Digital Commons Network^™

Endothelial Cells Adopt A Pro-Reparative Immune Responsive Signature During Cardiac Injury, Hali Long, Jeffrey D Steimle, Francisco Jose Grisanti Canozo, Jong Hwan Kim, Xiao Li, Yuka Morikawa, Minjun Park, Diwakar Turaga, Iki Adachi, Joshua D Wythe, Md Abul Hassan Samee, James F Martin

Faculty, Staff and Students Publications

Modulation of the heart’s immune microenvironment is crucial for recovery after ischemic events such as myocardial infarction (MI). Endothelial cells (ECs) can have immune regulatory functions; however, interactions between ECs and the immune environment in the heart after MI remain poorly understood. We identified an EC-specific IFN responsive and immune regulatory gene signature in adult and pediatric heart failure (HF) tissues. Single-cell transcriptomic analysis of murine hearts subjected to MI uncovered an EC population (IFN-ECs) with immunologic gene signatures similar to those in human HF. IFN-ECs were enriched in regenerative-stage mouse hearts and expressed genes encoding immune responsive transcription factors …

Anticoagulation With Osocimab In Patients With Kidney Failure Undergoing Hemodialysis: A Randomized Phase 2 Trial, Jeffrey I Weitz, László B Tankó, Jürgen Floege, Keith A A Fox, Deepak L Bhatt, Ravi Thadhani, James Hung, Ákos F Pap, Dagmar Kubitza, Wolfgang C Winkelmayer

Faculty, Staff and Students Publications

Individuals with kidney failure undergoing hemodialysis are at elevated risk for thromboembolic events. Factor (F) XI, which is in the intrinsic pathway of coagulation, is emerging as an attractive target for new anticoagulants that may be safer than existing agents. Osocimab-an inhibitory FXIa antibody-is a potential treatment option for such patients. We conducted a phase 2b, double-blind, placebo-controlled trial, in which 704 participants (448 male, 256 female) with kidney failure undergoing hemodialysis were randomized to receive lower- or higher-dose osocimab or placebo. In total, 686 participants (436 male, 250 female) received treatment for ≤18 months (planned minimal treatment period of …

Circulating Immune Signatures Across Clinical Stages Of Chronic Pancreatitis: A Pilot Study, Rasmus Hagn-Meincke, Phil A Hart, Dana K Andersen, Santhi S Vege, Evan L Fogel, Jose Serrano, Melena D Bellin, Mark D Topazian, Darwin L Conwell, Liang Li, Stephen K Van Den Eeden, Asbjørn M Drewes, Stephen J Pandol, Chris E Forsmark, William E Fisher, Dhiraj Yadav, Søren S Olesen, Walter G Park, Consortium For The Study Of Chronic Pancreatitis, Diabetes, And Pancreatic Cancer (Cpdpc)

Faculty, Staff and Student Publications

Objective: This pilot study seeks to identify serum immune signatures across clinical stages of patients with chronic pancreatitis (CP).

Methods: We performed a cross-sectional analysis of prospectively collected serum samples from the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translation StuDies-study. CP subjects were categorised into three clinical stages based on the presence/absence of metabolic complications: (1) CP with no diabetes and exocrine pancreatic dysfunction (EPD), (2) CP with either diabetes or EPD, and (3) CP with diabetes and EPD. Blinded samples were analysed using an 80-plex Luminex assay of cytokines/chemokines/adhesion molecules. Group and pairwise comparisons were performed to …

Nonchromosomal Birth Defects And Risk Of Childhood Acute Leukemia: An Assessment In 15 000 Leukemia Cases And 46 000 Controls From The Childhood Cancer And Leukemia International Consortium, Philip J Lupo, Tiffany M Chambers, Beth A Mueller, Jacqueline Clavel, John D Dockerty, David R Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E Heck, Claire Infante-Rivard, Alice Y Kang, Corrado Magnani, Carlotta Malagoli, Erin L Marcotte, Catherine Metayer, Helen D Bailey, Ana M Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S Pombo-De-Oliveira, Wafaa M Rashed, Eve Roman, Joachim Schüz, Catharina Wesseling, Logan G Spector, Michael E Scheurer

Faculty, Staff and Students Publications

Although recent studies have demonstrated associations between nonchromosomal birth defects and several pediatric cancers, less is known about their role on childhood leukemia susceptibility. Using data from the Childhood Cancer and Leukemia International Consortium, we evaluated associations between nonchromosomal birth defects and childhood leukemia. Pooling consortium data from 18 questionnaire-based and three registry-based case-control studies across 13 countries, we used multivariable logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between a spectrum of birth defects and leukemia. Our analyses included acute lymphoblastic leukemia (ALL, n = 13 115) and acute myeloid leukemia …

