Digital Commons Network^™

Batch Culture Models Of The Murine Gut Microbiome & The Impact Of Simple Dormancy On Dormancy-Capable Microorganisms Models, Ana C. Mendez

Mathematics Dissertations - Archive

The proposed mathematical biology research utilizes mathematical models to gain insight into biological systems. These systems of ordinary differential equations model diverse topics, ranging from gut microbiomes to harmful algal blooms. A complete stability analysis, supporting phase plane portraits, bifurcation diagrams, and numerical simulations will accompany the models presented. In Chapter 2, the murine gut microbiome is modeled to match laboratory experiments in the literature. In these experiments, mice eat plasmid-carrying “donor” bacteria and naturally carry plasmid-free “resident” bacteria in their gut. The models aim to capture the behavior of plasmids, donor bacteria, and resident bacteria. Chapter 3 explores dormancy …

Computational Study Of Proton Transfer At Transition Metal Hydrides, Megan Ford

Honors Theses

Energy storage in the bonds of common chemical feedstocks is an attractive solution to the unreliability of wind and solar power due to its long term efficiency and easy recoverability. Energy is stored by reducing chemicals like ammonia, formic acid, and hydrogen, the reaction of which is dependent on a catalyst. To catalyze the reaction, the catalyst undergoes a slow proton transfer (PT) step to form what is known as a metal hydride. The sluggish kinetics of this step lower the effectiveness of the catalyst, and therefore must be better understood in order to improve the efficiency of energy storage …

How We Make It: Disability Justice, Autoimmunity, Community, A Multimedia Project, Alexandra Juhasz, How We Make It Collective

Publications and Research

How We Make It: Disability Justice, Autoimmunity, Community is a born-digital multimedia piece that lives on the Scalar platform and that was submitted and eventually accepted into the Special Section on Autoimmunities in the Wake of COVID-19. The text below is a close reproduction of the Navigation page within the Scalar piece. While reading this text, one cracks open the door to glimpse the ten-person collective behind this project.

Novel Spirocyclic Dimer, Spid3, Targets Chronic Lymphocytic Leukemia Survival Pathways With Potent Preclinical Effects, Alexandria Eiken, Audrey L. Smith, Sydney A. Skupa, Elizabeth Schmitz, Sandeep Rana, Sarbjit Singh, Siddhartha Kumar, Jayapal Reddy Mallareddy, Aguirre A. De Cubas, Akshay Krishna, Achyuth Kalluchi, M. Jordan Rowley, Christopher R. D'Angelo, Matthew A. Lunning, Gregory Bociek, Julie M. Vose, Amarnath Natarajan, Dalia El-Gamal

Journal Articles: Oncology and Hematology

Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment (TME) driving activation of NFκB signaling and the unfolded protein response (UPR). Malignant cells have higher basal levels of UPR posing a unique therapeutic window to combat CLL cell growth using pharmacologic agents that induce accumulation of misfolded proteins. Frontline CLL therapeutics that directly target BCR signaling such as Bruton tyrosine kinase (BTK) inhibitors (e.g., ibrutinib) have enhanced patient survival. However, resistance mechanisms wherein tumor cells bypass BTK inhibition through acquired BTK mutations, and/or activation of alternative survival …

Myc Overexpression In Natural Killer Cell Lymphoma: Prognostic And Therapeutic Implications, Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A. Lunning, Wing C. Chan, Javeed Iqbal, Dennis D. Weisenburger, Julie M. Vose, Kai Fu

Journal Articles: Oncology and Hematology

The current clinical management of extranodal natural killer (NK)/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the prognostic index of NK cells lymphoma with Epstein-Barr virus (PINK-E) prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown in NK …

Demographic And Clinical Characteristics Of Venous Thromboembolism In Children, Deogracia Sindoiya Owende

Master of Medicine in Paediatrics and Child Health

Introduction: Venous thromboembolism in children is a cause of significant morbidity and mortality worldwide with an increasing annual incidence. The present study aimed to increase awareness as well as attempt to inform the management of paediatric venous thromboembolism in this setting.

Objective: To describe the demographic and clinical characteristics of venous thromboembolism in children aged one month to 18 years at two tertiary hospitals in Kenya.

