Digital Commons Network^™

Preliminary Results: Complementary C4:C3 Grazing Systems, M. Berry, P. Keyser, S. Jagadamma, H. Nauman, K. Coffey, C. Nieman, P. Owens, A. Ashworth, E. Bisangwa

IGC Proceedings (1977-2023)

Native warm-season grasses (NWSG) can produce high quality forage and high rates of gain for beef cattle. However, little data is available on how NWSG affect the productivity of cow-calf operations on a farm scale. Therefore, we implemented an experiment at three sites, Booneville, AR, Linneus, MO and Louisville, TN, with cow-calf pairs (mature cows over ≥ 3 years old, spring calving). We evaluated two forage systems that mix either a drought or drought/flood tolerant native C₄ species [big bluestem (BB) blend or eastern gamagrass (EG)] with a cool-season perennial, tall fescue (TF), and compared them to the most …

Fodder Scenario And Hortipastoral Opportunities To Enhance Fodder Production In India, Nagaratna Biradar, C. Lakshmi Devi, Vinod Kumar, Narendra S. Kulkarni, G. K. Kumar Anil, S. S. Guledagudda, A. Bheemappa

IGC Proceedings (1977-2023)

Food grain production and livestock production are closely related in India as crop-residue forms the major source of fodder for livestock. It’s thus assumed that increase in food grain production has positive effect on availability of dry matter to the livestock. Using land use classification, crop production (2015 to 2020) and livestock census (2019) data, dry matter (DM) availability for livestock for 28 states of India was estimated. Hortipastoral opportunities by estimating area available under orchards in southern India were done to assess the possibility of introducing fodder crops in orchards. Some of the fodder crops were introduced in orchards …

Productivity And Variability Of Pastures And Cover Crops In Lowland Rice-Pasture Rotations In Uruguay, Walter Ayala, J. Terra

IGC Proceedings (1977-2023)

No abstract provided.

Calming The Body, Calming The Mind: A Pilot Study On The Use Of Zero Balancing To Reduce Anxiety, Misty L. Rhoads, Mary Murphy

Journal of Transformative Touch

Background: The predominance of anxiety is currently at record levels, and the need for non-pharmaceutical approaches to help alleviate and decrease the harmful effects of anxiety on an individual and collective level is necessary. This study explored how Zero Balancing supports individuals with anxiety to manage their physical, mental, and emotional health more effectively. Researchers hypothesized that Zero Balancing would lower the perceived severity of general anxiety and lower perceived anxiety symptoms.

Methods: To honor the holistic nature of bodywork and the participants' lived experiences, the researchers utilized a concurrent mixed-methods phenomenological research design. Each participant received one Zero Balancing …

The Bison, February 9, 2024

The Bison Newspapers

No abstract provided.

Differing Radiation Exposure In Scrub Technicians And Rotating Staff In Cardiac Catheterization Laboratory: Occupation Matters, Nasir Rahman, Maleeha Javed, Ghufran Adnan, Maria Khan, Zeenat Nizar, Izat Shah

Section of Cardiology

Background: Radiation exposure is a significant hazard associated with invasive Cardiology, with most studies based on primary operator exposure. This prospective, observational study aimed to find out over lead radiation exposure as effective dose acquired by non-physician staff comprising scrub technicians and rotating staff in the cath laboratory. Effective dose (ED) measured per procedure via Raysafe i2®dosimeter badges worn by both rotating staff and scrub technicians over lead aprons along with dose area product (DAP), fluoroscopy time (FT) and procedure time (PT) in minutes was collected prospectively over forty-six invasive Cardiology procedures.
Results: This study shows that rotating staff acquire …

Enhancing The Career Exploration Of Undergraduate Students At A Public, Hispanic-Serving Institution: The Élite Career Mentoring Program, Laura De Lorenzo Barrios

HSC Education Days

No abstract provided.

