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Physiological And Histological Effects Of Apigenin And Luteolin On Cytarabine Injected Rats, Omar N. Sultan, Ghada A. Taqa Jan 2024

Physiological And Histological Effects Of Apigenin And Luteolin On Cytarabine Injected Rats, Omar N. Sultan, Ghada A. Taqa

Baghdad Science Journal

The present study was undertaken to study the effect of apigenin and luteolin on physiological and histological changes in rats treated with cytarabine drugs. Thirty-five albino healthy male adult rats with equal age weighing 250 -300g were enrolled. Rats were randomly divided into seven groups according to the treatment. Group “1” was treated with normal saline and served as the control group. Groups “2,3 and 4” received cytarabine, apigenin, and luteolin respectively, while groups 5, 6, and 7 received a combination of “apigenin + cytarabine”, “luteolin + cytarabine”, and “apigenin + luteolin + cytarabine”, respectively. After one week of treatment, …


A New Approach For Developing Spectrophotometric Determination Of Phenylephrine Drug In Pure, Pharmaceutics And Serum Samples Using Sodium Periodate As Oxidizing Agent Via A Green Method Of Cfia/Merging Zone Technique, Shahad L. Hamed, Bushra B. Qassim Jan 2024

A New Approach For Developing Spectrophotometric Determination Of Phenylephrine Drug In Pure, Pharmaceutics And Serum Samples Using Sodium Periodate As Oxidizing Agent Via A Green Method Of Cfia/Merging Zone Technique, Shahad L. Hamed, Bushra B. Qassim

Baghdad Science Journal

The research involved a rapid, automated and highly accurate developed CFIA/MZ technique for estimation of phenylephrine hydrochloride (PHE) in pure, dosage forms and biological sample. This method is based on oxidative coupling reaction of 2,4-dinitrophenylhydrazine (DNPH) with PHE in existence of sodium periodate as oxidizing agent in alkaline medium to form a red colored product at ʎmax (520 nm). A flow rate of 4.3 mL.min-1 using distilled water as a carrier, the method of FIA proved to be as a sensitive and economic analytical tool for estimation of PHE. Within the concentration range of 5-300 μg.mL-1, a calibration curve was …


Molecular Identification Of Methylorubrum Extorquens Using Pcr-Amplified Mxaf Gene Fragments As A Molecular Marker, Anwar A. Maki, Asaad M. R. Al-Taee, Zeenah Weheed Atwan Jan 2024

Molecular Identification Of Methylorubrum Extorquens Using Pcr-Amplified Mxaf Gene Fragments As A Molecular Marker, Anwar A. Maki, Asaad M. R. Al-Taee, Zeenah Weheed Atwan

Baghdad Science Journal

Methylotrophs bacteria are ubiquitous, and they have the ability to consume single carbon (C1) which makes them biological conversion machines. It is the first study to find facultative methylotrophic bacteria in contaminated soils in Iraq. Conventional PCR was employed to amplify MxaF that encodes methanol dehydrogenase enzyme. DNA templates were extracted from bacteria isolated from five contaminated sites in Basra. The gene specific PCR detected Methylorubrum extorquens as the most dominant species in these environments. The ability of M. extorquens to degrade aliphatic hydrocarbons compound was tested at the laboratory. Within 7 days, gas chromatographic (GC) studies of remaining utilized …


Effect Of Nanocapsules And Extract Of Metarhizium Anisopliae In Inhibiting Acetylcholine Esterase Enzyme In Musca Domestica Larvae., Aliaa Abdul Aziz Hammed, Hazim Idan Al Shammari, Soolaf A Kathiar Jan 2024

Effect Of Nanocapsules And Extract Of Metarhizium Anisopliae In Inhibiting Acetylcholine Esterase Enzyme In Musca Domestica Larvae., Aliaa Abdul Aziz Hammed, Hazim Idan Al Shammari, Soolaf A Kathiar

