Digital Commons Network^™

Skinny Labels: Changing Scenario Of Induced Infringement And Public Policy, Sandhu, Amit Dhillon

Santa Clara High Technology Law Journal

A patent is an exclusive right granted for an invention to the inventor. However, when it comes to life-sustaining products, these exclusive rights have a negative impact on people’s lives. The government has tried to develop initiatives, such as the Hatch-Waxman Act, to compensate and speed up the entry of affordable medicines into the market. But when one patent addressing one medical condition (indication) blocks the entry of the generic, the use of skinny labels makes it possible for the generic players to carve out the label and enter the market only with indications that are off-patent. This helps bring …

Developing Methods For Analysis Of Chiral Small Molecules And D-Amino Acid Containing Peptides, Joshua I. Putman

Chemistry & Biochemistry Dissertations - Archive

This dissertation covers the development of methods to analyze chiral small molecules and d-amino acid containing peptides. The first section covers the development of liquid chromatographic chiral screening approaches for newly synthesized chiral molecules. The next part of the dissertation covers methodologies for the analysis of d-amino acid containing peptides. Lastly the bacterial degradation of three commonly used pesticides by bacteria harvested from Colorado potato beetles (Leptinotarsa decemliniata) is presented.

Twelve new azole compounds and eleven racemic ethanolamine derivatives were synthesized. These twenty-three compounds were evaluated using eight chiral columns, four macrocylic glycopeptides, a cyclodextrin derivative …

The Sociological Eye 2024, Loyola Marymount University, Sociology Department

The Sociological Eye Student Journal

Faculty Advisor: Dr. Stacy Burns

Editor: Katie Shepherd

Attic Salt, 2024, Loyola Marymount University, The Honors Program

Attic Salt

No abstract provided.

Estradiol Signaling Improves Extinction Memory Recall To Combat Cue-Induced Heroin Relapse In Rats, Jordan S. Carter

MUSC Theses and Dissertations

We are in the midst of an opioid use disorder (OUD) epidemic. While several treatments mitigate a range of factors contributing to return to use, or relapse, the power of drug-conditioned environmental cues to precipitate relapse have not been adequately addressed. One treatment modality targeting cue reactivity, cue exposure therapy (CET), exacerbated relapse in individuals with OUD, perhaps due to a deficit in extinction memory recall (EMR). Here, EMR is the ability to override the drug-cue association and prevent relapse. Interest remains in combatting cue-induced relapse, potentially by introducing a pharmacologic adjunct with CET to enhance EMR. In the following …

The Study Of Baby Boomers And Generation Z’S Attitudes Towards Generational Mental Health Dynamics, Regina M. Luttrell Ph.D., Hunter Harpin, Emma Grace Reville, Yunxiang Yu, Abagail Sweeney

Real Chemistry Emerging Insights Lab

The purpose of this research is to compare and contrast how different historical events have impacted Generation Z members’ and the Baby Boomers’ attitudes towards mental health and how those attitudes have guided members of these generations to feel about medical experts and the technology that they use to deliver their services in the post-COVID era. Studying these topics allows our group to make recommendations as to how medical experts should go about interacting with members of the Generation Z and Baby Boomer generations respectively, based on how historical events have influenced their attitudes towards mental health topics, their perceived …

Unveiling Silent Seizures: Eeg Analysis In System Xc- Null Mice, Diana Erenburg

Renée Crown University Honors Thesis Projects - All

No abstract provided.

Sickle Cell Disease Reporting In The United States By Magazines Of People Of Color: A Content Analysis, Kelvin Boakye

Renée Crown University Honors Thesis Projects - All

No abstract provided.

