Digital Commons Network^™

Gap Junctions Or Hemichannel-Dependent And Independent Roles Of Connexins In Fibrosis, Epithelial-Mesenchymal Transitions, And Wound Healing, Yuting Li, Francisca M Acosta, Jean X Jiang

Faculty, Staff and Student Publications

Fibrosis initially appears as a normal response to damage, where activated fibroblasts produce large amounts of the extracellular matrix (ECM) during the wound healing process to assist in the repair of injured tissue. However, the excessive accumulation of the ECM, unresolved by remodeling mechanisms, leads to organ dysfunction. Connexins, a family of transmembrane channel proteins, are widely recognized for their major roles in fibrosis, the epithelial-mesenchymal transition (EMT), and wound healing. Efforts have been made in recent years to identify novel mediators and targets for this regulation. Connexins form gap junctions and hemichannels, mediating communications between neighboring cells and inside …

Recombination-Mediated Dissemination Of Methicillin-Resistant S Aureus Clonal Complex 1 In The Egyptian Health Care Settings, Salma W Elsayed, Reem A Elghaish, Eman Badr, Shaimaa F Mouftah, Nehal A Saif, Iman S Naga, Ahmed H Shata, Ben Pascoe, Samuel K Sheppard, Mohamed Elhadidy

Faculty, Staff and Student Publications

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly evolving pathogen that is frequently associated with outbreaks and sustained epidemics. This study investigated the population structure, resistome, virulome, and the correlation between antimicrobial resistance determinants with phenotypic resistance profiles of 36 representative hospital-acquired MRSA isolates recovered from hospital settings in Egypt.

Results: The community-acquired MRSA lineage, clonal complex 1 (CC1) was the most frequently detected clone, followed by three other globally disseminated clones, CC121, CC8, and CC22. Most isolates carried SCCmec type V and more than half of isolates demonstrated multi-drug resistant phenotypes. Resistance to linezolid, a last resort antibiotic for …

Impact Of Library Instruction Tutorial Format On Student Preference And Performance In First-Year Chemistry, Tara Stieglitz, Lindsey Whitson

Communications in Information Literacy

This research study investigates the effects of library instruction tutorial format (written versus video) on student preference and performance in chemistry education. The authors assessed the format of tutorials used to provide library instruction in an introductory chemistry course by observing 27 student participants as they took in instructions in either a video or a written format and then completed two chemistry information tasks. While participants expressed strong preferences for particular formats, neither the video tutorials nor the written instructions significantly improved task completion speed or performance. Rather, the authors determined that student preference alone is enough to justify the …

Race: An Efficient Redundancy-Aware Accelerator For Dynamic Graph Neural Network, Hui Yu, Yu Zhang, Jin Zhao, Yujian Liao, Zhiying Huang, Donghao He, Lin Gu, Hai Jin, Xiaofei Liao, Haikun Liu, Bingsheng He, Jianhui Yue

Michigan Tech Publications

Dynamic Graph Neural Network (DGNN) has recently attracted a significant amount of research attention from various domains, because most real-world graphs are inherently dynamic. Despite many research efforts, for DGNN, existing hardware/software solutions still suffer significantly from redundant computation and memory access overhead, because they need to irregularly access and recompute all graph data of each graph snapshot. To address these issues, we propose an efficient redundancy-aware accelerator, RACE, which enables energy-efficient execution of DGNN models. Specifically, we propose a redundancy-aware incremental execution approach into the accelerator design for DGNN to instantly achieve the output features of the latest graph …

Evaluation Of The Aggressive-Variant Prostate Cancer Molecular Signature In Clinical Laboratory Improvement Amendments (Clia) Environments, Paul V Viscuse, Rebecca S Slack-Tidwell, Miao Zhang, Prih Rohra, Keyi Zhu, F Anthony San Lucas, Eric Konnick, Patrick G Pilie, Bilal Siddiqui, Christopher J Logothetis, Paul Corn, Sumit K Subudhi, Colin C Pritchard, Rama Soundararajan, Ana Aparicio

