Digital Commons Network^™

Synthetic Neuroactive Steroids Targeting Gaba-A Receptors As A Potential Therapy For Contraceptive-Associated Mood Disorders, Alexandria A. Davis

Scripps Senior Theses

4-10% of women who use hormonal oral contraceptives (HOCs) discontinue use after experiencing symptoms of anxiety, irritability, and depression in the first 3 months of administration. Previous studies have acknowledged a relationship between HOCs and emotional dysregulation but have not identified mechanisms by which HOCs have this effect. As a result, effective treatment options for HOC-induced mood disorders are lacking. Current theories implicate combined-HOCs, particularly those containing ethinyl estradiol and levonorgestrel (EE-LNG), in reducing neuroactive steroid levels. Specifically, HOC users show decreases in allopregnanolone, a positive allosteric modulator associated with neuronal inhibition and emotional regulation. The objective of this study …

Living In A Land East Of Eden: Non-Teleological Thinking And Steinbeck's Last Theory Of Man, Erika Schwerdfeger

Scripps Senior Theses

This essay undertakes a critical reevaluation of John Steinbeck’s 1952 novel East of Eden, the author’s longest, most ambitious and potentially most misunderstood work of fiction. Drawing on excerpts from the eclectic nonfiction volume The Log from the Sea of Cortez, as well as the writer’s personal correspondence and journal entries, this thesis traces the influence of what Steinbeck called “non-teleological thinking” on this novel and on its peculiar brand of humanism, natural philosophy, religiosity and morality. East of Eden is best understood in light of Steinbeck’s abiding interest in and commitment to the natural sciences, particularly marine biology, and …

Serving C*Nt: An Intersectional Historical Look At The Reclamation Of A Taboo Word, Dominique Godinez

Scripps Senior Theses

While the word cunt has been part of reclamation projects for over fifty years in the United States, particularly in the last year (2023) on social media platforms, the revalued word has gained popularity. With increased usage of a slur historically used against women, we’re left to wonder if reclamation is appropriate and who is participating in these processes. This thesis explores the trailblazers who began cunt’s reclamation –– Queer Ballroom performers and women-artists –– contextualizes its usage through widely understood reclamation principles, and offers considerations for cunt-curious folks. In a society that has othered and marginalized women and Queer …

Migration-Associated Variation In Blood Parasitism, Body Condition, And Stress In Gambel’S White-Crowned Sparrows (Zonotrichia Leucophrys Gambelii), Julianna Deibel

Scripps Senior Theses

Migration is a widespread behavior in animals which both causes and is motivated by fluctuations in nutrient availability. Migration is ecologically important, as it connects areas of differing primary productivities and carries pathogens over distance. The relationship between migration and disease is complex, sensitive to anthropogenic disturbance, and influenced by ecological cycles as well as host, vector and parasite life cycles. Four central migration-infection mechanisms have been proposed: migratory susceptibility, migratory exposure, migratory escape, and migratory culling. These mechanisms may yield increased or decreased infection post-migration, based on migration’s physiological tax and the concentration of pathogens along migratory pathways.

To …

Crop Water Use And A Gravity Model Exploration Of Virtual Water Trade In Ghana's Cereal Agriculture, Alexander Sessi Kosi Tette, Golden Odey, Mirza Junaid Ahmad, Bashir Adelodun, Kyung-Sook Choi

Arusha Climate and Environmental Research Centre

Agricultural water productivity is crucial for sustainability amidst the escalating demand for food. Cereals are pivotal in providing nutritious food at affordable prices. This study was based on Ghanaian data spanning from 1992 to 2021 to evaluate water usage in the cultivation of major cereals. It also examined the virtual water losses or gains in cereal trade alongside influencing factors. The analysis utilized secondary data encompassing the virtual water content, production quantity, export and import quantities, distance, GDP per capita, population, and land per capita of Ghana and its 75 trade partners. In the last 5 years, crop water use …

Concepts In Animal Parasitology, Chapter 07: Biostatistics For Parasitologists: A Painless Introduction [Parascript Approaches], Jenő Reiczigel, Marco Marozzi, Fábián Ibolya, Lajos Rózsa

Concepts in Animal Parasitology

Covers biostatistics for parasitologists and includes discussion of taking samples, frequency distribution of host individuals across infection classes, sample size, prevalence, mean intesity, median intensity, stochasic equality of intensities, abundance, crowding, levels of aggregation, parasite sex ratio, parasite species richness, interactions between parasite species, and the tool Quantitative Parasitology on the Web (QPweb).

