Digital Commons Network^™

Herbage Responses And Performance Of Mature Horses Grazing Warm-Season Perennial Grass-Legume Mixed Pastures, A. C. Vasco, E. R. Santos, J. Lance, J. Dubeux, L. Sollenberger, M. Wallau, C. Wickens, L. Warren

IGC Proceedings (1977-2023)

Legume-grass mixtures may be a useful alternative to nitrogen-fertilized grass monocultures, but pasture and animal responses have not been assessed for pastures grazed by horses in Florida. This 2-yr study compared pasture and horse responses of continuously stocked, mixed pastures of rhizoma peanut (RP, Arachis glabrata Benth) and bahiagrass (BG, Paspalum notatum Flüggé) receiving 30 kg nitrogen (N)/ha (RP-BG) compared with BG pastures fertilized with 120 kg/N ha (BG-N) or with no N (BG-No N). Herbage mass was similar among treatments in 2020 and for most evaluation days in 2019. In 2019, stocking rate (AU/ha) was greater in …

Integrating Plant Secondary Metabolites And Foraging Behavior To Enhance Animal Health In Ruminant Production Systems, J. J. Villalba, J. W. Macadam, S. Van Vliet, F. D. Provenza

IGC Proceedings (1977-2023)

Legumes and forbs contain bioactives or plant secondary compounds (PSC) with potential to enhance animal health through their antibiotic, antioxidant and immunomodulatory properties that are evident even at small dietary concentrations. In turn, ruminants can regulate their ingestion of PSC through behavioral mechanisms that allow for the efficient achievement of homeostasis. High concentrations of PSC lead to food avoidance, whereas lower content of PSC in the diet achieved through regulatory mechanisms of ingestion could promote medicinal and/or prophylactic effects in the animal and concomitant health benefits to milk and meat products. Under this context, we discuss the restructuring of rangelands …

The Effect Of Spring Grass Availability On Dry Matter Intake Of Early Lactation Dairy Cows, S. Walsh, Z. C. Mckay, M. Egan

IGC Proceedings (1977-2023)

Spring grass availability has a major impact on dry matter intake (DMI) of dairy cows during early lactation. The objective of this study was to investigate the effects of opening farm cover (OFC) on DMI during early lactation. A twelve week experiment, which was split into two 6 week periods (Period 1 (Week 1 – 6) and period 2 (Week 7 – 12), was conducted over a two year period. A high and low OFC were established for two treatment groups; 1253 kg DM/ha (High grass = HG) and 887 kg DM/ha (Low grass = LG). Animals were randomly assigned …

Effects Of Stocking Rates On Water Use Efficiency Of Established Species In Stipa Breviflora Desert Steppe, M. Zhao, G. M. Yin, S. B. Liu, W. J. Meng

IGC Proceedings (1977-2023)

Plant water use efficiency reflects the survival adaptation strategies adopted by plants to obtain maximum carbon harvest. Understanding the water and resource utilization strategies of Stipa breviflora in desert steppe will help people understand its growth mechanism, and it is of great significance to analyze the ecological countermeasures of Stipa breviflora to cope with disturbance. In this study, the water use efficiency (WUE) of the established populations of Stipa breviflora in desert steppe was measured by stable carbon isotope method and photosynthometer method, and the adaptation mechanism of Stipa breviflora under different stocking rates was discussed based on the basic …

The Hindgut Microbiome Of Grazing Horses, J. R. Weinert, C. A. Williams

IGC Proceedings (1977-2023)

The hindgut microbiome plays an essential role in horses consuming forage-based diets high in fiber, such as pasture. The equine hindgut harbors a large microbial community that ferments dietary fiber and produces by-products which provide a substantial portion of daily energy requirements. Despite the importance in nutrition and health, research evaluating the hindgut microbiome of grazing horses is relatively limited. Grazing horse microbiome research has primarily focused on inter-diet comparisons with mixed diets including concentrates as well as with other forms of forage. Recent research has begun to explore responses of the gut microbiome to different pasture forage species and …

Horse And Pasture Responses To Stocking Methods: Rotational Versus Continuous, C. A. Williams, J. R. Weinert-Nelson