Analysis Of Us Food And Drug Administration New Drug And Biologic Approvals, Regulatory Pathways, And Review Times, 1980–2022, Enrique Seoane-Vazquez, Rosa Rodriguez-Monguio, John H. Powers Iii

Pharmacy Faculty Articles and Research

U.S. laws enacted since 1983 have aimed to enhance the development and marketing of new pharmaceutical products. We thoroughly characterized all new molecular entities, therapeutic biologics, and gene and cell therapies approved by the US Food and Drug Administration (FDA) during the period 1980–2022 in the context of these laws and regulations. Throughout the study period, the FDA approved 1355 new pharmaceutical products. The median FDA review time decreased from 26.6 months prior to the Prescription Drug User Fee Act (1992), which authorized the FDA to collect fees from drug companies to 9.9 months after the Food and Drug Administration …

Ani171.1 Foundations Of Computer Graphics: Micro Production Example 1, Sae University College

Exemplars

ANI171 Project 1 Exemplar

Perceptions Of Burden Among Informal Caregivers Of Older Adults In Assisted Living, Gösta H W Schlegel

Walden Dissertations and Doctoral Studies

Few studies have focused on the lived experiences of informal caregivers of residents of assisted living facilities (ALFs) and their perceptions of their caregiver burden, which can lead to decreased physical and mental health, decreased economic status, and negative effects on the care recipient’s wellbeing. A considerable knowledge and practice gap remains regarding how public health practitioners relate to informal caregiving. The purpose of this study was to understand what informal caregivers of ALF residents perceive as factors that affect their caregiver burden and the perceived impact caregiver burden has on the caregiver and their eldercare recipient. The social-ecological model …

Design, Synthesis, X-Ray Crystallography, And Biological Activities Of Covalent, Non-Peptidic Inhibitors Of Sars-Cov-2 Main Protease, Md Ashraf-Uz-Zaman, Teck Khiang Chua, Xin Li, Yuan Yao, Bala Krishna Moku, Chandra Bhushan Mishra, Vasanthi Avadhanula, Pedro A Piedra, Yongcheng Song

Faculty, Staff and Students Publications

Highly contagious SARS-CoV-2 coronavirus has infected billions of people worldwide with flu-like symptoms since its emergence in 2019. It has caused deaths of several million people. The viral main protease (Mpro) is essential for SARS-CoV-2 replication and therefore a drug target. Several series of covalent inhibitors of Mpro were designed and synthesized. Structure-activity relationship studies show that 1) several chloroacetamide- and epoxide-based compounds targeting Cys145 are potent inhibitors with IC50 values as low as 0.49 μM, and 2) Cys44 of Mpro is not nucleophilic for covalent inhibitor design. High resolution X-ray studies revealed the protein-inhibitor interactions and mechanisms of inhibition. …

Historical Analysis Of Urban Dust Generated By The Great Salt Lake Playa, Callum Flowerday, Jaron C. Hansen, Rebekah Stanley, Kaitlyn Brewster

ScholarsArchive Data

Historical PM10 filters, provided by the Utah Division of Air Quality, were analyzed for elemental composition of various metals. This was done using ICP-MS.

Also included, EPA PM10 historical data and bathymetry data provided by the Utah USGS.

Metabolic Stability And Metabolite Identification Of N-Ethyl Pentedrone Using Rat, Mouse And Human Liver Microsomes, Alexandre Barcia Godoi, Natalícia De Jesus Antunes, Kelly Francisco Cunha, Aline Franco Martins, Marilyn A. Huestis, Jose Luiz Costa

Institute of Emerging Health Professions Faculty Papers

New Psychoactive Substances (NPSs) are defined as a group of substances produced from molecular modifications of traditional drugs. These molecules represent a public health problem since information about their metabolites and toxicity is poorly understood. N-ethyl pentedrone (NEP) is an NPS that was identified in the illicit market for the first time in the mid-2010s, with four intoxication cases later described in the literature. This study aims to evaluate the metabolic stability of NEP as well as to identify its metabolites using three liver microsomes models. To investigate metabolic stability, NEP was incubated with rat (RLM), mouse (MLM) and human …

