Digital Commons Network^™

Quality & Credibility Ff Adhd Information On Social Media And Adhd Help-Seeking Intentions, Saara Zakkiya Nasruddin

Electronic Theses and Dissertations

Background: There is an increased prevalence of adult Attention-deficit/hyperactivity disorder (ADHD), and stimulant prescription use in the United States, especially when compared to years prior to 2020. Due to accessibility and popularity of ADHD on social media, many individuals gain information on ADHD from these sources. People may view information on social media as credible due to its ability to provide connection, community, and empowerment. However, content analyses of ADHD information on social media show the quality of content on social media is poor. These content analyses utilized outdated quality evaluation tools that are not specific for social media. Principles …

Substance Use Amongst Veterans Following Post-Deployment Reintegration: An Examination Through The Lens Of Acculturation, Brittany Hampton

Electronic Theses and Dissertations

Each year, approximately 46.3 million Americans are diagnosed with substance use disorder (SUD), which costs the United States healthcare system approximately $13 billion in annual costs. One group particularly at risk for SUD is veterans due to the unique stressors that veterans face (e.g., being apart from loved ones, exposure to life threatening events, transitioning between military and civilian life) and a military culture that often reinforces maladaptive patterns of substance use. Little research has been done to examine substance use as a negative outcome associated with the acculturative experience veterans face when transitioning from military life back to civilian …

Pi3k Signaling And Its Role In Cardiac Morphogenesis, Rabina Shrestha

Electronic Theses and Dissertations

The formation of the heart tube in vertebrates involves the coordinated movement of bilateral myocardial precursors to the midline, where they merge in a process known as cardiac fusion to form the primitive heart tube. While external influences from the anterior endoderm and the endocardium are known to be essential for cardiac fusion, intrinsic myocardial mechanisms are less understood. Here, we identify an intrinsic PI3K-dependent mechanism directing myocardial cells toward the midline during cardiac fusion. We found that inhibiting the PI3K pathway throughout the embryo using chemical inhibitors and injection of dnPI3K mRNA results in cardiac fusion defects. PI3K-inhibited embryos …

Isolation Of Novel Myxobacteria And Progress Towards Heterologous Expression Of Uncharacterized Secondary Metabolites, Andrew Ahearne

Electronic Theses and Dissertations

Myxobacteria, first observed by Roland Thaxter in the late 19th century, are known for their unique swarming behavior, complex fruiting body formation and biosynthetic potential. Myxobacteria are noted for their large genomes and the presence of numerous biosynthetic gene clusters (BGCs) that hint at their potential to produce novel metabolites with therapeutic properties. Isolation of myxobacteria utilizing E. coli and filter paper baiting yielded 20 myxobacteria isolated from rhizospheric soil samples in North America. Among these isolates, nine were identified as novel species, representing the genera Archangium, Myxococcus, Nannocystis, Polyangium, Pyxidicoccus, Sorangium, and Stigmatella. Comprehensive growth profiles, biochemical assays, and …

Make It Funny! Developing A Novel Humor-Based Digital Positive Psychology Intervention To Investigate The Influence Of Duchenne Laughter And Mirth On Psychological Distress In Daily Life, Joshua Semko

Electronic Theses and Dissertations

The aim of the present research was to develop a novel digital humor-based PPI (Make it Funny!) to investigate the influence of Duchenne laughter and mirth on psychological distress in daily life. Participants (N = 159; Agemedian = 39 years; 47.77% biologically female; 68.15% White) were tasked with completing Make it Funny! or a placebo activity every day for 7 days. Duchenne laughter frequency had a small negative cross-sectional moderation effect on the relationship between the occurrence of stressful events and psychological distress (t(79.71) = -2.33, b = -10.89, p = .022). Within participants, Duchenne laughter frequency slightly increased the …

Formulation Development Of Simvastatin Self-Emulsifying Drug Delivery System Using Hot Melt Extrusion, Srikanth Chilamula

Electronic Theses and Dissertations

Simvastatin, a potent HMG-CoA reductase inhibitor, lowers cholesterol levels. It prevents cardiovascular events like heart attacks and strokes in patients with high cholesterol and heart disease. However, its oral bioavailability is limited due to its poor aqueous solubility The current study aims to enhance the solubility of the poorly water-soluble drug simvastatin through the development of self-emulsifying drug delivery systems (SEDDS). Gelucire® 48/16 (oil), Gelucire 44/14 (surfactant), and Cremophor RH40 (co-surfactant) were assessed as potential excipients for SEDDS formulation. Initial SEDDS (Before adsorption) formulations were created based on the solubility of simvastatin in solid lipid excipients, as determined by a …

