Digital Commons Network^™

Chronic Wasting Disease: State Of The Science, Jason C Bartz, Rebeca Benavente, Byron Caughey, Sonja Christensen, Allen Herbst, Edward A Hoover, Candace K Mathiason, Debbie Mckenzie, Rodrigo Morales, Marc D Schwabenlander, Daniel P Walsh, The Nc North American Interdisciplinary Chronic Wasting Disease Research Consortium Members

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) is a prion disease affecting cervid species, both free-ranging and captive populations. As the geographic range continues to expand and disease prevalence continues to increase, CWD will have an impact on cervid populations, local economies, and ecosystem health. Mitigation of this "wicked" disease will require input from many different stakeholders including hunters, landowners, research biologists, wildlife managers, and others, working together. The NC1209 (North American interdisciplinary chronic wasting disease research consortium) is composed of scientists from different disciplines involved with investigating and managing CWD. Leveraging this broad breadth of expertise, the Consortium has created a state-of-the-science …

Exosome-Based Smart Drug Delivery For Cancer Treatment, Shabnam Malik, Mohammed Sikander, Sheema Khan, Daniel Zubieta, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

Advances in nanoscale materials have become indispensable for targeted drug delivery, early detection, and personalized approaches for cancer treatment. Among various nanoscale materials investigated, exosomes hold significant promise in drug delivery. Exosomes are nanoscale vesicles that are usually 30–150 nm in size and produced by cells for intercellular communication. Due to their unique composition and inherent tumor-targeting capacity, these particles are well suited for tumor-specific delivery systems. This chapter discusses exosome isolation, therapeutic loading methods, key roles of exosomes in the tumor microenvironment, current applications of exosomes in drug delivery, and possible clinical implications.

Blood Cell Image Segmentation And Classification: A Systematic Review, Muhammad Shahzad, Farman Ali, Syed Hamad Shirazi, Assad Rasheed, Awais Ahmad, Babar Shah, Daehan Kwak

All Works

Background Blood diseases such as leukemia, anemia, lymphoma, and thalassemia are hematological disorders that relate to abnormalities in the morphology and concentration of blood elements, specifically white blood cells (WBC) and red blood cells (RBC). Accurate and efficient diagnosis of these conditions significantly depends on the expertise of hematologists and pathologists. To assist the pathologist in the diagnostic process, there has been growing interest in utilizing computer-aided diagnostic (CAD) techniques, particularly those using medical image processing and machine learning algorithms. Previous surveys in this domain have been narrowly focused, often only addressing specific areas like segmentation or classification but lacking …

Nature Of The Evidence Base And Approaches To Guide Nutrition Interventions For Individuals: A Position Paper From The Academy Of Nutrition Sciences, Mary Hickson, Constantina Papoutsakis, Angela M. Madden, Mary Anne Smith, Kevin Whelan

School of Health Professions

This Position Paper from the Academy of Nutrition Sciences is the third in a series which describe the nature of the scientific evidence and frameworks that underpin nutrition recommendations for health. This paper focuses on evidence which guides the application of dietary recommendations for individuals. In some situations, modified nutrient intake becomes essential to prevent deficiency, optimise development and health, or manage symptoms and disease progression. Disease and its treatment can also affect taste, appetite and ability to access and prepare foods, with associated financial impacts. Therefore, the practice of nutrition and dietetics must integrate and apply the sciences of …

The Student Movement Volume 108 Issue 14: Elevating Our Way To Black History Month, Lauren Kim, Grace No, Nick Bishop, Amelia Stefanescu, Audrey Lim, Madison Vath, Andrew Francis, Melissa Moore, Anna Rybachek, Jonathan Clough, Katie Davis, Reagan Westerman, Nate Miller, Nicole Compton-Gray, Wambui Karanja, Caitlin Adap, Gio Lee

The Student Movement v. 108 (2023-2024)

HUMANS

BSCF President & Black History Month: Skyler Campbell, Interviewed by Lauren Kim

A Modern Renaissance man: Nate Miller, Interviewed by Nick Bishop

Brushstrokes of Hope: Painting Smiles and Building Bonds in Honduras, Interviewed by Nick Bishop

ARTS & ENTERTAINMENT

A Little Taste of "A Little Life", Amelia Stefanescu

Bring Fall Fest Back!, Amelia Stefanescu

Remakes and Reboots, Audrey Lim

"Wild Geese" and the Acceptance of Being Human, Madison Vath

NEWS

Student Speakers "Activate" Peers' Faith at Week of Prayer, Andrew Francis

New BOBA Shop Offers Students Tea-licious Drinks, Melissa Moore

Recording Policy Rules 101, Anna Rybachek

Warmer in the …

Covid-19 National Football League (Nfl) Injury Analysis: Follow-Up Study, Troy B. Puga, Joshua Schafer, Grace Thiel, Nicholas Scigliano, Tiffany Ruan, Andres Toledo, Prince N. Agbedanu, Kevin Treffer

