Digital Commons Network^™

Risk Detection Of Gestational Diabetes In Early Pregnancy Depend On Artificial Neural Network, Sanaa Hammad Dhahi

Al-Esraa University College Journal for Engineering Sciences

Early prediction of gestational diabetes mellitus (GDM) risk is particularly important because it may enable more effective interventions and reduce cumulative maternal and fetal injury. The aim of this study is to develop machine learning (ML) models for early prediction of GDM using widely available variables, facilitating early intervention, and enabling the application of prediction models in settings where more complex tests are not accessible. In this paper, an artificial neural network (ANN) was used to detect the risk of gestational diabetes. A global dataset was used to collect clinical and experimental data from pregnant women and people with diabetes …

Analysis Of Drug Diffusion In Human Connective Tissue In Neutrosophic Environment, Supriya Mukherjee, Ashish Acharya, Animesh Mahata, Subrata Paul, Said Broumi, Banamali Roy

Neutrosophic Sets and Systems

No abstract provided.

Multi-Attribute Group Decision-Making Based On Aggregation Operator And Score Function Of Bipolar Neutrosophic Hypersoft Environment, Faisal Al-Sharqi, Ashraf Al-Quran, Zahari Md. Rodzi

Neutrosophic Sets and Systems

No abstract provided.

Waste To Energy Treatment For India Using Critic-Waspas Method Under Interval-Valued Pythagorean Neutrosophic Fuzzy Set, R.Narmada Devi, S. Sowmiya, R. Sundareswaran, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

The Concise Guide To Pharmacology 2023/24: Catalytic Receptors, Stephen P.H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Annie Beuve, Peter Brouckaert, Clare Bryant, John C. Burnett, Richard W. Farndale, Andreas Friebe, John Garthwaite, Adrian J. Hobbs, Gavin E. Jarvis, Doris Koesling, Michaela Kuhn, David Macewan, Tom P. Monie, Lincoln R. Potter, Michael Russwurm, Harald H.H.W. Schmidt, Johannes-Peter Stasch, Scott A. Waldman

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It …

The Potential For Development Of Clinically Relevant Microbial Resistance To Rifaximin-Α: A Narrative Review, Herbert L Dupont

Faculty, Staff and Student Publications

Rifaximin-α is a gut-targeted antibiotic indicated for numerous gastrointestinal and liver diseases. Its multifaceted mechanism of action goes beyond direct antimicrobial effects, including alterations in bacterial virulence, cytoprotective effects on host epithelial cells, improvement of impaired intestinal permeability, and reduction of proinflammatory cytokine expression via activation of the pregnane X receptor. Rifaximin-α is virtually non-absorbed, with low systemic drug levels contributing to its excellent safety profile. While there are high concentrations of drug in the colon, low water solubility leads to low colonic drug bioavailability, protecting the gut microbiome. Rifaximin-α appears to be more active in the bile-rich small bowel. …

Innovation And Practice On Biodiversity Conservation In Sanjiangyuan National Park, Xinquan Zhao, Shixiao Xu, Liang Zhao, Tongzuo Zhang, Linyong Hu, Qi Li, Tongqing Guo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Sanjiangyuan National Park, is one of the first batch of national parks in China, and serves as the largest national park in China. As an important ecological security barrier and a alpine biological germplasm resource base, it has significant conservation value in China and even in the world. Lots of protocols have been taken aiming at ecological tacking protection issues including loss of biodiversity and wildlife habitats, degradation of alpine grassland and overgrazing in Sanjiangyuan National Park. It promotes the implementation of major ecological restoration projects, and has formed the Sanjiangyuan National Park Biodiversity Conservation and Ecological Protection Program with …

Atmospheric 14Co2 Observation: A Novel Method To Evaluate Carbon Emissions, Zhenchuan Niu, Peng Wang, Shugang Wu, Weijian Zhou

Bulletin of Chinese Academy of Sciences (Chinese Version)

As an important carbon emitter, China faces the stress of carbon peaking and carbon neutrality goals and international carbon reduction duty. The accurate data of carbon emissions are important to evaluate the carbon peaking and carbon neutrality goals and fulfill the international duty of carbon reduction. The Intergovernmental Panel on Climate Change (IPCC) report recommends the combination of top-down atmospheric CO₂ observation with atmospheric inversion to verify the bottom-up inventory of carbon emissions, and the atmospheric ¹⁴CO₂ observation can make the verification more accurate. Radiocarbon (14C) is the most precise tracer of fossil fuel CO₂ and …

