Digital Commons Network^™

Idhwt Glioblastomas Can Be Stratified By Their Transcriptional Response To Standard Treatment, With Implications For Targeted Therapy., Georgette Tanner, Rhiannon Barrow, Shoaib Ajaib, Muna Al-Jabri, Nazia Ahmed, Steven Pollock, Martina Finetti, Nora Rippaus, Alexander F Bruns, Khaja Syed, James A Poulter, Laura Matthews, Thomas Hughes, Erica Wilson, Colin Johnson, Frederick S Varn, Anke Brüning-Richardson, Catherine Hogg, Alastair Droop, Arief Gusnanto, Matthew A Care, Luisa Cutillo, David R Westhead, Susan C Short, Michael D Jenkinson, Andrew Brodbelt, Aruna Chakrabarty, Azzam Ismail, Roel G W Verhaak, Lucy F Stead

Faculty Research 2024

BACKGROUND: Glioblastoma (GBM) brain tumors lacking IDH1 mutations (IDHwt) have the worst prognosis of all brain neoplasms. Patients receive surgery and chemoradiotherapy but tumors almost always fatally recur.

RESULTS: Using RNA sequencing data from 107 pairs of pre- and post-standard treatment locally recurrent IDHwt GBM tumors, we identify two responder subtypes based on longitudinal changes in gene expression. In two thirds of patients, a specific subset of genes is upregulated from primary to recurrence (Up responders), and in one third, the same genes are downregulated (Down responders), specifically in neoplastic cells. Characterization of the responder subtypes indicates subtype-specific adaptive treatment …

Small Polymorphisms Are A Source Of Ancestral Bias In Structural Variant Breakpoint Placement., Peter A Audano, Christine R Beck

Faculty Research 2024

High-quality genome assemblies and sophisticated algorithms have increased sensitivity for a wide range of variant types, and breakpoint accuracy for structural variants (SVs, ≥50 bp) has improved to near base pair precision. Despite these advances, many SV breakpoint locations are subject to systematic bias affecting variant representation. To understand why SV breakpoints are inconsistent across samples, we reanalyzed 64 phased haplotypes constructed from long-read assemblies released by the Human Genome Structural Variation Consortium (HGSVC). We identify 882 SV insertions and 180 SV deletions with variable breakpoints not anchored in tandem repeats (TRs) or segmental duplications (SDs). SVs called from aligned …

5 Million Global Downloads: Expanding The Reach & Impact Of The University Of Northern Iowa, University Of Northern Iowa. Rod Library.

Library Documents & Reports (entire collection)

UNI ScholarWorks, UNI’s institutional repository, reached 5 million global downloads! Our repository showcases the knowledge, creativity and innovative spirit of UNI. UNI ScholarWorks demonstrates the reach and impact of campus departments and programs on a global platform. Works by UNI authors are being used to help solve global society issues and problems. The repository contains over 43,500 works and receives over 1 million downloads per year. The top downloaded work is a student article, “Factors Affecting Economic Growth in Developing Countries” (Major Themes in Economics), by Parash Upreti, with over 73,000 downloads. The Graduate College …

Genomemuster Mouse Genetic Variation Service Enables Multitrait, Multipopulation Data Integration And Analysis., Robyn L Ball, Molly A. Bogue, Hongping Liang, Anuj Srivastava, David G Ashbrook, Anna Lamoureux, Matthew Gerring, Alexander S Hatoum, Matthew J Kim, Hao He, Jake Emerson, Alexander Berger, David O Walton, Keith Sheppard, Baha El Kassaby, Francisco Castellanos, Govindarajan Kunde-Ramamoorthy, Lu Lu, John Bluis, Sejal Desai, Beth A. Sundberg, Gary Peltz, Zhuoqing Fang, Gary Churchill, Robert W Williams, Arpana Agrawal, Carol J Bult, Vivek M. Philip, Elissa J Chesler