Generation Of A Dcx-Creert2 Knock-In Mouse For Genetic Manipulation Of Newborn Neurons, Gabriella A Perez, Kyung-Won Park, Denise Lanza, Jenna Cicardo, M Danish Uddin, Joanna L Jankowsky

Faculty, Staff and Students Publications

A wide variety of CreERT2 driver lines are available for genetic manipulation of adult-born neurons in the mouse brain. These tools have been instrumental in studying fate potential, migration, circuit integration, and morphology of the stem cells supporting lifelong neurogenesis. Despite a wealth of tools, genetic manipulation of adult-born neurons for circuit and behavioral studies has been limited by poor specificity of many driver lines targeting early progenitor cells and by the inaccessibility of lines selective for later stages of neuronal maturation. We sought to address these limitations by creating a new CreERT2 driver line targeted to the endogenous mouse …

A Zika Virus Protein Expression Screen In Drosophila To Investigate Targeted Host Pathways During Development, Nichole Link, J Michael Harnish, Brooke Hull, Shelley Gibson, Miranda Dietze, Uchechukwu E Mgbike, Silvia Medina-Balcazar, Priya S Shah, Shinya Yamamoto

Faculty, Staff and Students Publications

In the past decade, Zika virus (ZIKV) emerged as a global public health concern. Although adult infections are typically mild, maternal infection can lead to adverse fetal outcomes. Understanding how ZIKV proteins disrupt development can provide insights into the molecular mechanisms of disease caused by this virus, which includes microcephaly. In this study, we generated a toolkit to ectopically express ZIKV proteins in vivo in Drosophila melanogaster in a tissue-specific manner using the GAL4/UAS system. We used this toolkit to identify phenotypes and potential host pathways targeted by the virus. Our work identified that expression of most ZIKV proteins caused …

Deep Learning Prediction Boosts Phosphoproteomics-Based Discoveries Through Improved Phosphopeptide Identification, Xinpei Yi, Bo Wen, Shuyi Ji, Alexander B Saltzman, Eric J Jaehnig, Jonathan T Lei, Qiang Gao, Bing Zhang

Faculty, Staff and Students Publications

Shotgun phosphoproteomics enables high-throughput analysis of phosphopeptides in biological samples. One of the primary challenges associated with this technology is the relatively low rate of phosphopeptide identification during data analysis. This limitation hampers the full realization of the potential offered by shotgun phosphoproteomics. Here we present DeepRescore2, a computational workflow that leverages deep learning-based retention time and fragment ion intensity predictions to improve phosphopeptide identification and phosphosite localization. Using a state-of-the-art computational workflow as a benchmark, DeepRescore2 increases the number of correctly identified peptide-spectrum matches by 17% in a synthetic dataset and identifies 19% to 46% more phosphopeptides in biological …

Biallelic Creld1 Variants Cause A Multisystem Syndrome, Including Neurodevelopmental Phenotypes, Cardiac Dysrhythmias, And Frequent Infections, Lauren Jeffries, Emily K Mis, Kirsty Mcwalter, Sandra Donkervoort, Nina N Brodsky, Jean-Marie Carpier, Weizhen Ji, Cristian Ionita, Bhaskar Roy, Jon S Morrow, Armine Darbinyan, Krishna Iyer, Ritu B Aul, Siddharth Banka, Katherine R Chao, Laura Cobbold, Stacey Cohen, Helena M Custodio, Margaret Drummond-Borg, Frances Elmslie, Erika Finanger, Bryan E Hainline, Ingo Helbig, Stacy Hewson, Ying Hu, Adam Jackson, Dragana Josifova, Monica Konstantino, Meganne E Leach, Bryan Mak, David Mccormick, Elisabeth Mcgee, Stanley Nelson, Joanne Nguyen, Kimberly Nugent, Lucy Ortega, Howard P Goodkin, Elizabeth Roeder, Sani Roy, Katie Sapp, Dimah Saade, Sanjay M Sisodiya, Karen Stals, Shelley Towner, William Wilson, Deciphering Developmental Disorders, Genomics England Research Consortium, Undiagnosed Disease Network, Mustafa K Khokha, Carsten G Bönnemann, Carrie L Lucas, Saquib A Lakhani

Faculty, Staff and Students Publications

PURPOSE: We sought to delineate a multisystem disorder caused by recessive cysteine-rich with epidermal growth factor-like domains 1 (CRELD1) gene variants.

