Digital Commons Network^™

Forage Brassica Use In New Zealand And Australia Farming Systems, A. Dumbleton, H. G. Judson

IGC Proceedings (1977-2023)

Forage brassica, genus Brassica, are annual feed crops grown on farming enterprises throughout New Zealand and Australia. These crops provide a source of high-yielding, high-quality feed, which is particularly useful to complement pasture production during periods when pasture growth is reduced. There are six forage brassica species and subspecies of agricultural importance including bulb turnip, swede, kale, forage rape, leafy turnip, and raphanobrassica. All of these, as well as interspecific crosses and individual cultivars, offer a range of characteristics to fit various environmental and livestock production challenges. Consumption of forage brassica crops in ruminant animals may reduce methane emissions …

Machine Learning Model And Molecular Docking For Screening Medicinal Plants As Hiv-1 Reverse Transcriptase Inhibitors, Muthia Rahayu Iresha, Firdayani Firdayani, Agam Wira Sani, Nihayatul Karimah, Shelvi Listiana, Irfansyah Yudhi Tanasa, Arief Sartono, Ayu Masyita

Karbala International Journal of Modern Science

The human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) plays a significant role in viral replication and is one of the targets for anti-HIV. However, a mutation in viral strains rapidly developed the resistance of the com-pounds to the protein, reducing the effectiveness of the inhibitors. This work seeks to utilize machine learning-based quantitative structure-activity relationship (QSAR) analysis in combination with molecular docking simulations to forecast the presence of active compounds derived from medicinal plants. Specifically, the objective is to identify com-pounds that have the potential to operate as inhibitors of HIV-1 reverse transcriptase (RT), encompassing both wild-type and …

Petition To List The American Horseshoe Crab Under The U.S. Endangered Species Act As An Endangered Or Threatened Species And To Concurrently Designate Critical Habitat, Will Harlan, William Snape Iii, Soleil Gaylord

PEEL Faculty Scholarship

Pursuant to Section 4(b) of the Endangered Species Act (“ESA”), 16 U.S.C. § 1533(b); Section 553(e) of the Administrative Procedure Act, 5 U.S.C. § 553(e); and 50 C.F.R. § 424.14(a), the Center for Biological Diversity (Center, Petitioner) and its partners submit to the Secretary of Commerce and the National Oceanographic and Atmospheric Administration (NOAA) through the NOAA Fisheries a petition to list the American horseshoe crab (Limulus polyphemus) as threatened or endangered and to concurrently designate critical habitat.

Faculty Senate Executive Committee Agenda February 20, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Call to Order
• Approval of Minutes - January 22, 2024
• University Business
• Faculty Senate Business
• Information
• Education Policies Committee - December 7, 2023 | January 4, 2024
• New Limited English Proficiency (LEP) Policy
• Reports
• Faculty Diversity, Development, & Equity Annual Report
• Parking and Transportation Committee Annual Report
• Sustainability Council Annual Report
• Old Business
• Update on IRB Ad Hoc Committee
• Update on Faculty Code 405
• New Business
• 
  Faculty Code 407 Redline - Clean | 408 Redline - Clean
• Adjourn: 5:00 pm

The Utah Statesman, February 12, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Effectiveness Of Counseling Juveniles And Guardians As A Measure Of Recidivism, Robert D. Johnson

Walden Dissertations and Doctoral Studies

This study explored the lived experiences and perceptions of 10 juvenile justice professionals who had interacted with juvenile offenders and their guardians. This phenomenological qualitative study aimed to examine the outcomes of functional family therapy (FFT) between juvenile offenders and their guardians and their impact on recidivism rates in the National Capital Region portion of the Washington Metropolitan area. The theoretical framework that guided this study was FFT, which focuses on family dynamics and interactions while addressing a youth’s problem behavior. During semi-structured interviews (conducted via Zoom (due to COVID-19 restrictions), participants were asked open-ended questions about their feelings, experiences, …