Faculty Research 2024

Hundreds of inbred mouse strains and intercross populations have been used to characterize the function of genetic variants that contribute to disease. Thousands of disease-relevant traits have been characterized in mice and made publicly available. New strains and populations including consomics, the collaborative cross, expanded BXD, and inbred wild-derived strains add to existing complex disease mouse models, mapping populations, and sensitized backgrounds for engineered mutations. The genome sequences of inbred strains, along with dense genotypes from others, enable integrated analysis of trait-variant associations across populations, but these analyses are hampered by the sparsity of genotypes available. Moreover, the data are …

Advancing Cr(Vi) Electroreduction: A Redox Mediator To Catalyze The Electrochemical Reduction Of Cr(Vi) In Water While Preventing Fouling Of Carbon Electrodes, Callie M. Stern, Malithi M. Abeythunga, Noémie Elgrishi

Faculty Publications

Hexavalent chromium is a contaminant of concern and is found in drinking water supplies. Electrochemical methods are well-suited to accomplish the reduction of toxic Cr(VI) to Cr(III). However, high overpotentials and plating of Cr(III) products on electrodes have stymied the development of efficacious purification methods. The Cr(VI) reduction reaction necessitates the transfer of multiple protons and electrons, which is accompanied by a high kinetic barrier. Following recent advances in the electrocatalytic energy storage community, we report that the use of [Fe(CN)6]^3- as a small molecular electrocatalyst not only diminishes the overpotential for Cr(VI) reduction on carbon electrodes by 0.575 …

Artificial Intelligence-Based Evaluation Of The Factors Affecting The Sales Of An Iron And Steel Company, Mehmet Pekkaya, Zafer Uysal, Aytaç Altan, Seçkin Karasu

Turkish Journal of Electrical Engineering and Computer Sciences

It is important to predict the sales of an iron and steel company and to identify the variables that influence these sales for future planning. The aim in this study was to identify and model the key factors that influence the sales volume of an iron and steel company using artificial neural networks (ANNs). We attempted to obtain an integrated result from the performance/sales levels of 5 models, to use the ANN approach with hybrid algorithms, and also to present an exemplary application in the base metals industry, where there is a limited number of studies. This study contributes to …

A Descriptive Study Of Namibian Child Sex Offenders, Ndeyapo Emma Nafuka

Walden Dissertations and Doctoral Studies

The sexual abuse of children is a worldwide traumatic event with potential for adverse long-term physical and psychological consequences. There has been a plethora of research in the Western societies that examined offenders of child sexual abuse. Due to a number of methodological limitations, the findings of these studies cannot be used to effectively explain African offenders of child sexual abuse. This study employed a quantitative non-experimental, descriptive research approach method to examine the demographic and criminological characteristics of adult men who sexually abused children in Namibia. The data were collected by reviewing 183 files of Namibian male offenders incarcerated …

High-Sensitivity Cardiac Troponins I And T And Cardiovascular Outcomes: Findings From The Systolic Blood Pressure Intervention Trial (Sprint), Xiaoming Jia, Vijay Nambi, Jarett D Berry, Djhenne Dalmacy, Simon B Ascher, Addison A Taylor, Ron C Hoogeveen, James A De Lemos, Christie M Ballantyne

Faculty, Staff and Students Publications

Background: Cardiac troponins are associated with adverse cardiovascular disease (CVD) outcomes. The value of high-sensitivity cardiac troponin I (hs-cTnI) independently and in concert with troponin T (hs-cTnT) in the management of hypertension has not been well studied.

Methods: We assessed the utility of hs-cTnI independently and with hs-cTnT in identifying the highest risk individuals in the Systolic Blood Pressure Intervention Trial (SPRINT). Among 8796 eligible SPRINT participants, hs-cTnI was measured at baseline and 1 year. The association of baseline level and 1-year change in hs-cTnI with CVD events and all-cause death was evaluated using adjusted Cox regression models. We further …

An Excitatory Projection From The Basal Forebrain To The Ventral Tegmental Area That Underlies Anorexia-Like Phenotypes, Jing Cai, Yanyan Jiang, Yuanzhong Xu, Zhiying Jiang, Claire Young, Hongli Li, Joshua Ortiz-Guzman, Yizhou Zhuo, Yulong Li, Yong Xu, Benjamin R Arenkiel, Qingchun Tong

