Jamison

Faculty Publications

Objective: We explored how young adults discussed their experiences with singlehood and their reasons for being single.

Background: Despite singlehood being normative during young adulthood, less research has focused on the diversity of singlehood compared to that of romantic involvement.

Method: In Study 1, 35 young adults participated in in-depth qualitative interviews about their romantic histories. We explored singlehood meanings and reasons in the context of their relationship histories. In Study 2 we used data from 155 single young adults to explore the factor structure, internal reliability, and initial validity of the Reasons for Being Single (RBS) scale, which we …

Teaching Engineering Design-Based Integrated Stem In Rural Contexts: Nurturing Future Designers, Jung Han, Euisuk Sung, Todd Kelley, John Geoffrey Knowles

Publications and Research

There is a notable shift towards prioritizing the teaching of engineering design within K-12 education, coupled with a strong recommendation for engineering design-based integrated STEM education. This approach underscores the sharing of science and engineering practices as a means to facilitate the learning of various STEM disciplines. Nonetheless, the implementation of integrated STEM education in rural schools poses challenges due to constrained resources and a shortage of high-quality programs. To present a tangible instance of design-based integrated STEM education within a rural setting, this study presents a model lesson that showcases the integration of interdisciplinary problem-solving skills within a genuine …

Establishing A Novel Lipid-Polyamine Metabolic Connection To Virus Replication, Yazmin Edith Cruz Pulido

Dissertations

Polyamines are small positively charged alkylamines found in all living cells. These ubiquitous molecules have been found to play a variety of roles ranging from stabilizing nucleic acids (DNA and RNA) to cellular proliferation. Studies have also identified roles for polyamines in viral packaging and viral enzyme function. However, the role of polyamines on cellular components and their effect on viral replication is less known. In our efforts to identify the lipid-polyamine metabolic connection to virus replication we utilized a human hepatocyte cell line in which polyamines were depleted via pharmacological or genetic approaches and studied the effects on lipid …