IGC Proceedings (1977-2023)

Rotational grazing management offers potential advantages for economic and environmental sustainability, as well as for horse health. Rotational grazing has the potential to increase pasture yields and available forage for grazing, and therefore reduce supplemental feed costs. A rotational grazing management strategy can also prevent or mitigate negative effects of overgrazing, with implications for pasture productivity and the environment. Overgrazing can reduce vegetative cover over time, increasing the potential for erosion and nutrient run-off. Overgrazing may also result in long-term decreased forage stand persistence and weed invasion, necessitating more frequent pasture renovation. All of this can negatively impact the horse’s …

Building Connections: The Power Of Embedding Literacy And Math Content Into Science And Social Studies Contexts, Rachel Hallett-Njuguna Edd

Constellations: Online STEM Teacher Education Journal

Nationally, the lack of improvement in literacy scores continues to baffle experts. Instructional leaders from math, science, and social studies in one district knew the value of leveraging their subject areas to support literacy achievement in secondary students. Starting with an engaging STEM-related novel, the group of curriculum experts developed meaningful literacy connected tasks for their teacher and teacher leader participants. Working through the activities as their students would, the group found a new appreciation for the importance of leveraging the relevance of science and social studies content and the usefulness of math content when creating literacy lessons. The group’s …

Energetic Value Estimates Of Wild And Domesticated Food Items Consumed By Congolese Bayaka Foragers, Lucie Benoit, Sheina Lew-Levy, Yann R. Ouamba, Alyssa N. Crittenden

Journal of Ecological Anthropology

We present a dataset that systematically estimates the energetic value of wild and domesticated food resources collected and consumed by Congolese BaYaka foragers. This dataset is unique in that it accounts for everyday practices of food processing and consumption. Reported values of inedible portions, moisture content, and estimated energetic values (kcal/g) were extracted from field research and the published food chemistry and nutrition literature. These data are central to understanding how nutritional needs are met in rainforest environments and will allow for current and future tracking of diet composition in this and similar ecologies. The dataset is available at https://doi.org/10.6084/m9.figshare.19446938.v9

Cannabidiol Exposure During Rat Pregnancy Leads To Labyrinth-Specific Vascular Defects In The Placenta And Reduced Fetal Growth, Daniel Hardy, David Natale, Kendrick Lee

Data and Test Instruments

Introduction: Cannabis use is increasing among pregnant people, and cannabidiol (CBD), a constituent of cannabis, is often perceived as ‘‘natural’’ and ‘‘safe’’ as it is non-intoxicating. In utero, cannabis exposure is associated with negative health outcomes, including fetal growth restriction (FGR). The placenta supplies oxygen and nutrients to the fetus, and alterations in placental development can lead to FGR. While there has been someinvestigation into the effects of D9-THC, there has been limited investigation into the impacts of in utero gestational CBD exposure on the placenta.Methods: This study used histological and transcriptomic analysis of embryonic day (E)19.5 rat placentas from …

The Santa Clara, 2024-02-16, Santa Clara University

The Santa Clara

No abstract provided.

Board Of Trustees Agenda, Feb. 16 2024, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

2024 February 16 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Copper−Cystine Biohybrid-Embedded Nanofiber Aerogels Show Antibacterial And Angiogenic Properties, Anik Karan, Navatha S. Polavaram, Margarita Darder, Yajuan Su, Syed Muntazir Andrabi, S M Shatil Shahriar, Johnson V. John, Zeyu Luo, Mark A. Decoster, Yu Shrike Zhang, Jingwei Xie

Department of Mechanical and Materials Engineering: Faculty Publications

Copper−cystine-based high aspect ratio structures (CuHARS) possess exceptional physical and chemical properties and exhibit remarkable biodegradability in human physiological conditions. Extensive testing has confirmed the biocompatibility and biodegradability of CuHARS under diverse biological conditions, making them a viable source of essential Cu²⁺. These ions are vital for catalyzing the production of nitric oxide (NO) from the decomposition of Snitrosothiols (RSNOs) found in human blood. The ability of CuHARS to act as a Cu²⁺ donor under specific concentrations has been demonstrated in this study, resulting in the generation of elevated levels of NO. Consequently, this dual function makes …