Baghdad Science Journal

M. domestica is the most important insect that transmit pathogens for diseases in the world. The use of nanotechnology is eco-friendly method in control pests. The study aims to investigate the feasibility of bio-manufacturing nanocapsules of fungal secondary metabolites in order to improve the efficiency of metabolite and assess their inhibitory effect on the acetylcholine esterase enzyme in housefly larvae. An equal mixture of organic solvents, ethyl acetate and dichloromethane, was used to extract the metabolic products of the fungus M. anisopliae, (PEG4000) and chitosan was used in the preparation of nanocapsules. The results of the DLS granular size assay …


Enhanced Photocatalytic Activity Of Cu2o/Zno/Go Nanocomposites On The Methylene Blue Degradation, Frikson Jony Purba, Zuriah Sitorus, Kerista Tarigan, Nurdin Siregar Jan 2024

Enhanced Photocatalytic Activity Of Cu2o/Zno/Go Nanocomposites On The Methylene Blue Degradation, Frikson Jony Purba, Zuriah Sitorus, Kerista Tarigan, Nurdin Siregar

Baghdad Science Journal

This study synthesized nanocomposite photocatalyst materials from a mixture of Cu2O nanoparticles, ZnO nanoparticles, and graphene oxide (GO) through coprecipitation and hydrothermal methods. This study aims to determine the optimum composition of Cu2O/ZnO/GO nanocomposites in degrading methylene blue. The nanocomposite was synthesized in two steps: 1 the synthesis of Cu2O and ZnO nanoparticles through the coprecipitation method and the preparation of GO through the modified Hummer method. 2 The preparation of Cu2O and ZnO nanoparticles mixtures with GO through the hydrothermal method to form Cu2O/ZnO/GO nanocomposites. The adsorption-photocatalysis process of methylene blue was done with UV light from a halogen …


Relationship Between Serum Nesfatin-1, Adiponectin, Resistin Concentration, And Obesity With Type 2 Diabetes Mellitus, Baydaa Ahmed Abed, Layla Othman Farhan, Ashgan Slman Dawood Jan 2024

Relationship Between Serum Nesfatin-1, Adiponectin, Resistin Concentration, And Obesity With Type 2 Diabetes Mellitus, Baydaa Ahmed Abed, Layla Othman Farhan, Ashgan Slman Dawood

Baghdad Science Journal

Diabetes mellitus caused by insulin resistance is prompted by obesity. Neuropeptide Nesfatin-1 was identified in several organs, including the central nervous system and pancreatic islet cells. Nesfatin-1 peptide appears to be involved in hypothalamic circuits that energy homeostasis and control food intake. Adiponectin is a plasma collagen-like protein produced by adipocytes that have been linked to the development of insulin resistance (IR), diabetes mellitus type 2 (DMT2), and cardiovascular disease (CVD). Resistin was first identified as an adipose tissue–specific hormone that was linked to obesity and diabetes. The aim of this study was to estimate the relationship between human serum …


An Integrative Study On Wood-Boring Beetle Larvae: Nutritional Properties, Gut Microbiota And Isolation Of Bioactive Compounds, Shadrack Kibet Jan 2024

An Integrative Study On Wood-Boring Beetle Larvae: Nutritional Properties, Gut Microbiota And Isolation Of Bioactive Compounds, Shadrack Kibet

All Master’s Theses

Edible insects are increasingly recognized as a solution to several problems faced by mankind, including hunger, malnutrition and microbial infections. Additionally, the gut symbionts of insects, along with their associated metabolites and enzymes, hold promising potential for industrial and pharmaceutical applications. However, the detailed nutritional properties, gut microbiota, and microbial secondary metabolites associated with the gut symbionts of various insects, including wood-boring beetles, have not yet been comprehensively reported. In this current study, the nutritional properties, and the characteristics of the gut microbiota of two wood-boring species (Titocerus jaspideus and Passalus punctiger) collected from two indigenous forested areas was investigated. …


Physicochemical Characterization Of Edible Insect Oils: Insights Into Fatty Acid Composition, Thermal Behavior And Quality Parameters, Eng-Tong Phuah, Yee-Ying Lee, Teck-Kim Tang, Guanghui Li, Shyang-Pei Hong, Syazana Abdullah Lim Jan 2024

Physicochemical Characterization Of Edible Insect Oils: Insights Into Fatty Acid Composition, Thermal Behavior And Quality Parameters, Eng-Tong Phuah, Yee-Ying Lee, Teck-Kim Tang, Guanghui Li, Shyang-Pei Hong, Syazana Abdullah Lim