METHODS: The impact of CRELD1 variants was characterized through an international collaboration utilizing next-generation DNA sequencing, gene knockdown, and protein overexpression in Xenopus tropicalis, and in vitro analysis of patient immune cells.

RESULTS: Biallelic variants in CRELD1 were found in 18 participants from 14 families. Affected individuals displayed an array of phenotypes involving developmental delay, early-onset epilepsy, and hypotonia, with about half demonstrating cardiac arrhythmias and some experiencing recurrent infections. Most harbored a frameshift in trans with a missense …

Cocaine Use And Head And Neck Cancer Risk: A Pooled Analysis In The International Head And Neck Cancer Epidemiology Consortium, Mingyan Zhang, Chu Chen, Guojun Li, Alzina Koric, Yuan-Chin Amy Lee, Hal Morgenstern, Stephen M Schwartz, Erich M Sturgis, Paolo Boffetta, Mia Hashibe, Zuo-Feng Zhang

Faculty, Staff and Students Publications

BACKGROUND: Cocaine is an illegal recreational drug used worldwide, yet little is known about whether cocaine inhalation (smoking/snorting) increases the risk of head and neck cancer (HNC).

METHODS: The analyses were conducted by pooling data from three case-control studies with 1639 cases and 2506 controls from the International Head and Neck Cancer Epidemiology Consortium. Epidemiologic data, including cocaine use histories, were obtained in face-to-face interviews. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using hierarchical logistic regression models.

RESULTS: Controlling for cumulative tobacco and alcohol use, we observed a weak positive association between cocaine use and HNC …

Changes In Bone Marrow Fibrosis During Momelotinib Or Ruxolitinib Therapy Do Not Correlate With Efficacy Outcomes In Patients With Myelofibrosis, Stephen T Oh, Et Al.

2020-Current year OA Pubs

Bone marrow fibrosis (BMF) is a pathological feature of myelofibrosis, with higher grades associated with poor prognosis. Limited data exist on the association between outcomes and BMF changes. We present BMF data from Janus kinase (JAK) inhibitor-naive patients from SIMPLIFY-1 (NCT01969838), a double-blind, randomized, phase 3 study of momelotinib vs ruxolitinib. Baseline and week 24 bone marrow biopsies were graded from 0 to 3 as per World Health Organization criteria. Other assessments included Total Symptom Score, spleen volume, transfusion independence status, and hemoglobin levels. Paired samples were available from 144 and 160 patients randomized to momelotinib and ruxolitinib. With momelotinib …

Examining The Influence Of Adult Mentors On Fostering Prosocial Behaviors Among Teens, John H. Weaver Iii

Electronic Theses and Dissertations

This dissertation addressed a critical public health concern stemming from the prevalence of antisocial behavior among U.S. teenagers. The study specifically tackled the lack of information regarding the components of an effective risk-reduction mentoring program for teens. The primary aim was to explore how young adult alums of a central Florida mentoring program articulated the influence of mentoring relationships that have shaped their attitudes and perceptions concerning prosocial behavior during adolescence. As a bounded qualitative case study, this research employed semistructured interviews with 11 young adult mentees from a mentoring program. Additionally, a focus group of five adult mentors who …

Increasing Folic Acid Self-Efficacy In College-Age Women Of Childbearing Age, Kristie Lynn Buchanan

Electronic Theses and Dissertations

Preventative measures taken by women of childbearing age before and during conception limit the risk of fetal defects or complications. One specific measure that is recommended by the Centers for Disease Control and Prevention is that all women of childbearing age take folic acid 400 mcg daily. Evidence-based research suggests that taking 400 mcg daily limits the risk of fetal neural tube defects if taken daily and started at least two months before conception. Fetal neural tube defects are classified as defects that damage the baby’s spine and brain. The researcher conducted an evidence-based practice project that sought to determine …

Mucosal Boosting Enhances Vaccine Protection Against Sars-Cov-2 In Macaques, Katherine Mcmahan, Adrianus C M Boon, Et Al.