Ten Problems And Solutions For Restoration Of Karst Ecosystem In Southwest China, Xiaoyong Bai, Sirui Zhang, Chen Ran, Luhua Wu, Chaochao Du, Lei Dai, Xingyi Yang, Zilin Li, Yingying Xue, Mingkang Long, Minghui Li, Shu Yang, Qing Luo, Xiaoyun Zhang, Xiaoqian Shen, Fei Chen, Qin Li, Yuanhong Deng, Zeyin Hu, Chaojun Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

The karst areas in southwest China are one of the key but difficult areas targeted in the “Beautiful China” construction initiative, which focuses on soil erosion, proportion of farmland, water pollution, karst drought, ecological restoration, carbon sink, ecological effects of urbanization, rocky desertification management indicators, and biodiversity and sustainability assessment. The study synthesizes the knowledge accumulated during ecological restoration practice in karst areas into 10 problems and solutions that are strong, universal and empirically supported. These problems and solutions help to explain the challenges of achieving sustainability in karst ecology restoration and thus point to solutions. They constitute a core …

Control Of Invasive Plant Spartina Alterniflora: Concept, Technology And Practice, Baohua Xie, Guangxuan Han

Bulletin of Chinese Academy of Sciences (Chinese Version)

Alien Species Spartina alterniflora occupy the living space of native animals and plants, and lead to the reduction of biodiversity in the intertidal zone and wetland ecological service functions. Therefore, it is urgent to curb the rapid expansion of S. alterniflora in China’s coastal areas. This paper introduced the invasion situation and main ecological hazards of S. alterniflora in China, as well as put forward the concept of S. alterniflora control of “hazard assessment – zoning control – monitoring and early warning”. We summarized the control technologies of S. alterniflora at home and abroad and the current situation of S. …

Conception On Asian Elephant Ecological Corridor Planning With Implications For Conservation, Xueyou Li, Qiupeng Yu, Zhechang Hu, Xuelong Jiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

In order to practice the concept of coordinated development of “Lucid Waters and Lush Mountains are Invaluable Assets” and “mountains, rivers, forests, farmlands, lakes, grasslands and deserts are part of the community of life”, this study takes “pursuing green development and promoting harmony between humanity and nature” proposed in the report of the 20th National Congress of the Communist Party of China as the theoretical guidance. With the goal of enhancing ecosystem integrity and connectivity, enhancing population communication, enhancing population viability, and providing a model for the construction of ecological corridors for flagship species, based on the current distribution and …

Research On Geographical Landscape Design Of Ecological Civilization Construction In China, Wenzhong Zhang, Jianhui Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

As the fundamental goal of ecological civilization construction in the new era of China, the building of a Beautiful China is an important measure to promote the study of Chinese man-land relationships to a higher level and a new stage of development. This study takes the construction of ecological civilization of Beautiful China as the orientation, and carries on the frame design to the geographical landscape. The geographical landscape takes the elements of geoscience as the research object and makes a series of reasonable outlook about man-land system according to the interaction mechanism of human-land relationship and the influence of …

Impacts, Contributing Factors And Countermeasures Of Extreme Droughts In Poyang Lake, Qi Zhang, Chenyang Xue, Jun Xia

Bulletin of Chinese Academy of Sciences (Chinese Version)

In the past 20 years, the hydrological regime of Poyang Lake changed significantly. The lake water level has been continuously decreasing, resulting in severe droughts. In particular, an extreme drought occurred in 2022, when the lake area shrank to less than 300 km2. The 2022 extreme drought in Poyang Lake had great impacts on economy, society and ecological environment, which aroused great attentions and wide concerns. Based on long-term data series of meteorological and hydrological data and the existing research outcomes and with the aid of hydrological modeling, this study analyzed the impacts and contributing factors of the 2022 drought …

Stereotactic Mr-Guided On-Table Adaptive Radiation Therapy (Smart) For Borderline Resectable And Locally Advanced Pancreatic Cancer: A Multi-Center, Open-Label Phase 2 Study, Michael Chuong, Percy Lee, Daniel Low, Joshua Kim, Kathryn Mittauer, Michael Bassetti, Carri Glide-Hurst, Ann Raldow, Yingli Yang, Lorraine Portelance, Kyle Padgett, Bassem Zaki, Rongxiao Zhang, Hyun Kim, Lauren Henke, Alex Price, Joseph Mancias, Christopher Williams, John Ng, Ryan Pennell, M Raphael Pfeffer, Daphne Levin, Adam Mueller, Karen Mooney, Patrick Kelly, Amish Shah, Luca Boldrini, Lorenzo Placidi, Martin Fuss, Parag Jitendra Parikh

