Digital Commons Network^™

Kif3a Tail Domain Phosphorylation Is Not Required For Ciliogenesis In Mouse Embryonic Fibroblasts, Ayoola Fasawe, Jessica M. Adams, Martin Engelke

Faculty Publications – Biological Sciences

Primary cilia are essential signaling organelles that protrude from most cells in the body. Heterodimeric kinesin-2 (KIF3A/KIF3B/KAP3) powers several intracellular transport processes, including intraflagellar transport (IFT), essential for ciliogenesis. A long-standing question is how a motor protein is differentially regulated for specific cargos. Since phosphorylation of the KIF3A tail domain was suggested to regulate the activity of kinesin-2 for ciliogenesis, similarly as for the cytosolic cargo N-Cadherin, we set out to map the phosphosites involved in this regulation. Using well-characterized Kif3a−/−; Kif3b−/− mouse embryonic fibroblasts, we performed ciliogenesis rescue assays with a library of phosphomimetic mutants comprising all …

Assessment Of Conjugation Pathways In N-Methylporphyrins That Are Fused To Acenaphthylene, Phenanthrene Or Pyrene: Evidence For The Presence Of Alternative Aromatic Circuits, Jared S. Salrin, Brian G. Carpenter, Deyaa Abusalim, Timothy D. Lash

Faculty Publications – Chemistry

Acenaphtho-, phenanthro-, and pyrenopyrrole esters, readily available from Barton-Zard reactions of ethyl isocyanoacetate with nitroarenes, were reacted with methyl iodide and KOH in DMSO to give N-methylpyrroles and subsequent cleavage of the ester moieties was accomplished with KOH in ethylene glycol at 200 °C. Condensation with two equiv of an acetoxymethylpyrrole in refluxing acetic acid-2-propanol afforded a series of annulated tripyrranes. Cleavage of the terminal tert-butyl ester groups with trifluoroacetic acid, followed by condensation with a diformylpyrrole and oxidation with FeCl3, gave N-methyl acenaphtho-, phenanthro-, and pyrenoporphyrins. The N-methyl substituent effectively freezes the tautomeric equilibria to maximize interactions between the …

Expanded Transference: A Humanities Perspective On The Generative Core Of Ernest Becker's Theory Of Human Nature, Daniel Liechty, Jerry Piven

Faculty Publications - Social Work

The death anxiety thesis is widely considered to be Ernest Becker’s primary contribution to social theory and is associated with his most widely read book, The Denial of Death (1973). This essay suggests Becker is understood in a more sophisticated and nuanced way when his death anxiety thesis is situated in the context of his earlier work in the humanities and social sciences. The death anxiety thesis itself is one component of a much broader theoretical conceptualization of expanded transference, a constant thread through all of Becker’s writings from his doctoral dissertation through his final posthumously published works. Furthermore, the …

Protections For Lgbtq+ Students And Athletes: Title Ix In Light Of Bostock V. Clayton County, Katherine Considine

Student Works

No abstract provided.

Ai Manipulation At The Uspto: The Patent Bargain The Public Did Not Ask For, Matthew Korwin

Student Works

No abstract provided.

State Regulation Of Cultured Meat: Would A Meat By Any Other Name Taste As Good?, Ethan Granoff

Student Works

No abstract provided.

United States Of America Needs To Learn From The World: "Nonhuman Legal Personhood" - The Right Of Animals, Tiya Singh

Student Works

No abstract provided.

Considerations For A New Ai Agency: Risks, Framework, And Inter-Agency Coordination, Robert W. Stewart

Student Works

No abstract provided.

Laws Banning Gender Affirming Care For Transgender Youth Are Unconstitutional, Danielle Mcgough

Student Works

No abstract provided.

Getting Paid To Watch Grass Grow, Maddison J. Hueter

Student Works

No abstract provided.

Bridging The Gap: Expanding Medical “Aid” In Dying For Als Patients, Morgan Schultz

Student Works

No abstract provided.

