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Genetic Diversity Of Paxistima Canbyi A. Gray: Conserving A Rare Plant Species Endemic To The Eastern United States, Isaac Buabeng

Master’s Theses

Premise: The glacial cycles of the Pleistocene period likely had a profound impact on the genetic diversity and phylogeographic patterns of numerous plant taxa in North America. However, the genetic diversity of rare, limestone-endemic woody species has not been highlighted. This study assesses genetic diversity in Paxistima canbyi A. Gray (Canby’s mountain lover or rat stripper), a rare limestone endemic small woody plant.

Methods: We investigated the genetic diversity of P. canbyi using genomic Single Nucleotide Polymorphism (SNP) data from 165 individuals from 14 populations sampled from across the entire range distribution. We first; de novo assembled the SNP …

Transient Diode Laser Absorption Spectroscopy For Measuring Collisional Quenching Rates Of Co And Its Potential For Studying H2o, Jordan M. Polvere

Master’s Theses

Motivated by the necessity of non-LTE models that account for species that are not in Local Thermodynamic Equilibrium (LTE) in Titan’s and Earth’s atmospheres, collisional quenching rates of CO and H2O_(g) have been studied. Providing more accurate and precise values of collisional quenching rate coefficients is crucial in the development of more advanced atmospheric models, which are important to fields of science such as meteorology and astronomy. Rates of collisional quenching of CO(v=1,2) by CO and CO(v=2) by N₂ at approximately 301-321 K were measured by transient diode laser absorption spectroscopy. The rate coefficients of CO(v=1)-CO, CO(v=2)-CO, and …

Bibliography, Charles H. Smith

Faculty/Staff Personal Papers

Bibliography of publications by Charles H. Smith.

Optimization Of Buffers Used In Phycobiliprotein Extraction From The Cyanobacterium Acaryochloris Marina, Rinah Fleisher

Williams Honors College, Honors Research Projects

Optimization of buffers used in phycocyanin extraction from A. marina was explored including acetate, phosphate, and citrate buffers as well as deionized water as a negative control. Samples were extracted in triplicates for each trial with two extraction trials completed overall for citrate buffer (n=6), phosphate buffer (n=6), acetate buffer (n=6), and deionized water (n=6). Results reflect no statistical difference in phycocyanin content (μg/mL) between each buffer or deionized water control. Though no statistically significant differences between treatment groups were found, phosphate buffer yielded the greatest phycocyanin content and the deionized water negative control yielded the lowest phycocyanin content overall. …

The Climate Crisis And The Class System: An Ethical Analysis, Alia Baig

Williams Honors College, Honors Research Projects

Climate change is a concerning subject that more and more people are beginning to care about. The climate crisis is continuing to affect populations across the globe and shows no signs of slowing. While everyone has been affected by climate change in some capacity, the climate crisis disproportionately affects low-income communities around the world and, specifically, within the United States. I plan to research the ethics of the relationship between climate change and the class system and the goal o f this project is to prove the claim that the class system is the reason for climate change's disproportionate effect …

Psychotropic Polypharmacy On Heart Rate Of Daphnia Magna, Gwendolynne Miller, Brian Bagatto

Williams Honors College, Honors Research Projects

The prevalence of patients being prescribed multiple medications concurrently is significantly rising, and so is the importance of investigating any interactions between medications. One common example—sertraline and clomipramine have been used together to treat obsessive compulsive disorder. Clomipramine, however, is known to cause tachyarrhythmias in some patients. The present study set out to investigate the role of this drug combination on the heart rate of a simple animal model, Daphnia magna, or the water flea. The water flea was exposed to saline, sertraline, clomipramine, or sertraline plus clomipramine, and heart rate was measured subsequently. It was found that the …

Farmland Effect On Local Water Quality, Rachel Burns

Williams Honors College, Honors Research Projects

I will be conducting water quality testing in bodies of water in the area. The goal is to determine if there is a correlation between the water quality and the proximity to farmland or if areas are equally affected by nonpoint sources of pollution despite the distance. The data collection will take place over the course of a month or less, with a more detailed schedule in the proposal. Several samples will be taken at each body of water, with 3-5 bodies of water per treatment group. I will be testing the pH, nitrates, and dissolved oxygen levels of the …

The Smell Of Fear: Responses Of Native And Invasive Geckos To Predator Scent Cues On Moorea, French Polynesia, Haley Dreisbach, Tessa Bodo