Department of Radiation Oncology Faculty Papers

BACKGROUND AND PURPOSE: Radiation dose escalation may improve local control (LC) and overall survival (OS) in select pancreatic ductal adenocarcinoma (PDAC) patients. We prospectively evaluated the safety and efficacy of ablative stereotactic magnetic resonance (MR)-guided adaptive radiation therapy (SMART) for borderline resectable (BRPC) and locally advanced pancreas cancer (LAPC). The primary endpoint of acute grade ≥ 3 gastrointestinal (GI) toxicity definitely related to SMART was previously published with median follow-up (FU) 8.8 months from SMART. We now present more mature outcomes including OS and late toxicity.

MATERIALS AND METHODS: This prospective, multi-center, single-arm open-label phase 2 trial (NCT03621644) enrolled 136 …

Research Priorities For Children’S Cancer: A James Lind Alliance Priority Setting Partnership In The Uk, Susie Aldiss, Rachel Hollis, Bob Phillips, Ashley Ball-Gamble, Alex Brownsdon, Julia Chisholm, Scott Crowther, Rachel Dommett, Jonathan Gower, Nigel J Hall, Helen Hartley, Jenni Hatton, Louise Henry, Loveday Langton, Kirsty Maddock, Sonia Malik, Keeley Mcevoy, Jessica Elizabeth Morgan, Helen Morris, Simon Parke, Sue Picton, Rosa Reed-Berendt, Dan Saunders, Andy Stewart, Wendy Tarplee-Morris, Amy Walsh, Anna Watkins, David Weller, Faith Gibson

Faculty, Staff and Student Publications

OBJECTIVES: To engage children who have experienced cancer, childhood cancer survivors, their families and professionals to systematically identify and prioritise research questions about childhood cancer to inform the future research agenda.

DESIGN: James Lind Alliance Priority Setting Partnership.

SETTING: UK health service and community.

METHODS: A steering group oversaw the initiative. Potential research questions were collected in an online survey, then checked to ensure they were unanswered. Shortlisting via a second online survey identified the highest priority questions. A parallel process with children was undertaken. A final consensus workshop was held to determine the Top 10 priorities.

PARTICIPANTS: Children and …

Bacterial Outer Membrane Vesicles Provide An Alternative Pathway For Trafficking Of Escherichia Coli O157 Type Iii Secreted Effectors To Epithelial Cells, Natalie Sirisaengtaksin, Eloise J O'Donoghue, Sara Jabbari, Andrew J Roe, Anne Marie Krachler

Faculty, Staff and Student Publications

Outer membrane vesicles (OMVs) are proteoliposomes shed by Gram-negative bacteria. Their secretion is enhanced by the transition into the intra-host milieu, and OMVs play critical roles during pathogenesis. Enterohemorrhagic Escherichia coli O157 (EHEC) can cause diarrheal disease in humans, and soluble toxins including Shiga-like toxins that contribute to disease severity and clinical complications like hemolytic uremic syndrome have been shown to be OMV associated. In addition to Shiga-like toxins, EHEC produces a type III secretion system (T3SS), and T3SS effectors are associated with colonization and disease severity in vivo. Here, we show that type III secreted substrates including translocators …

Colonization Of Larval Zebrafish (Danio Rerio) With Adherent-Invasive Escherichia Coli Prevents Recovery Of The Intestinal Mucosa From Drug-Induced Enterocolitis, Erika Flores, Soumita Dutta, Rachel Bosserman, Ambro Van Hoof, Anne-Marie Krachler

Faculty, Staff and Student Publications

Although inflammatory bowel diseases are on the rise, what factors influence IBD risk and severity, and the underlying mechanisms remain to be fully understood. Although host genetics, microbiome, and environmental factors have all been shown to correlate with the development of IBD, cause and effect are difficult to disentangle in this context. For example, AIEC is a known pathobiont found in IBD patients, but it remains unclear if gut inflammation during IBD facilitates colonization with AIEC, or if AIEC colonization makes the host more susceptible to pro-inflammatory stimuli. It is critical to understand the mechanisms that contribute to AIEC infections …

The Faculty-To-Faculty Mentorship Experience: A Survey On Challenges And Recommendations For Improvements, Sarvenaz Sarabipour, Natalie M Niemi, Steven J Burgess, Christopher T Smith, Alexandre W Bisson Filho, Ahmed Ibrahim, Kelly Clark