Methods: A descriptive retrospective chart review of patients aged one month to 18 years diagnosed with venous thromboembolism between January 2014 and December 2022 in two tertiary hospitals in Kenya was …

Metacognitive Learning Strategies And English Language Proficiency Of Efl Undergraduate Science Students : The Mediating Role Of Self-Efficacy, Montha Polrak, Akadet Kedcham, Charinee Chansri

PASAA

No abstract provided.

2024 Georgia Southern University Football Roster, Georgia Southern University

Men's Football Records

No abstract provided.

Chickpea Seed Endophyte Enterobacter Sp. Mediated Yield And Nutritional Enrichment Of Chickpea For Improving Human And Livestock Health, Arpan Mukherjee, Anand Kumar Gaurav, Gowardhan Kumar Chouhan, Saurabh Singh, Ankita Sarkar, Saman Abeysinghe, Jay Prakash Verma

Articles

Chickpeas (Cicer arietinum L.) are used as a good source of proteins and energy in the diets of various organisms including humans and animals. Chickpea straws can serve as an alternative option for forage for different ruminants. This research mainly focussed on screening the effects of adding beneficial chickpea seed endophytes on increasing the nutritional properties of the different edible parts of chickpea plants. Two efficient chickpea seed endophytes (Enterobacter sp. strain BHUJPCS-2 and BHUJPCS-8) were selected and applied to the chickpea seeds before sowing in the experiment conducted on clay pots. Chickpea seeds treated with both endophytes showed improved …

Development And Validation Of Green Stability-Indicating Rp-Hplc Method For Estimation Of Ertapenem: Degradation Kinetics And Structural Mass Elucidation Using Ms, Sohair M. Aboelghar, Hebatallah A. Wagdy, Maha A. Hegazy

Pharmacy

Ertapenem is an antibiotic that is used in the treatment of several bacterial infections, and it was recently approved for the treatment of the COVID-19 virus. A simple validated stability-indicating reversed phase High Performance Liquid Chromatographic (RP-HPLC) method was developed for ertapenem estimation. The separation was done using Pronto SIL® C18 (300 × 4.6 mm, 5 μm) as the stationary phase, methanol, and acidified water as the mobile phase in gradient mode with a flow rate of 1 mL/min and a pH 4.0 adjusted by orthophosphoric acid. The method was validated according to ICH guidelines. The linearity ranges from 5.00-120.00 …

Hierarchical Multi-Label Text Classification In Earth Science Datasets, Rajashree Dahal

Theses

This thesis addresses the challenging problem of hierarchical multi-label text classification and introduces a novel zero-shot approach that recommends the label up to the depth of hierarchy in which it is confident. In order to validate the efficacy of the proposed method, we experimented using various potential embedding models such as text-embedding-ada-002, mpnet-all, instructor embeddings, and nasa-smd-ibm-st on Earth science datasets. The experimental results reveal that all considered embedding models surpass the baseline model supervised learning classifier, demonstrating the superiority of the proposed zero-shot approach. This proposed solution can minimize the label imbalance problem typically observed in the supervised learning …

Sunitinib Induced Gomerular Thrombotic Microangiopathy, Aisha Khan

Gulf Coast Division GME Research Symposium 2024

No abstract provided.

Colon Cancer With Ovarian Metastasis Presenting As Syncope And Melena, Raul E. Zambrana Valenzuela, Bryan Kharbanda

Gulf Coast Division GME Research Symposium 2024

No abstract provided.

Deficiency In Detail Among Ventral Hernia Repair Operative Notes And The Impact On Patient Outcomes, Alexys N. Ramos, Duyen Quach, Kayla Nguyen, Said Maldonado, Nicole B. Lyons, Jonathan S. Lall, Scott Zimmerle, Brendan Rosamond, Ashlynn Mills, Yoolim Alex Seo, Angelica C. Rodriguez, Mike Liang

Gulf Coast Division GME Research Symposium 2024

No abstract provided.

Clinical Impact Of Indeterminate Quantiferon-Tb Test Results For A Patient With Recurrent Inflammatory Bowel Disease Flares, Asad Rehman, Bushra Bangash, Aashka Patel, Anam Zara, Hong Thai, Ismail Hader

Gulf Coast Division GME Research Symposium 2024

No abstract provided.