Faculty, Staff and Student Publications

Aggressive-variant prostate cancers (AVPCs) are a subset of metastatic castrate-resistant prostate cancers (mCRPCs) characterized by defects in ≥ two of three of TP53, RB1, and PTEN (AVPCm), a profile linked to lineage plasticity, androgen indifference, and platinum sensitivity. Men with mCRPC undergoing biopsies for progression were assessed for AVPCm using immunohistochemistry (IHC), next-generation sequencing (NGS) of solid tumor DNA (stDNA), and NGS of circulating tumor DNA (ctDNA) assays in CLIA-certified labs. Biopsy characteristics, turnaround times, inter-reader concordance, and inter-assay concordance were assessed. AVPCm was detected in 13 (27%) patients via IHC, two (6%) based on stDNA, and seven …

A Comprehensive Program Evaluation Of Colorectal Rescreening Initiatives In Rural Virginia, Sarah E. Stowell

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Background: Despite low-cost and effective screening tools, colorectal cancer (CRC) mortality remains high in the U.S., particularly in rural areas like Virginia’s Northern Shenandoah Valley, where screening rates are low. While literature highlights barriers to CRC screening in these communities and suggests improvement strategies, few studies focus on long-term adherence to screening in rural health clinics (RHCs).

Purpose: This program evaluation assessed the impact and effectiveness of the Rural Colorectal Cancer Rescreening Initiative (RCRI), a pilot program to increase colorectal cancer rescreening rates in a local RHC. It also offers recommendations for optimizing future RCRI efforts. Methods: The program evaluation …

Adaptation Of Several Hybrid Maize In West Nusa Tenggara Drylands Using Modified Plant Spacing For Optimal Seed And Biomass Productions, Karlina Syahruddin, Suwardi, Slamet Bambang Priyanto, Roy Efendi, Herawati, Abdul Fattah, Rahman, Hasbi, Aminah, Fatmawati, Sigit Budi Santoso, Lesty Ayu Bidhari, Muhammad Abid

Jurnal Kultivasi

Maize is a crucial multipurpose strategic food crop in Indonesia. Land expansion employing dry land, row-space technology, and suitable varieties, is emerging as the solution to fulfill the rising need for seeds and biomass. The study was carried out from August to December using a factorial randomized block design consisting of two treatment factors, namely the treatment factor of 6 varieties and 2 row-spacings, to verify the new superior hybrid maize, which is adaptable in dry land Senayan village, Poto Tano sub-district, West Sumbawa district, and West Nusa Tenggara (NTB). The results showed that JH 37 and JH 29 varieties …

Improved Image Recognition Via Synthetic Plants Using 3d Modelling With Stochastic Variations, Chris C. Napier, David M. Cook, Leisa Armstrong, Dean Diepeveen

Research outputs 2022 to 2026

This research extends previous plant modelling using L-systems by means of a novel arrangement comprising synthetic plants and a refined global wheat dataset in combination with a synthetic inference application. The study demonstrates an application with direct recognition of real plant stereotypes, and augmentation via a plant-wide stochastic growth variation structure. The study showed that the automatic annotation and counting of wheat heads using the Global Wheat dataset images provides a time and cost saving over traditional manual approaches and neural networks. This study introduces a novel synthetic inference application using a plant-wide stochastic variation system, resulting in improved structural …

Investigating The Role Of Bhlhe40 In Host Responses To Mycobacterium Tuberculosis Infection And Myeloid Cell Development, Skyler Hendrix

Arts & Sciences Graduate Student Theses and Dissertations

Infections with Mycobacterium tuberculosis (Mtb), the causative agent of the disease tuberculosis (TB), remain a prominent global health threat that affects millions of people annually. While antibiotic treatments for Mtb infections are available, the increased prevalence of drug-resistant Mtb cases has highlighted the urgent need to develop additional therapeutic options such as host-directed therapies. Development of host-directed therapies, however, first requires a better understanding of the protective immune responses required to control Mtb infection. Such responses must strike a precise balance between pro-inflammatory and anti-inflammatory responses that promote bacterial clearance while also minimizing tissue damage. Here we show that the …

Deep Learning-Based Phenotyping Reclassifies Combined Hepatocellular-Cholangiocarcinoma, Julien Calderaro, Pooja Navale, Et Al.