2020-Current year OA Pubs

A limitation of current SARS-CoV-2 vaccines is that they provide minimal protection against infection with current Omicron subvariants

Racial Differences In Treatment And Survival Among Older Patients With Multiple Myeloma, Rong Wang, Natalia Neparidze, Xiaomei Ma, Graham A Colditz, Su-Hsin Chang, Shi-Yi Wang

2020-Current year OA Pubs

BACKGROUND: Treatments for multiple myeloma (MM) have evolved over time and improved MM survival. While racial differences in MM treatment and prognosis between non-Hispanic African American (NHAA) and non-Hispanic White (NHW) patients are well-established, it is unclear whether they have persisted after the introduction of novel agents.

METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare linked database, our study investigated racial difference in the receipt of treatment within 1 year following diagnosis and assessed survival outcomes among Medicare beneficiaries (≥66 years) diagnosed with MM from 2007 to 2017. We applied multivariable Cox proportional hazards models to estimate the association between …

Stem Cell Modeling Of Nervous System Tumors, Frank B Furnari, Corina Anastasaki, Shan Bian, Howard A Fine, Tomoyuki Koga, Lu Q Le, Fausto J Rodriguez, David H Gutmann

2020-Current year OA Pubs

Nervous system tumors, particularly brain tumors, represent the most common tumors in children and one of the most lethal tumors in adults. Despite decades of research, there are few effective therapies for these cancers. Although human nervous system tumor cells and genetically engineered mouse models have served as excellent platforms for drug discovery and preclinical testing, they have limitations with respect to accurately recapitulating important aspects of the pathobiology of spontaneously arising human tumors. For this reason, attention has turned to the deployment of human stem cell engineering involving human embryonic or induced pluripotent stem cells, in which genetic alterations …

Divergent Responses Of Highly Migratory Species To Climate Change In The California Current, Nerea Lezama-Ochoa, Stephanie Brodie, Heather Welch, Michael G. Jacox, Mercedes Pozo Buil, Jerome Fiechter, Megan Cimino, Barbara Muhling, Heidi Dewar, Elizabeth A. Becker, Karin A. Forney, Daniel Costa, Scott R. Benson, Nima Farchadi, Camrin Braun, Rebecca Lewison, Steven Bograd, Elliott L. Hazen

Faculty Research, Scholarly, and Creative Activity

Aim: Marine biodiversity faces unprecedented threats from anthropogenic climate change. Ecosystem responses to climate change have exhibited substantial variability in the direction and magnitude of redistribution, posing challenges for developing effective climate-adaptive marine management strategies. Location: The California Current Ecosystem (CCE), USA. Methods: We project suitable habitat for 10 highly migratory species in the California Current System using an ensemble of three high-resolution (~10 km) downscaled ocean projections under the Representative Concentration Pathway 8.5 (RCP8.5). Spanning the period from 1980 to 2100, our analysis focuses on assessing the direction and distance of distributional shifts, as well as changes in core …

When Evolutionary Computation Meets Privacy, Bowen Zhao, Wei-Neng Chen, Xiaoguo Li, Ximeng Liu, Qingqi Pei, Jun Zhang

Research Collection School Of Computing and Information Systems

Recently, evolutionary computation (EC) has experienced significant advancements due to the integration of machine learning, distributed computing, and big data technologies. These developments have led to new research avenues in EC, such as distributed EC and surrogate-assisted EC. While these advancements have greatly enhanced the performance and applicability of EC, they have also raised concerns regarding privacy leakages, specifically the disclosure of optimal results and surrogate models. Consequently, the combination of evolutionary computation and privacy protection becomes an increasing necessity. However, a comprehensive exploration of privacy concerns in evolutionary computation is currently lacking, particularly in terms of identifying the object, …

Frameworks For Measuring Population Health: A Scoping Review, Sze Ling Chan, Clement Zhong Hao Ho, Nang Ei Ei Khaing, Ezra Ho, Candelyn Pong, Jia Sheng Guan, Calida Chua, Zongbin Li, Trudi Lim Wenqi, Sean Shao Wei Lam, Lian Leng Low, Choon How How

Research Collection School Of Computing and Information Systems

Introduction Many regions in the world are using the population health approach and require a means to measure the health of their population of interest. Population health frameworks provide a theoretical grounding for conceptualization of population health and therefore a logical basis for selection of indicators. The aim of this scoping review was to provide an overview and summary of the characteristics of existing population health frameworks that have been used to conceptualize the measurement of population health. Methods We used the Population, Concept and Context (PCC) framework to define eligibility criteria of frameworks. We were interested in frameworks applicable …

Detecting Outdated Code Element References In Software Repository Documentation, Wen Siang Tan, Markus Wagner, Christoph Treude