Faculty, Staff and Students Publications

Maladaptation in balancing internal energy needs and external threat cues may result in eating disorders. However, brain mechanisms underlying such maladaptations remain elusive. Here, we identified that the basal forebrain (BF) sends glutamatergic projections to glutamatergic neurons in the ventral tegmental area (VTA) in mice. Glutamatergic neurons in both regions displayed correlated responses to various stressors. Notably, in vivo manipulation of BF terminals in the VTA revealed that the glutamatergic BF → VTA circuit reduces appetite, increases locomotion, and elicits avoidance. Consistently, activation of VTA glutamatergic neurons reduced body weight, blunted food motivation, and caused hyperactivity with behavioral signs of …

2024-02-07 Message From The President, Morehead State University. Office Of The President.

Staff Congress Records

Message sent by the President to the campus community regarding upcoming dates, congratulatory recognitions, Board of Regents meeting summary, college and departmental reorganization, and campus renovations on February 7, 2024.

Transcription Factor Bach1 In Cancer: Roles, Mechanisms, And Prospects For Targeted Therapy, Dian Hu, Zerui Zhang, Xiangyuan Luo, Siwen Li, Junqing Jiang, Jiaqian Zhang, Zhangfan Wu, Yijun Wang, Mengyu Sun, Xiaoping Chen, Bixiang Zhang, Xiao Xu, Shuai Wang, Shengjun Xu, Yufei Wang, Wenjie Huang, Limin Xia

Faculty, Staff and Student Publications

Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates epigenetic modifications, heme homeostasis, and oxidative stress. Additionally, it is involved in immune system development. More importantly, BACH1 is highly expressed in and plays a key role in numerous malignant tumors, affecting cellular metabolism, tumor invasion and metastasis, proliferation, different cell death pathways, drug resistance, and the tumor microenvironment. However, few articles systematically summarized the roles of BACH1 in cancer. This review aims to highlight the research status …

Digital Commons And Open Access: Utilizing Digitalcommons@Uno And Uno's Open Access Publishing Agreements To Make Your Work Open And Accessible, Jennie Tobler-Gaston

Criss Library Faculty Proceedings & Presentations

This presentation covered the University of Nebraska at Omaha's institutional repository, DigitalCommons@UNO, the basics and different types of Open Access and this many open access publishing agreements available for UNO authors.

How Does Covid-19 Vaccination Affect Long-Covid Symptoms?, Ali Akbar Asadi-Pooya, Meshkat Nemati, Mina Shahisavandi, Hamid Nemati, Afrooz Karimi, Anahita Jafari, Sara Nasiri, Seyyed Saeed Mohammadi, Zahra Rahimian, Hossein Bayat, Ali Akbari, Amir Emami, Owrang Eilami

Department of Neurology Faculty Papers

OBJECTIVE: The current study aimed to identify the association between COVID-19 vaccination and prolonged post-COVID symptoms (long-COVID) in adults who reported suffering from this condition.

METHODS: This was a retrospective follow-up study of adults with long-COVID syndrome. The data were collected during a phone call to the participants in January-February 2022. We inquired about their current health status and also their vaccination status if they agreed to participate.

RESULTS: In total, 1236 people were studied; 543 individuals reported suffering from long long- COVID (43.9%). Chi square test showed that 15 out of 51 people (29.4%) with no vaccination and 528 …

The Bg News February 7, 2024, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 07, 2024. Volume 103-Issue 16.

Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu, Emma Adhikari, Daniel K Lester, Bin Fang, Joseph O Johnson, Yijun Tian, Andrea T Mockabee-Macias, Victoria Izumi, Kelly M Guzman, Michael G White, John M Koomen, Jennifer A Wargo, Jane L Messina, Jianfei Qi, Eric K Lau

Faculty, Staff and Student Publications

Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mechanisms underlying these sex-associated discrepancies are poorly defined. Here, we delineate a previously undisclosed mechanism by which androgen-activated AR transcriptionally upregulates fucosyltransferase 4 (FUT4) expression, which drives melanoma invasiveness by interfering with adherens junctions (AJs). Global phosphoproteomic and fucoproteomic profiling, coupled with in vitro and in vivo functional validation, further reveal that AR-induced FUT4 fucosylates L1 cell adhesion molecule (L1CAM), which is required for FUT4-increased metastatic …