Pluripotency Of A Founding Field: Rebranding Developmental Biology, Crystal D. Rogers, Chris Amemiya, Swathi Arur, Leslie Babonis, Michael Barresi, Madelaine Bartlett, Richard Behringer, Blair Benham-Pyle, Dominique Bergmann, Ben Blackman, C. Titus Brown, Bill Browne, Jasmin Camacho, Chiswili Y. Chabu, Ida Chow, Ondine Cleaver, Jonah Cool, Megan Y. Dennis, Alexandra J. Dickinson, Stefano Di Talia, Margaret Frank

Pacific Faculty Work

The field of developmental biology has declined in prominence in recent decades, with off-shoots from the field becoming more fashionable and highly funded. This has created inequity in discovery and opportunity, partly due to the perception that the field is antiquated or not cutting edge. A 'think tank' of scientists from multiple developmental biology-related disciplines came together to define specific challenges in the field that may have inhibited innovation, and to provide tangible solutions to some of the issues facing developmental biology. The community suggestions include a call to the community to help 'rebrand' the field, alongside proposals for additional …

The 10,000-Year Biocultural History Of Fallow Deer And Its Implications For Conservation Policy, Karis H. Baker, Holly Miller, Sean Doherty, Howard W. I. Gray, Julie Daujat, Çakırlard Çakırlar, Nikolai Spassov, Katerina Trantalidou, Richard Madgwick, Angela L. Lamb, Carly Ameen, Levent Atici, Polydora Baker, Fiona Beglane, Helene Benkert, Robin Bendrey, Annelise Binois-Roman, Ruth F. Carden, Antonio Curci, Bea De Cupere, Cleia Detry, Erika Gál, Chloé Genies, Günther K. Kunst, Robert Liddiard, Rebecca Nicholson, Rossana Villa-Rojas, Joris Peters, Fabienne Pigière, Aleksander G. Pluskowski, Peta Sadler, Sandra Sicard, Lena Strid, Jack Sudds, Robert Symmons, Katie Tardio, Alejandro Valenzuela, Monique Van Veen, Sonja Vuković, Jaco Weinstock, Barbara Wilkens, Roger J. A. Wilson, Jane A. Evans, A. Rus Hoelzel, Naomi Sykes

School of Global Integrative Studies: Faculty Publications

Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no consensus regarding their natural ranges or the timing and circumstances of their human-mediated translocations and extirpations. Our mitochondrial analyses of modern and archaeological specimens revealed two distinct clades of European fallow deer present in Anatolia and the Balkans. Zooarchaeological evidence …

Hazara University's Monocot Specimen Data In Openherbarium.Org On 20 December 2023, Mary Barkworth, Liaqat Ullah, Abdul Majid, Ghulam Mujtaba Shah, Jan Alam

Browse all Datasets

Northern Pakistan is interpreted here as including three administrative regions: Khyber Pakhtunkhwa, Gilgit-Baltistan, and Azad Jammu and Kashmir. It is dominated by multiple mountain ranges whose valleys drain, directly or indirectly, into the Indus River. Hazara University, which is in Khyber Pakhtunkhwa, was started in 2002 and its herbarium (HUP) in 2005. Digitization of the herbarium's vascular plants began in 2021 with its records being shared in OpenHerbarium and GBIF. Its online presence is now growing more rapidly than any other Pakistani herbarium. This paper summarizes the taxonomic diversity and geographic origin of its monocot holdings in 2023. In 2023, …

Predictors Of Bystander Intervention: Examining The Heteronormative Bias In Bystander Intervention Research, Mellisa Holtzman

The Journal of Public and Professional Sociology

Although numerous studies have explored the factors that impact bystander intervention in sexual assault situations, findings have been inconsistent and all prior studies have depicted sexual violence as an exclusively female and heterosexual issue. This study explores the many individual-level and assault-level characteristics that can impact bystander intervention while also accounting for non-heteronormativity in sexual assault situations. Based on a content analysis of interview data with college students, the findings suggest that assault ambiguity, severity, and timing, as well as the gender and friendship statuses of the individuals involved, impact who bystanders intervene with and how they do so. Importantly, …

Sex-Dependent Effects Of Chronic Circadian Disruption In Aβpp/Ps1 Mice., Jesse Britz, Emmanuel Ojo, Nazmul Haque, Asmita Dhukhwa, Erin R Hascup, Kevin N Hascup, Shelley A Tischkau

Articles

BACKGROUND: Chronic disruption of the circadian timing system, often reflected as a loss of restful sleep, also includes myriad other pathophysiological effects.

