Digital Commons Network^™

Outcome-Based Patient-Therapist Matching Implementation: A Study Of Clinician Beliefs And Attitudes, Ashleigh Smith

Electronic Theses & Dissertations (2024 - present)

Background. Implementation science aims to identify methods that support the adoption of evidence-based practices (EBPs), including measurement-based care (MBC) and MBC-informed patient-therapist matching. Examining clinician attitudes can elucidate potential barriers to implementing EBPs, and attitudinal differences may exist across groups of therapists. In the context of a patient-therapist matching implementation project, this multi-method study investigated the relationship between clinician characteristics, attitudes toward EBPs/MBC, and implementation climate. Method. A sample of N = 72 therapists completed measures of demographic and clinical characteristics, attitudes toward EBPs, perceptions of implementation climate, and attitudes toward monitoring and feedback. A subset of N …

A Study Of Mercury Speciation Analysis Of Blood Using Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry For Human Biomonitoring And Clinical Applications, Emily Jean Pacer

Electronic Theses & Dissertations (2024 - present)

Mercury (Hg) exposure from environmental sources and consumer products presents a significant public health concern. The toxicity of methylmercury (MeHg) differs considerably from inorganic mercury (iHg), such that their separation and quantification in whole blood is helpful in identifying sources and possible pathways of exposure. Speciation methods provide a more detailed picture regarding human exposure to toxic mercury species and their effects on human health. This dissertation focuses on advanced analytical techniques for human biomonitoring and clinical diagnosis of Hg exposure. The primary aim of this research is to address important knowledge gaps and analytical challenges in studies of Hg …

The Guild House: A Mixed-Methods Case Study Of Game-Utilizing Information/Learning Design For Autonomy-Supportive Instruction In An Asynchronous Online Course, Sturdy Knight

Electronic Theses & Dissertations (2024 - present)

Gamification has emerged over the past ~10-12 years as a popular design approach to problems of motivation in online or blended learning, with a particular emphasis on distinguishing between extrinsic motivation driven by points, grades, class rank, etc, vs. intrinsic motivation driven by personal values and interest in the curriculum. Self-Determination Theory (SDT) forms the theoretical basis of much of this literature, yet the mediating constructs of learner self-regulation and autonomous vs. controlled regulatory styles, which describe the processes by which extrinsic motivators like game rewards or curriculum requirements are integrated with intrinsic goals, are under-addressed. This has led to …

Intrinsic Lipid Curvature And Bilayer Elasticity As Regulators Of Channel Function: A Comparative Single-Molecule Study, Mohammad Ashrafuzzaman, Roger E. Koeppe Ii, Olaf S. Andersen

Chemistry & Biochemistry Faculty Publications and Presentations

Perturbations in bilayer material properties (thickness, lipid intrinsic curvature and elastic moduli) modulate the free energy difference between different membrane protein conformations, thereby leading to changes in the conformational preferences of bilayer-spanning proteins. To further explore the relative importance of curvature and elasticity in determining the changes in bilayer properties that underlie the modulation of channel function, we investigated how the micelle-forming amphiphiles Triton X-100, reduced Triton X-100 and the H_II lipid phase promoter capsaicin modulate the function of alamethicin and gramicidin channels. Whether the amphiphile-induced changes in intrinsic curvature were negative or positive, amphiphile addition increased gramicidin channel …

Transcription And Translation Regulation Of Germ Cell To Maternal Transition, Noor Kotb

Electronic Theses & Dissertations (2024 - present)

In sexually reproducing organisms, the process of gametogenesis produces mature eggs and sperms required for fertilization to occur. The egg's quality is crucial for the healthy development of the next generation, making oogenesis a tightly regulated process with multiple benchmarks. To investigate the intricacies of oogenesis, we utilized the Drosophila oogenesis system as our primary model. This choice was motivated by several factors. Firstly, the process of egg development in Drosophila is conserved across species, making it a valuable proxy for understanding oogenesis in other organisms, including humans. Secondly, Drosophila melanogaster has long been established as a powerhouse in genetic …