Diaphragmatic Breathing Influences Recovery Metrics After Aerobic Exercise, Trace L. Cruz

Masters Theses

Recovery from aerobic exercise is multifaceted and highly complex. Recovery includes cellular repair, substrate availability, autonomic nervous system status, and many other factors that comprise homeostasis. The present study is designed to assess the influence of diaphragmatic breathing after aerobic exercise to exhaustion. Diaphragmatic breathing is deep rhythmical breathing that is known to influence the autonomic nervous system, specifically through cranial nerve X (Vagus nerve). Subjects (n=12, age = 22.3±1.15 years old, height = 67.882.17 inches, weight =154.4515.20 pounds, BF% = 15.785.43). Performed four VO2max tests on two different days (2 each day). On each day, subjects performed a 20:00 …

Meet The Spring '24 B Impact Clinic Cohort, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

Revolutionizing Psoriasis Topical Treatment: Enhanced Efficacy Through Ceramide/Phospholipid Composite Cerosomes Co-Delivery Of Cyclosporine And Dithranol: In-Vitro, Ex-Vivo, And In-Vivo Studies, Sammar F. Elhabal, Nashwa Abdelaal, Saeed A.S. Al-Zuhairy, Mohamed F. Mohamed Elrefai, Mohamed M. Khalifa, Mohammad A. Khasawneh, Ahmed M. Elsaid Hamdan, Passant M. Mohie, Rania A. Gad, Soad L. Kabil, Mohamed K. El-Ashery, Bhaskara R. Jasti, Nahla A. Elzohairy, Nehal Elfar, Tayseer Elnawawy, Fatma E. Hassan, Mohamed A. El-Nabarawi

Pacific Faculty Work

Purpose: Improving the treatment of psoriasis is a serious challenge today. Psoriasis is an immune-mediated skin condition affecting 125 million people worldwide. It is commonly treated with cyclosporine-A (CsA) and dithranol (DTH). CsA suppresses the activation of T-cells, immune cells involved in forming psoriatic lesions. Meanwhile, DTH is a potent anti-inflammatory and anti-proliferative drug that effectively reduces the severity of psoriasis symptoms such as redness, scaling, and skin thickness. CsA and DTH belong to BCS class II with limited oral bioavailability. We aim to develop a drug delivery system for topical co-delivery of CsA and DTH, exploring its therapeutic potential. …

A Review Of Current And Pipeline Drugs For Treatment Of Melanoma, Nicole Natarelli, Sarah J. Aleman, Isabella M. Mark, Jasmine T. Tran, Sean Kwak, Elizabeth Botto, Shaliz Aflatooni, Michael J. Diaz, Shari R. Lipner

School of Medicine Faculty Publications

Malignant melanoma is the most aggressive form of skin cancer. Standard treatment options include surgery, radiation therapy, systemic chemotherapy, targeted therapy, and immunotherapy. Combining these modalities often yields better responses. Surgery is suitable for localized cases, sometimes involving lymph node dissection and biopsy, to assess the spread of the disease. Radiation therapy may be sometimes used as a standalone treatment or following surgical excision. Systemic chemotherapy, while having low response rates, is utilized as part of combination treatments or when other methods fail. The development of resistance to systemic chemotherapies and associated side effects have prompted further research and clinical …

Validation Of A Novel, Rapid Sepsis Diagnostic For Emergency Department Use, Hollis R. O'Neal, Roya Sheybani, David R. Janz, Robert Scoggins, Tonya Jagneaux, James E. Walker, Daniel J. Henning, Elizabeth Rosenman, Simon A. Mahler, Hariharan Regunath, Christopher S. Sampson, D. Clark Files, Richard D. Fremont, Michael J. Noto, Erica E. Schneider, Wesley R. Shealey, Matthew S. Berlinger, Thomas C. Carver, Morgan K. Walker, Nathan A. Ledeboer, Ajay M. Shah, Henry T.K. Tse, Dino Dicarlo, Todd W. Rice, Christopher B. Thomas