2020-Current year OA Pubs

Faculty at research institutions play a central role in advancing knowledge and careers, as well as promoting the well-being of students and colleagues in research environments. Mentorship from experienced peers has been touted as critical for enabling these myriad roles to allow faculty development, career progression, and satisfaction. However, there is little information available on who supports faculty and best ways to structure a faculty mentorship programme for early- and mid-career academics. In the interest of advocating for increased and enhanced faculty mentoring and mentoring programmes, we surveyed faculty around the world to gather data on whether and how they …

Effects Of Episodic Food Insecurity On Psychological And Physiological Responses In African American Women With Obesity (Responses): Protocol For A Longitudinal Observational Cohort Study, Candice A. Myers, Robbie A. Beyl, Daniel S. Hsia, Melissa N. Harris, Isabella J. Reed, Danielle D. Eliser, Lauren Bagneris, John W. Apolzan

School of Public Health Faculty Publications

Background; Food insecurity is a risk factor for multiple chronic diseases, including obesity. Importantly, both food insecurity and obesity are more prevalent in African American women than in other groups. Furthermore, food insecurity is considered a cyclic phenomenon, with episodes of food adequacy (ie, enough food to eat) and food shortage (ie, not enough food to eat). More research is needed to better understand why food insecurity is linked to obesity, including acknowledging the episodic nature of food insecurity as a stressor and identifying underlying mechanisms. Objective; The objective of this study is to investigate the episodic nature of food …

Rethinking The Presumption Of Enablement In Nonpatent Prior Art, Gabrielle Carlini

Duke Law Journal

The rising popularity of tools such as preprint servers, open-access data sources, and generative artificial intelligence has resulted in a proliferation of prior art that has never been seen before under the current patent system. In a rapidly changing world, patent law is slow to catch up, and the current system is not equipped to handle the flood of incoming prior art. In the academic research setting in particular, while the use of preprint servers and open-source data has allowed researchers to participate in widespread information exchange, these tools have also generated a new, large class of prior art dedicated …

Storage Protein Activator Controls Grain Protein Accumulation In Bread Wheat In A Nitrogen Dependent Manner, Anne Plessis, Catherine Ravel, Thierry Risacher, Nathalie Duchateau, Mireille Dardevet, Marielle Merlino, François Torney, Pierre Martre

School of Biological and Marine Sciences

The expression of cereal grain storage protein (GSP) genes is controlled by a complex network of transcription factors (TFs). Storage protein activator (SPA) is a major TF acting in this network but its specific function in wheat (Triticum aestivum L.) remains to be determined. Here we generated an RNAi line in which expression of the three SPA homoeologs was reduced. In this line and its null segregant we analyzed GSP accumulation and expression of GSP and regulatory TF genes under two regimes of nitrogen availability. We show that down regulation of SPA decreases grain protein concentration at maturity under low …

Rapidiron Trial Follow-Up Study - The Rapidiron-Kids Study: Protocol Of A Prospective Observational Follow-Up Study, Richard Derman, Roopa Bellad, Mrutyunjaya Bellad, Jesse Bradford-Rogers, Michael Georgieff, Zubair Aghai, Simal Thind, Michael Auerbach, Rupsa Boelig, Benjamin Leiby, Vanessa Short, S. Yogeshkumar, Umesh Charantimath, Manjunath Somannavar, Ashalata Mallapur, Ramesh Pol, Umesh Ramadurg, Radha Sangavi, Basavaraj Peerapur, Nasima Banu, Praveen Patil, Amaresh Patil, Subarna Roy, Phaniraj Vastrad, Dennis Wallace, Hemang Shah, Shivaprasad Goudar

Global Health Articles

BACKGROUND: Anemia is a worldwide problem with iron deficiency being the most common cause. When anemia occurs in pregnancy, it increases the risk of adverse maternal, fetal, and postnatal outcomes. It induces preterm births and low birth weight (LBW) deliveries, long-term neurodevelopmental sequelae, and an increased risk of earlier onset of postnatal iron deficiency. Anemia rates are among the highest in South Asia, and India's National Family Health Survey (NFHS-5) for 2019-2021 indicated that over half of pregnant women, and more than 65% of children, in the country are classified as anemic (Sciences IIfP, National Family Health Survey-5, 2019-21, India …