The Representation Of Women With Disabilities In Shahira Al-Hasan's Cochlea's Secrets, Mohamad Abou Adel, Amr M. Mohamed, Mubarak Altwaiji

CoHSS Faculty Work

This study examines the representation of women living with disabilities in Shahira Al-Hassan's novel Cochlea's Secrets. This is an important endeavor as it highlights fiction's role in advocating for women with disabilities, particularly in the Arab region. Such a study is crucial for increasing awareness and support for women with disabilities, especially in literary writing. By addressing this topic from the perspective of an Arab narrative, the study aims to highlight the contributions of Arab novels in addressing injustices against women living with disabilities and exploring opportunities for their empowerment. The paper also seeks to reveal how Arab novelistic innovation …

Eco-Cultural Restoration Of Mouralherwaqh: Site Description And Invasive Species Treatment Plan In King Salmon, California, Natalie Bridget Calderon, Myion Rickey, King Baptista, Owen Bardsley, Jillian Snowhook

Undergraduate Scholarship

In July of 2022, the Wiyot Tribe bought back one of their first pieces of ancestral forest within the Mouralherwaqh "more-RAH-share-wahg" village area (Wiyot, 2022). Before this repatriation, the Tribe owned less than 1% of their ancestral lands; after, the Tribe’s land holdings increased by 10% (Reclaiming Mouralherwaqh | Humboldt NOW | Cal Poly Humboldt, 2022). Mouralherwaqh is a 46 acre coastal site located near present day King Salmon, California and has high ecological and culturally significant values (Wiyot, 2022). Prior to the change of ownership, Mouralherwaqh was privately-owned and in 2014 underwent a clear-cut timber harvest within eight-acres of …

Influence Of Elevation On Plant Survivorship In Baduwa’T Estuary, Richard Louis Toledo Jr., Celine Aguilera, Rivé Prater, Claire Durbin

Undergraduate Scholarship

The Baduwa’t is a river in Humboldt County, California that has been adversely impacted by agricultural operations. Disturbances from agriculture have altered the surrounding ecosystems and hydrology of the river. The conservation stewardship group, California Trout, initiated a collaborative restoration project that created a new channel and off-channel pond to provide habitat for salmonids and other native fish in the estuary. As an extension of this project, sections of the site underwent revegetation efforts. The survivorship rates of this new vegetation were lower than anticipated and we were asked by California Trout to assess if the elevation on the site …

Implications Of Using Edna As A Monitoring Tool In The Elk River Estuary, Trinity Brooke Spencer, Christy Elaine Wheatley, Fernando Edgar Martinez

Undergraduate Scholarship

This study compares the efficacy of environmental DNA (eDNA) sampling to traditional capture-based methods such as seine netting and minnow trapping for monitoring fish assemblages in the Elk River estuary. The Elk River estuary is located in Humboldt County, California and hosts a diverse range of fish species due to its tidal influences and brackish habitat. A restoration is planned for this area, thus it is important to explore the effectiveness of different fish monitoring methods that could be used to evaluate restoration success. For this capstone project, we conducted a pilot study at five sites within the Elk River …

Riparian Revegetation: Re-Indigenizing The Powers Creek Tributary Of The Baduwa’T Watershed At Blue Lake Rancheria, California, Genesis Beltran, Ruben Lopez, Ben Stock

Undergraduate Scholarship

This project focuses on the ecological and cultural restoration of Powers Creek, a tributary of the Baduwa’t watershed at Blue Lake Rancheria, California. Riparian ecosystems play a critical role in biodiversity, water quality, and climate resilience, particularly for species like salmonids reliant on cold-water refugia. The restoration efforts, guided by Indigenous knowledge, addressed the removal of non-native competitive species such as Scotch broom (Cytisus scoparius) and French broom (Genista monspessulana) – which are shown to increase wildfire severity and challenge native plant communities – in addition to freeing established plantings of vegetative competition. Through collaborative planning …

Baduwa’T Estuary Riparian Restoration & Revegetation Plan, Brandon Patino, Blake Kennedy, Xitlalli Rodriguez

Undergraduate Scholarship

The Baduwa’t estuary Restoration Project in McKinleyville, California is a place of interest to community members for a variety of reasons – ecological, recreational, and tribal among some of them. The estuary connects the Mad River Watershed to the Pacific Ocean. The project opened four acres of habitat to juvenile salmon and steelhead populations that utilize the watershed while migrating to the ocean. Complications regarding the size and success of plant species and riparian zone expansion remained. Using a list of 9 targeted native plants, we created a botanical literature review focusing on native plants to guide future efforts to …