Florida Undergraduate Research Conference, University Of North Florida

University Events General Printed Material

FURC serves as a multi-disciplinary conference through which undergraduate students from the state of Florida can present their research. February 16-17, 2024

Some Nonprofit Leaders Lack Strategies To Support Financial Change Management In An Organization For Sustainability, Ebony Billups

Walden Dissertations and Doctoral Studies

Walden University College of Management and Human Potential This is to certify that the doctoral study by Ebony S. Billups has been found to be complete and satisfactory in all respects, and that any and all revisions required by the review committee have been made. Review Committee Dr. Meridith Wentz, Committee Chairperson, Doctor of Business Administration Faculty Dr. Peter Anthony, Committee Member, Doctor of Business Administration Faculty Chief Academic Officer and Provost Sue Subocz, Ph.D. Walden University 2024 Some nonprofit leaders lack strategies for financial change management, resulting in long-term organizational health and sustainability challenges. Grounded in general systems theory, …

2024 February 16 - Board Of Trustees Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Detection Of Small Drizzle Droplets In A Large Cloud Chamber Using Ultrahigh-Resolution Radar, Zeen Zhu, Fan Yang, Pavlos Kollias, Raymond A. Shaw, Alexander Kostinski, Steve Krueger, Katia Lamer, Nithin Allwayin, Mariko Oue

Michigan Tech Publications

A large convection-cloud chamber has the potential to produce drizzle-sized droplets, thus offering a new opportunity to investigate aerosol-cloud-drizzle interactions at a fundamental level under controlled environmental conditions. One key measurement requirement is the development of methods to detect the low-concentration drizzle drops in such a large cloud chamber. In particular, remote sensing methods may overcome some limitations of in situ methods. Here, the potential of an ultrahigh-resolution radar to detect the radar return signal of a small drizzle droplet against the cloud droplet background signal is investigated. It is found that using a small sampling volume is critical to …

Functionally Refined Encoding Of Threat Memory By Distinct Populations Of Basal Forebrain Cholinergic Projection Neurons, Prithviraj Rajebhosale, Mala R. Ananth, Ronald Kim, Richard B. Crouse, Li Jiang, Gretchen Y. López-Hernández, Chongbo Zhong, Christian Arty, Shaohua Wang, Alice Jone, Niraj Desai, Yulong Li, Marina R. Picciotto, Lorna W. Role, David A. Talmage

Faculty and Staff Publications

Neurons of the basal forebrain nucleus basalis and posterior substantia innominata (NBM/SIp) comprise the major source of cholinergic input to the basolateral amygdala (BLA). Using a genetically-encoded acetylcholine (ACh) sensor in mice, we demonstrate that BLA-projecting cholinergic neurons can 'learn' the association between a naïve tone and a foot shock (training) and release ACh in the BLA in response to the conditioned tone 24h later (recall). In the NBM/SIp cholinergic neurons express the immediate early gene, Fos following both training and memory recall. Cholinergic neurons that express Fos following memory recall display increased intrinsic excitability. Chemogenetic silencing of these learning-activated …

Papain-Catalyzed Synthesis Of Oligolysine In Low-Water Organic Reaction Media, Lakshmi Priya Ravikrishna, Krishnamurthi Tamilarasan, Vairamani Mariappanadar, Shubhender Kapila, Mathur Rajesh

Chemistry Faculty Research & Creative Works

Oligopeptides of l-lysine have the potential for applications in various scientific and technical areas. The number of residues in polycationic compounds such as oligolysine is also reported to have an effect on its biological properties. Hence, there is a necessity for developing efficient oligolysine synthesis methods where the oligopeptide dispersity can be tailored, along with optimum yield values. The ability of proteases to reverse their proteolytic activity to synthesize peptides has been reported in the literature. However, protease-catalyzed synthesis of oligopeptides of basic amino acids such as lysine in aqueous buffers is hindered by unfavorable thermodynamics. In this work, a …

Achieving Wheat Self-Sufficiency In Brazil, Rogerio De S. Noia Junior, Maicon Nardino, Elvis F. Elli, Diego Pequeno, Clyde Fraisse

Crop, Soil and Environmental Sciences Faculty Publications and Presentations

Brazil is a leading grain producer and exporter, producing on average 6.6 million tons (Mt) of wheat per year from 2013 to 2023. However, to meet its average annual domestic consumption of 11.1 Mt over the same period, the country continued to rely on imports of 4.5 Mt of wheat each year. This dependency on imports leads to high wheat prices in Brazil compared to the global average.