Chapter 7 in Concepts in Animal Parasitology on biostatistics for parasitologists by Jenő Reiczigel, Marco Marozzi, Fábián Ibolya, and Lajos Rózsa. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap007

Concepts In Animal Parasitology, Chapter 58: Acanthocephala Rudolphi, 1808 (Phylum), Scott Monks

Concepts in Animal Parasitology

An overview of the phylum Acanthocephala Rudolphi, 1808, also called the thorny-headed or spiny-headed worms, including discussion of their general morphology, life cycles, classification, and phylogenetic relationships.

Chapter 58 in Concepts in Animal Parasitology, by Scott Monks. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap058

A Growing Dome In The Clouds Of Everest: An Applied Anthropology Project In The High Himalaya, Gary Mark Lesley

All Graduate Theses, Dissertations, and Other Capstone Projects

Presented is a novel approach to addressing food insecurity within a remote indigenous community situated in the high Himalaya of Nepal. The village faces challenges in accessing fresh, affordable produce, particularly during harsh winter seasons. This threatens the community's food sovereignty and adversely affects the stability of the Sir Edmund Hillary School, a site of historical and cultural importance. Through the integration of indigenous knowledge and technological advancements, this APP details a strategy to augment local agriculture, drawing on applied anthropological methodologies. The genesis of this project stems from the creative leadership of the school principal and his vision for …

“Even The Hardest Stone Can Fracture:” Racialization, Reproductive Control, And The Wake Of Slavery In N.K. Jemisin’S The Fifth Season, Elsbeth Sanders

All Graduate Theses, Dissertations, and Other Capstone Projects

When the science fiction and fantasy novel The Fifth Season by N.K. Jemisin won the Hugo Award in 2016, Jemisin became the first Black author to win the prestigious literary science fiction award. A departure from similar novels at the time, The Fifth Season has a strong understanding of systems of oppression and how they are built and upheld. This thesis argues that The Fifth Season by N.K. Jemisin follows the conventions of the neo-slave/meta-slave narrative to explore themes of racialization and reproductive control under enslavement and oppression. I conduct a feminist literary of the novel, focusing on these themes, …

Genetic Diversity Of Paxistima Canbyi A. Gray: Conserving A Rare Plant Species Endemic To The Eastern United States, Isaac Buabeng

Master’s Theses

Premise: The glacial cycles of the Pleistocene period likely had a profound impact on the genetic diversity and phylogeographic patterns of numerous plant taxa in North America. However, the genetic diversity of rare, limestone-endemic woody species has not been highlighted. This study assesses genetic diversity in Paxistima canbyi A. Gray (Canby’s mountain lover or rat stripper), a rare limestone endemic small woody plant.

Methods: We investigated the genetic diversity of P. canbyi using genomic Single Nucleotide Polymorphism (SNP) data from 165 individuals from 14 populations sampled from across the entire range distribution. We first; de novo assembled the SNP …

Transient Diode Laser Absorption Spectroscopy For Measuring Collisional Quenching Rates Of Co And Its Potential For Studying H2o, Jordan M. Polvere

Master’s Theses

Motivated by the necessity of non-LTE models that account for species that are not in Local Thermodynamic Equilibrium (LTE) in Titan’s and Earth’s atmospheres, collisional quenching rates of CO and H2O_(g) have been studied. Providing more accurate and precise values of collisional quenching rate coefficients is crucial in the development of more advanced atmospheric models, which are important to fields of science such as meteorology and astronomy. Rates of collisional quenching of CO(v=1,2) by CO and CO(v=2) by N₂ at approximately 301-321 K were measured by transient diode laser absorption spectroscopy. The rate coefficients of CO(v=1)-CO, CO(v=2)-CO, and …

Bibliography, Charles H. Smith

Faculty/Staff Personal Papers

Bibliography of publications by Charles H. Smith.

Optimization Of Buffers Used In Phycobiliprotein Extraction From The Cyanobacterium Acaryochloris Marina, Rinah Fleisher

Williams Honors College, Honors Research Projects

Optimization of buffers used in phycocyanin extraction from A. marina was explored including acetate, phosphate, and citrate buffers as well as deionized water as a negative control. Samples were extracted in triplicates for each trial with two extraction trials completed overall for citrate buffer (n=6), phosphate buffer (n=6), acetate buffer (n=6), and deionized water (n=6). Results reflect no statistical difference in phycocyanin content (μg/mL) between each buffer or deionized water control. Though no statistically significant differences between treatment groups were found, phosphate buffer yielded the greatest phycocyanin content and the deionized water negative control yielded the lowest phycocyanin content overall. …