Research Collection School Of Computing and Information Systems

Outdated documentation is a pervasive problem in software development, preventing effective use of software, and misleading users and developers alike. We posit that one possible reason why documentation becomes out of sync so easily is that developers are unaware of when their source code modifications render the documentation obsolete. Ensuring that the documentation is always in sync with the source code takes considerable effort, especially for large codebases. To address this situation, we propose an approach that can automatically detect code element references that survive in the documentation after all source code instances have been deleted. In this work, we …

The Dichotomy Of Threat And Deprivation As Subtypes Of Childhood Maltreatment: Differential Functional Connectivity Patterns Of Threat And Reward Circuits In An Adult Trauma Sample, Michael T. Liuzzi, Farah Harb, Kevin Petranu, Ashley A. Huggins, E. Kate Webb, Jacklynn M. Fitzgerald, Jessica L. Krukowski, Tara A. Miskovich, Terri A. Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background

Childhood maltreatment is associated with reduced activation of the nucleus accumbens, , a central region in the reward network, and overactivity in the amygdala, a key region in threat processing. However, the long-lasting impact of these associations in the context of later-life stress is not well understood. The current study explored the association between childhood threat and deprivation and functional connectivity of threat and reward regions in an adult trauma sample.

Methods

Trauma survivors (N = 169; mean age [SD] = 32.2 [10.3] years; female = 55.6%) were recruited from a level I trauma center. Two weeks after …

Experiences Of Racial Discrimination And Adverse Gene Expression Among Black Individuals In A Level 1 Trauma Center Sample, Claire M. Bird, E. Kate Webb, Steven W. Cole, Carissa W. Tomas, Jennifer M. Knight, Sydney C. Timmer-Murillo, Christine L. Larson, Terri A. Deroon-Cassini, Lucas Torres

Psychology Faculty Research and Publications

Up to 40% of individuals who sustain traumatic injuries are at risk for posttraumatic stress disorder (PTSD) and the conditional risk for developing PTSD is even higher for Black individuals. Exposure to racial discrimination, including at both interpersonal and structural levels, helps explain this health inequity. Yet, the relationship between racial discrimination and biological processes in the context of traumatic injury has yet to be fully explored. The current study examined whether racial discrimination is associated with a cumulative measure of biological stress, the gene expression profile conserved transcriptional response to adversity (CTRA), in Black trauma survivors. Two-weeks (T1) and …

Inulin-Based Formulations As An Emerging Therapeutic Strategy For Cancer: A Comprehensive Review, Eswara Naga H K Ghali, Pranav, Subhash Chauhan, Murali M. Yallapu

School of Medicine Publications

Highlights

• Inulin is a naturally occurring prebiotic fiber with therapeutic roles.

• Inulin can act as an excellent carrier for drug delivery in cancer therapy.

• Inulin exhibits an improved therapeutic efficacy in its combination treatments.

• Inulin interventions activate phagocytosis and the TLR4 signaling pathway.

Abstract

Cancer stands as the second leading cause of death in the United States (US). Most chemotherapeutic agents exhibit severe adverse effects that are attributed to exposure of drugs to off-target tissues, posing a significant challenge in cancer therapy management. In recent years, inulin, a naturally occurring prebiotic fiber has gained substantial attention for its potential in …

Validating Indigenous Farmers’ Practice In The Management Of The Fall Armyworm Spodoptera Frugiperda (J. E. Smith) In Maize Cropping Systems In Africa, Saliou Niassy, Evanson Rigan Omuse, John Emanuel Khang’Ati, Ines Bächinger, David Mfuti Kupesa, Xavier Cheseto, Benjamin W. Mbatha, Robert S. Copeland, Samira Abuelgasim Mohamed, Mphatso Gama, Joyce Mulila Mitti, Yeneneh Belayneh, Nicolas Delabays, François Lefort, Sunday Ekesi, Sevgan Subramanian

All Peer-Reviewed Publications

Before the invasion of the fall armyworm (FAW) Spodoptera frugiperda into Africa, smallholder farmers had been using indigenous practices such as applying fish soup to plants to manage stemborer pests. Although farmers have since begun adapting this practice against FAW, no attempt has been made to scientifically evaluate this practice. Therefore, we assessed the efficacy of applying fish soup to maize plants that were artificially infested with FAW under semi-field conditions. Our results showed that foliar damage is inversely correlated with the concentration of a fish soup and sugar solution, with the highest (100%) concentration resulting in the lowest foliar …