A Small Molecule With Big Impact: Mrtx1133 Targets The Krasg12d Mutation In Pancreatic Cancer, Daoyan Wei, Liang Wang, Xiangsheng Zuo, Anirban Maitra, Robert S Bresalier

Faculty, Staff and Student Publications

KRAS mutations drive oncogenic alterations in numerous cancers, particularly in human pancreatic ductal adenocarcinoma (PDAC). About 93% of PDACs have KRAS mutations, with G12D (∼42% of cases) and G12V (∼32% of cases) being the most common. The recent approval of sotorasib (AMG510), a small-molecule, covalent, and selective KRASG12C inhibitor, for treating patients with non-small cell lung cancer represents a breakthrough in KRAS targeted therapy. However, there is a need to develop other much-needed KRAS-mutant inhibitors for PDAC therapy. Notably, Mirati Therapeutics recently developed MRTX1133, a small-molecule, noncovalent, and selective KRASG12D inhibitor through extensive structure-based drug design. MRTX1133 has demonstrated potent …

Sting Licensing Of Type I Dendritic Cells Potentiates Antitumor Immunity, Jian Wang, Suxin Li, Maggie Wang, Xu Wang, Shuqing Chen, Zhichen Sun, Xiubao Ren, Gang Huang, Baran D Sumer, Nan Yan, Yang-Xin Fu, Jinming Gao

Faculty, Staff and Student Publications

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-AMP (cGAMP) in response to self or microbial cytosolic DNA as a danger signal. STING is ubiquitously expressed in diverse cell populations including cancer cells with distinct cellular functions such as activation of type I interferons, autophagy induction, or triggering apoptosis. It is not well understood whether and which subsets of immune cells, stromal cells, or cancer cells are particularly important for STING-mediated antitumor immunity. Here using a polymeric STING-activating nanoparticle (PolySTING) with a “shock-and-lock” dual activation mechanism, we show type 1 conventional dendritic cell (cDC1) is …

Mutant P53 Protects Triple-Negative Breast Adenocarcinomas From Ferroptosis In Vivo, Denada Dibra, Shunbin Xiong, Sydney M Moyer, Adel K El-Naggar, Yuan Qi, Xiaoping Su, Elisabeth K Kong, Anil Korkut, Guillermina Lozano

Faculty, Staff and Student Publications

The TP53 tumor suppressor gene is mutated early in most of the patients with triple-negative breast cancer (TNBC). The most frequent TP53 alterations are missense mutations that contribute to tumor aggressiveness. Here, we used an autochthonous somatic TNBC mouse model, in which mutant p53 can be toggled on and off genetically while leaving the tumor microenvironment intact and wild-type for p53 to identify physiological dependencies on mutant p53. In TNBCs that develop in this model, deletion of two different hotspot p53R172H and p53R245W mutants triggers ferroptosis in vivo, a cell death mechanism involving iron-dependent lipid peroxidation. Mutant p53 protects cells …

Inter-Individual Variations In Circadian Misalignment-Induced Nafld Pathophysiology In Mice, Nobuya Koike, Yasuhiro Umemura, Hitoshi Inokawa, Isao Tokuda, Yoshiki Tsuchiya, Yuh Sasawaki, Atsushi Umemura, Naoko Masuzawa, Kazuya Yabumoto, Takashi Seya, Akira Sugimoto, Seung-Hee Yoo, Zheng Chen, Kazuhiro Yagita