Student Publications

Background:

In 2020, COVID-19 spread across the world and brought normal daily life to a halt, causing the shutdown of nearly everything in order to prevent its spread. The National Football League (NFL) similarly experienced shutdowns and the resulting effects, leaving athletes unable to train in some of the most advanced facilities with many of the best trainers in the world. A previous study, titled COVID-19 Return to Sport: NFL Injury Prevalence Analysis, determined that there was increased injury prevalence during the 2020 season, likely due to decreased physiological adaptations within athletes’ bodies as a result of facility shutdowns. …

Invisible Labours: The Reproductive Politics Of Second Trimester Pregnancy Loss In England, Aimee Middlemiss

School of Nursing and Midwifery

REVIEWS“In this original and conceptually sophisticated project Middlemiss handles incredibly difficult interview material with extraordinary sensitivity and care. She does not shy away from difficult details but makes these often very raw stories more understandable through serious analytic work.” • Linda L. Layne, University of Cambridge“This is an excellent book … As someone working in the field of reproduction/family studies (though not specifically on pregnancy loss), this book has expanded my thinking regarding how legal, medical, kinship systems and cultures come together in defining our understandings of life/death, personhood and relatedness.” • Leah Gilman, University of Manchester“This is an excellent, …

A Relational Approach To Knowledge Exchange In Higher Education, Harriet Dismore, Verity Campbell-Barr, Rachel Manning, Paul Warwick

School of Law, Humanities and Social Sciences

Reference to Knowledge Exchange (KE) in UK Higher Education Institutions (HEIs) has become common place, reflecting the continued changing role of universities within society. Arguably, KE draws together notions of HEIs as purveyors of knowledge, with students helping to create a tripartite relationship with HEIs and the wider community as well as a civic responsibility to contribute to the wider public good. Realising the potential benefits of this inter-relationship required a problematising of the meanings of both knowledge and the notion of an exchange, drawing on the work of Dewey and Bernstein. Our paper offers an analysis of the different …

Analysis Of The Impact Of Water Treatment By Liming Sedimentation And Dredging On The Content Of Heavy Metals In Fish Intended For Consumption, Asfie Maidie, Ismail Fahmy Almadi, Muchlis Efendi, Rekha Yusdha Nilawardhani, Komsanah Sukarti, Henny Pagoray

Journal of Sustainable Mining

The present study sought to determine the presence of metals and arsenic, a metalloid, among the fish of a coal mine reservoir, where the water was treated regularly through liming sedimentation combined with dredging, and the fish living in an adjoining river. The potential hazard of metals in fish as human food was analyzed. Except for selenium (an important metal to the human body), which was higher among the river fish than in the reservoir fish (P < 0.01), there were no particular patterns of other studied metals found in either habitat (P > 0.05), and apparently not related to the fish family that consumed by local people. Measurements of bioaccumulation factor (BAF) yielded scattered values from …

Antes Muerta Que Sencilla: Language And The Construction Of Feminine Beauty In The Spanish-Speaking World, Eva Michelle Wheeler

International Journal of the Linguistic Association of the Southwest

Much has been written on the topic of feminine beauty, and existing studies suggest that ideas about beauty are a powerful cultural mirror that reveal what we value as a society and how we are valued by society (e.g., Etcoff 1999; Rhodes 2006; Whitefield-Madrano 2016; Wolf 2002). Despite critical advances made in beauty research, few existing studies in this area explicitly examine the lexicon of beauty as a critical site of analysis (e.g., Démuth et al. 2022; Gladkova 2021; Gladkova & Romero-Trillo 2021; Miller & Stevens 2021; Tayebi 2021; Wong & Or 2021). In the context of Spanish, no existing …

Fostering Empathy In Communication Sciences And Disorders Through Interprofessional Simulation: Bridging The Gap Between Lecture And Practice, Cynthia A. Hovland, Carol Spears, Melissa Volk

Teaching and Learning in Communication Sciences & Disorders

This exploratory study sought to understand the experiences of CSD students participating in an interprofessional simulation focused on empathy development and how it could inform their future practice. This study used a non-random, purposive sample of 29 CSD students from one United States university who attended one of three Team STEPPS seminar training days that were offered during three separate semesters. Post-seminar surveys were completed, and conventional content analysis used to analyze data. Three primary themes, and corresponding subthemes emerged: (a) establish trust (build rapport; identify patient care goals; and encourage active participation; (b) facilitate collaborative plan of care (provide …