Quantum Diamonds At The Beach: Chemical Insights Into Silica Growth On Nanoscale Diamond Using Multimodal Characterization And Simulation, Perla J. Sandoval, Karen Lopez, Andres Arreola, Anida Len, Nedah Basravi, Pomaikaimaikalani Yamaguchi, Rina Kawamura, Camron X. Stokes, Cynthia Melendrez, Davida Simpson, Sang Jun Lee, Charles James Titus, Virginia Altoe, Sami Sainio, Dennis Nordlund, Kent Irwin, Abraham Wolcott

Faculty Research, Scholarly, and Creative Activity

Surface chemistry of materials that host quantum bits such as diamond is an important avenue of exploration as quantum computation and quantum sensing platforms mature. Interfacing diamond in general and nanoscale diamond (ND) in particular with silica is a potential route to integrate room temperature quantum bits into photonic devices, fiber optics, cells, or tissues with flexible functionalization chemistry. While silica growth on ND cores has been used successfully for quantum sensing and biolabeling, the surface mechanism to initiate growth was unknown. This report describes the surface chemistry responsible for silica bond formation on diamond and uses X-ray absorption spectroscopy …

Abnormal Patterns Of Sleep And Waking Behaviors Are Accompanied By Neocortical Oscillation Disturbances In An Ank3 Mouse Model Of Epilepsy-Bipolar Disorder Comorbidity, Juan E Villacres, Nicholas Riveira, Sohmee Kim, Laura L Colgin, Jeffrey L Noebels, Angel Y Lopez

Faculty, Staff and Students Publications

ANK3 is a leading bipolar disorder (BD) candidate gene in humans and provides a unique opportunity for studying epilepsy-BD comorbidity. Previous studies showed that deletion of Ank3-1b, a BD-associated variant of Ank3 in mice leads to increased firing threshold and diminished action potential dynamic range of parvalbumin (PV) interneurons and absence epilepsy, thus providing a biological mechanism linking epilepsy and BD. To explore the behavioral overlap of these disorders, we characterized behavioral patterns of Ank3-1b KO mice during overnight home-cage activity and examined network activity during these behaviors using paired video and EEG recordings. Since PV interneurons contribute to the …

Developing Characteristic Resource Plants To Build A Beautiful China, Lei Shi, Zheng'an Liu, Lijun Wang, Qingyan Shu, Meiyu Sun, Wei Duan, Hui Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

It is an important way to solve the contradiction among ecology, production and life in natural protected areas and ecologically fragile region by constructing the three-production integration mode of characteristic resource plants. In order to fully tap and make use of the outstanding characteristics of oil tree peony, wine grape and aromatic plants, this study carried out technology integration of variety screening, planting, harvesting, processing, product research and development, and industrialization demonstration in and around natural protected areas and ecologically fragile region. Through the economic benefits generated, the life of the people in the natural protected areas and ecologically fragile …

Exploring The Relationships Between Psychological Variables And Loot Box Engagement, Part 1: Pre-Registered Hypotheses, James Close, Stuart Gordon Spicer, Laura Louise Nicklin, Maria Uther, Ben Whalley, Chris Fullwood, Jonathan Parke, J Lloyd, H Lloyd

Peninsula Medical School

Loot boxes are purchasable randomized rewards in video games that share structural and psychological similarities with gambling. Systematic review evidence has established reproducible associations between loot box purchasing and both problem gambling and problem video gaming, perhaps driven by a range of overlapping psychological processes (e.g. impulsivity, gambling-related cognitions, etc.) It has also been argued that loot box engagement may have negative influences on player financial and psychological wellbeing. We conducted a pre-registered survey of 1495 loot box purchasing gamers (LB cohort) and 1223 gamers who purchase other, non-randomized game content (nLB cohort). Our survey confirms 15 of our 23 …

Observation Of A Calling Assemblage In The Collared Trogon (Trogon Collaris)., Cristina Sainz-Borgo

Ornitología Neotropical

No abstract provided.

Book Reviews–Reseñas De Libros–Resenhas De Livros., Ornitología Neotropical

Ornitología Neotropical

No abstract provided.

Index To Volume 25, 2014. Reviewers For Ornitología Neotropical, Volume 25., Ornitología Neotropical

Ornitología Neotropical

No abstract provided.

Nesting Of The Short-Tailed Antthrush (Chamaeza Campanisona) In The Atlantic Forest Of Argentina., Alejandro Bodrati, Kristina L. Cockle, Facundo G. Di Sallo

Ornitología Neotropical

No abstract provided.