Student Interaction With Generative Ai: An Exploration Of An Emergent Information-Search Process, Ryan M. Schuetzler, Justin Scott Giboney, Taylor M. Wells, Benjamin Richardson, Tom Meservy, Cole Sutton, Clay Posey, Jacob Steffen, Amanda Lee Hughes

Faculty Publications

ChatGPT, a generative artificial intelligence, is one of the fastest-adopted tools in history and has quickly become a valued tool in education. This study seeks to understand how generative artificial intelligence has changed the information search process. We collected prompts submitted to ChatGPT and thoughts about ChatGPT responses through a survey of 455 students at a US university. Using thematic analysis, we identified ways that ChatGPT changes the information search process of students by supporting diverse information needs, allowing cycling of prompt adjustments, and promoting easy adoption of results.

In Vivo Measurement Of Nadh Fluorescence Lifetime In Skeletal Muscle Via Fiber-Coupled Time-Correlated Single Photon Counting, Kathryn M. Priest, Jacob V. Schluns, Nathania Nischal, Colton L. Gattis, Jeffery C. Wolchok, Timothy J. Muldoon

Biomedical Engineering Faculty Publications and Presentations

Nicotinamide adenine dinucleotide (NADH) is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis, the tricarboxylic acid cycle, and oxidative phosphorylation (OXPHOS). NADH is autofluorescent, and its fluorescence lifetime can be used to infer metabolic dynamics in living cells. Fiber-coupled time-correlated single photon counting (TCSPC) equipped with an implantable needle probe can be used to measure NADH lifetime in vivo, enabling investigation of changing metabolic demand during muscle contraction or tissue regeneration. This study illustrates a proof of concept for point-based, minimally-invasive NADH fluorescence lifetime measurement in vivo. Volumetric muscle loss (VML) injuries were …

The Need For More Inclusive Deliberation On Ethics And Governance In Agricultural And Food Biotechnology, Catherine Kendig, Theresa Selfa, Paul B. Thompson, Raymond Anthony, Wenda Bauchspies, Gwendolyn Blue, Ashmita Das, Rebecca Harrison, Chris Henke, Shan Jin, Jennifer Kuzma, Forbes Lipschitz, Kurt Lichter, Morgan Ruelle, Timothy Silberg, Bruno Takahashi

Sustainability and Social Justice

An inclusive and socially legitimate governance structure is absent to address concerns over new agricultural biotechnologies. Establishing an agricultural bioethics commission devoted to inclusive deliberation on ethics and governance in agricultural and food biotechnology is urgent. Highlighting the social and ethical dimensions of current agricultural bioengineering disputes in the food system, we discuss how a nationally recognized policy forum could improve decision-making and increase public understanding of the issues. We clarify ways the concepts that are used to categorize food and frame governance of food affect consumer choices, and how dissemination of information and the mode of dissemination can contribute …

Before Amplification: The Role Of Experts In The Dynamics Of The Social Attenuation And Amplification Of Risk, Lisbet Fjaeran, Kenneth Pettersen Gould, Rob Goble

Sustainability and Social Justice

In this article, we use system/network theory together with the social amplification of risk framework (SARF) to show how expert actors over time and across multiple events can contribute to social risk amplification and attenuation. The framework and the theory, in particular the concepts of risk emplacement and displacement, are employed in the analysis of an illustrative case related to the use of the feed additive, narasin, and provide explanations of how risks are part of continuously ongoing and dynamic social processes. By emphasizing the role of experts in such developments, connecting what happens in expert communities with the processing …

Not Just A Simple Survey: A Case Study Of Pitfalls In Interdisciplinary, Multiorganizational, Multinational Research For Development, Fleur B.M. Kilwinger, Cynthia Caron, Anne M. Reitveld, Ynte K. Van Dam

Sustainability and Social Justice

Surveys are common research methods in agricultural research for development. Despite the multitude of well-documented warnings for pitfalls in survey research, it appears challenging to avoid these in practice. We use a case study in agricultural research for development to illustrate what complicates survey research within an interdisciplinary, multiorganizational and multinational team. The survey research process, rather than the survey outcome, is our object of study. Using the Methodology of Interdisciplinary Research (MIR) framework we identify different steps within survey research. We overlay a technographic lens to understand “the making of a survey”. We thereby focus on the transformations made …