Williams Honors College, Honors Research Projects

Hemidactylus frenatus, a globally invasive species, is syntopic with the native gecko Lepidodactylus lugubris on the island of Moorea, French Polynesia. The success of an invasive species, H. frenatus can be attributed to many factors and is the subject of much study. Some research suggests that invasive and native geckos may differ in their response to chemosensory cues from predators. We compared the responses of H. frenatus and L. lugubris to the scents of both a native local predator; centipede, and a common predator of geckos that is not present on Moorea; snake. While neither gecko species showed any …

Sources And Termination Patterns Of Cholinergic Input To The Ventral Nucleus Of The Lateral Lemniscus, Emily Echols

Williams Honors College, Honors Research Projects

Neurons transmit signals through an electrochemical reaction: synapses on dendrites and the cell body receive neurotransmitters, and their effect on the cell determines the signal the cell will transmit. From dendrites to axon and then to another cell at a synaptic cleft, signals can propagate, enhance each other, or inhibit other transmissions until the message is received by the target area. Understanding the science behind neural signaling and structural function begins at the level of the synapse. The neurotransmitter acetylcholine (ACh) plays a substantial role in modulating neural activity in the auditory system, but for many brainstem nuclei the source …

Localization And Quantification Of Atpase, Ca2+ Transporting, Plasma Membrane 2 (Atp2b2) In The Developing Euthyroid And Hypothyroid Cochlea, Emily Gregersen

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone (TH) is essential for auditory system development. Proper auditory function requires remodeling and transformation of cochlear structures during a critical developmental period. In rodent models, low TH during this timeframe delays remodeling and impacts ion channel function required for hearing to occur. TH receptors are ligand-dependent transcription factors that regulate expression of genes. Considering this, auditory deficits observed in hypothyroidism are thought to be largely the result of altered expression of specific TH receptor target genes. TH is reported to impact calcium signaling in several tissues, but whether regulators of calcium signaling are altered following developmental hypothyroidism is …

Machine Learning-Based Analysis Of Dna Methylation Patterns In E.Lenta, Tsion Tsegaye Sherbeza

All Graduate Theses, Dissertations, and Other Capstone Projects

Methylation patterns in bacterial genomes, such as those found in Eggerthella lenta, take roles in mediating microbial interactions with their environment, host, and external stressors. These patterns are formed by DNA methylation with diverse sequence specificities that provide insights into the DNA sequence regulation and defense against bacteriophages. We utilize computational approaches and machine learning models to identify and analyze 5mC and 6mA methylation motifs in E. lenta genomes. By integrating host characteristics such as age, birth country, gender, and medication history, we explore 1) the predictive relationships between 5mC & 6mA methylation types in E. lenta strains and …

Calculation Of Elastic Constants Of Bulk Metallic Glasses From Indentation Tests, Zhitong Xu, Ming Liu, Fuqian Yang

Chemical and Materials Engineering Faculty Publications

One of the challenges in the applications of instrumented indentation is to simultaneously measure elastic modulus and Poisson’s ratio of homogeneous, isotropic materials. This work proposes empirical equations for simultaneous calculation of elastic modulus and Poisson’s ratio of bulk metallic glasses (BMGs) from the ratio of the short diagonal length to the long diagonal length and the area of the Knoop imprint. The parameters pre- sented in the empirical equations are determined first by Knoop microhardness tests of 24 BMGs, whose elastic moduli and Poisson’s ratios are measured by resonant ultrasound spectroscopy. These empirical equations are further validated by the …

Research News, Publications, 2024, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2024.

Research News, Publications, 2024, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 1 through September 30, 2024.

Research News, Publications, 2024, Volume 4, Joshua Sharp

Publications (2015-)

Publications that appeared during the period of October 1 - December 31, 2024.

Biomolecule Screen Identifies Several Inhibitors Of Salmonella Enterica Surface Colonization, Joseph Headrick, Amital Ohayon, Shannon Elliott, Jacob Schultz, Erez Mills, Erik Petersen

Faculty Open Access Works

Salmonella enterica is a foodborne pathogen commonly found in agricultural facilities; its prevalence, as well as increasing levels of disinfectant- and antibiotic-resistance, has significant costs for agriculture as well as human health. In an effort to identify potential new inhibitors of S. enterica on abiotic surfaces, we developed a biomolecule screen of nutrient-type compounds because nutrients would have lower toxicity in animal facilities and bacterial nutrient utilization pathways might prove less susceptible to the development of bacterial resistance. After screening 285 nutrient-type compounds, we identified ten that significantly inhibited the ability of S. enterica to colonize a plastic surface. After …

Research News, Grants, 2024, Volume 3, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July - September 2024 - Revised 10/22/24

Observed Effects Of Physiological Melatonin Dosing On Mda-Mb-231 Breast Cancer Cell Proliferation, Wenli Wu

Williams Honors College, Honors Research Projects

This project seeks to evaluate pharmacological dosing of melatonin on the cell proliferation of MDA-MB-231 breast cancer cell line in culture, using the two solubility carriers: DMSO/water and ethanol. This experiment is a component of ongoing research at the Eaton lab which will elucidate melatonin dose-response toxicology in zebrafish and a possible breast cancer xenograft model for novel treatment therapies.