Graduate Program Survey Report 2023-2024, University Of Northern Iowa. Office Of Institutional Effectiveness & Planning.

Institutional Effectiveness & Planning Documents

Contents:

Graduate College Staff --- 01
Graduate Degrees Awarded Summer 2023 - Fall 2024 --- 02
Survey Methodology --- 04
Survey Highlights --- 05
Respondent Demographics --- 06
Principal Activities After Graduation --- 07
Activities Participated in at UNI --- 08
Comparison Between 2022-2023 & 2023-2024 --- 09
Reasons For Attending UNI --- 10
Academic Experience --- 11
Comparison of Academic Experience From 2021 - 2024 --- 13
Financing Graduate Education --- 15

Dna Origami-Assisted Regioselective Organization Of Anisotropic Gold Nanotriangle Clusters, Wenyan Liu, Prashant Gupta, Yuwei Zhang, Krishna Thapa, Srikanth Singamaneni, Risheng Wang

Chemistry Faculty Research & Creative Works

The manipulation of anisotropic nanoparticles, such as gold nanorods and nano prisms, has attracted great attention in nanotechnology due to their sensitive geometry-dependent properties. However. traditional synthesis and assembly methods for these particles face challenges in size uniformity and higher-order structuring. To address these limitations, this study presents a strategy using DNA origami triangles, not just as templates, but as encapsulating agents for gold nanotriangles (AuNTs). This method enables the construction of diverse nanoparticle clusters with precisely controlled distance and orientation. The formed clusters exhibit unique optical characteristics, demonstrated by UV-visible spectroscopy and supported by finite-difference time domain (FDTD) simulations. …

2024 Faculty Summer Seminar - Gracious Catastrophes: Contemporary Representations Of Mystery And Mercy In The Catholic Literary Imagination, Center For Catholic Studies, Seton Hall University

Center for Catholic Studies Faculty Seminars and Core Curriculum Seminars

About the 2024 Faculty Seminar & the Facilitator – p.6

Josephine De Vito – p.8 The Images of Motherhood as Reflective in Catholic Writings and Art

Matthew Higgins – p.12 Love of Things Invisible: A Theological Look at the Catholic Imagination

Mary Grace Mangano – p.18 The Catastrophe of Faith: A Close Reading of “The Expert on God” by John L’Heureux

Elizabeth Brewer Redwine – p. 22 “Mad Ireland Hurt You into Poetry: Gerard Manley Hopkins in Dublin

Judith Stark – p. 27 The Catholic Literary Tradition and Climate Changes

Gloria Thurmond – p.33 The Pre-Christian Celtic Roots of the …

Multifaceted Challenges And Opportunities: Concurrent Mixed Methods Research To Investigate Chinese Exchange Students' Experiences In The Us Transnational Online Learning Ecology, Xinyue Ren, Yi Zhou

STEMPS Faculty Publications

Transnational online education has become an emerging trend in promoting academic collaboration and exchange in higher education during and after the pandemic. Guided by the learning ecology framework, we conducted concurrent mixed methods research by distributing an online survey to Chinese students (N=51) to collect quantitative and qualitative data. This helped us deeply understand their experiences and perceptions of a cross-cultural online learning environment in the United States. We applied multiple regression and thematic analysis to analyze the data. The merging of both types of data analysis indicated the confirmation of the importance of discipline-based English learning environments, the transformation …

Effect Of Δnp63Β On Cell Cycle And Apoptosis In T98g Cells, Buse Turegun Atasoy, Fi̇kret Sahin

Turkish Journal of Medical Sciences

Background/aim: The p53 protein, a crucial tumor suppressor, governs cell cycle regulation and apoptosis. Similarly, p63, a member of the p53 family, exhibits traits of both tumor suppression and oncogenic behavior through its isoforms. However, the functional impact of ΔNp63β, an isoform of the p63 protein, on human glioma cancer cells like T98G cells remains poorly understood, representing the novelty of this study in the current literature.Materials, methods: Employing the pRetroX-Tet-On vector system, we investigated ΔNp63β's apoptotic effects on T98G cell lines and assessed its influence on the cell cycle. Initially, we established a rtTA-expressing vector, a component of the …