The Impact Of Parent-Child Interactions On Emotion Regulation In Adulthood, Bridget Burgoyne, Holly Grant-Marsney

Modern Psychological Studies

Childhood is a time where emotional skills are formed. These skills often reflect the primary caregiver(s) modeling and interactions which may shape emotional intelligence. This research aimed to assess if specific parenting approaches have lasting effects on a person’s ability to emotionally regulate. The sample included 141 adults, who responded to questions reflecting the parenting approaches they observed, and their current state of emotional regulation. Results from our regression analysis showed when controlling for age, parental warmth in childhood predicted one’s later ability to use cognitive reappraisal skills. Results from our correlational analysis showed strong positive associations between overindulgence, cognitive …

Motivated Gifts: A Self-Determination Perspective, Sharise Love, Liudmila Titova

Modern Psychological Studies

Gift-giving can strengthen relationships and facilitate favor requests. Previous researchers have found that 'motivated gifts' (gifts given with the intention of asking a favor) decrease recipients' satisfaction and willingness to help. The current study investigated the role of basic psychological need satisfaction (BPNS) in this effect. BPNS is said to facilitate the integration of autonomous motivation, which was hypothesized to mediate the relationship between motivated gifts and prosociality. In the current study, a sample of 426 undergraduate students was randomly given a hypothetical scenario in which they imagined receiving a motivated gift or not, while also being asked a favor. …

Post-Traumatic Stress Disorder In Trafficking In Persons Survivors: A Systematic Review, Gavin C. Newberry

Modern Psychological Studies

This systematic review examines post-traumatic stress disorder (PTSD) prevalence in adult and child trafficking in persons (TIP) survivors through analysis of 17 studies, including cross-sectional, cohort, and retrospective studies, from PubMed and PTSDpubs. 4,738 participants yielded an overall median PTSD prevalence of 32.63% (IQR = 20.78–54.42). Age stratification revealed median prevalences of 26.45% in children and 31.87% in adult survivors. Sex stratification indicated 22.68% in males and 38.07% in females, aligning with documented sex differences in PTSD prevalence. Further stratification by trafficking type showed 41.60% in commercial sexual exploitation and 30.67% in labor exploitation survivors. Limitations include methodological heterogeneity and …

Capture History Data From Hair Snare Sampling Of Wild Pigs In Mississippi, Tyler S. Evans, Eric T. Hileman, Melanie R. Boudreau, Bronson K. Strickland, Raymond B. Iglay

CFR Publications

Capture histories of wild pigs (Sus scrofa) identified using nuclear DNA markers from hair snare samples activated on the Sam D. Hamilton Noxubee National Wildlife Refuge in Mississippi between 2021 and 2022. Hair snares were active for 8 weeks (occassions) with non-grain attractants placed at the center of each snare. Dat includes unique pig identifiers (Pig_ID), capture histories (Capture_Occassion), and associated capture year (Group).

Data From: Phylogenomic Species Delimitation Of Studfishes (Fundulidae: Fundulus): Evidence For Cryptic Species In Agreement With The Central Highlands Vicariance Hypothesis, Kayla M. Fast, Peter J. Hundt, Zachariah D. Alley, Michael W. Sandel

CFR Publications

The Central Highlands ecoregion of the eastern United States represents a hotspot of freshwater biodiversity, with replicated patterns of vicariant speciation east and west of the Mississippi River. Previous phylogeographic investigation of the studfishes (Fundulus subgenus Fundulus) revealed evidence for vicariant speciation in the Central Highlands, but data were limited to a small number of gene sequences generated with Sanger sequencing. We used double digest restriction-site associated DNA sequencing (ddRADseq) to improve resolution of phylogeographic patterns and better characterize population genetic variation. Our sample design included individuals from the Fundulus catenatus species group (F. catenatus, F. bifax, …

Coping With Coppa: Exploring Alternatives To The Children's Online Privacy Protection Act, Andrew Parra

Indiana Journal of Law and Social Equality

The Children’s Online Privacy Protection Act of 1998 (COPPA) stands as one of the greatest protectors of children’s privacy for nearly twenty-five years. However, COPPA has struggled to keep pace with technological changes during this time, and the COVID-19 pandemic highlighted the shortcomings of COPPA regulations as children were forced to spend increased amounts of time in digital spaces. As the Federal Trade Commission (FTC) is set to make changes to COPPA, it is necessary to consider what changes would be most beneficial to protect children. This paper will explore the current regulatory framework, its strengths and weaknesses, and then …

Effects Of Rock Covering On Underlying Engineered Media In Bioretention Practices In Middle Tennessee, Usa, Blue Curry, Andrea Ludwig, Michael Essington