ASEAN Journal on Science and Technology for Development

Edible insects are emerging as a sustainable food source due to their high nutritional value. This study employed the three-phase partitioning (TPP) method to extract oils from sago worm (Rhynchophorus ferrugineus), superworm (Zophobas morio), and cricket (Acheta domesticus). The study evaluated and compared the physicochemical properties of these insect oils, including iodine value (IV), peroxide value (PV), p-anisidine value (p-AV), acid value (AV), refractive index (RI), thermal behavior, and fatty acid compositions. Results revealed that the sago worm exhibited the highest oil yield (47.8 ± 2.2%) compared to the superworm (23.8 ± 1.4%) and cricket (6.4 ± 0.6%). Cricket oil …


Assessing The Organic Acids-Solubilized Collagen Derived From The Skin Of Unicornfish (Naso Reticulatus Randall, 2011) On Physicochemical And Structural Characteristics: Toward Alternative Source For Industrial Applications, Dayang Fazrianie Harianto, Abdul Aziz Jaziri, Rossita Shapawi, Ruzaidi Azli Mohd Mokhtar, Wan Norhana Md. Noordin, Masmunira Rambli, Nurul Huda Jan 2024

Assessing The Organic Acids-Solubilized Collagen Derived From The Skin Of Unicornfish (Naso Reticulatus Randall, 2011) On Physicochemical And Structural Characteristics: Toward Alternative Source For Industrial Applications, Dayang Fazrianie Harianto, Abdul Aziz Jaziri, Rossita Shapawi, Ruzaidi Azli Mohd Mokhtar, Wan Norhana Md. Noordin, Masmunira Rambli, Nurul Huda

ASEAN Journal on Science and Technology for Development

Converting skin by-product of unicornfish (Naso reticulatus Randall, 2011) into a valuable commodity like collagen is a good strategy to explore alternative sources for land-based animals. Additionally, marine fish collagens are preferable due to their safer and great properties. This project aimed to compare extractability of collagens prepared with three organic acids (i.e., acetic, lactic and citric acids), and their characteristics were also discussed. Collagen extracted with citric acid (CSCUS) (7.10%) had a significantly higher yield (p


Non-Invasive Digital Refractometer To Measure Maturation Of Climacteric Fruits, Jhoorhanah A. Halim, Denni Kurniawan, Dina S. Laila, Allysa Norjemee, Nuur A. L. Nesseruddin, Asrarul A. Noraidi, Beston F. Nore Jan 2024

Non-Invasive Digital Refractometer To Measure Maturation Of Climacteric Fruits, Jhoorhanah A. Halim, Denni Kurniawan, Dina S. Laila, Allysa Norjemee, Nuur A. L. Nesseruddin, Asrarul A. Noraidi, Beston F. Nore

ASEAN Journal on Science and Technology for Development

Sugar content is a superior quality indicator for the post-harvesting and ripening status of climacteric fruits. Total soluble solids (TSS) represented by °Brix index is a measure of the sugar content. The conventional way to measure TSS is by invasive (IN) technique using manual or digital refractometers. While non-invasive (NIN) infrared refractometer devices have been developed in recent years for various agricultural and food science applications, its accuracy to measure fruit TSS directly is not straightforward, as the device is only dedicated to uses for a specific fruit. This study aims to investigate the suitability of the use of a …


Development Of Halalan Tayyiban Plant-Based Cheese Formulations, Hasna B. Mazalana, Mas M. Rambli, Syazana A. Lim, Beston F. Nore Jan 2024

Development Of Halalan Tayyiban Plant-Based Cheese Formulations, Hasna B. Mazalana, Mas M. Rambli, Syazana A. Lim, Beston F. Nore

ASEAN Journal on Science and Technology for Development

The worldwide cheese production is dominated by animal milk sources with various industrial procedures, including animal rennet. There is a need to diversify the animal-based dairy products into plant-based one, not only to nurture the halalan tayyiban concept for Muslims, but also to accommodate the dietary restriction of some consumers. The objective of this work is to formulate a cheese type derived from plant-based milk with permissible ingredients to create a product for Muslim and non-Muslim consumers. In this study, we explored the use of conventional and non-conventional cheese-making procedures. A total of four experimental formulations (EF1-4) combinations were conducted …