Investigating The Biomarker Potential And Molecular Targets Of Tigd1 In Lung Cancer Using Bioinformatics, Merve Gulsen Bal Albayrak, Tuğcan Korak, Murat Kasap, Gurler Akpinar

Turkish Journal of Medical Sciences

Background/aimLung cancer, a predominant contributor to cancer mortality, is characterized by diverse etiological factors, including tobacco smoking and genetic susceptibilities. Despite advancements, particularly in non-small cell carcinoma (NSCC), therapeutic options for squamous cell carcinoma (LUSC) are limited. Transposable elements (TE) and their regulatory proteins, such as Transposable element derived (TIGD) family proteins, have been implicated in cancer development. TIGD1, upregulated in various cancers, including LUSC, lacks a defined function. This study aimed to elucidate the biological functions, associated pathways, and interacting proteins of TIGD1.Materials and methodsThe GSE229260 microarray dataset were investigated using GEO2R tool to identify the differentially expressed genes …

Approaching A Nationwide Registry: Analyzing Big Data In Patients With Heart Failure, Tuğçe Çöllüoğlu, Anil Şahi̇n, Ahmet Çeli̇k, Emi̇ne Arzu Kanik

Turkish Journal of Medical Sciences

Background/aim:Randomized controlled trials usually lack generabilizity to real-world context.Real-world data, enabled by the use of big data analysis, serve as a connection between the results of trials and the implementation of findings in clinical practice.Nevertheless, using big data in the healthcare has difficulties such as ensuring data quality and consistency.This article aimed to examine the challenges in accessing and utilizing healthcare big data for heart failure (HF) research, drawing from experiences in creating a nationwide HF registry in Turkiye.Materials and methods:We established a team including cardiologists, HF specialists, biostatistics experts, and data analysts. We searched certain key words related to …

Gendered Orientalism And The Agency Of Syrian, Muslim Women Refugees, Karen Culcasi

Faculty & Staff Scholarship

Orientalist discourses have long recirculated the idea that Muslim women are oppressed victims of Islam; an idea that has denigrated Muslims and positioned white, Christians as superior. For Muslim women refugees specifically, the gendered orientalist discourse of victimization has reappeared on both sides of the debate on Syrian refugee resettlement in the United States (U.S.) (and other Western states). Within anti-resettlement circles, the narrative of Muslim women as oppressed victims has been leveraged as a reason to stop Syrian refugee resettlement; based on a rationale that their lifestyles and values are incompatible with liberal, Western societies. Pro-resettlement circles, on the …

Evaluation Of The Aquaporin Molecules Characterization In The Sperm Cells Of Men From Different Aged, Fikret Gevrek, Osman Serden Gencel, Selim Görgün, Mikail Kara, Muzaffer Katar

Turkish Journal of Medical Sciences

Male infertility rises for many reasons, along with age; therefore, we aimed to research the characterization of aquaporin-3, 7, and 8 in human sperm belonging to different age groups. Material and methods: This study was conducted on sperm samples of men aged over 18 years. A total of 60 men were included in the study and divided into three age groups: group 1, age 18–25 years (n = 20); group 2, age 26–35 years (n = 20); and group 3, age ≥35 years (n = 20). Sperm ejaculates obtained from each participant were used for spermiogram tests, Kruger strict morphology …

Risk Factors Of Congenital Nomalies Of The Kidney And Urinary Tract (Cakut): Exposureto Mobile Phones During Pregnancy, Kübra Çeleğen, Esra Özgül, Zeynep Yeşi̇ldağ, Erdem Yusuf Çamirci, Mehmet Çeleğen, Ayşegül Bükülmez