Luminal Transport Through Intact Endoplasmic Reticulum Limits The Magnitude Of Localized Ca2+ Signals, Laura M. Westrate, Cécile C. Crapart, Zubenelgenubi C. Scott, Tasuku Konno, Aman Sharma, Pierre Parutto, David M. D. Bailey, Edward Avezov, Elena F. Koslover

University Faculty Publications and Creative Works

The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching throughout the cell. Understanding how ER functionality relies on its structural organization is crucial for elucidating cellular vulnerability to ER perturbations, which have been implicated in several neuronal pathologies. One of the key functions of the ER is enabling Ca2+ signaling by storing large quantities of this ion and releasing it into the cytoplasm in a spatiotemporally controlled manner. Through a combination of physical modeling and live-cell imaging, we demonstrate that alterations in ER shape significantly impact its ability to support efficient local Ca2+ releases, due to hindered transport …

Pisa Printing Microneedles With Controllable Aqueous Dissolution Kinetics, Aaron Priester, Jimmy Yeng, Yuwei Zhang, Krista Hilmas, Risheng Wang, Anthony J. Convertine

Chemistry Faculty Research & Creative Works

This study focused on the development of high-resolution polymeric structures using polymer-induced self-assembly (PISA) printing with commercially available digital light-processing (DLP) printers. Significantly, soluble solids could be 3D-printed using this methodology with controllable aqueous dissolution rates. This was achieved using a highly branched macrochain transfer agent (macro-CTA) containing multiple covalently attached CTA groups. In this work, the use of acrylamide as the self-assembling monomer in isopropyl alcohol was explored with the addition of N-(butoxymethyl)acrylamide to modulate the aqueous dissolution kinetics. PISA-printed microneedles were observed to have feature sizes as small as 27 μm, which was close to the resolution limit …

Sox On Tumors, A Comfort Or A Constraint?, Junqing Jiang, Yufei Wang, Mengyu Sun, Xiangyuan Luo, Zerui Zhang, Yijun Wang, Siwen Li, Dian Hu, Jiaqian Zhang, Zhangfan Wu, Xiaoping Chen, Bixiang Zhang, Xiao Xu, Shuai Wang, Shengjun Xu, Wenjie Huang, Limin Xia

Faculty, Staff and Student Publications

The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role in determining cell fate, the dysregulation of SOX family members is closely associated with tumorigenesis, including tumor invasion, metastasis, proliferation, apoptosis, epithelial-mesenchymal transition, stemness and drug resistance. Despite considerable research to investigate the mechanisms and functions of the SOX family, confusion remains regarding aspects such as the role of the SOX family in tumor immune microenvironment (TIME) and contradictory impacts the SOX family exerts on tumors. This review summarizes …

Functional Epas1/ Hif2a Missense Variant Is Associated With Hematocrit In Andean Highlanders, Elijah S Lawrence, Wanjun Gu, Ryan J Bohlender, Cecilia Anza-Ramirez, Amy M Cole, James J Yu, Hao Hu, Erica C Heinrich, Katie A O'Brien, Carlos A Vasquez, Quinn T Cowan, Patrick T Bruck, Kysha Mercader, Mona Alotaibi, Tao Long, James E Hall, Esteban A Moya, Marco A Bauk, Jennifer J Reeves, Mitchell C Kong, Rany M Salem, Gustavo Vizcardo-Galindo, Jose-Luis Macarlupu, Rómulo Figueroa-Mujíca, Daniela Bermudez, Noemi Corante, Eduardo Gaio, Keolu P Fox, Veikko Salomaa, Aki S Havulinna, Andrew J Murray, Atul Malhotra, Frank L Powel, Mohit Jain, Alexis C Komor, Gianpiero L Cavalleri, Chad D Huff, Francisco C Villafuerte, Tatum S Simonson