Nanocellulose Synthesized From Sugarcane Bagasse (S. Officinarum) Via Alkaline-Mechanical Process And Its Characterization, Wafiqah Daim, Hiroshi Uyama, Syazana Abdullah Lim Jan 2024

Nanocellulose Synthesized From Sugarcane Bagasse (S. Officinarum) Via Alkaline-Mechanical Process And Its Characterization, Wafiqah Daim, Hiroshi Uyama, Syazana Abdullah Lim

ASEAN Journal on Science and Technology for Development

Nanocellulose is one of many promising materials that have garnered the attention of researchers and industries. In this study, sugarcane bagasse (S. officinarum) was used to synthesize cellulose nanofiber (SB-CNF) via an alkaline-mechanical process. A comprehensive characterization of SB-CNF was conducted to explore its morphology via scanning electron microscopy (SEM) and dynamic force microscopy (DFM), assess its functional groups using Fourier transform infrared spectroscopy (FT-IR), analyze its thermal properties through thermogravimetric analysis (TGA), and lastly, evaluate light absorbance and transmittance using a UV-VIS spectrophotometer. Our findings revealed that SB-CNF resulted in a highly intertwined nanofiber structure within a nano-scale dimension. …


Green Synthesis Of Carbon Dots From Mangosteen Peel For Fluorescent Cancer Cells, Supaluck Amloy, Tanachporn Lukprang, Monthon Lertworapreecha, Pakorn Preechaburana Jan 2024

Green Synthesis Of Carbon Dots From Mangosteen Peel For Fluorescent Cancer Cells, Supaluck Amloy, Tanachporn Lukprang, Monthon Lertworapreecha, Pakorn Preechaburana

Journal of Metals, Materials and Minerals

Recently, carbon dots (CDs) have received significant attention owing to their outstanding optical properties, good solubility, and low toxicity. In this research, CDs were synthesized by a hydrothermal method based on an environmentally friendly and straightforward strategy, using only mangosteen peel and deionized water. The synthesized CDs had an average size of 3.09 ± 0.38 nm. The absorbance spectrum peak for the CDs was seen at 282 nm, and the central wavelength of fluorescence emission was observed at 433 nm under an excitation wavelength of 355 nm. An aqueous solution of CDs exhibited bright green fluorescence when observed with the …


The Effects Of The Crystallinity Index Of Cellulose On The Flexural Properties Of Hybrid-Cellulose Epoxy Composites, Nathawat Poopakdee, Warut Thammawichai Jan 2024

The Effects Of The Crystallinity Index Of Cellulose On The Flexural Properties Of Hybrid-Cellulose Epoxy Composites, Nathawat Poopakdee, Warut Thammawichai

Journal of Metals, Materials and Minerals

This work investigated the effects of the crystallinity index (CI) of cellulose on the flexural properties of hybrid-cellulose epoxy composites. The CI was varied by combining cellulose microfibrils (CMF) and microcrystalline cellulose (MCC), extracted from coir and eucalyptus, respectively, in various mixing ratios. From the XRD analysis, it was shown that the CI values and the CMF/MCC content follow a parabolic-fitting pattern, reaching a maximum value of 82.06% for the CMF/MCC of 30/70. The composites with cellulose of different CI values were fabricated and the flexural properties were measured. The results showed that the flexural strength increased as the CI …


Adhesive Wear Characteristics Of Mono And Hybrid Cf/Ep Composite With Nano-Hap Filler, Divya Gurkar Somashekar, Naveena Bettahalli Eswaregowda, Suresha Bheemappa Jan 2024

Adhesive Wear Characteristics Of Mono And Hybrid Cf/Ep Composite With Nano-Hap Filler, Divya Gurkar Somashekar, Naveena Bettahalli Eswaregowda, Suresha Bheemappa