Assessing Wood Jam Formation In The South Fork Elk River In Headwaters Forest Reserve, California, Grant D. Bruchacek, Mark W. Buckton, Gus R. Figueroa, Kevin J. Hill

Undergraduate Scholarship

Salmonids are considered keystone species and play an integral role in the health of river ecosystems. Many of these species are federally recognized as threatened due to habitat loss and degradation. Large woody debris in streams and rivers creates suitable refugia and spawning habitat for salmonid species. Between 2021-2023 the Bureau of Land Management placed approximately 200 pieces of wood into the South Fork Elk River, as part of their accelerated recruitment program in an effort to reintroduce habitat complexity. A survey was conducted on a stretch of the Elk River to gather information on the size, type, composition, and …

Observing And Estimating Soil Freeze Thaw Processes: From Remote Sensing To Land Surface Modeling, Mahsa Moradikhaneghahi

Doctoral Dissertations

Freezing conditions affect more than half of the exposed land in the Northern Hemisphere in cold seasons, where transitions between frozen and thawed states impact surface and subsurface water and energy budget. Recognized as an Essential Climate Variable (ECV), accurate, reliable and efficient estimates of soil freeze/thaw (FT) processes with a moderate spatiotemporal resolution are needed to fully resolve highly-dynamic processes taking place at the land-atmosphere interface. Active microwave remote sensing and land surface modeling are promising tools for advancing the monitoring of FT as an ECV. My dissertation addresses key scientific gaps in estimating soil FT conditions using active …

Natural Laboratories Of The Deep Sea: Linking Community Composition And Environmental Variables On Low-Temperature Venting Outcrops Of Ridge Flank Hydrothermal Systems To Explore Potential Impacts Of Climate Change, Inform Habitat Suitability Models, And To Understand The Impacts Of High Bathymetric Resolution On Seafloor Characterization, Anne Marie Hartwell

Doctoral Dissertations

The deep sea covers over two-thirds of the globe and represents 95% of the ocean. Most life on Earth is suspected to live on or near the seabed. Yet, these ecosystems are the least known on Earth and are important to explore as they are home to a diverse array of species that are currently under threat because of multiple anthropogenic pressures, including warming oceans. Exploration of these systems is critical to further the understanding of species interactions, biodiversity and their overall relationship to environmental and terrain variables. Many of these variables are used in species distribution models and technological …

Rational Design Of Polymers For Specific Interactions With Liquid And Solid-State Water, Nick Mitchell

Doctoral Dissertations

Many plants and animals that live in arctic regions possess biological cryoprotecting agents (CPAs) known as antifreeze proteins (AFPs) which protect them against cryoinjury in their native subfreezing environment. AFPs and their synthetic biomimetics have received increasing attention as potential candidates for various industrial and bio-medical applications. Despite the interest in developing synthetic, macromolecular CPAs; a full understanding of the antifreeze process induced by these remains elusive. To explore this, we have synthesized a series of water- soluble polyol-based polymers with systematic variation of their chain architectures.While AFPs are well-known for their ice nucleation and recrystallization inhibition activity along with …

Connecting Conservation: Modeling And Socializing Climate Connectivity For Land Conservation, Melissa M. Clark

Doctoral Dissertations

As the climate changes, species must either adapt, relocate, or face extinction. This pressing reality underscores the importance of promoting climate connectivity, which ensures that habitats and landscapes remain interconnected, allowing species to move and adapt as climate conditions shift. Given the challenges posed by ongoing climate change, it is crucial that land conservation decisions incorporate climate connectivity. Conservation goals should be informed by the latest connectivity models and be practical for implementation by on-the-ground practitioners. This dissertation aims to bridge the gap between these two critical needs, which are not always well-integrated in conservation work. Modeling connectivity in a …

Senior Mental Health Clinicians’ Understanding Of Their Self-Efficacy While Providing Services At Community-Based Agencies, Rukiya Symister

Walden Dissertations and Doctoral Studies

Many mental health clinicians strive to provide their clients with rehabilitative and psychotherapy services resulting in a client gaining stable income and housing. However, the role of a senior mental health clinician (SMHC) is not without its challenges of trying to balance their well-being while dealing with increased coworker turnover, demanding caseloads, and limited access to community resources to provide clients with getting their lives back on track, thereby impacting clinicians’ understanding of their self-efficacy. Much of the research on self-efficacy has focused on mental health clients, mental health graduate students, and mental health trainees, often leaving out the lived …