Journal of Contemporary Water Research and Education

Bioretention practices have become a common way to protect natural waterways in urban and suburban landscapes across the United States. However, optimal design, implementation, operation, and maintenance are still in need of study. A field survey of 52 bioretention practices was conducted in Davidson County, Tennessee, to address research questions related to operation and maintenance. A suite of site conditions were documented, such as size, signs of erosion, and dominant surface cover. Samples were collected from the surface of the engineered media layer and analyzed for organic matter content and bulk density. Vegetation was described in terms of dominant species …

Assessment Of Recycled And Manufactured Adsorptive Materials For Phosphate Removal From Municipal Wastewater, Deja Drummond, Shannon Brink, Natasha Bell

Journal of Contemporary Water Research and Education

Elevated concentrations of phosphorus (P) and other nutrients common in wastewater treatment plant (WWTP) effluent have been shown to contribute to the proliferation of harmful algal blooms, which may lead to fish kills related to aquatic hypoxia. Increased understanding of the negative effects associated with elevated P concentrations have prompted more strict regulation of WWTP effluent in recent years. The use of low-cost and potentially regenerative adsorptive phosphate filters has the potential to decrease P concentrations in WWTP effluent released to natural waters. This research focuses on assessing the capacities of recycled concrete aggregate (RCA), expanded slate, and expanded clay …

On-Field Agroecosystem Research Experience: An Undergraduate Perspective, Elysee Ndayishimiye, Japhet Dushimeyesu, Yvon Ukwishaka, Chittaranjan Ray, David Fleisher, Dennis Timlin, Vangimalla Reddy, Arindam Malakar

Journal of Contemporary Water Research and Education

Undergraduate hands-on research can foster innovation and critical thinking among young scholars to delve into real-world challenges. Specifically, exploring the critical nexus between water usage and agricultural yield, can foster academic growth and holds the key to addressing global food security in an era of increasing environmental constraints, where students can unlock insights crucial to enhancing crop yield and sustainability. Investigating the intricate relationship between water management and crop productivity through undergraduate research is exemplified in this article. Undergraduate students acquired hands-on research experience by collecting, processing, and analyzing destructive (crop biomass samples) and non-destructive (plant height, nodes, and leaf …

More Than Sleep Problems? Testing Five Key Health Behaviors As Reasons For Quality Of Life Issues Among Shift Workers, Yuxin Chen, Kaiyi Deng, Ian M. Hughes, Claire E. Smith, Hongdao Meng, Minh Quan Le, Min Sun, Xianyan Zhang, Danping Liu

Psychology Faculty Publications

The shift work schedule is a common work arrangement that can disrupt typical sleep-wake rhythms and lead to negative health consequences. The present study aims to examine the effect of shift work on health-related quality of life (QoL) and explore potential behaviorial mediators (i.e., sleep, eating, exercise, smoking, drinking). A cross-sectional survey was conducted among 4,449 petroleum workers in southwest China. Data on shift work status, health behaviors, and physical and mental health QoL were collected. We tested our model using path analysis and the Monte Carlo approach among 2,129 included participants. After adjusting for covariates, shift work did not …

Early Modern Gender Fluidity In The Episode Of Dorotea In Don Quijote De La Mancha, Stacey L. Parker Aronson

Spanish Publications

No abstract provided.

Exploring The Link Between Self-Image And Eating Disorders In Female Students At Belmont University, Caitlin Rain Roberts

SPARK Symposium Presentations

Introduction: Body image concerns among college students are a significant issue, often contributing to eating disorders as societal pressures intensify during young adulthood (Kapoor, 2022). Self-image influences eating behaviors, psychological perceptions of nutrition, and the development of disordered eating patterns (Kapoor, 2022). Understanding the link between body image and eating disorders is essential for creating effective interventions that support mental and physical well-being during this critical life stage. Methods: This study examined the relationship between body image dissatisfaction and eating disorder behaviors among undergraduate female students at Belmont University in Fall 2024. Using a cross-sectional survey with a mixed-methods approach, …