Complex, Diverse And Changing Agribusiness And Livelihood Systems In The Amazon [Complexidade, Diversidade E Mudanças No Cenário Agricultural Na Amazônia], Francisco De Assis Costa, Eduardo D. Assad, Denise Humphreys Bebbington, Eduardo S. Brondizio, Philip M. Fearnside, Rachael Garrett, Susanna Hecht, Sebastian Heilpern, David Mcgrath, Gustavo Oliveira, Henrique Dos Santos Pereira, Marianne Schmink

Sustainability and Social Justice

Finding pathways to more sustainable agriculture and resource use remains the most pressing challenge for Amazonian countries. Characterizing recent changes in the structure and types of agrarian production systems, this review identifies responses to deal with the challenges and opportunities to promote more sustainable production and extraction economies in the Amazon. While regional agriculture and resource economies rest on a rich diversity of producers, knowledge, and production systems, the expansion of agribusiness enterprises has come to dominate the distribution of subsidies, institutional support, and logistical infrastructure. These trends are associated with forest loss and degradation, pollution of waterways, pressures on …

Development Of A Measure Assessing Adolescent Aggression: The Aggressive Behavior Risk Assessment- Adolescent- Parent Report (Abra-A-Pr), Katherine Fallon

College of Graduate Studies: Theses & Dissertations

Although parent-report scales for general behavioral difficulties and aggression (e.g., verbal and physical aggression) exist, there are currently no measures assessing sexual behaviors in this context. Commonly, parent-report measures provide a few items relevant to behavioral aggression, and items encompassing sexually aggressive behaviors are frequently vague and non-specific in the actions being committed by the adolescent. The primary purpose of this project was to develop a comprehensive and multifaceted parent-report measure for aggressive behavior in adolescents. Three separate studies were conducted to evaluate the psychometric properties of the measure. Exploratory (EFA) and confirmatory factor analysis (CFA) were used to investigate …

Metabolink Is A Novel Algorithm For Unveiling Cell-Specific Metabolic Pathways In Longitudinal Datasets, Jared Lichtarge, Gerarda Cappuccio, Soumya Pati, Alfred Kwabena Dei-Ampeh, Senghong Sing, Lihua Ma, Zhandong Liu, Mirjana Maletic-Savatic

Duncan NRI Faculty and Staff Publications

Introduction: In the rapidly advancing field of 'omics research, there is an increasing demand for sophisticated bioinformatic tools to enable efficient and consistent data analysis. As biological datasets, particularly metabolomics, become larger and more complex, innovative strategies are essential for deciphering the intricate molecular and cellular networks.

Methods: We introduce a pioneering analytical approach that combines Principal Component Analysis (PCA) with Graphical Lasso (GLASSO). This method is designed to reduce the dimensionality of large datasets while preserving significant variance. For the first time, we applied the PCA-GLASSO algorithm (i.e., MetaboLINK) to metabolomics data derived from Nuclear Magnetic Resonance (NMR) spectroscopy …

Ethically Informed Design, Brett Cook-Snell

Educational Leadership & Workforce Development Faculty Publications

This design case presents my experiences, successes, and challenges, in the design and delivery of a six-week special topics course on culturally inclusive instructional design. The course was delivered synchronously with a diverse group of 15 individuals enrolled in the instructional design and technology degree program. The focus of the course was uncovering implicit and explicit biases in design practices. Topics addressed included the systemic isms of society, such as racism, ableism, genderism, and many more. Relevant to this special issue, ethical design practices are viewed in the light of the Association for Educational Communications and Technology (AECT) standards and …

Exploring Angiotensin Ii And Oxidative Stress In Radiation-Induced Cataract Formation: Potential For Therapeutic Intervention, Vidya P. Kumar, Yali Kong, Riana Dolland, Sandra R. Brown, Kan Wang, Damian Dolland, David Mu, Milton L. Brown