Traumatic Heterotopic Ossification: Pathophysiological Mechanisms, Epidemiological Characteristics, And Risk Factors, Nicola Kate Foster

Theses

Traumatic heterotopic ossification (tHO) refers to the complication of pathological formation of ectopic bone in soft tissues, which follows tissue insult secondary to burn, neurological and orthopaedic injury [2]. Common to these diagnoses is the involvement of central and or peripheral nervous system trauma. Although known risk factors are associated with developing tHO, the underlying cellular and molecular mechanisms are not fully understood. Research to date, primarily in single injury cohorts, has provided minimal translatable results [2]. Thus, clinical guidelines for early screening and prophylactic drug therapy are lacking, and treatment options are limited. To move the body of knowledge …

The Development, Implementation, And Evaluation Of An Online Program For Emergency Nurses Caring For Victims Of Interpersonal Violence: A Mixed Methods Study, Melanie Brown

Theses

Forensic nursing encompasses a range of skills that can be utilised across healthcare services and legal services. The delivery of forensic nursing care covers a vast number of roles and practice areas that can improve patient outcome, including the care of victims of interpersonal violence who often face multiple barriers in achieving a positive medicolegal outcome. A nurse’s ability to identify a potential victim and initiate forensic nursing care in an emergency care setting can positively influence the patient’s engagement with support services and the justice system. Despite this, a review of the Australian literature has identified inconsistencies in forensic …

Ernst Jünger’S Epistemology And Metaphysics, Angus Baird

Theses

Jünger is typically interpreted in the philosophical literature according to a Heideggerian reading to be a metaphysical Nietzschean who took the will to power to be the essence of reality. This is especially so for Jünger's “Gestalt of the worker.” Yet Jünger likened his Gestalt to Goethe’s “Urpflanze,” a phenomenological, not metaphysical, conception. And Jünger's uses of "will to power" and "eternal return" are inconsistent with cosmological readings of Nietzsche.

This thesis will argue that the core of Jünger’s epistemology is an account of “intuitive perceptions.” Through these intuitive perceptions Jünger thought he grasped metaphysical reality. Through this grasping Jünger …

The Leader We Wish We All Had Is You: Insights From The Covid-19 Pandemic, Amy Acton Md, Mph

Health Matrix: The Journal of Law-Medicine

This is an essay based on Dr. Amy Acton's Schroeder Lecture at Case Western Reserve University School of Law in October 2023. Dr. Acton was the Director of the Ohio Department of Health during the early months of the COVID-19 pandemic. She discusses lessons learned from serving in this capacity and leading Ohio’s pandemic response.

Dazed & Confused . . . And . . . Psychotic?, Judy A. Clausen, Joanmarie I. Davoli, Benjamin W. Lacy Md

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Covid-19 Tort Reform, Clayton J. Masterman

Health Matrix: The Journal of Law-Medicine

In 2020 and 2021, 44 states and Washington, D.C. passed laws that limited tort liability related to COVID-19. The most common reforms immunized health care providers from malpractice or similar liability. A second category is limited liability to individuals or businesses for exposing others to the novel coronavirus. And a third category protected manufacturers of supplies used to detect and prevent COVID- 19 from products liability suits. The goals of these reforms included protecting health care providers from uncertainty in providing care for a novel disease, limiting the macroeconomic consequences of the pandemic, and encouraging the distribution of critical supplies …

Before The Memory Fades: Evaluating The Need For A National Quarantine Strategy As Part Of A Modernized Public Health Response To The Next Pandemic, Michelle Richards

Health Matrix: The Journal of Law-Medicine

No abstract provided.

No Way Fda, Let States Lead The Way On Expanding The Prescriptive Authority Of Pharmacists, Corey A. Whetzel

Health Matrix: The Journal of Law-Medicine

No abstract provided.