Unveiling Spanish Language Attitudes In A Los Angeles School And A Third-Generation Multigenerational Mexican-American Family, Eric Alvarez

International Journal of the Linguistic Association of the Southwest

This chapter unearths some of the diverse attitudes towards Spanish of a third-generation child in Los Angeles (L.A.), California, her family members, and school personnel. L.A. is a tension-ridden contact zone (Pratt, 1991) where Spanish has traditionally been subjugated and is still a lesser-taught language (LTL) despite decades of research showing that bilingual education positively impacts student attitudes (Potowski & Muñoz-Basols, 2020). Lack of continuity (Caloi & Torregrossa, 2021) in formal instruction and inconsistent heritage Spanish use in the home may entail divergent attitudes towards Spanish, possibly hindering multigenerational transmission. Decades-long turbulent California language policies (CLP) (Macias, 2001) have consistently …

Efficient High-Resolution Time Series Classification Via Attention Kronecker Decomposition, Aosong Feng, Jialin Chen, Juan Garza, Brooklyn Berry, Francisco Salazar, Yifeng Gao, Rex Ying, Leandros Tassiulas

Computer Science Faculty Publications

The high-resolution time series classification problem is essential due to the increasing availability of detailed temporal data in various domains. To tackle this challenge effectively, it is imperative that the state-of-theart attention model is scalable to accommodate the growing sequence lengths typically encountered in highresolution time series data, while also demonstrating robustness in handling the inherent noise prevalent in such datasets. To address this, we propose to hierarchically encode the long time series into multiple levels based on the interaction ranges. By capturing relationships at different levels, we can build more robust, expressive, and efficient models that are capable of …

Self Pre-Training With Topology- And Spatiality-Aware Masked Autoencoders For 3d Medical Image Segmentation, Pengfei Gu, Yejia Zhang, Huimin Li, Chaoli Wang, Danny Z. Chen

Computer Science Faculty Publications

Masked Autoencoders (MAEs) have been shown to be effective in pre-training Vision Transformers (ViTs) for natural and medical image analysis problems. By reconstructing missing pixel/voxel information in visible patches, a ViT encoder can aggregate contextual information for downstream tasks. But, existing MAE pre-training methods, which were specifically developed with the ViT architecture, lack the ability to capture geometric shape and spatial information, which is critical for medical image segmentation tasks. In this paper, we propose a novel extension of known MAEs for self pre-training (i.e., models pre-trained on the same target dataset) for 3D medical image segmentation. (1) We propose …

Σ-Ary, Minnesota State University Moorhead, Mathematics Department

Math Department Newsletters

No abstract provided.

Zebrafish Drug Screening Identifies Erlotinib As An Inhibitor Of Wnt/ Β-Catenin Signaling And Self-Renewal In T-Cell Acute Lymphoblastic Leukemia, Majd A. Al-Hamaly, Anna H. Cox, Meghan G. Haney, Wen Zhang, Emma C. Arvin, Shilpa Sampathi, Mary Wimsett, Chunming Liu, Jessica S. Blackburn

Markey Cancer Center Faculty Publications

The Wnt/β-catenin pathway’s significance in cancer initiation, progression, and stem cell biology underscores its therapeutic potential. However, the clinical application of Wnt inhibitors remains limited due to challenges posed by off-target effects and complex cross-talk of Wnt signaling with other pathways. In this study, we leveraged a zebrafish model to perform a robust and rapid drug screening of 773 FDA-approved compounds to identify Wnt/β-catenin inhibitors with minimal toxicity. Utilizing zebrafish expressing a Wnt reporter, we identified several drugs that suppressed Wnt signaling without compromising zebrafish development. The effi- cacy of the top hit, Erlotinib, extended to human cells, where it …

Chem 361-002: Environmental Chemistry Ii, Alexei Khalizov

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Chem 244a-104: Organic Chemistry Lab, Lu Chunmeng

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Eps 202-452: Society Techn & Environmnt, Bonchonsky Michael

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Evsc 623-852: Environmental Health, Bonchonsky Michael

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.

Evsc 340-452: Environmental Health, Bonchonsky Michael

Chemistry, Environmental and Forensic Science Syllabi

No abstract provided.