Department of Biomedical and Translational Sciences Faculty Publications

Radiation-induced cataracts (RICs) represent a significant public health challenge, particularly impacting individuals exposed to ionizing radiation (IR) through medical treatments, occupational settings, and environmental factors. Effective therapeutic strategies require a deep understanding of the mechanisms underlying RIC formation (RICF). This study investigates the roles of angiotensin II (Ang II) and oxidative stress in RIC development, with a focus on their combined effects on lens transparency and cellular function. Key mechanisms include the generation of reactive oxygen species (ROS) and oxidative damage to lens proteins and lipids, as well as the impact of Ang II on inflammatory responses and cellular apoptosis. …

The Sources And Fates Of Nutrients In The Deep Lake Watershed, Kiler Austin Kenison

EWU Masters Thesis Collection

This water quality survey determined the sources and fates of nutrients within the Deep Lake watershed located in Stevens County, WA. Deep Lake is a 191-acre exorheic lake found just below the Canadian border in northeast Washington state. It is situated at the bottom of a narrow valley with steep walls and is fed throughout the year by snowmelt from tributaries descending the mountains surrounding it. Above and to the north of the lake, the tributaries are utilized by cattle ranchers as a water source for livestock while a small community of homes surrounds the lake. Water samples, discharge, and …

Sialylation As A Mechanism For Preferential Ligand Binding In Cfs1r, Eric J. Beaulaurier

EWU Masters Thesis Collection

Macrophages are immune cells that help provide the first line of defense against a wide range of internal and external insults and create the bridge between innate and adaptive immune responses. When macrophage homeostasis is disrupted, disease states occur. Associated disease states include rheumatoid arthritis, Alzheimer’s disease, and multiple sclerosis. The survival and proliferation of macrophages is largely controlled by signaling through colony stimulating factor 1 receptor (CSF1R). Notably, this receptor can be activated by two non-homologous ligands, colony stimulating factor 1 (CSF1) and interleukin- 34 (IL-34). These two ligands are differentially required for macrophage homeostasis across body systems and …

Revegetation Of Two Drained Reservoirs On The Elwha River Ten Years After Dam Removal, Michael Trier

EWU Masters Thesis Collection

The Elwha and Glines Canyon dams on the Elwha River, Washington, USA were removed between 2011 and 2014 after being in place for a century, and at the time were the largest dams ever removed. The resulting dewatering of Lake Aldwell, the reservoir of the Elwha dam, and Lake Mills, the reservoir of the Glines Canyon dam exposed over 270 hectares of land that had been submerged. While several studies have examined the revegetation of these drained reservoirs, none have gone beyond 5 years since dam removal. These studies found that sediment grain size and reservoir landform (valley walls, terraces …

Disability In Education From A Neurodiversity Standpoint: A Multi-Article Dissertation, Isabelle Kluge

Antioch University Dissertations & Theses

This theoretical multi-article dissertation is a broad examination of education, including trends in our school system, juvenile justice system, and cultural/media system to address the disproportionate targeted failure of students with disabilities from a neurodiversity standpoint. Research shows how our current education system is not the practice of freedom for all learners, but rather a reproductive practice that teaches forms of group-based privilege that results in the disproportionate outcome of school failure, oppression, and incarceration for students with disabilities. Creating liberatory learning spaces for neurodiverse students of all races must include challenging White supremacy, neurotypical superiority, and a standardized one-size-fits-all …

Navigating The Noise: Implications Of Increasing Ship Noise For An Arctic Ocean Soundscape, Andrea Lynn

Antioch University Dissertations & Theses

There is no quiet way to churn water. Noise pollution caused by ships is increasing in the Arctic Ocean as sea ice melts, creating more open channels for vessels. This study provides a glimpse into the sources and balance of sounds in a portion of the Arctic Ocean soundscape surrounding the Norwegian archipelago of Svalbard. Characterization of the soundscape provides essential data as the region quickly transforms. This study also considers human perceptions of underwater ocean noise and its impacts in the region, and it reviews current ocean policy, suggesting mitigation strategies and ways forward. Before the rapid development of …

The Development Of Internalized Sexism In Young Adult Women, Kylie Schwabe

Antioch University Dissertations & Theses

The present study utilized Interpretative Phenomenological Analysis in order to examine the lived experiences of young adult, cisgender women and the development of internalized sexism. Eight participants completed semi–structured interviews focused on their relationships with other women and subsequent views of womanhood. Themes found were (a) womanhood is taught by women throughout the lifespan, (b) women are sexually responsible for men, (c) women are emotional caregivers, (d) there are biological bases of womanhood, (e) women are expected to “do it all,” (f) expectations of women are fueled by media portrayal, (g) traditional femininity is seen as oppositional to the feminist …