Punishing Gender, Erin Collins

Law Faculty Publications

As jurisdictions across the country grapple with the urgent need to redress the impact of mass incarceration, there has been renewed interest in reforms that reduce the harms punishment inflicts on women. These "gender-responsive" reforms aim to adapt traditional punishment practices that, proponents claim, were designed "for men." The push to change how we punish based on gender, while perhaps well intentioned, is misguided. As abolition feminist principles reveal, these gender-responsive practices not only reify traditional gender norms, but also strengthen the operation of the carceral state. This Article catalogs the ways in that the gender-responsive approach currently influences various …

First Comes Love: Advocating For A Revival Of Pre-Obergefell Estate Planning Vigor For Lgbtq+ Couples And Families, Kimberly N. Furtado

Law Student Publications

On June 24, 2022, the Supreme Court of the United States handed down its decision in Dobbs v. Jackson Women’s Health Organization. Beyond the obvious devastation this opinion wreaked on abortion rights nationwide, it also unleashed a fear in communities that have gained substantive rights through the Court’s decisions based on similar reasoning. News organizations and LGBTQ+ advocacy groups quickly published stories discussing the fate of same-sex marriage in a post-Dobbs society. If the Supreme Court were to overturn Obergefell v. Hodges, it would be a crushing loss to the LGBTQ+ community. Not only would it signal the lack of …

Biopiracy: Using New Laws And Databases To Protect Indigenous Communities, Cleo-Symone Scott

Law Student Publications

Indigenous people have a historical link to those who inhabited a country or region at the time when people of different cultures or origins arrived. Traditionally, indigenous people have a special relationship with their ancestral environments. But their way of living has long been under threat. The land that indigenous people live on is home to over 80% of our planet’s biodiversity, but it continues to be appropriated and plundered due to bioprospecting or, as some call it, biopiracy. Bioprospecting is defined as “the exploration and information gathering of genetic and biochemical material to develop commercial products.” While innovation is …

Biology News 2024, University Of Northern Iowa. Department Of Biology.

Biology News

Contents:

Letter from the Department Head --- 2
Bolton Award Winner --- 3
Goldwater Scholarship Winner --- 3
Purple and Old Gold Award Winner --- 3
Faculty News Roundup --- 4
New Hires --- 6
UNI Botanical Center --- 7
Alumni Information Request --- 7
Support Our Programs --- 8
Floyd Fellowship Award Winner --- 8

A Survey Of Strongyle Nematodes In New England Dairy Goats, D.J. Richardson, E.M. Wray, D. Watters, U. Hanif, E. Jalbert, E. Thompson, G. Trajkovic, A.R. Sirois, N. Pilotte

Journal of the Arkansas Academy of Science

The paucity of information concerning the occurrence of strongyle nematodes in New England dairy goats prompted a survey of 241 dairy goats from throughout New England. Of the 241 goats examined using the McMaster technique, 104 (42.7%) were infected with strongyles with a mean intensity (+ SE) of 369.7 + 45.8 eggs per gram. Subsequent molecular examination of 50 random samples from these goats revealed a prevalence of 88% infection specifically with Haemonchus contortus. Haemonchus contortus is the most important internal parasite of sheep and goats, exerting a crushing economic burden on the livestock industry worldwide due to lowered milk …

Updating Senator Borah: A Nuclear Kellogg-Briand Pact, David A. Koplow

Georgetown Law Faculty Publications and Other Works

In recognizing the legacy of Senator William E. Borah, the author shares his remarks from the Borah Symposium at the University of Idaho, about the Senator's personality and character, his contribution and later characterization to international law and national security, specifically the 1928 Kellogg-Briand Pact, and finally, a proposal to a modern reincarnation to the Kellogg-Briand Pact and the newer threats of this era.

Electromechanical Mapping Of The In Vivo Porcine Heart And Stomach, Haley Nesmith Patton

All ETDs from UAB

Electrical excitation and mechanical function are integral to the physiologic activity of both the heart and stomach. Electrical depolarization through the myocardium triggers contraction in the heart. When normal sequences of electrical activity are disturbed, the heart’s mechanical function may also be disturbed, affecting its ability to pump blood effectively, sometimes fatally. Similarly, electrical waves called slow waves initiate gastric peristalsis. Abnormalities in slow wave propagation patterns can disturb the stomach’s ability to mechanically process gastric contents, sometimes resulting in delayed gastric emptying, nausea, and vomiting. The relationship between mechanical function and electrophysiology is not unidirectional, though. Mechanical stimuli can …