Journal of Metals, Materials and Minerals

Composites materials with more than two reinforcing materials are called hybrid composites.  Tailoring the composites by hybridizing fillers, fibers and matrix will yield better properties compared to mono-composites. Hence, an effort has been made in the current research work to develop carbon fiber epoxy hybrid nanocomposites, comprising different weight percentage of Hydroxyapatite (HAP) to evaluate the potential effects on tribological properties using two body sliding wear method. Taguchi technique (L27 array) has been adopted to investigate the impact of parameters such as filler inclusion (0%, 1.5%, and 3%), load (30, 45, and 60 N), sliding velocity (1, 2, and 3 …


Optimization Of Ultrasound-Assisted Anthocyanin Extraction From Agricultural Waste Purple Corn Silk For Multifunctional Hemp Finishes, Benjamas Klaykruayat, Nattaya Vuthiganond, Pisutsaran Chitichotpanya Jan 2024

Optimization Of Ultrasound-Assisted Anthocyanin Extraction From Agricultural Waste Purple Corn Silk For Multifunctional Hemp Finishes, Benjamas Klaykruayat, Nattaya Vuthiganond, Pisutsaran Chitichotpanya

Journal of Metals, Materials and Minerals

The utilization of agricultural wastes for textile dyeing has gained popularity due to their safe and environmentally friendly properties, as well as the resource sustainability. Natural dye extraction is usually achieved through solvent extraction, which is time-consuming, requires a lot of solvent, and degrades desired compounds at high temperatures. Thus, this study investigated ultrasound-assisted anthocyanin extraction from agricultural waste purple corn silk as natural functional colorants for hemp finishes, given the numerous health benefits associated with anthocyanin. In order to optimize the extraction processes and evaluate the synergistic impact of these conditions, response surface methodology was implemented. The optimum conditions …


Photoluminescent Carbon Nanodots For Artificial Photosynthesis, Rajie A. Medina, Michael E. Franco, Lyn Marie De Juan-Corpuz, Ryan D. Corpuz Jan 2024

Photoluminescent Carbon Nanodots For Artificial Photosynthesis, Rajie A. Medina, Michael E. Franco, Lyn Marie De Juan-Corpuz, Ryan D. Corpuz

Journal of Metals, Materials and Minerals

The emerging field of carbon dots (CDs), a type of carbon nanostructure that has gained significant attention due to its unique properties and potential applications. CDs possess remarkable attributes, including photoluminescence, electrochemical potential, compatibility with living organisms, solubility in water, chemical stability, and versatile surface properties. The chemical structure, particle size, and surface functionalities of CDs all have an impact on their photoluminescent properties, which are the focus of this review. The photoluminescence mechanism in CDs is discussed, highlighting their amorphous structure, and comparing them to graphene quantum dots. The paper delves into the application of CDs in artificial photosynthesis, …


Lldpe Film Development Surface With Nucleating Agents To Reduce Fat Stains From Food Adherence On The Film Surface For Easy Rinsing Before Recycling, Nattapong Pinpru, Chiranicha Ninthap, Supang Sripraphot, Supharada Khaisaat Jan 2024

Lldpe Film Development Surface With Nucleating Agents To Reduce Fat Stains From Food Adherence On The Film Surface For Easy Rinsing Before Recycling, Nattapong Pinpru, Chiranicha Ninthap, Supang Sripraphot, Supharada Khaisaat

Journal of Metals, Materials and Minerals

The purpose of this research was to enhance the surface of linear low-density polyethylene (LLDPE) film by using single and hybrid nucleating agents to reduce fat stains from food adherence on the film surface for easy rinsing before recycling, consequently reducing energy consumption before recycling. The process begins with the preparation of a high-concentration masterbatch of LLDPE with nucleating agents and polyethylene glycol (PEG), followed by blown film and test analysis. The results showed that both single and hybrid nucleating agents resulted in substantial modifications in the surface characteristics of the film. The altered surface texture of the film makes …


Institute For Global Health And Development : Annual 2024, Institute For Global Health And Development Jan 2024

Institute For Global Health And Development : Annual 2024, Institute For Global Health And Development