The Climate Crisis And The Class System: An Ethical Analysis, Alia Baig

Williams Honors College, Honors Research Projects

Climate change is a concerning subject that more and more people are beginning to care about. The climate crisis is continuing to affect populations across the globe and shows no signs of slowing. While everyone has been affected by climate change in some capacity, the climate crisis disproportionately affects low-income communities around the world and, specifically, within the United States. I plan to research the ethics of the relationship between climate change and the class system and the goal o f this project is to prove the claim that the class system is the reason for climate change's disproportionate effect …

Psychotropic Polypharmacy On Heart Rate Of Daphnia Magna, Gwendolynne Miller, Brian Bagatto

Williams Honors College, Honors Research Projects

The prevalence of patients being prescribed multiple medications concurrently is significantly rising, and so is the importance of investigating any interactions between medications. One common example—sertraline and clomipramine have been used together to treat obsessive compulsive disorder. Clomipramine, however, is known to cause tachyarrhythmias in some patients. The present study set out to investigate the role of this drug combination on the heart rate of a simple animal model, Daphnia magna, or the water flea. The water flea was exposed to saline, sertraline, clomipramine, or sertraline plus clomipramine, and heart rate was measured subsequently. It was found that the …

Farmland Effect On Local Water Quality, Rachel Burns

Williams Honors College, Honors Research Projects

I will be conducting water quality testing in bodies of water in the area. The goal is to determine if there is a correlation between the water quality and the proximity to farmland or if areas are equally affected by nonpoint sources of pollution despite the distance. The data collection will take place over the course of a month or less, with a more detailed schedule in the proposal. Several samples will be taken at each body of water, with 3-5 bodies of water per treatment group. I will be testing the pH, nitrates, and dissolved oxygen levels of the …

The Smell Of Fear: Responses Of Native And Invasive Geckos To Predator Scent Cues On Moorea, French Polynesia, Haley Dreisbach, Tessa Bodo

Williams Honors College, Honors Research Projects

Hemidactylus frenatus, a globally invasive species, is syntopic with the native gecko Lepidodactylus lugubris on the island of Moorea, French Polynesia. The success of an invasive species, H. frenatus can be attributed to many factors and is the subject of much study. Some research suggests that invasive and native geckos may differ in their response to chemosensory cues from predators. We compared the responses of H. frenatus and L. lugubris to the scents of both a native local predator; centipede, and a common predator of geckos that is not present on Moorea; snake. While neither gecko species showed any …

Sources And Termination Patterns Of Cholinergic Input To The Ventral Nucleus Of The Lateral Lemniscus, Emily Echols

Williams Honors College, Honors Research Projects

Neurons transmit signals through an electrochemical reaction: synapses on dendrites and the cell body receive neurotransmitters, and their effect on the cell determines the signal the cell will transmit. From dendrites to axon and then to another cell at a synaptic cleft, signals can propagate, enhance each other, or inhibit other transmissions until the message is received by the target area. Understanding the science behind neural signaling and structural function begins at the level of the synapse. The neurotransmitter acetylcholine (ACh) plays a substantial role in modulating neural activity in the auditory system, but for many brainstem nuclei the source …

Localization And Quantification Of Atpase, Ca2+ Transporting, Plasma Membrane 2 (Atp2b2) In The Developing Euthyroid And Hypothyroid Cochlea, Emily Gregersen

All Graduate Theses, Dissertations, and Other Capstone Projects

Thyroid hormone (TH) is essential for auditory system development. Proper auditory function requires remodeling and transformation of cochlear structures during a critical developmental period. In rodent models, low TH during this timeframe delays remodeling and impacts ion channel function required for hearing to occur. TH receptors are ligand-dependent transcription factors that regulate expression of genes. Considering this, auditory deficits observed in hypothyroidism are thought to be largely the result of altered expression of specific TH receptor target genes. TH is reported to impact calcium signaling in several tissues, but whether regulators of calcium signaling are altered following developmental hypothyroidism is …

Machine Learning-Based Analysis Of Dna Methylation Patterns In E.Lenta, Tsion Tsegaye Sherbeza

All Graduate Theses, Dissertations, and Other Capstone Projects

Methylation patterns in bacterial genomes, such as those found in Eggerthella lenta, take roles in mediating microbial interactions with their environment, host, and external stressors. These patterns are formed by DNA methylation with diverse sequence specificities that provide insights into the DNA sequence regulation and defense against bacteriophages. We utilize computational approaches and machine learning models to identify and analyze 5mC and 6mA methylation motifs in E. lenta genomes. By integrating host characteristics such as age, birth country, gender, and medication history, we explore 1) the predictive relationships between 5mC & 6mA methylation types in E. lenta strains and …