Faculty, Staff and Student Publications

Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. EPAS1, a notable target of hypoxia adaptation, is associated with relatively lower hemoglobin concentration in Tibetans. We provide evidence for an association between an adaptive EPAS1 variant (rs570553380) and the same phenotype of relatively low hematocrit in Andean highlanders. This Andean-specific missense variant is present at a modest frequency in Andeans and absent in other human populations and vertebrate species except the coelacanth. CRISPR-base-edited human cells with this variant exhibit shifts in hypoxia-regulated gene expression, while metabolomic analyses reveal both genotype and phenotype associations …

Thematic Analysis Through Artificial Intelligence (Ai), Prokopis A. Christou Phd

The Qualitative Report

Thematic analysis, a well-enforced qualitative analytic method, is likely to continue evolving with the adoption of AI technologies. This how-to report does not delve into the details of thematic analysis itself, as there are ample existing studies on the topic. Instead, it acknowledges the potential impacts, dynamics, and pitfalls of AI in thematic analysis while offering valuable advice, particularly for novice analysts, on how to incorporate and document AI tools in each phase of a thematic analysis. The author underscores the importance of not allowing AI to overshadow the analyst's critical evaluative and interpretive skills but instead supporting the use …

Draft Genome Of Staphylococcus Capitis O112, Isolated From The Cheek Swab Of A Healthy Female, Sandra Jablonska, Alex Kula, Catherine Putonti

Biology: Faculty Publications and Other Works

Staphylococcus capitis is a Gram-positive bacterium that is part of the normal human flora, found in multiple anatomical sites. Here, we present the 2.5-Mbp draft genome of S. capitis O112, isolated from a cheek swab collected from a healthy female.

Comprehensive Landscape Of Braf Variant Classes, Clonalities, And Co-Mutations In Metastatic Colorectal Cancer Using Ctdna Profiling, Benny Johnson, Van Morris, Xuemei Wang, Arvind Dasari, Kanwal Raghav, John Paul Shen, Michael S Lee, Ryan Huey, Christine Parseghian, Jason Willis, Robert Wolff, Leylah M Drusbosky, Michael J Overman, Scott Kopetz

Faculty, Staff and Student Publications

Although V600E accounts for the majority of the BRAF mutations in metastatic colorectal cancer (mCRC), non-V600 BRAF variants have been shown in recent years to represent a distinct molecular subtype. This study provides a comprehensive profile of BRAF variants in mCRC using a large genomic database of circulating tumor DNA (ctDNA) and analyzing clinical outcomes in a cohort of patients with atypical (non-V600) BRAF variants (aBRAF; class II, class III, unclassified). Overall, 1733 out of 14,742 mCRC patients in the ctDNA cohort had at least one BRAF variant. Patients with atypical BRAF variants tended to be younger and …

An Observational Framework For Constructing Ozone Isopleths From Long-Term Monitoring Data: Demonstration In Salt Lake City, Utah, Callum Flowerday, Isaac Sudweeks, Brad Adams, Jaron C. Hansen

ScholarsArchive Data

EPA quality assured data, collected by the Utah Division of Air Quality, was used for this analysis.

Repeatability Of Beach Morphology Change Under Identical Wave Forcing, Chris E. Blenkinsopp, Alan J. Hunter, Tom E. Baldock, Paul M. Bayle, Judith Bosboom, Daniel Conley, Gerd Masselink

School of Biological and Marine Sciences

Laboratory investigations of beach morphology change under wave action are undertaken to gain insight into coastal processes, design coastal structures and validate the predictions of numerical models. For the results of such experiments to be reliable, it is necessary that they are repeatable. The equilibrium beach concept, that beach morphology will evolve to a quasi-static equilibrium shape for a given forcing suggests that experiments should be repeatable to some degree. However, sediment transport in turbulent breaking and broken waves is complex and highly variable and the level of repeatability at different temporal and spatial scales is challenging to measure, as …