Enhancing 21 U.S.C. §§ 355, 356, And 360 To Encompass Artificial Intelligence-Based Drug Design And Manufacturing Methods, Aj Tsang

Michigan Technology Law Review

Despite newfound attention to how artificial intelligence (AI) may accelerate pharmaceutical development, federal regulators may find that current statutes are ambiguous or silent about their applicability to AI-based drug design and manufacturing methods. This poses a serious problem in the era of Loper Bright and the Major Questions Doctrine. As federal agencies struggle to adjust to courts’ growing demand for Congress to craft clear, explicit, and express delegations of authority, this note develops a statutory framework in which the Food and Drug Administration (FDA) would have more flexibility to regulate the use of AI in advanced drug manufacturing. Guided by …

Molecular And Cellular Programs Underlying The Development Of Bovine Pre-Implantation Embryos, Zongliang Jiang

Faculty Publications

Early embryonic mortality is a major cause of infertility in cattle, yet the underlying molecular causes remain a mystery. Over the past half century, assisted reproductive technologies such as in vitro fertilisation and somatic cell nuclear transfer have been used to improve cattle reproductive efficiency; however, reduced embryo developmental potential is seen compared to their in vivo counterparts. Recent years have seen exciting progress across bovine embryo research, including genomic profiling of embryogenesis, new methods for improving embryo competence, and experimenting on building bovine embryos from stem cell cultures. These advances are beginning to define bovine embryo molecular and cellular …

Variant Of The Lactase Lct Gene Explains Association Between Milk Intake And Incident Type 2 Diabetes, Kai Luo, Guo Chong Chen, Yanbo Zhang, Jee Young Moon, Jiaqian Xing, Brandilyn A. Peters, Mykhaylo Usyk, Zheng Wang, Gang Hu, Jun Li, Elizabeth Selvin, Casey M. Rebholz, Tao Wang, Carmen R. Isasi, Bing Yu, Rob Knight, Eric Boerwinkle, Robert D. Burk, Robert C. Kaplan, Qibin Qi

Population and Public Health Science Faculty Publications

Cow’s milk is frequently included in the human diet, but the relationship between milk intake and type 2 diabetes (T2D) remains controversial. Here, using data from the Hispanic Community Health Study/Study of Latinos, we show that in both sexes, higher milk intake is associated with lower risk of T2D in lactase non-persistent (LNP) individuals (determined by a variant of the lactase LCT gene, single nucleotide polymorphism rs4988235) but not in lactase persistent individuals. We validate this finding in the UK Biobank. Further analyses reveal that among LNP individuals, higher milk intake is associated with alterations in gut microbiota (for example, …

An Examination Of Homo Naledi Early Juveniles Recovered From The Rising Star Cave System, South Africa, Juliet K. Brophy, Debra R. Bolter, Marina Elliott, John Hawks, Lee R. Berger

Faculty Publications

Background: Six Homo naledi early juveniles were recovered from U.W. 101 (Dinaledi Chamber), U.W. 102 (Lesedi Chamber), and U.W. 110 in the Rising Star cave system. Aim: This paper develops the information for the H. naledi early juvenile life stage, as defined by a combination of deciduous and permanent dentition, and the eruption of the first permanent molar. Subjects and methods: The growing number of young individuals recovered from the Rising Star cave system allows us to gain a better understanding of their variation, or lack thereof, and provides a basis to estimate broad ranges for age at death of …

Flooded Mangrove Landscapes Hide Ancient Maya Coastal Sites In Belize, Heather I. Mckillop

Faculty Publications

Evidence of ancient Maya exploitation of salt, other marine resources, settlement, and sea trade is hidden in flooded mangrove landscapes on the cays, mainland, and in shallow offshore locations on the south coast of Belize. This article includes a discussion of the coastal economy from the Middle Preclassic through the Postclassic periods (600 B.C.–A.D. 1500). Data from sites discovered and excavated since 1982 in the coastal area of the Port Honduras and Paynes Creek National Park support a model of coastal reliance on marine resources and tree crops. The need for a regular supply of coastal salt to inland cities …

Formulation Design And Development For Extended-Release Drug Delivery System, Sheng Feng

Electronic Theses and Dissertations

The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional, non-controlled drug delivery systems are unable to deliver the drug at a sustained rate which leads to poor bioavailability, fluctuations in plasma drug concentration, and potential side effects. The extended drug delivery system enables drug delivery at a sustained or predetermined rate to achieve maximum efficacy and safety. Different routes of drug administration, along with various extended-release dosage forms have been extensively developed such as oral delivery, parenteral delivery, transdermal delivery, ocular delivery, and tumor delivery among others. This dissertation developed …