Calculation Of Elastic Constants Of Bulk Metallic Glasses From Indentation Tests, Zhitong Xu, Ming Liu, Fuqian Yang

Chemical and Materials Engineering Faculty Publications

One of the challenges in the applications of instrumented indentation is to simultaneously measure elastic modulus and Poisson’s ratio of homogeneous, isotropic materials. This work proposes empirical equations for simultaneous calculation of elastic modulus and Poisson’s ratio of bulk metallic glasses (BMGs) from the ratio of the short diagonal length to the long diagonal length and the area of the Knoop imprint. The parameters pre- sented in the empirical equations are determined first by Knoop microhardness tests of 24 BMGs, whose elastic moduli and Poisson’s ratios are measured by resonant ultrasound spectroscopy. These empirical equations are further validated by the …

Research News, Publications, 2024, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2024.

Research News, Publications, 2024, Volume 3, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of July 1 through September 30, 2024.

Research News, Publications, 2024, Volume 4, Joshua Sharp

Publications (2015-)

Publications that appeared during the period of October 1 - December 31, 2024.

Biomolecule Screen Identifies Several Inhibitors Of Salmonella Enterica Surface Colonization, Joseph Headrick, Amital Ohayon, Shannon Elliott, Jacob Schultz, Erez Mills, Erik Petersen

Faculty Open Access Works

Salmonella enterica is a foodborne pathogen commonly found in agricultural facilities; its prevalence, as well as increasing levels of disinfectant- and antibiotic-resistance, has significant costs for agriculture as well as human health. In an effort to identify potential new inhibitors of S. enterica on abiotic surfaces, we developed a biomolecule screen of nutrient-type compounds because nutrients would have lower toxicity in animal facilities and bacterial nutrient utilization pathways might prove less susceptible to the development of bacterial resistance. After screening 285 nutrient-type compounds, we identified ten that significantly inhibited the ability of S. enterica to colonize a plastic surface. After …

Research News, Grants, 2024, Volume 3, Soumyajit Majumdar

Grants (2015-)

Grants and contracts awarded during July - September 2024 - Revised 10/22/24

Observed Effects Of Physiological Melatonin Dosing On Mda-Mb-231 Breast Cancer Cell Proliferation, Wenli Wu

Williams Honors College, Honors Research Projects

This project seeks to evaluate pharmacological dosing of melatonin on the cell proliferation of MDA-MB-231 breast cancer cell line in culture, using the two solubility carriers: DMSO/water and ethanol. This experiment is a component of ongoing research at the Eaton lab which will elucidate melatonin dose-response toxicology in zebrafish and a possible breast cancer xenograft model for novel treatment therapies.

Zebrafish Electroretinogram Responses, Brooke Campbell

Williams Honors College, Honors Research Projects

The goal of this project is to be able to streamline a protocol for conducting ERGs on zebrafish from mice ERG protocol already present in Dr. Renna’s lab. The objective is to create a protocol specifically for zebrafish and to eliminate any issues that occur when transiting from a mice ERG protocol to a zebrafish ERG protocol and to obtain a light response from zebrafish retinae in differing light intensities. Dr. Renna’s lab has designed an Ex Vivo ERG system with less electrical interference creating defined electrical responses from mouse retina. The setup allows for continual perfusion of the retinal …

Compliance And Roughness In Relation To Gecko Locomotion, Brooklynn Campbell

Williams Honors College, Honors Research Projects

Geckos move efficiently through a variety of substrates, from swaying branches to wooden fences to the sides of structures. Previous studies have studied locomotion and adhesion on manmade and rough substrates; however, the work is limited when discussing locomotion and adhesion as a relationship of compliance and roughness. Ease of movement was quantified by speed, under the assumption that the faster a gecko moves, the easier it is for the gecko to cross the substrate. Gehyra oceanica geckos from Moorea, French Polynesia were tested on substrates varying in compliance and roughness with four different treatments in total. Compliance, roughness, and …

The Effect Of Early Intervention On Reducing Recidivism, Claire Meyer

Williams Honors College, Honors Research Projects

The current punishment-based system has not led to promising recidivism rates showing the lack of effect it has on changing behavior. By working to understand the effect interventions can have on reducing recidivism, society can improve the criminal justice system. The intention of this paper is to show the benefits of moving to a system focused on rehabilitation instead of punishment, specifically for juvenile offenders. By conducting a literature review of available research, it can be seen that an incarceration-based system is not as effective as the implementation of intervention and prevention methods can be. Cognitive behavioral therapy and community-based …