A Scoping Review Of The Oral Health Status, Oral Health Behaviours And Interventions To Improve The Oral Health Of Children And Young People In Care And Care Leavers, Joelle Booth, Jo Erwin, Lorna Burns, Nick Axford, Jane Horrell, Hannah Wheat, Robert Witton, Jill Shawe, Janine Doughty, Sarah Kaddour, Skye Boswell, Urshla Devalia, Abigail Nelder, Martha Paisi

Peninsula Dental School

BACKGROUND: Children and young people (CYP) in care experience poorer physical health and overall wellbeing in comparison to their peers. Despite this, relatively little is known about what their oral health needs and behaviours are. The aim of this scoping review was to provide a global perspective on the oral health status and behaviours of CYP in care and care leavers. It also aimed to synthesise interventions that have been trialled in this population to improve oral health.

METHODS: Five databases were searched, Ovid Embase, Ovid MEDLINE, CINAHL (EBSCOhost), SocINDEX (EBSCOhost) and Dentistry and Oral Sciences Source (EBSCOhost), alongside grey …

Dose Tapering And Discontinuation Of Biologic Dmards In Axial Spondyloarthritis: A Narrative Review (2023 Spartan Annual Meeting Proceedings), Haseeb Chaudhary, Ansaam Daoud, Marina Magrey

Faculty Scholarship

Purpose of Review: Limited data is available for tapering or discontinuation of biologic therapy in patients with axSpA who are in disease remission. The current review concentrates on published studies regarding dose tapering or withdrawal of biologics in axSpA. Recent Findings: Recent evidence in light of randomized controlled trials suggests that tapering of b-DMARDs is a feasible strategy to maintain remission or low disease activity in axSpA patients. TNF inhibitors were the studied biologics in most of these trials. The disease flare rates were comparable to those maintained on standard dose in most of these studies, although with variable tapering …

Survivorship Care For Women Living With Ovarian Cancer: Protocol For A Randomized Controlled Trial, Elizabeth Kvale, Farya Phillips, Samiran Ghosh, Jayanthi Lea, Claire Hoppenot, Anthony Costales, Jan Sunde, Hoda Badr, Eberechi Nwogu-Onyemkpa, Nimrah Saleem, Rikki Ward, Bijal Balasubramanian

Faculty, Staff and Student Publications

BACKGROUND: Ovarian cancer ranks 12th in cancer incidence among women in the United States and 5th among causes of cancer-related death. The typical treatment of ovarian cancer focuses on disease management, with little attention given to the survivorship needs of the patient. Qualitative work alludes to a gap in survivorship care; yet, evidence is lacking to support the delivery of survivorship care for individuals living with ovarian cancer. We developed the POSTCare survivorship platform with input from survivors of ovarian cancer and care partners as a means of delivering patient-centered survivorship care. This process is framed by the chronic care …

Large Airway T Cells In Adults With Former Bronchopulmonary Dysplasia, Jing Gao, Petra Um-Bergström, Melvin Pourbazargan, Eva Berggren-Broström, Chuan X. Li, Heta Merikallio, Riitta Kaarteenaho, Nichole S. Reinke, Craig E. Wheelock, Erik Melén, Lindén Anders, Åsa M. Wheelock, Georgios Rassidakis, Cristian Ortiz-Villalon, Magnus C. Sköld

Research outputs 2022 to 2026

Background: Bronchopulmonary Dysplasia (BPD) in infants born prematurely is a risk factor for chronic airway obstruction later in life. The distribution of T cell subtypes in the large airways is largely unknown.

Objective: To characterize cellular and T cell profiles in the large airways of young adults with a history of BPD.