OBJECTIVE: The current study examined how chronic circadian disruption (CD) could contribute to pathology and rate of progression in the AβPP/PS1 mouse model of Alzheimer's disease (AD).

METHODS: A chronic CD was imposed until animals reached 6 or 12 months of age in AβPP/PS1 and C57BL/6J control mice. Home cage activity was monitored for a period of 3-4 weeks prior to the endpoint along with a single timepoint measure of glucose sensitivity. To assess long term effects of …

Heterogeneity In Maternal Mrnas Within Clutches Of Eggs In Response To Thermal Stress During The Embryonic Stage, Atsuko Sato, Yukie Mihirogi, Christine Wood, Yutaka Suzuki, Manuela Truebano, John Bishop

School of Biological and Marine Sciences

Background: The origin of variation is of central interest in evolutionary biology. Maternal mRNAs govern early embryogenesis in many animal species, and we investigated the possibility that heterogeneity in maternal mRNA provisioning of eggs can be modulated by environmental stimuli. Results: We employed two sibling species of the ascidian Ciona, called here types A and B, that are adapted to different temperature regimes and can be hybridized. Previous study showed that hybrids using type B eggs had higher susceptibility to thermal stress than hybrids using type A eggs. We conducted transcriptome analyses of multiple single eggs from crosses using eggs …

Effects Of Metformin On Glucose Metabolism And Mitochondrial Function In Patients With Obstructive Sleep Apnea: A Pilot Randomized Trial, Elizabeth R.M. Zunica, Elizabeth C. Heintz, Wagner S. Dantas, R. Caitlin Hebert, Ma Kayla Tanksley, Robbie A. Beyl, Edward C. Mader, John P. Kirwan, Christopher L. Axelrod, Prachi Singh

School of Medicine Faculty Publications

Obstructive sleep apnea (OSA) is associated with increased risk for diabetes, and standard treatment with positive airway pressure (PAP) device shows inconsistent effects on glucose metabolism. Metformin is known to treat and prevent diabetes, but its effects on skeletal muscle mitochondrial function are not completely understood. Here, we evaluate the effects of metformin on glucose metabolism and skeletal muscle mitochondrial function in patients with OSA. Sixteen adults with obesity (50.9 ± 6.7 years, BMI: 36.5 ± 2.9 kg/m2) and moderate-to-severe OSA were provided with PAP treatment and randomized to 3 months of placebo (n = 8) or metformin (n = …

Physio-Chemical Modifications To Re-Engineer Small Extracellular Vesicles For Targeted Anticancer Therapeutics Delivery And Imaging, Rahmat Asfiya, Lei Xu, Anjugam Paramanantham, Kuanysh Kabytaev, Anna Chernatynskaya, Grace Mccully, Hu Yang, Akhil Srivastava

Chemical and Biochemical Engineering Faculty Research & Creative Works

Cancer theranostics developed through nanoengineering applications are essential for targeted oncologic interventions in the new era of personalized and precision medicine. Recently, small extracellular vesicles (sEVs) have emerged as an attractive nanoengineering platform for tumor-directed anticancer therapeutic delivery and imaging of malignant tumors. These natural nanoparticles have multiple advantages over synthetic nanoparticle-based delivery systems, such as intrinsic targeting ability, less immunogenicity, and a prolonged circulation time. Since the inception of sEVs as a viable replacement for liposomes (synthetic nanoparticles) as a drug delivery vehicle, many studies have attempted to further the therapeutic efficacy of sEVs. This article discusses engineering strategies …