IGHD Newsletters

  • Message From The Director
  • Workshops & Conferences
  • Climate Change, Agriculture, Human Nutrition & Development in Pakistan
  • What Works Climate Solutions Summit, Berlin
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  • Climate Change and Health Symposium
  • Collaborating For Change
  • IGHD Hosts Workshop on Research Concepts & Basic Methodology
  • SDSN Pakistan Leadership Council Meeting – 2024
  • AKDN Technical Working Group (TWG) Meeting 2024
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Research Access To Social Media Data: Lessons From Clinical Trial Data Sharing, Christopher J. Morten, Gabriel Nicholas, Salomé Vilgoen Jan 2024

Research Access To Social Media Data: Lessons From Clinical Trial Data Sharing, Christopher J. Morten, Gabriel Nicholas, Salomé Vilgoen

Articles

For years, social media companies have sparred with lawmakers over how much independent access to platform data they should provide researchers. Sharing data with researchers allows the public to better understand the risks and harms associated with social media, including areas such as misinformation, child safety, and political polarization. Yet researcher access is controversial. Privacy advocates and companies raise the potential privacy threats of researchers using such data irresponsibly. In addition, social media companies raise concerns over trade secrecy: the data these companies hold and the algorithms powered by that data are secretive sources of competitive advantage. This Article shows …


Rethinking Innovation At Fda, Rachel E. Sachs, Nicholson Price, Patricia J. Zeitler Jan 2024

Rethinking Innovation At Fda, Rachel E. Sachs, Nicholson Price, Patricia J. Zeitler

Articles

In several controversial drug approval decisions in recent years, the Food & Drug Administration (“FDA”) has publicly justified its decision partly on the ground that approving the drugs in question would support innovation in those fields going forward. To some observers, these arguments were surprising, as the Agency’s determination whether a drug is “safe” and “effective” does not seem to depend on whether its approval also supports innovation. But FDA’s use of these innovation arguments in drug approval decisions is just one example of the ways in which the Agency has come to make many innovation-related judgments as part of …


Cognitive Dissonance In The Antebellum South About The Lawfulness Of Slavery, Peter K. Westen Jan 2024

Cognitive Dissonance In The Antebellum South About The Lawfulness Of Slavery, Peter K. Westen

Articles

The institution of slavery, by its nature, was necessarily grounded in law. For whenever a society adjudges one class of persons as free and another as enslaved, law-like norms must exist to identify and distinguish the free from the enslaved. And whenever a society institutionalizes slavery, law-like norms must exist to establish the privileges and disabilities possessed by masters, by the enslaved, and by third persons in relation to masters and slaves. Such master-slave norms may not always be enforced. But, until societies disavow or disremember them, they constitute standards of right and wrong that master-slave societies profess to embrace. …


Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs Jan 2024

Empowering Providers To Empower Their Patients: One Model To Expand Knowledge, Competency, And Awareness For The Perinatal Substance Use Workforce, Jacqueline Jacobs

Graduate School of Professional Psychology: Doctoral Papers and Masters Projects

Perinatal substance use (PSU) is a serious and growing public health concern. It is associated with a variety of adverse health outcomes for both mother and child and has been shown to negatively impact the parent-child relationship. Despite the growing prevalence of PSU, there are notable deficits in provider knowledge regarding, and comfortability with, PSU. Moreover, providers report feelings of judgment, resentment, fear, and hesitancy related to their work with women with PSU. Subsequently, women with PSU struggle to find appropriate, compassionate, and effective treatment for their substance misuse. Widespread and accessible training is needed to bolster provider knowledge base, …


Queer: Litigating Gender Non-Conformity, Eliot Tracz Jan 2024

Queer: Litigating Gender Non-Conformity, Eliot Tracz

American University Journal of Gender, Social Policy & the Law

Section I of this article provides background information on the complexity of gender identity. This section addresses some of the different terminology used by members of the LGBTQ community to describe their gender identity, including the relatively well-known term “nonbinary” and continuing through to the less concrete term “queer.” Section II looks at the history of state action policing queer bodies and identities. It outlines statutes enacted to prevent individuals from hiding their identities and how such laws were used to target queer individuals. Section III discusses the case of Grimm v. Gloucester County School Boardand the two approaches …


Why Play? Exploring The Realities Of Play-Based Learning In Kindergarten, Sofia Josephine Steele Jan 2024

Why Play? Exploring The Realities Of Play-Based Learning In Kindergarten, Sofia Josephine Steele