Zebrafish Electroretinogram Responses, Brooke Campbell

Williams Honors College, Honors Research Projects

The goal of this project is to be able to streamline a protocol for conducting ERGs on zebrafish from mice ERG protocol already present in Dr. Renna’s lab. The objective is to create a protocol specifically for zebrafish and to eliminate any issues that occur when transiting from a mice ERG protocol to a zebrafish ERG protocol and to obtain a light response from zebrafish retinae in differing light intensities. Dr. Renna’s lab has designed an Ex Vivo ERG system with less electrical interference creating defined electrical responses from mouse retina. The setup allows for continual perfusion of the retinal …

Compliance And Roughness In Relation To Gecko Locomotion, Brooklynn Campbell

Williams Honors College, Honors Research Projects

Geckos move efficiently through a variety of substrates, from swaying branches to wooden fences to the sides of structures. Previous studies have studied locomotion and adhesion on manmade and rough substrates; however, the work is limited when discussing locomotion and adhesion as a relationship of compliance and roughness. Ease of movement was quantified by speed, under the assumption that the faster a gecko moves, the easier it is for the gecko to cross the substrate. Gehyra oceanica geckos from Moorea, French Polynesia were tested on substrates varying in compliance and roughness with four different treatments in total. Compliance, roughness, and …

The Effect Of Early Intervention On Reducing Recidivism, Claire Meyer

Williams Honors College, Honors Research Projects

The current punishment-based system has not led to promising recidivism rates showing the lack of effect it has on changing behavior. By working to understand the effect interventions can have on reducing recidivism, society can improve the criminal justice system. The intention of this paper is to show the benefits of moving to a system focused on rehabilitation instead of punishment, specifically for juvenile offenders. By conducting a literature review of available research, it can be seen that an incarceration-based system is not as effective as the implementation of intervention and prevention methods can be. Cognitive behavioral therapy and community-based …

Microglia Regulate Light Evoked Retinal Responses In The Zebrafish Retina., Brittney Moore

Williams Honors College, Honors Research Projects

The primary goal of the project is to investigate the role of the interferon regulatory factor 9 (irf8) gene in the retinal function of zebrafish. My research aims to examine and compare the retinal responses of two subject groups: wildtype zebrafish and zebrafish with the irf8 gene knocked out. This project seeks to determine if irf8 knockout zebrafish lose visual system functionality before experiencing changes in retinal morphology. The primary technique to answer this research question is the electroretinogram, a commonly used method to examine retinal function. The final outcome of this project will be a scientific paper describing the …

The Effects Of Ethanol Exposure On Glucose And Lactate Levels In Crayfish, Mackenzie Kirwan

Williams Honors College, Honors Research Projects

The goal of the project is to investigate and determine the effects of sunlight exposure and hormone levels. The circadian rhyth, which is heavily influenced by sunlight, not only affects the amount of sleep someone achieves, but is also related to behavior and mood, and heavily relies on the body’s hormones for proper regulation. The hormones that are prevelant to the circadian rhythm, and which will be studied in this experiment are cortisol, serotonin and melatonin. In this experiment, these three hormones will be extracted prior to alterations of light exposure. Animal test subjects will then undergo treatment of light …

Climate Change's Effect On Flow Regime, Alexander Ialenti

Williams Honors College, Honors Research Projects

This project will test to see if there is a percent increase in non-perennial streams sampled from 2003-2021. Using data provided by The Cleveland Metroparks, sampling events will be separated by date, flow regime classification, and rain data. Current literature supports the claim that many perennial streams, streams that flow year-round, will become non-perennial streams over time. This shift is predicted to be caused by a change in rain patterns. Both the interval between rain events and the intensity of rainfall per event are predicted to increase. My hypothesis is that there will be an increase in the percentage of …

The Midwest Feminist Papers: A Facsimile Edition 1980–1997. Part I (1980–1983), Mary Jo Deegan, Michael R. Hill