Addressing Bias In Slp Problem-Based Tutorials Through Critical Reflexivity, Curriculum Development And Instructor Training, Harmonie Chan, Courtney Tidd, Justine Hamilton, Deidre Sperry, Michelle Phoenix

Teaching and Learning in Communication Sciences & Disorders

Racism is prevalent in the fields of healthcare and education in North America and speech-language pathology and audiology are no exception. Systemic and individual racism in educational, training, and clinical settings creates barriers for student entry and success, and negatively impacts client care. Although the ability to serve clients of diverse backgrounds is a crucial skill for students and clinicians, current educational curricula appears insufficient in supporting culturally diverse students and preparing all students to work with culturally diverse populations. This is, in part, due to a lack of diverse representation in education and clinical settings, bias experienced by SLP …

Analyzing Global Utilization And Missed Opportunities In Debt-For-Nature Swaps With Generative Ai, Nataliya Tkachenko, Simon Frieder, Ryan-Rhys Griffiths, Christoph Nedopil

Sim Kee Boon Institute for Financial Economics

We deploy a prompt-augmented GPT-4 model to distill comprehensive datasets on the global application of debt-for-nature swaps (DNS), a pivotal financial tool for environmental conservation. Our analysis includes 195 nations and identifies 21 countries that have not yet used DNS before as prime candidates for DNS. A significant proportion demonstrates consistent commitments to conservation finance (0.86 accuracy as compared to historical swaps records). Conversely, 35 countries previously active in DNS before 2010 have since been identified as unsuitable. Notably, Argentina, grappling with soaring inflation and a substantial sovereign debt crisis, and Poland, which has achieved economic stability and gained access …

Medical School Watercooler Newsletter - February 1, 2024, Lindsey Lyle

Watercooler Newsletter

This is the February 1, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• New pediatric surgeon joins Whiddon COM faculty
• Meet a Med Student: Cade Smelley
• USA scientists explore role of MYB transcription factors in cancer

Convergence: Eos News And Updates, February 2024, Unh Institute For The Study Of Earth, Oceans And Space

Convergence: EOS News and Updates

No abstract provided.

How The Ribosome Shapes Cotranslational Protein Folding, Ekaterina Samatova, Anton A. Komar, Marina Rodnina

Biological, Geological, and Environmental Faculty Publications

During protein synthesis, the growing nascent peptide chain moves inside the polypeptide exit tunnel of the ribosome from the peptidyl transferase center towards the exit port where it emerges into the cytoplasm. The ribosome defines the unique energy landscape of the pioneering round of protein folding. The spatial confinement and the interactions of the nascent peptide with the tunnel walls facilitate formation of secondary structures, such as a-helices. The vectorial nature of protein folding inside the tunnel favors local intra- and inter-molecular interactions, thereby inducing cotranslational folding intermediates that do not form upon protein refolding in solution. Tertiary structures start …

Faculty Senate Meeting Minutes February 2024, Faculty Senate

Faculty Senate Minutes

No abstract provided.

Honors Oracle, February 2024, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

Enhancing Workplace Neuro Health And Productivity: The Synergy Of Wearable Technology With Biophilic And Oxygenation Strategies, Piper Hutson, James Hutson

Faculty Scholarship

In the contemporary workplace, where a staggering 62% of employees reported experiencing burnout in 2023 according to a Medium article, the integration of wearable technology with biophilic and oxygenation strategies emerges as a vital Neurohemal initiative. This approach is particularly relevant for supporting neurodivergent individuals, as well as those recovering from stroke and long-COVID, in the context of return-to-office mandates. The article underscores the significance of research on increased hydrostatic pressure in circulation, particularly its impact on spinal and spinal cord blood flow during water immersion. This insight lays the groundwork for innovations like non-wet water massage devices, which could …

2023 Celebration Of Rollins Scholarship, Olin Library, Rollins College, The Office Of The Dean Of The College Of Liberal Arts, Rollins College

Celebration of Rollins Scholarship

No abstract provided.

Dna Playbill, Providence College

Playbill and Promotion

Providence College Department of Theatre, Dance & Film

Angell Blackfriars Theatre

DNA, written by Dennis Kelly

February 1-3, 2024, 7:30pm

February 3 & 4, 2024, 2pm

Director, Aaron Andrade

Scenic Design, Renee Surprenant Fitzgerald

Lighting Design, Elissa Cerros

Vocal Coach, Megan Chang

Costume Design, Jaimy Escobedo

Sound Design, Stuart Holland

Properties Design, Claire Dancause

Makeup Design, Maxine Wheelock

Cast: Luke MacDonald - Mark; Maddie Rich - Jan; Sarah D'Andrea - Leah; Jack Jozefowski - Phil; Molly McGoldrick - Lou; Anthony Maldonado - John Tate; Anthony Joseph - Danny; Holli Hay - …