School of Medicine Faculty Publications

OBJECTIVES: To assess the in vitro IntelliSep test, a microfluidic assay that quantifies the state of immune activation by evaluating the biophysical properties of leukocytes, as a rapid diagnostic for sepsis. DESIGN: Prospective cohort study. SETTING: Five emergency departments (EDs) in Louisiana, Missouri, North Carolina, and Washington. PATIENTS: Adult patients presenting to the ED with signs (two of four Systemic Inflammatory Response Syndrome criteria, where one must be temperature or WBC count) or suspicion (provider-ordered culture) of infection. INTERVENTIONS: All patients underwent testing with the IntelliSep using ethylene diamine tetraacetic acid-anticoagulated whole blood followed by retrospective adjudication for sepsis by …

Assessing Adequacy: A Meta-Analysis Of Rapid Onsite Evaluation Of Thyroid Nodules, Peter P. Issa, Christina Mccarthy, Mohammad Hussein, Aaron L. Albuck, Essam Emad, Mohamed Shama, Krzysztof Moroz, Eman Toraih, Emad Kandil

School of Medicine Faculty Publications

Introduction: Fine-needle aspiration (FNA) is the standard form of preoperative evaluation of thyroid nodule cytological status. A significant number FNAs are classified as inadequate for interpretation, requiring a repeat FNA which is potentially avoidable, costly, and delays treatment. To address these concerns and maximize first-time FNA adequacy, rapid onsite evaluation (ROSE) of FNA specimens was introduced. Our study aims to determine the impact of ROSE on FNA adequacy. Methods: PubMed, Embase, and Web of Science were searched for primary articles assessing the adequacy of ROSE in thyroid nodules. Results: A total of 17 studies were included for a total of …

Student Success Through First-Year Experience Programs: A Transcendental Phenomenological Study, Jeffrey Scott Downs

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to describe the persistence and retention after the First Year Experience (FYE) program for second-year college students at Northern Nevada College. The theory guiding this study is Astin’s student involvement theory which links student success in college to the level of involvement students have at their academic institution. This study explores how first-time full-time students being part of the FYE program have been encouraged to be involved at their institution on several levels. In this transcendental phenomenological study, data were collected using interviews, a focus group, and journaling prompts. After the data were …

Some Aspects Of The Theology Of The City In Ane Literature And Biblical Protology And Eschatology: A Comparative Study, Vlatko Dir

Doctoral Dissertations and Projects

The city is an essential accomplishment that is embedded in the foundations of human civilization. From its mature appearance in Sumer and its developed forms throughout the ANE world, the city held a high place in cosmology, cosmogony, and anthropogony. The ideology and theology of the city created by the ANE peoples were built around and presented through the interplay of the triangle of influences and dependencies formed by the city, the temple, and kingship in conjunction with the gods. The question is whether the same construct is ingeminated in the Bible. This dissertation strives to provide an appropriate context …

Does Intergenerational Trauma Influence Growth Or Fixed Mindset Among Ethnic Minorities?, Kevin Ladunn Thomas

Doctoral Dissertations and Projects

Intergenerational trauma is a phenomenon commonly experienced by ethnic minorities in the United States. This type of trauma can profoundly affect individuals, families, and communities. Despite the prevalence and importance of intergenerational trauma, little research has investigated the link between intergenerational trauma and individuals’ mindsets. Therefore, the purpose of this qualitative descriptive study was to understand the perceptions, experiences, and beliefs of ethnic minorities with intergenerational trauma regarding fixed and growth mindsets. The theory guiding this study was Carol Dweck’s mindset theory. To assess the influence of intergenerational trauma on ethnic minorities’ mindsets, 12 individuals from ethnic minority backgrounds were …

Gender Differences In Compassion Fatigue And Burnout Among Sheriff's Deputies, Charity Creech

Doctoral Dissertations and Projects

Law enforcement has a long and sordid history with mental health. Recently researchers have begun to dissect the effect of professional and occupational stressors on LEOs. I focused on secondary constructs, compassion fatigue and burnout, that contribute to mental health concerns. Compassion fatigue (CF) and burnout (BO) have been studied most thoroughly in medical settings, but less so in law enforcement settings. While most researchers study law enforcement as a genderless mass, I hypothesized that there is a gender difference in burnout and compassion fatigue levels among Sheriff Deputies (SD). Research aimed to identify how gender differences can contribute to …