Impact Of Ableist Microaggressions On Dis / Abled Youth: Perceptions Of School Climate And Academic Motivation, Nitza M. Torres Gonzalez

Theses and Dissertations

Ableist microaggressions are often subtle and covert negative attributions and behaviors towards people with dis/abilities that perpetuate stereotypes and inequities (Conover et al., 2021). Although limited research exists that has explored the impact of ableist microaggressions, some scholars have noted similar findings to studies to that have focused on racial microaggressions. Specifically, exposure to ableist microaggressions has been associated with negative mental health outcomes and increased negative affect, feelings of exclusion, and low academic performance and self-concept (Kattari, 2017; Kattari, 2020; Keller & Galgay, 2010; Lett et al., 2019; Nadal et al., 2014; Storey, 2007). Most of these findings have …

Molecular-Guided Therapy For The Treatment Of Patients With Relapsed And Refractory Childhood Cancers: A Beat Childhood Cancer Research Consortium Trial., Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C. Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B. Nagulapally, Karl Dykema, Valerie I Brown, Michael S. Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K. Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K. Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F Halperin, Abigail Moore, Sara A. Byron, William P D Hendricks, Jeffrey M. Trent

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors.

METHODS: Subjects were divided into three strata: stratum 1-relapsed/refractory neuroblastoma; stratum 2-relapsed/refractory CNS tumors; and stratum 3-relapsed/refractory rare solid tumors. Tumor samples were sent for tumor/normal whole-exome (WES) and tumor whole-transcriptome (WTS) sequencing, and the genomic data were used in a multi-institutional MTB to make real‑time treatment …

Circuit-Based Intervention Corrects Excessive Dentate Gyrus Output In The Fragile X Mouse Model, Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A Klyachko

2020-Current year OA Pubs

Abnormal cellular and circuit excitability is believed to drive many core phenotypes in fragile X syndrome (FXS). The dentate gyrus is a brain area performing critical computations essential for learning and memory. However, little is known about dentate circuit defects and their mechanisms in FXS. Understanding dentate circuit dysfunction in FXS has been complicated by the presence of two types of excitatory neurons, the granule cells and mossy cells. Here we report that loss of FMRP markedly decreased excitability of dentate mossy cells, a change opposite to all other known excitability defects in excitatory neurons in FXS. This mossy cell …

Board Of Directors Meeting Minutes (February 12, 2024), Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on February 12, 2024.

Flow Cytometry Of Dnmt1 As A Biomarker Of Hypomethylating Therapies, Philip G. Woost, Basem M. William, Brenda W. Cooper, Masumi Ueda Oshima, Folashade Otegbeye, Marcos J. De Lima, David Wald, Reda Z. Mahfouz, Yogen Saunthararajah, Tammy Stefan, James W. Jacobberger

Faculty Scholarship

The 5-azacytidine (AZA) and decitabine (DEC) are noncytotoxic, differentiation-inducing therapies approved for treatment of myelodysplastic syndrome, acute myeloid leukemias (AML), and under evaluation as maintenance therapy for AML postallogeneic hematopoietic stem cell transplant and to treat hemoglobinapathies. Malignant cell cytoreduction is thought to occur by S-phase specific depletion of the key epigenetic regulator, DNA methyltransferase 1 (DNMT1) that, in the case of cancers, thereby releases terminal-differentiation programs. DNMT1-targeting can also elevate expression of immune function genes (HLA-DR, MICA, MICB) to stimulate graft versus leukemia effects. In vivo, there is a large inter-individual variability in DEC and 5-AZA activity because of …