2020-Current year OA Pubs

Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal or mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping of multiple cohorts of patients. We show that deep learning can reproduce the diagnosis of HCC vs. CCA with a high performance. We analyze a series of 405 cHCC-CCA patients and demonstrate that the model can reclassify the tumors as HCC or ICCA, and that the predictions are consistent with clinical …

Re-Thinking Education For Sustainable Development: Key Learning Insights From The Sdsn Usa Transformative Education Summit 2023, Radhika Iyengar, Sumie Song, Deepak Sridhar, Wendy M. Purcell, Ann Nielsen, Iveta Silova, Matthew A. Witenstein, Wen-Wen Tung

Journal of Contemplative and Holistic Education

This paper summarizes key learning insights from the 2023 U.S. Summit on Transformative Education organized by the Sustainable Development Solutions Network USA. Over 400 members from higher education institutions, non-governmental organizations, think tanks, students, and teachers, joined the online event held February 23-25. The Summit created a bridge between social justice issues with an historical lens and sustainable development. Learning insights include those shared by session speakers, dialogue among participants during thematic conversations and regional networking forums, comments made by attendees on session Jamboards and the Zoom Chat function, and post-Summit feedback. A high-level thematic review was undertaken to cluster …

Effect Of Different Levels Of Postbiotic And Phytobiotic Combination On Growth Performance, Economic Production, And Immune Response Of Broiler Chickens, Jamil Mobarak Mahmoud Doski, Karwan Yaseen Kareem

Polytechnic Journal

A total of two hundred and eighty eight day old unsexed chicks from a Ross 308 cross were randomly assigned to eight treatment and four replicates and each replicator had twelve birds. The experimental groups includes, N-control= negative control (basal diet), P-control = basal diet + 0.01% Doxin200 (positive control) (w/w), 0.1% Pos+Phy = basal diet + 0.05% thyme oil (v/w) + 0.05% postbiotic, 0.2% Pos+Phy = basal diet + 0.1% thyme oil (v/w) + 0.1% postbiotic, 0.3% Pos+Phy = basal diet + basal diet + 0.15% thyme oil (v/w) + 0.15% postbiotic, and 0.4% Pos+Phy = basal diet + …

Utilization Of Semiconductor Nanocrystals In Cancer Diagnose And Treatment, Yasir Q. Almajidi, Ahmed A. Albadri, Mazen M. Jwaid, Yaseen T. Khalaf

Maaen Journal for Medical Sciences

In contemporary times, nanotechnology has emerged as a notably sophisticated technological discipline. It possesses an interdisciplinary and multidisciplinary nature, spanning a wide array of domains including medical science, engineering, biology, physics, materials science, and chemistry. Utilization of nanotechnology offers a significant advantage by enabling precise manipulation and control of properties to effectively address specific challenges in various applications. In the fields of science and biomedicine, there has been extensive exploration into the use of functional nanomaterials, emerging as rapidly advancing and captivating areas of research. Diverse types of nanomaterials, including silicon nanowires, quantum dots, carbon nanotubes, and gold/silver nanoparticles, which …

Leveraging Existing Services To Support Evidence Synthesis Researchers Outside Of The Health Sciences, Elizabeth Kline

Journal of Graduate Librarianship

The author presents a case study for the development of an evidence synthesis service serving researchers outside of the health sciences at a large academic library. The purpose of this project was to highlight the importance of integrating existing core services and workflows that create seamless delivery of evidence synthesis support and yield quality service. The paper provides decisions that university libraries must consider as they are planning the implementation of these services.

The research-intensive nature of evidence synthesis projects provides liaison librarians with a perfect entry to deliver high-quality and relevant services, especially to graduate students and researchers. Through …

Stem's Missing Women: Why Biology's Undergraduate Pipeline Is Diverging From Career Paths, Rosemary Roberto

Graduate Student and Postdoctoral Fellow Symposium

No abstract provided.