Exploring The Impact Of Early Adversity On Young Children With Autism, Kelsea M. Batista

Antioch University Dissertations & Theses

This dissertation builds on a small but growing literature exploring the association between early adverse childhood experiences (ACEs) and children diagnosed with autism spectrum disorder (ASD). Research suggests that children with ASD are more likely to experience ACEs throughout their lifetime due to increased vulnerability to victimization and social communication deficits. Still, to date, there is scant research explicitly exploring the impact of ACEs on young children diagnosed with ASD. This study utilized a biopsychosocial framework to further examine whether a relationship exists between ACEs and ASD. The objectives of this study include: (a) to determine whether a relationship exists …

Spatial And Temporal Variation In Population Genetic Diversity In Seagrasses And The Implications For Resilience, Anna Maria Frouws

Theses: Doctorates and Masters

Seagrass ecosystems are highly productive and fulfil vital roles in the coastal environment as ecosystem engineers and keystone species. Unfortunately, anthropogenic pressures have resulted in a significant loss of seagrass habitat and associated ecosystem services. The complex and unpredictable nature of these pressures, and their increasing extent and intensity globally, makes resilience-based ecosystem management a valuable approach. Resilience-based management requires knowledge on processes enhancing ecosystem resilience and on actions supporting these processes. Genetic diversity, which is the allelic variation among individuals of a population, has been recognised as one of the pillars of resilient ecosystems. Genetic diversity within a population …

Content Analysis Of The Omani Sciences Textbooks Of Grades (5-8) In The Light Of Timss 2019 Requirements, Raed Abdelkarim, Youssef A. Al Barami, Sobhy A. Soliman, Alaa Aladini

Journal of Educational and Psychological Studies

Abstract: The current study aimed to determine the requirements of Trends of International Mathematics and Science Study (TIMSS 2019) and to find out the extent to which the content of science textbooks for grades (5-8) in the Sultanate of Oman includes the requirements of (TIMSS 2019). Only the content dimension has been taken into account when conducting the content analysis. The study population includes all science books from the fifth to the eighth grade for the academic year 2021-2022. The study identified and organized the requirements in the study tool, and after confirming its validity and reliability, the analysis was …

Documents From The February 28, 2024 Meeting Of The Associated Students Of The University Of Montana (Asum), University Of Montana--Missoula. Associated Students

Senate Meeting Agendas and Minutes, 2007-Present

Agenda and meeting minutes from the February 21, 2024 meeting of the Associated Students of the University of Montana (ASUM).

Effects Of Bioprosthetic Valve Fracturing On Valve-In-Valve Transcatheter Aortic Valve Implantation Transvalvular Gradients, Osama Hallak, Karley Fischer, Shaina Ailawadi, Damian Valencia, Yan Yatsynovich, Raja Nazir, Brian Schwartz

The Texas Heart Institute Journal

BACKGROUND: Valve-in-valve (ViV) transcatheter aortic valve implantation (TAVI) is quickly becoming a routine and effective means by which to treat degenerated bioprosthetic valves. A known complication of ViV-TAVI is patient-prosthesis mismatch, which substantially affects survival. Bioprosthetic valve fracture is a method by which to reduce the risk of patient-prosthesis mismatch and post-ViV-TAVI transvalvular gradients. This study sought to determine the safety and efficacy of post-ViV-TAVI bioprosthetic valve fracture.

METHODS: Patients with a history of surgical aortic valve replacement undergoing ViV-TAVI bioprosthetic valve fracture (N = 25) at the corresponding institution from 2015 to 2022 were cataloged for a retrospective analysis. …

"A Double-Edged Sword": A Brief History Of Genomic Data Governance And Genetic Researcher Perspectives On Data Sharing, Kayte Spector-Bagdady, Kerry A Ryan, Amy L Mcguire, Chris D Krenz, M Grace Trinidad, Kaitlyn Jaffe, Amanda Greene, J Denard Thomas, Madison Kent, Stephanie Morain, David Wilborn, J Scott Roberts

Center for Medical Ethics and Health Policy Staff Publications

As the federal government continues to expand upon and improve its data sharing policies over the past 20 years, complex challenges remain. Our interviews with U.S. academic genetic researchers (n=23) found that the burden, translation, industry limitations, and consent structure of data sharing remain major governance challenges.