Zea E-Books Collection

Mary Jo Deegan and Michael R. Hill, compilers. The Midwest Feminist Papers: A Facsimile Edition 1980–1997, with prefaces and author indices by Mary Jo Deegan and Michael R. Hill. 3 volumes: Part I (1980–1983)

The Midwest Feminist Papers was a creative, group-generated initiative that gave voice to the scholarly questions, research interests, and social concerns of a growing cohort of Midwestern feminist sociology graduate students and their feminist faculty mentors during the last quarter of the Twentieth Century. They were active members of Midwest Sociologists for Women in Society, a regional expression of the larger national Sociologists for Women …

Critical Race Theory Model Measure And Implementation In Curriculum, Taifha Natalee Alexander, Ahilan Arulanantham

Faculty Publications

(Excerpt)

This memorandum aims to explain the purpose of the following model measure. The proposed legislation would preserve the freedom of teachers to teach—and students to learn—about racism, including its history and on-going effects in this country. It does this by providing a framework through which state governments can encourage the teaching and learning of Critical Race Theory ("CRT") principles as a lens through which to teach and learn about racial inequality in America, its history, and its current manifestations, to enhance K-12 public school curricula.

We believe the model measure should be of interest to a broad range of …

Impacts To Anxiety, Depression, And Psycho-Spiritual Metrics After Ketamine-Assisted Psychotherapy In Palliative Care Patients At The Aims Institute, Thomas Luedeke

Doctor of Nursing Practice Projects

There is considerable evidence that palliative care patients disproportionately experience anxiety, depression, and existential distress related to their chronic illnesses. Additionally, conventional therapies tend to be less effective in the treatment of this patient population. As such, research is being conducted into novel therapies. One of the promising therapies currently under active investigation is ketamine-assisted psychotherapy (KAP) which involves a combination of the administration of the dissociative anesthetic ketamine combined with psychotherapy.

Two clinical trials are being conducted at the Advanced Integrative Medical Sciences (AIMS) Institute in Seattle, WA, the purposes of which are to evaluate integrative care for patients …

Nursing Staff Training On Compounded Intranasal Ketamine For Treatment-Resistant Depression, Rimisha Lal, Gabrielle Son

Doctor of Nursing Practice Projects

A large proportion of individuals with major depressive disorder (MDD) do not receive adequate therapy benefits from conventional monoaminergic antidepressant drugs, leading to treatment-resistant depression (TRD) (Di Vincenzo et al., 2021). Treating MDD with two failed antidepressant trials can lead to TRD, a condition wherein patients are twice as likely to be hospitalized in comparison to depressed patients who are not treatment-resistant (Gaynes et al., 2020). MDD and dysthymia are jointly responsible for 46.9 million disability-adjusted life years (DALYs) globally, with each DALY equivalent to a healthy year of life lost to the disability caused by depressive disorders (Vos et …

Evaluation Of Pain Neuroscience Education Among Veterans With Chronic Pain, Amanda Black, Tandeep Kaur

Doctor of Nursing Practice Projects

Background: Chronic pain is a significant public health issue, especially among veterans. The traditional approach to chronic pain management has relied heavily on opioids, but nonopioid therapies are now recommended. Pain Neuroscience Education (PNE) aims to improve pain management by educating patients about the complex nature of chronic pain.

Objective: This project evaluates the impact of PNE on veterans’ pain perception and management.

Methods: A tailored PNE program was implemented for veterans at a housing facility. Participants completed pre- and post-intervention questionnaires assessing pain knowledge, severity, and psychosocial factors.

Results: The intervention appears to have improved participants’ understanding of …

Comprehensive Pavement Patching Tools And Web-Based Software For Pavement Condition Assessment And Visualization, Sneha Jha, Yaguang Zhang, Tandra Bagchi, Andrew Balmos, Bongsuk Park, John E. Haddock, Seonghwan Cho, James V. Krogmeier

JTRP Technical Reports

It is a common practice among state agencies to manually inspect road segments and decide maintenance requirements based on the pavement condition index (PCI). However, standalone PCI only evaluates the pavement surface condition. When coupled with the variability in human perception of pavement distress, this limits the accuracy of current pavement maintenance practices and undermines the automated pavement maintenance suggestions systems, especially for actionable recommendations related to accurate patching location, depth, and priority. This project explores integrating pavement structural and surface condition assessment with pavement ratings of distress to estimate the appropriate pavement patching strategy for accurate location, depth, and …