Turkish Journal of Medical Sciences

Congenital anomalies of the kidney and urinary tract(CAKUT) are the leading causes of childhood chronic kidney disease (CKD). The etiology of most of the cases is thought to be multifactorial. In this study, risk factors for CAKUT and the effect of mobile phone-related electromagnetic field (EMF) exposure during pregnancy were investigated.Materials and methods: Fifty-seven cases and 57 healthy controls under 2 years of age were included and their mothers were subjected to a questionnaire. Groups were compared for parents’ demographics, pregestational (chronic disease, body mass index, use of the folic acid supplements) and antenatal variables (gestational disease, weight gain during …

Evaluation Of Bone Health In Terms Of Osteoporosis In Adult Patients With Neuromuscular Disease, Özgür Zeliha Karaahmet, Eda Gürçay, Yasemin Tombak Yildizkan, Damla Cankurtaran, Zeynep Tuba Bahti̇yarca, Ebru Umay

Turkish Journal of Medical Sciences

There are no current guidelines to help clinicians decide whether patients with adult neuromuscular disease (NMD) should be screened or treated for osteoporosis (OP). This study was undertaken to investigate the presence of OP in patients with various types of NMD and to examine the relationship between OP evaluation parameters and functional status, daily living activities, balance, and ambulation levels.Materials and methods: This cross-sectional study included 45 patients with NMDs. The patients were divided into 3 groups, depending on the affected component of the motor unit (neuronopathy group, neuropathy group, and myopathy group). The laboratory and demographic data were recorded …

The Private Law Of Self-Help, João Marinotti

Articles by Maurer Faculty

Individuals regularly take steps to protect themselves, their property, and their broader legal interests. They carry pepper spray, have guard dogs, and install fences. Such measures are colloquially deemed methods of self-help. Yet, despite its ubiquity, self-help as a legal concept has been chronically understudied. Consequently, American private law is missing a doctrinally coherent and prescriptively useful framework for self-help. As a matter of legal theory, this conceptual void is problematic in and of itself; the doctrinal incoherence stemming from this analytical gap decreases the law’s stability and undermines its predictability.

But the concern is not merely theoretical. The magnitude …

Mechanistic Insights Into Direct Interactions That Mediate The Activity Of Dot1l Complex In Mll-Rearranged Leukemia, Ali Cihan

Student Theses and Dissertations

Acute leukemia can arise from the translocation-mediated fusion of the N terminus of the Mixed Lineage Leukemia (MLL) protein to various partner proteins. Although more than 60 different translocation-based fusion proteins have been identified, fusion partners such as AF9, AF10, and ENL constitute the majority of the MLL-rearranged leukemia cases; additionally, these fusion partners are also a part of the DOT1L (disruptor of telomeric silencing 1-like) complex. Aberrant histone H3 Lysine 79 (H3K79) methylation catalyzed by DOT1L was shown to be crucial for the maintenance of MLL-rearranged leukemia. DOT1L is the only known H3K79 methyltransferase, and further, a DOT1L inhibitor …

Rna Therapeutics For Fibrolamellar Hepatocellular Carcinoma, Christoph Neumayer

Student Theses and Dissertations

Fibrolamellar hepatocellular carcinoma (FLC) is a rare liver cancer characterized by a recurrent fusion of the heat shock protein DNAJB1 and the catalytic subunit of protein kinase A (PRKACA). Due to limited efficacy of conventional treatments such as chemotherapy and radiation my work explored new therapeutic options. As DNAJB1::PRKACA is known to initiate tumorigenesis, I reasoned that it would be an ideal target for a therapeutic. However, it was not known if FLC tumors are still dependent on DNAJB1::PRKACA or if cells achieved independence of the initial oncogene. To test if FLC is dependent on the oncokinase I screened short …

Updating Cost Allocation And Revenue Attribution, Isaiah C. Mwamba, Deepak Benny, Ajuna P. John, David O. Holguin Mejia, Dongyoon Song, Jelin Sabu, Jiqian Dong, Mohammadhosein Pourgholamali, Sashank Modali, Richard O. Ajagu, Bismark R. Agbelie, Matthew Volovski, Konstantina Gritzka, Kumares C. Sinha, Samuel Labi

JTRP Technical Reports

This report presents a synopsis of the results from the 2024 study commissioned by the Indiana Department of Transportation (INDOT) in fall 2023 at the request of the Indiana General Assembly.