A Phenomenological Study Of The Lived Experiences Of Mainstream Classroom Teachers And Overly Active, Distracted Students, Elizabeth I. Minney

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to explore those lived experiences that predispose some mainstream elementary teachers to initially modify in-classroom instruction to meet the needs of their overly active, distracted students before referring them for an ADHD evaluation. Bandura’s (1977) social learning theory was the lens through which this study was examined. In essence, social learning theory suggests that individuals learn what they know and how they should act through formal and informal interactions with others. The central research question around which this study revolved was: What are the lived experiences of mainstream classroom teachers who prefer …

Machine Learning Approaches In Comparative Studies For Alzheimer’S Diagnosis Using 2d Mri Slices, Zhen Zhao, Joon Huang Chuah, Chee-Onn Chow, Kaijian Xia, Yee Kai Tee, Yan Chai Hum, Khin Wee Lai

Turkish Journal of Electrical Engineering and Computer Sciences

Alzheimer’s disease (AD) is an illness that involves a gradual and irreversible degeneration of the brain. It is crucial to establish a precise diagnosis of AD early on in order to enable prompt therapies and prevent further deterioration. Researchers are currently focusing increasing attention on investigating the potential of machine learning techniques to simplify the automated diagnosis of AD using neuroimaging. The present study involved a comparison of models for the detection of AD through the utilization of 2D image slices obtained from magnetic resonance imaging brain scans. Five models, namely ResNet, ConvNeXt, CaiT, Swin Transformer, and CVT, were implemented …

Spectrum, Volume 52, Issue 2, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: The Results are in: Student Government Election - SHU's New Distillation Science Certificate Program - Chi-O Goes to Chicago for Leadership Training - FTMA at Sundance - A Heartfelt Impact: Social Work Club - Need to Get Your Nails Done? - Meet 2026 Snowboard Hopeful and SHU Student, Joey Okesson - navigating the News: A Guide to Staying Informed in a Digital Age - Bat Boy Signing at the Edgerton - SHU Celebrates Black History Month - Women's Basketball Leading the NEC

Iwu One Of 14 Institutions Selected For Prestigious Beckman Scholars Program, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Aspscr1-Tfe3 Reprograms Transcription By Organizing Enhancer Loops Around Hexameric Vcp/P97, Amir Pozner, Li Li, Shiv Prakash Verma, Shuxin Wang, Jared J Barrott, Mary L Nelson, Jamie S E Yu, Gian Luca Negri, Shane Colborne, Christopher S Hughes, Ju-Fen Zhu, Sydney L Lambert, Lara S Carroll, Kyllie Smith-Fry, Michael G Stewart, Sarmishta Kannan, Bodrie Jensen, Cini M John, Saif Sikdar, Hongrui Liu, Ngoc Ha Dang, Jennifer Bourdage, Jinxiu Li, Jeffery M Vahrenkamp, Katelyn L Mortenson, John S Groundland, Rosanna Wustrack, Donna L Senger, Franz J Zemp, Douglas J Mahoney, Jason Gertz, Xiaoyang Zhang, Alexander J Lazar, Martin Hirst, Gregg B Morin, Torsten O Nielsen, Peter S Shen, Kevin B Jones

Faculty, Staff and Student Publications

The t(X,17) chromosomal translocation, generating the ASPSCR1::TFE3 fusion oncoprotein, is the singular genetic driver of alveolar soft part sarcoma (ASPS) and some Xp11-rearranged renal cell carcinomas (RCCs), frustrating efforts to identify therapeutic targets for these rare cancers. Here, proteomic analysis identifies VCP/p97, an AAA+ ATPase with known segregase function, as strongly enriched in co-immunoprecipitated nuclear complexes with ASPSCR1::TFE3. We demonstrate that VCP is a likely obligate co-factor of ASPSCR1::TFE3, one of the only such fusion oncoprotein co-factors identified in cancer biology. Specifically, VCP co-distributes with ASPSCR1::TFE3 across chromatin in association with enhancers genome-wide. VCP presence, its hexameric assembly, and its …