Weakness Is The New Strength: How Vulnerability Makes Leaders Stronger, Scott Dick

Transform

Weakness is the new strength: How vulnerability makes leaders stronger is the result from the meta-analysis of five phenomenological studies designed to generate a theory that explains how exemplar leaders from five different fields used “soft-skills” and four domains of behavior to create mutual shared knowledge, resolve conflict and transform relationships to produce breakthrough results. The four domains of behavior are communication, collaboration, ethics, and emotional intelligence. The sample was composed of 75 exemplar leaders from five different professional fields and included an analysis of over 1,300 pages of interview transcripts as the main data source for the study. The …

Kangaroo Care And Improved Physiological Status In Preterm Infants, Kira Harkonen

Wisdom & Compassion: The LUSON Journal

Preterm births continue to cause long-term sequelae for infants worldwide. Interventions in the neonatal intensive care unit (NICU) that promote better outcomes can make an impact on preterm infants’ futures. The purpose of this review was to determine if kangaroo care has positive physiological effects on preterm infants in the NICU. Practice changes to enhance kangaroo care in the NICU include reducing barriers such as medical complexity and staff misconceptions as well as facilitating increased parental presence. The review of the literature found evidence to support the positive outcomes that kangaroo care has on neonates’ growth, vital signs, stress outcomes, …

Why Autistic Sociality Is Different: Reduced Interest In Competing For Social Status, Catherine L. Caldwell-Harris, Anna M. Schwartz

Ought: The Journal of Autistic Culture

The complexity of human organizations poses the challenge of understanding and navigating social hierarchies. If 'social impairment' is a defining feature of autism, then these challenges may be heightened for autistic persons. We reject the premise of social deficits but follow recommendations to investigate how autistic social behavior diverges from neurotypical norms. We review autistic writings and also scholarship on reputation management, non-conformity and moral reasoning to argue that autistic people dislike social hierarchies, find status-seeking illogical, prefer egalitarian relationships, and often seek to report wrong-doing by authorities. We outline three possible causes: (1) reduced social motivation; (2) emergent property …

The Future Of Critical Autism Studies (Cas): Thinking Through Critical Discourse Studies And Postcolonial Feminism, Cansu Elmadagli

Ought: The Journal of Autistic Culture

The field of Critical Autism Studies (CAS) has evolved significantly since its inception, with scholars continually redefining its key tenets and objectives. CAS emerged as a response to conventional medical and social deficit-based models of autism and seeks to challenge the prevailing norm that considers neurotypicality as the unquestioned standard. This article, written by an autistic scholar, aims to contribute to the ongoing discussions in CAS. The article introduces novel perspectives by suggesting connections between CAS, Critical Discourse Studies (CDS), and postcolonial feminism. It advocates for the incorporation of concepts and tools from these traditions to enrich CAS’s approach. Furthermore, …

Sharp Stick Grasps At Autistic Women’S Liminal Vulnerability, Meaghan Krazinski

Ought: The Journal of Autistic Culture

This film analysis of Sharp Stick by Lena Dunham critically explores how the film uptakes representations of the ideas around the vulnerabilities of Autistic women in popular culture, and yet does not explicitly name them as such. This liminality is critical and plays into the intersectional analysis that the author engages around the way vulnerability and Autistic identity is interpreted and read. The author draws upon McDermott's (2022) "neurotypical gaze" in an analysis that shows how traditional tropes around Autistic women’s vulnerability are social constructions that are brought into relief by stereotypes around race, gender, and ability. The author uses …

Critical Autism Studies Beyond Academia: An Annotated List, Alyssa Hillary Zisk

Ought: The Journal of Autistic Culture

This is an introduced and annotated list of sources from beyond academia which are, have been, or may yet be important texts for critical autism or neurodiversity studies. The defining actions of critical autism studies, or of critical neurodiversity studies, have been taken outside academia and will continue to be taken outside academia. This list serves as a reminder of this reality through examples.

The Minutes Of The Marshall University Board Of Governors Meeting, December 13, 2023, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

Mastery Learning: Second Chances, Instructor Workload, And Student Confidence, Judith Puncochar

Conference Presentations

No abstract provided.

Genomic Analysis Reveals New Species And Subspecies Of Butterflies, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Large-scale genomic sequencing of butterfly taxa reveals new findings that are presented here. While we focus on detecting species by comparative genomics and define subspecies as groups of populations genetically differentiated from each other but not as strongly as species (that is, subspecies as species in the making), we report other adjustments to butterfly classification. As a result, 4 subgenera, 11 species, and 6 subspecies are proposed as new. New subgenera are: Rapis Grishin, subgen. n. (type species Papilio rapae Linnaeus, 1758, genus Pieris Schrank, 1801) in Pieridae Swainson, 1820 and Callitera Grishin, subgen. n. (type species Eurygona? pulcherrima …