Creating A Climate Change Intervention To Reduce Students' Psychological Distance, Emily Holt, Jessica Duke

Assessment Mini Grant Reports

While most undergraduate students in the United States accept that climate change is occurring, they often harbor alternative conceptions associated with its distance spatially, temporally, hypothetically, and socially (Duke & Holt, 2022; Spence et al., 2012). The construct of psychological distance (PD) explains that an individual may recognize that climate change is a problem; however, they may believe it 1) is only affecting other people (high social distance), 2) is occurring far from their location (high spatial distance), 3) will occur in the future, but is not impacting them now (high temporal distance), or 4) is uncertain and therefore not …

Cc Magazine, Winter 2024, Connecticut College

Alumni News/Connecticut College Magazine

No abstract provided.

Baseball Media Guide 2024, Wofford College. Departmet Of Athletics

Media Guides

No abstract provided.

Annual Report 2024, University Libraries

Annual Reports & Newsletters

No abstract provided.

Gpf New Faces (February 2024), Grand Prairie Friends

Newsletters

No abstract provided.

Computational Discovery Of Microstructured Composites With Optimal Stiffness-Toughness Trade-Offs, Beichen Li, Bolei Deng, Wan Shou, Tae-Hyun Oh, Yuanming Hu, Yiyue Luo, Liang Shi, Wojciech Matusik

Mechanical Engineering Faculty Publications and Presentations

The conflict between stiffness and toughness is a fundamental problem in engineering materials design. However, the systematic discovery of microstructured composites with optimal stiffness-toughness trade-offs has never been demonstrated, hindered by the discrepancies between simulation and reality and the lack of data-efficient exploration of the entire Pareto front. We introduce a generalizable pipeline that integrates physical experiments, numerical simulations, and artificial neural networks to address both challenges. Without any prescribed expert knowledge of material design, our approach implements a nested-loop proposal-validation workflow to bridge the simulation-to-reality gap and find microstructured composites that are stiff and tough with high sample efficiency. …

Diversity And Prevalence Of Zoonotic Infections At The Animal-Human Interface Of Primate Trafficking In Peru, A. Patricia Mendoza, Ana Muñoz-Maceda, Bruno M. Ghersi, Micaela De La Puente, Carlos Zariquiey, Nancy Cavero, Yovana Murillo, Miguel Sebastian, Yohani Ibañez, Patricia G. Parker, Alberto Perez, Marcela Uhart, Janine Robinson, Sarah H. Olson, Marieke H. Rosenbaum

Biology Department Faculty Works

Wildlife trafficking creates favorable scenarios for intra- and inter-specific interactions that can lead to parasite spread and disease emergence. Among the fauna affected by this activity, primates are relevant due to their potential to acquire and share zoonoses - infections caused by parasites that can spread between humans and other animals. Though it is known that most primate parasites can affect multiple hosts and that many are zoonotic, comparative studies across different contexts for animal-human interactions are scarce. We conducted a multi-parasite screening targeting the detection of zoonotic infections in wild-caught monkeys in nine Peruvian cities across three contexts: captivity …

Ksp1 Is An Autophagic Receptor Protein For The Snx4-Assisted Autophagy Of Ssn2/Med13, Sara E Hanley, Stephen D Willis, Steven J Doyle, Randy Strich, Katrina F Cooper

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Ksp1 is a casein II-like kinase whose activity prevents aberrant macroautophagy/autophagy induction in nutrient-rich conditions in yeast. Here, we describe a kinase-independent role of Ksp1 as a novel autophagic receptor protein for Ssn2/Med13, a known cargo of Snx4-assisted autophagy of transcription factors. In this pathway, a subset of conserved transcriptional regulators, Ssn2/Med13, Rim15, and Msn2, are selectively targeted for vacuolar proteolysis following nitrogen starvation, assisted by the sorting nexin heterodimer Snx4-Atg20. Here we show that phagophores also engulf Ksp1 alongside its cargo for vacuolar proteolysis. Ksp1 directly associates with Atg8 following nitrogen starvation at the interface of an Atg8-family interacting …

Assessment Of The Status Of The Pilbara Demersal Scalefish Resource, Corey Wakefield, Ainslie Denham, Fabian Trinnie, Sybrand A. Hesp, Rachel Marks, Dion Boddington, Stephen J. Newman

Fisheries Research Reports

Executive Summary

For this assessment of the Pilbara Demersal Scalefish Resource (PDSR) of Western Australia, red emperor and bluespotted emperor are the indicator species used to represent the status of the resource. In addition, goldband snapper, though not an indicator species, is relatively abundant in the annual catches, particularly in deeper waters (around 100 m) and in the western Pilbara region and its status has also been assessed.