Efficient Design Of Neural Network Hardware Accelerator For Enhanced Performance In Deep Learning Systems, Tamador Nadem Mohaidat

Electronic Theses and Dissertations

Artificial intelligence (AI) hardware accelerator is an emerging research for several applications and domains. The hardware accelerator aims to provide high computational speed while retaining low cost and high learning performance. The main challenge is to design complex machine learning models on hardware with high performance. In this thesis, the aim is to develop the hardware implementation of perceptron within a neural network. Innovative hardware-based approaches are explored to optimize perceptron networks, enhancing accuracy, reliability, and fault tolerance while minimizing resource requirements and power consumption.

A thorough investigation into machine learning accelerators and associated challenges was initially conducted. The hardware …

Heterologous Expression, Isolation, And Metabolomic Profiling Of Myxobacteria To Explore Their Potential In Natural Product Biosynthesis, Nawal Mohamed Hamed Elsayed Shehata

Electronic Theses and Dissertations

Myxobacteria are distinguished by their ability to produce a spectrum of natural products,positioning them as an active resource for therapeutic discovery. These products include metabolites with significant antibacterial, antifungal, cytotoxic, antiviral, and immunosuppressive properties. Current synthetic biology tools for the exploration of myxobacteria are not as advanced as those for the well-studied Streptomyces. This thesis presents an evolution of synthetic biology techniques specifically designed for the exploitation of myxobacteria in the realm of natural product discovery. Chapter One investigates the potential of myxobacteria to act as heterologous hosts due to their large genomes and their capacity for diverse biosynthetic processes. …

An Argument Against Positivist Separability, Nichalus Zoltan Vali

Electronic Theses and Dissertations

One of the most influential views associated with legal positivism is that of the separability thesis. Primarily associated with H.L.A Hart, this thesis is widely understood to be the view that there is no necessary connection between law and morality. However, John Gardner takes this to be a naïve interpretation of separability that fails to adequately characterize legal positivism and which Hart himself did not endorse. Instead, Hart and other legal positivists were committed to the view that whether a norm is legally valid depends on its sources (i.e., social facts such as official engagement with the norm) and not …

Iuphar-Review: The Integration Of Classic Psychedelics Into Current Substance Use Disorder Treatment Models, David Yaden, Andrea Berghella, Peter Hendricks, Mary Yaden, Michael Levine, Julia Rohde, Sandeep Nayak, Matthew Johnson, Albert Garcia-Romeu

SKMC Student Presentations and Publications

Substance use disorders (SUDs) have an enormous impact on public health. With classic psychedelic-assisted therapies showing initial promise in treating multiple SUDs, it is possible that these treatments will become legally available options for patients with SUDs in the future. This article highlights how classic psychedelic-assisted therapies might be integrated into current clinical practice. We first describe contemporary evidence-based treatments for SUDs and highlight how classic psychedelic-assisted therapies might fit within each treatment. We suggest that classic psychedelic-assisted therapies can be integrated into most mainstream evidence-based SUD treatments that are currently used in clinical settings, indicating broad compatibility of classic …

Effect Of Fluid Elasticity On The Emergence Of Oscillations In An Active Elastic Filament, Kathryn G. Link, Robert D. Guy, Becca Thomases, Paulo E. Arratia

Mathematics Sciences: Faculty Publications

Many microorganisms propel themselves through complex media by deforming their flagella. The beat is thought to emerge from interactions between forces of the surrounding fluid, the passive elastic response from deformations of the flagellum and active forces from internal molecular motors. The beat varies in response to changes in the fluid rheology, including elasticity, but there are limited data on how systematic changes in elasticity alter the beat. This work analyses a related problem with fixed-strength driving force: the emergence of beating of an elastic planar filament driven by a follower force at the tip of a viscoelastic fluid. This …

Atomistic Simulation Of Pfas And Graphene: Interactions For Water Applications, Bashar Moufeed Awawdeh

Electronic Theses and Dissertations

The contamination of drinking water by per- and polyfluorinated alkyl substances (PFAS) is a global issue. PFAS have been widely utilized in a variety of applications, including water and stain-resistant coatings, fire suppression foams, cosmetics, paints, and adhesives. They have been detected in soils and rivers globally due to their widespread use and resistance to degradation. The strong C–F bonds of PFAS make them exceedingly stable and hard to remove. In order to remediate PFAS contamination in the environment, it is essential to develop selective adsorbent materials that can effectively capture a wide range of PFAS structures. On April 10, …