A Pilot Study In Healthcare: Salivary Cortisol Levels And Burnout, Hannah Oggerino

Graduate Theses & Non-Theses

This pilot study investigated levels of burnout in non-clinical workers in a healthcare setting and compared them to salivary cortisol concentrations. Mashlach’s Burnout Inventory-Human Service Survey for Medical Personnel (MBI-HSS(MP)) was used to evaluate self-perceived levels of burnout and saliva samples were collected to determine cortisol concentrations at four times during participants’ shift. The study was comprised of subjects exposed to multiple high-stress factors, including working in a healthcare setting, post-COVID ramifications, and demographic effects of Montana. The data revealed a statistically significant correlation (P-value < 0.05) between morning salivary cortisol secretion concentrations and mean survey scores. Significance (P-value < 0.05) was also found between the three dimensions measured by the MBI-HSS(MP): burnout, depersonalization, and personal achievement. The study discusses several limitations that should be considered when interpreting results. Findings do suggest that future investigation among this group is needed. Results may help guide interventions that support the mental health and wellbeing of medical support personnel, reduce stress, and avoid burnout.

Unleashing The Beast: Confronting Animal Trafficking As Organized Crime In The Americas, Erick J. Wilson

University of Miami Inter-American Law Review

Wildlife trafficking is a serious yet often overlooked issue across the Americas. This Note examines wildlife trafficking across the Americas, analyzing the legal frameworks and challenges facing countries like the United States, Guatemala, Argentina, Peru, Mexico, and Brazil. Three key obstacles emerge: the lack of recognition of trafficking as organized crime, limited resources for enforcement, and deficient penalties. Though the United States has laws like the Lacey Act to address importation of illegally traded wildlife, weak foreign laws constrain efficacy. Many Latin American nations do not categorize wildlife trafficking as organized crime, despite its intricate parallels with activities like drug …

2023 December 13 - Undergraduate Curriculum Council Minutes, Undergraduate Curriculum Council, East Tennessee State University

Undergraduate Curriculum Council Minutes

No abstract provided.

Memory Cd8 T Cells Promote Pathogenic Plaque Buildup Of The Arteries In Aged Mice, Jeff Hansen

Browse All News

No abstract provided.

Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Human Reproductive Cancers, Dr. Amy T. Desaulniers, Brett White

School of Veterinary and Biomedical Sciences: Faculty Publications

Gonadotropin-releasing hormone (GnRH1) and its receptor (GnRHR1) drive reproduction by regulating gonadotropins. Another form, GnRH2, and its receptor (GnRHR2), also exist in mammals. In humans, GnRH2 and GnRHR2 genes are present, but coding errors in the GnRHR2 gene are predicted to hinder full-length protein production. Nonetheless, mounting evidence supports the presence of a functional GnRHR2 in humans. GnRH2 and its receptor have been identified throughout the body, including peripheral reproductive tissues like the ovary, uterus, breast, and prostate. In addition, GnRH2 and its receptor have been detected in a wide number of reproductive cancer cells in humans. Notably, GnRH2 analogues …

Développement De Méthodes Analytiques Pour Les Composés Organiques Volatils Microbiens (Covm) Dans Les Matrices Biologiques : Vers L’Évaluation Des Covm Comme Biomarqueurs D’Exposition Aux Moisissures, Badr El Aroussi, Sarah Tabbal, Wissam Berkane, Michèle Bouchard, Geneviève Marchand, Sami Haddad

Rapports de recherche scientifique

Préalablement, vingt composés organiques volatils microbiens (COVM), avec un potentiel d’être utilisés comme biomarqueurs de contamination et d’exposition aux moisissures en milieu de travail, avaient été identifiés, en considérant plusieurs paramètres, comprenant l’intérêt pour la santé des espèces de moisissures, l’occurrence d’émission ainsi que les paramètres physicochimiques et pharmacocinétiques.

Dans la présente étude, de nouvelles méthodes analytiques, pour mesurer simultanément 21 COVM incluant ceux identifiés préalablement dans les matrices biologiques et l’air ambiant, en se basant sur les techniques H-SPME-GC-MS/MS (sang et urine) et TD-GCMS/MS (exhalât et air ambiant), ont été développées et validés. Celles-ci ont exhibé des performances analytiques …