Tumor- And Circulating-Free Dna Methylation Identifies Clinically Relevant Small Cell Lung Cancer Subtypes, Simon Heeke, Carl M Gay, Marcos R Estecio, Hai Tran, Benjamin B Morris, Bingnan Zhang, Ximing Tang, Maria Gabriela Raso, Pedro Rocha, Siqi Lai, Edurne Arriola, Paul Hofman, Veronique Hofman, Prasad Kopparapu, Christine M Lovly, Kyle Concannon, Luana Guimaraes De Sousa, Whitney Elisabeth Lewis, Kimie Kondo, Xin Hu, Azusa Tanimoto, Natalie I Vokes, Monique B Nilsson, Allison Stewart, Maarten Jansen, Ildikó Horváth, Mina Gaga, Vasileios Panagoulias, Yael Raviv, Danny Frumkin, Adam Wasserstrom, Aharona Shuali, Catherine A Schnabel, Yuanxin Xi, Lixia Diao, Qi Wang, Jianjun Zhang, Peter Van Loo, Jing Wang, Ignacio I Wistuba, Lauren A Byers, John V Heymach

Faculty, Staff and Student Publications

Small cell lung cancer (SCLC) is an aggressive malignancy composed of distinct transcriptional subtypes, but implementing subtyping in the clinic has remained challenging, particularly due to limited tissue availability. Given the known epigenetic regulation of critical SCLC transcriptional programs, we hypothesized that subtype-specific patterns of DNA methylation could be detected in tumor or blood from SCLC patients. Using genomic-wide reduced-representation bisulfite sequencing (RRBS) in two cohorts totaling 179 SCLC patients and using machine learning approaches, we report a highly accurate DNA methylation-based classifier (SCLC-DMC) that can distinguish SCLC subtypes. We further adjust the classifier for circulating-free DNA (cfDNA) to subtype …

Unh Student Interns Critical Voice, Support To Advance Unh's Sustainability Efforts, Sustainability Institute

Sustainability Institute Blog

No abstract provided.

Hymenopteran Parasitoid Complex And Fall Armyworm: A Case Study In Eastern India, Subhajit Pal, Swarnali Bhattacharya, Tapamay Dhar, Ankita Gupta, Arunava Ghosh, Sandip Debnath, Nikhitha Gangavarapu, Prajna Pati, Nilanjana Chaudhuri, Hirak Chatterjee, Sabita Kumar Senapati, Prateek Madhab Bhattacharya, Mahesh Kumar Gathala, Alison M. Laing

Department of Entomology: Faculty Publications

Fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) has significantly affected maize crop yields, production efficiency, and farmers’ incomes in the Indian Eastern Gangetic Plains region since it was first observed in India in 2018. A lack of awareness by maize growers of the appropriate selection, method, and timing of insecticide application not only creates a barrier to sustainable FAW control but also contributes to increased environmental pollution, reduced human health and increased production costs. We demonstrated that FAW inflicted the most damage in early whorl growth stage of maize, regardless of whether chemical insecticides were applied. FAW egg masses and …

Charting Early Trajectories Of Executive Control With The Shape School, Caron A. C. Clark, Tiffany D. Sheffield, Nicolas Chevalier, Jennifer Mize Nelson, Sandra A. Wiebe, Kimberly Andrews Espy

Department of Psychology: Faculty Publications

Despite acknowledgement of the importance of executive control for learning and behavior, there is a dearth of research charting its developmental trajectory as it unfolds against the background of children’s sociofamilial milieus. Using a prospective, cohort-sequential design, this study describes growth trajectories for inhibitory control and cognitive flexibility across the preschool period in relation to child sex and sociofamilial resources. At ages 3, 3.75, 4.5, and 5.25 years, children (N = 388) from a broad range of social backgrounds were assessed using the Shape School, a graduated measure of executive control incorporating baseline, inhibitory control, and cognitive flexibility conditions. …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M. Taylor, Kang Ho Kim, J. Marc Rhoads, Yuying Liu

School of Medicine Faculty Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Food Labeling: Ingredient Exemptions And Product Claims, Elena Krasovkaia, Bradley J. Rickard, Brenna Ellison, Brandon R. Mcfadden, Norbert Wilson