Struvite-Phosphorus Effects On Greenhouse Gas Emissions And Plant And Soil Response In A Furrow-Irrigated Rice Production System In Eastern Arkansas, Diego Della Lunga, Kristofor R. Brye, Trenton L. Roberts, Jonathan Brye, Michelle Evans-White, Christopher G. Henry, Daniel J. Lessner, Chandler Arel

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Phosphorus (P) fertilizers with low water solubility, like struvite (MgNH₄PO₄·6H₂O), have been identified to possibly reduce nutrient losses in furrow-irrigated cropping systems. However, there is a lack of research on the impacts of P and nitrogen (N) fertilization on greenhouse gas [GHG; i.e., methane (CH₄), nitrous oxide (N₂O), and carbon dioxide (CO₂)] production in furrow-irrigated rice (Oryza sativa). The objective of this study was to evaluate the effects of electrochemically precipitated struvite (ECST), chemically precipitated struvite (CPST), triple superphosphate (TSP), diammonium phosphate (DAP), environmentally smart nitrogen …

Mathematicians Going East, Pasha Zusmanovich

Journal of Humanistic Mathematics

I survey emigration of mathematicians from Europe, before and during WWII, to Russia. The emigration started at the end of 1920s, the time of “Great Break”, and accelerated in 1930s, after the introduction in Germany of the “non-Aryan laws”. Not everyone who wanted to emigrate managed to do so, and most of those who did spent a relatively short time in Russia, being murdered or deported, or fleeing the Russian regime. After 1937, the year of “Great Purge”, only a handful of emigrant mathematicians remained, and even fewer managed to leave a trace in the scientific milieu of their new …

Symposium: Gender, Health, And The Constitution: The New Gender Panic In Sport: Why State Laws Banning Transgender Athletes Are Unconstitutional, Deborah L. Brake

ConLawNOW

This essay considers the role of sport in the new gender panic of legislative activity targeting transgender individuals, which now extends into health and family governance. Sport was one of the first settings—the gateway—to ignite the current culture war on transgender youth. This analysis examines how Title IX of the Education Act of 1972, the popular law responsible for the growth of opportunities for girls and women in sports, has been mobilized in service of a broader gender agenda. Far from providing a persuasive justification for the state laws banning transgender girls from girls’ sports, Title IX, properly understood, supports …

The Fallacy Of Systemic Racism In The American Criminal Justice System, Paul J. Larkin, Giancarlo Canaparo

Liberty University Law Review

Critics of the criminal justice system have repeatedly charged it with systemic racism. It is a tenet of the “war” on the “War on Drugs,” it is a justification used by the so-called “progressive prosecutors” to reject the “Broken Windows” theory of law enforcement, and it is an article of faith of the “Defund the Police!” movement. Even President Joe Biden and his chief lieutenants leveled the same allegation early in this administration. Although the President has eschewed the belief that Americans are a racist people, others have not, proclaiming that virtually anyone who is white is a racist.

Yet, …

Memory As A Foundation For Learning, Manuel Vicuna, Juan Manuel Vicuna

Undergraduate Research Symposium

The object of this research is to emphasize the importance of memory in the professional environment and to suggest a change in the direction of educational plans to endow students with a powerful cognitive tool – memory - for the rest of their lives. Presently, memory is a fundamental human function that the educational process dismisses, making learning more difficult. Memory and professional intuition – both the result of knowledge and experience - should be a natural adjunct to any training and not a sudden source of inspiration as intuition, in particular, needs conscious and subconscious cultivation. In both subjects, …

A Vaccine Against Holocaust Denial: Knowledge, Riley Andreasen

Undergraduate Research Symposium

Holocaust denial is founded on antisemitism and hatred. Understanding the psychology behind Holocaust denial and the associated risks is vital to protecting the public.

Studying The Genes And Conditions That Influence Root Development, Tessa Holtkamp, Hannah Ordonez Webb

Undergraduate Research Symposium

Root development in plants is essential for their survival and understanding how hormones influence their development can explain how plants grow under different circumstances. Researching how Indole-3-butyric acid (IBA), a hormone that induces root production, affects the plant model Arabidopsis thaliana helps explain the hormone's effect in agricultural crop systems. To understand root pathways, we performed assays on mutant lines of Arabidopsis by growing plants on varying concentrations of IBA. For wild-type and mutant lines, phenotyping experiments like branching of roots, lengths of stems, and root length were conducted along with PCR and restriction digest genotyping experiments to compare their …