Expenditures: Lighter vehicle classes saw their share of cost responsibility decline between 2015 and 2024, while the heavier vehicle classes saw their responsibilities increase within this period. This change is explained by a diametric shift in expenditure type patterns between the two eras from construction-dominant to maintenance-dominant expenditures. In this context, it is worth noting that these expenditure types have different ratios of attributable costs to common costs.

Revenues: …

Full-Scale Dynamic Wireless Power Transfer And Pilot Project Implementation, Oscar Moncada, Zainab Imran, Connor Vickers, Konstantina Gkritza, Steven Pekarek, Dionysios Aliprantis, Aaron Brovont, Behnam Jahangiri, John E. Haddock

JTRP Technical Reports

Considering the challenges hindering the widespread adoption of electric vehicles (EVs) and heavy-duty electric vehicles(HDEVs), the integration of dynamic wireless power transfer (DWPT) technology into roadways has gained interest. By embedding DWPT components into pavement, electrical power can be delivered to an EV or HDEV as they are in motion. Yet, large-scale implementation depends on further in-depth research, both to explore optimal construction methods and to understand the impact of embedment on the pavement’s resultant behavior. The objective of this project was trifold: (1) design and evaluate a transmitter-receiver topology for DWPT, (2) enhance the understanding of the interaction between …

Indot Project Change Orders: Root Causes And Recommendations, Suyash Padhye, Aishwarya Sharma, Hesam Arefkhani, Deepak Benny, Konstantina Gkritza, Samuel Labi, Makarand Hastak

JTRP Technical Reports

This study analyzed the historical trends in change orders (COs) associated with the Indiana Department of Transportation (INDOT) highway contracts. It also investigated correlations between COs and base factors (district, project type, contract type, award amount, geographical area (rural vs. urban)), and sought to understand the effect of the root causes but not to predict CO based on root causes. Unlike the base factors, the root causes are unknown prior to construction. The study developed models that forecasted CO characteristics—CO likelihood, CO frequency (count), and CO severity (magnitude) and CO impacts (cost overrun and schedule delay). To address these research …

Urban Nature Indexes Tool Offers Comprehensive And Flexible Approach To Monitoring Urban Ecological Performance, Jennifer Rae Pierce, Laura Costadone, Lelani Mannetti, Joeri Morpurgo, Charlyn Elaine Green, Michael D. Halder, Pablo Arturo Lopez Guijosa, Abner L. Bogan, Russell Galt, Jonathan Hughes

ODU Articles

We present the Urban Nature Indexes (UNI), a comprehensive tool that measures urban ecological performance under one standard framework linked to global commitments. The UNI was developed by interdisciplinary experts and evaluated by practitioners from diverse cities to capture each city’s ecological footprint from local to global scale. The UNI comprises six themes (consumption drivers, human pressures, habitat status, species status, nature’s contributions to people, and governance responses) that encompass measurable impacts on climate change, biodiversity loss, ecosystem services, pollution, consumption, water management, and equity within one comprehensive system. Cities then adapt the UNI to their context and capacity by …

Is Gut Microbiota Of Patients With Als Different From That Of Healthy Individuals?, Zeri̇n Özaydin Aksun, Seyda Erdoğan, Ayşe Kalkanci, Eli̇f Ayça Şahi̇n, Tuğba Çuhadar, H. Özden Şener

Turkish Journal of Medical Sciences

Background/aim: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Several studies shown that alterations of microbiota, increase the risk of neurodegenerative disorders. We aimed to reveal whether there is a difference in the gut microbiota of patients with ALS.Materials and methods: The participants are divided into three groups. Group 1 formed patients with ALS. Healthy family members living in the same house of the patients formed Group 2. Lastly, sex, age-matched healthy people were included in Group 3. Fecal samples were collected in 15 mL falcon tubes and stored at -80 °C. Genomic DNA isolation was performed on samples. …