Honors Program Theses

By nature, children are curious and love to explore the world around them. Play is one way that children can fulfill that innate curiosity. Through play-based learning, educators can utilize that innate curiosity and wonder in children to create valuable learning experiences that will engage and teach them. This pedagogical approach is used in early childhood education to help children develop their academic, social, and emotional skills through appropriate learning experiences that consider their abilities and interests. However, in recent years, there has been a shift away from play-based learning in kindergarten classrooms. The reasoning behind this shift may be …


Autoregulatory Mechanism Of Enzyme Activity By The Nuclear Localization Signal Of Lysine-Specific Demethylase 1, Dulmi Senanayaka, Danyun Zeng, Sahar Alishiri, William J. Martin, Khadijah I. Moore, Roshni Patel, Zigmund Luka, Alexander Hirschi, Nicholas J. Reiter Jan 2024

Autoregulatory Mechanism Of Enzyme Activity By The Nuclear Localization Signal Of Lysine-Specific Demethylase 1, Dulmi Senanayaka, Danyun Zeng, Sahar Alishiri, William J. Martin, Khadijah I. Moore, Roshni Patel, Zigmund Luka, Alexander Hirschi, Nicholas J. Reiter

Chemistry Faculty Research and Publications

The N-terminal region of the human lysine-specific demethylase 1 (LSD1) has no predicted structural elements, contains a nuclear localization signal (NLS), undergoes multiple posttranslational modifications (PTMs), and acts as a protein-protein interaction hub. This intrinsically disordered region (IDR) extends from core LSD1 structure, resides atop the catalytic active site, and is known to be dispensable for catalysis. Here, we show differential nucleosome binding between the full-length and an N terminus deleted LSD1 and identify that a conserved NLS and PTM containing element of the N terminus contains an alpha helical structure, and that this conserved element impacts demethylation. Enzyme assays …


Efficient Synthesis Of Thiazole-Fused Bisnoralcohol Derivatives As Potential Therapeutic Agents, Subrata Roy, Hansa Raj Kc, Sanjay Adhikary, Alexander N. Erickson, Mohammad Abrar Alam Jan 2024

Efficient Synthesis Of Thiazole-Fused Bisnoralcohol Derivatives As Potential Therapeutic Agents, Subrata Roy, Hansa Raj Kc, Sanjay Adhikary, Alexander N. Erickson, Mohammad Abrar Alam

Chemistry Faculty Research and Publications

Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.


Screen Time And Problematic Behavior: Piloting A Family- Based Intervention, Naomi Morissette Jan 2024

Screen Time And Problematic Behavior: Piloting A Family- Based Intervention, Naomi Morissette

PCOM Psychology Dissertations

School-aged children are increasingly growing up in a technology-driven society. The amount of time children spend engaged with screens is problematic, as is the subsequent impact on the development of their executive functioning skills. The current study investigated the feasibility of an online, asynchronous, family-based intervention to limit screen usage for elementary-aged children. It was hypothesized that removing screens from children’s bedrooms and one hour before bedtime was a feasible strategy to limit screen use and would result in positive behavior change, specifically regarding the ability to self-cue the use of executive skills. Additionally, it was hypothesized that an online …


Nsu Florida Undergraduate Student Catalog 2024-2025, Nova Southeastern University Jan 2024

Nsu Florida Undergraduate Student Catalog 2024-2025, Nova Southeastern University

Undergraduate Programs Course Catalogs

No abstract provided.


Diversity Across Disciplines: Student Response To Dei Content In College Curricula, Angela Pettitt Jan 2024

Diversity Across Disciplines: Student Response To Dei Content In College Curricula, Angela Pettitt

Theses and Dissertations

Discussion and inclusion of diversity-related topics in higher education are often confined to specific courses designated as fulfilling a university-mandated diversity requirement such as courses in women's studies, Black history or literature, Eastern religions, among others. Mainstream general education courses in disciplines such as psychology, chemistry, or communications typically do not address diversity, equity, and inclusion (DEI) topics as part of the curriculum, even if individual textbooks, courses, or faculty work to improve such courses' pluralism. However, as the U.S. population becomes both more diverse and segregated, and as DEI initiatives come under fire from state legislators, students receive conflicting …