Methods: Forty-three young adults born prematurely (preterm (n = 20), BPD (n = 23)) and 45 full-term-born (asthma (n = 23), healthy (n = 22)) underwent lung function measurements, and bronchoscopy with large airway bronchial wash (BW). T-cells subsets in BW were analyzed by immunocytochemistry.

Results: The proportions …

Srf-Deficient Astrocytes Provide Neuroprotection In Mouse Models Of Excitotoxicity And Neurodegeneration, Surya Chandra Rao Thumu, Monika Jain, Sumitha Soman, Soumen Das, Vijaya Verma, Arnab Nandi, David H Gutmann, Balaji Jayaprakash, Deepak Nair, James P Clement, Swananda Marathe, Narendrakumar Ramanan

2020-Current year OA Pubs

Reactive astrogliosis is a common pathological hallmark of CNS injury, infection, and neurodegeneration, where reactive astrocytes can be protective or detrimental to normal brain functions. Currently, the mechanisms regulating neuroprotective astrocytes and the extent of neuroprotection are poorly understood. Here, we report that conditional deletion of serum response factor (SRF) in adult astrocytes causes reactive-like hypertrophic astrocytes throughout the mouse brain. These

Dieta Y Eficiencia Digestiva Del Lechosero Pechiblanco Saltator Orenocensis / Diet And Digestive Effi Ciency Of The Orinocan Saltator Saltator Orenocensis, María Alexandra García-Amado, Adriana Rodríguez-Ferraro, Carlos Bosque

Revista Venezolana de Ornitología

El objetivo de este estudio fue realizar una descripción de los hábitos y las preferencias alimenticias del Lechosero pechiblanco Saltator orenocensis en los llanos de Venezuela, así como estimar la tasa de ingesta, la eficiencia digestiva y los tiempos de retención del alimento en cautiverio utilizando dos dietas artificiales. En cuanto a la dieta natural, esta ave se alimenta principalmente de frutas, maduras e inmaduras (47%), flores y yemas florales (29,8%) y hojas y yemas foliares (11,9%). Al analizar el presupuesto de tiempo, las aves pasaron la mayor parte del tiempo (cerca del 40%) en reposo y sólo pasaron entre …

Impact Of Equine Interaction During Psychotherapy On Anxiety And Depression For Residential Treatment Program Patients Experiencing Substance Withdrawal, Molly M. Friend, Molly C. Nicodemus, Clay Cavinder, Caleb Lemley, Pauline Prince, Katherine A. Cagle-Holtcamp, Rebecca M. Swanson

People and Animals: The International Journal of Research and Practice

As incidences of substance use disorders (SUD) increase in the wake of the COVID-19 pandemic, there is a need for more effective treatment approaches. Further, treatment approaches currently available struggle to retain patients during the period of substance withdrawal in early treatment due to patients’ withdrawal symptoms including increased feelings of anxiety and depression. Withdrawal symptoms have been linked to dysregulated cortisol concentrations present in this period. Psychotherapy incorporating equine interaction (PIE) has emerged in other populations as a treatment that decreases cortisol concentrations and improves treatment retention. The present study investigated the impact of 4 weeks of PIE on …

“Here, Kitty, Kitty.” Community Perceptions Of Free-Roaming Cats: A Northern Canadian Case Study, Annie Booth, Ken Otter

People and Animals: The International Journal of Research and Practice

Free-roaming domestic cats (Felis catus) create controversy, due to their tendency to invade neighbors’ gardens, hunt wildlife, and create disturbances. Municipal governments are often under pressure to address concerns regarding free-roaming cats. As approximately 28% of the 8.8 million cats owned in Canada free-roam (are allowed outside unsupervised and unconstrained), understanding owner rationales for letting the cat out is important for officials tasked with addressing public concerns. In 2019, we studied attitudes toward cats within a north-central British Columbia, Canada, city. The rationales cat owners use to justify free-roaming, as well as their perceptions about the risks and …