Agricultural Economics and Agribusiness Faculty Publications and Presentations

New breeding methods have provided scientists with opportunities to improve traits in a wide range of crops, however, there remains resistance to foods that are produced from these crops, and mandates on labels used to describe such processes continue to be a source of policy debate. Here we focus on gene editing and examine (i) whether consumer acceptance varies when the technology is applied to different ingredients (unrefined versus highly refined ingredients) and (ii) the impact of two different claims related to gene editing (health-focused claim versus an environment-focused claim). Our results show that consumers are less likely to purchase …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Probiotic Limosilactobacillus Reuteri Dsm 17938 Changes Foxp3 Deficiency-Induced Dyslipidemia And Chronic Hepatitis In Mice, Erini Nessim Kostandy, Ji Ho Suh, Xiangjun Tian, Beanna Okeugo, Erin Rubin, Sara Shirai, Meng Luo, Christopher M Taylor, Kang Ho Kim, J Marc Rhoads, Yuying Liu

Faculty, Staff and Student Publications

The probiotic Limosilactobacillus reuteri DSM 17938 produces anti-inflammatory effects in scurfy (SF) mice, a model characterized by immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (called IPEX syndrome in humans), caused by regulatory T cell (Treg) deficiency and is due to a Foxp3 gene mutation. Considering the pivotal role of lipids in autoimmune inflammatory processes, we investigated alterations in the relative abundance of lipid profiles in SF mice (± treatment with DSM 17938) compared to normal WT mice. We also examined the correlation between plasma lipids and gut microbiota and circulating inflammatory markers. We noted a significant upregulation of plasma lipids …

Insights From The Histopathologic Analysis Of Acquired And Genetic Thoracic Aortic Aneurysms And Dissections, L Maximilian Buja, Bihong Zhao, Humaira Sadaf, Michelle Mcdonald, Ana M Segura, Li Li, Alana Cecchi, Siddharth K Prakash, Rana O Afifi, Charles C Miller, Anthony L Estrera, Dianna M Milewicz

Faculty, Staff and Student Publications

OBJECTIVE: The purpose of this study was to apply contemporary consensus criteria developed by the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology to the evaluation of aortic pathology, with the expectation that the additional pathologic information may enhance the understanding and management of aortic diseases.

METHODS: A scoring system was applied to ascending aortic specimens from 42 patients with heritable thoracic aortic disease and known genetic variations and from 86 patients from a single year, including patients with known genetic variations (n = 12) and patients with sporadic disease (n = 74).

RESULTS: The various types …

Belzutifan, Hif-2Α Inhibitor, And Clear Cell Renal Cell Carcinoma With Somatic Von-Hippel-Lindau Loss-Of-Function Mutation, Kok Hoe Chan, Ningjing Li, Ran Lador, Mark Amsbaugh, Anneliese Gonzalez, Putao Cen

Faculty, Staff and Student Publications

The Von-Hippel-Lindau (VHL) gene, acting as a tumor suppressor, plays a crucial role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Approximately 90% of individuals with advanced ccRCC exhibit somatic mutations in the VHL gene. Belzutifan, orally administered small-molecule inhibitor of hypoxia-induced factor-2α, has demonstrated promising efficacy in solid tumors associated with germline loss-of-function mutations in VHL, including ccRCC. However, its impact on cases with somatic or sporadic VHL mutations remains unclear. Here, we present 2 cases where belzutifan monotherapy was employed in patients with advanced ccRCC and somatic loss-of-function mutations in VHL. Both patients exhibited a swift …

Chimes: February 12, 2024, Calvin University

Chimes

"Our strategy is enrollment growth" Calvin's updated Vision 2030 plan reflects institutional optimism by Savannah Shustack

Spectator turnout for athletic games climbs by Lauren Nyong

Calvin student's home-brewed app achieves success after success by Jacob Westra

Honors program seeks renewed emphasis on interdisciplinarity by Maya Oeverman

Calvin athletics hosts multiple sporting events throughout siblings' weekend by Dillion Baumchen

Calvin's homemade dune continues to provide research opportunities by Ethan Meyers

Faculty orientation seminar celebrates thirty years anniversary by Nolan Cowan

OCD representation on screen should encompass all facets of the mental illness by Liana Hirner