Klebsiella Pneumoniae Carbapenemase Variant 44 Acquires Ceftazidime-Avibactam Resistance By Altering The Conformation Of Active-Site Loops, Zhizeng Sun, Hanfeng Lin, Liya Hu, Neetu Neetu, Banumathi Sankaran, Jin Wang, B V Venkataram Prasad, Timothy Palzkill

Faculty, Staff and Students Publications

Klebsiella pneumoniae carbapenemase 2 (KPC-2) is an important source of drug resistance as it can hydrolyze and inactivate virtually all β-lactam antibiotics. KPC-2 is potently inhibited by avibactam via formation of a reversible carbamyl linkage of the inhibitor with the catalytic serine of the enzyme. However, the use of avibactam in combination with ceftazidime (CAZ-AVI) has led to the emergence of CAZ-AVI-resistant variants of KPC-2 in clinical settings. One such variant, KPC-44, bears a 15 amino acid duplication in one of the active-site loops (270-loop). Here, we show that the KPC-44 variant exhibits higher catalytic efficiency in hydrolyzing ceftazidime, lower …

Inhibition Of Src-3 As A Potential Therapeutic Strategy For Aggressive Mantle Cell Lymphoma, Imani Bijou, Yang Liu, Dong Lu, Jianwei Chen, Shelby Sloan, Lapo Alinari, David M Lonard, Bert W O'Malley, Michael Wang, Jin Wang

Faculty, Staff and Students Publications

Mantle cell lymphoma (MCL) has a poor prognosis and high relapse rates despite current therapies, necessitating novel treatment regimens. Inhibition of SRC-3 show effectiveness in vivo and in vitro in other B cell lymphomas. Additionally, previous studies have shown that SRC-3 is highly expressed in the lymph nodes of B cell non-Hodgkin's lymphoma patients, suggesting SRC-3 may play a role in the progression of B cell lymphoma. This study aimed to investigate novel SRC-3 inhibitors, SI-10 and SI-12, in mantle cell lymphoma. The cytotoxic effects of SI-10 and SI-12 were evaluated in vitro and demonstrated dose-dependent cytotoxicity in a panel …

Faslpr Gene Dosage Tunes The Extent Of Lymphoproliferation And T Cell Differentiation In Lupus, Ritu Bohat, Xiaofang Liang, Yanping Chen, Chunyu Xu, Ningbo Zheng, Ashley Guerrero, Jiakai Hou, Roshni Jaffery, Nicholas A Egan, Yaxi Li, Yitao Tang, Esra Unsal, Adolfo Robles, Si Chen, Angela M Major, Hadil Elldakli, Sang-Hyuk Chung, Han Liang, M John Hicks, Yong Du, Jamie S Lin, Xiqun Chen, Chandra Mohan, Weiyi Peng

Faculty, Staff and Student Publications

Sle1 and Fas^lpr are two lupus susceptibility loci that lead to manifestations of systemic lupus erythematosus. To evaluate the dosage effects of Fas^lpr in determining cellular and serological phenotypes associated with lupus, we developed a new C57BL/6 (B6) congenic lupus strain, B6.Sle1/Sle1.Fas^lpr/+ (Sle1homo.lprhet) and compared it with B6.Fas^lpr/lpr (lprhomo), B6.Sle1/Sle1 (Sle1homo), and B6.Sle1/Sle1.Fas^lpr/lpr (Sle1homo.lprhomo) strains. Whereas Sle1homo.lprhomo mice exhibited profound lymphoproliferation and early mortality, Sle1homo.lprhet mice had a lifespan comparable to B6 mice, with no evidence of splenomegaly or lymphadenopathy. Compared to B6 monogenic lupus strains, Sle1homo.lprhet mice exhibited significantly …