Faculty, Staff and Student Publications

Pathological consequences of circadian misalignment, such as shift work, show considerable individual differences, but the lack of mechanistic understanding hinders precision prevention to prevent and mitigate disease symptoms. Here, we employed an integrative approach involving physiological, transcriptional, and histological phenotypes to examine inter-individual differences in pre-symptomatic pathological progression, preceding irreversible disease onset, in wild-type mice exposed to chronic jet-lag (CJL). We observed that CJL markedly increased the prevalence of hepatic steatosis with pronounced inter-individual differences. Stratification of individual mice based on CJL-induced hepatic transcriptomic signature, validated by histopathological analysis, pinpoints dysregulation of lipid metabolism. Moreover, the period and power of …

Backfilling Patients In Phase I Dose-Escalation Trials Using Bayesian Optimal Interval Design (Boin), Yixuan Zhao, Ying Yuan, Edward L Korn, Boris Freidlin

Faculty, Staff and Student Publications

In recent years, there has been increased interest in incorporation of backfilling into dose-escalation clinical trials, which involves concurrently assigning patients to doses that have been previously cleared for safety by the dose-escalation design. Backfilling generates additional information on safety, tolerability, and preliminary activity on a range of doses below the maximum tolerated dose (MTD), which is relevant for selection of the recommended phase II dose and dose optimization. However, in practice, backfilling may not be rigorously defined in trial protocols and implemented consistently. Furthermore, backfilling designs require careful planning to minimize the probability of treating additional patients with potentially …

Neoadjuvant Trebananib Plus Paclitaxel-Based Chemotherapy For Stage Ii/Iii Breast Cancer In The Adaptively Randomized I-Spy2 Trial-Efficacy And Biomarker Discovery, Kathy S Albain, Christina Yau, Emanuel F Petricoin, Denise M Wolf, Julie E Lang, A Jo Chien, Tufia Haddad, Andres Forero-Torres, Anne M Wallace, Henry Kaplan, Lajos Pusztai, David Euhus, Rita Nanda, Anthony D Elias, Amy S Clark, Constantine Godellas, Judy C Boughey, Claudine Isaacs, Debu Tripathy, Janice Lu, Rachel L Yung, Rosa I Gallagher, Julia D Wulfkuhle, Lamorna Brown-Swigart, Gregor Krings, Yunn Yi Chen, David A Potter, Erica Stringer-Reasor, Sarah Blair, Smita M Asare, Amy Wilson, Gillian L Hirst, Ruby Singhrao, Meredith Buxton, Julia L Clennell, Ashish Sanil, Scott Berry, Adam L Asare, Jeffrey B Matthews, Angela M Demichele, Nola M Hylton, Michelle Melisko, Jane Perlmutter, Hope S Rugo, W Fraser Symmans, Laura J Van't Veer, Douglas Yee, Donald A Berry, Laura J Esserman

Faculty, Staff and Student Publications

Purpose: The neutralizing peptibody trebananib prevents angiopoietin-1 and angiopoietin-2 from binding with Tie2 receptors, inhibiting angiogenesis and proliferation. Trebananib was combined with paclitaxel±trastuzumab in the I-SPY2 breast cancer trial.

Patients and methods: I-SPY2, a phase II neoadjuvant trial, adaptively randomizes patients with high-risk, early-stage breast cancer to one of several experimental therapies or control based on receptor subtypes as defined by hormone receptor (HR) and HER2 status and MammaPrint risk (MP1, MP2). The primary endpoint is pathologic complete response (pCR). A therapy "graduates" if/when it achieves 85% Bayesian probability of success in a phase III trial within a given subtype. …

Circulating Microrna Panel For Prediction Of Recurrence And Survival In Early-Stage Lung Adenocarcinoma, Mei-Chee Tai, Leonidas E Bantis, Gargy Parhy, Taketo Kato, Ichidai Tanaka, Chi-Wan Chow, Junya Fujimoto, Carmen Behrens, Tetsunari Hase, Koji Kawaguchi, Johannes F Fahrmann, Edwin J Ostrin, Kohei Yokoi, Toyofumi F Chen-Yoshikawa, Yoshinori Hasegawa, Samir M Hanash, Ignacio I Wistuba, Ayumu Taguchi

Faculty, Staff and Student Publications

Early-stage lung adenocarcinoma (LUAD) patients remain at substantial risk for recurrence and disease-related death, highlighting the unmet need of biomarkers for the assessment and identification of those in an early stage who would likely benefit from adjuvant chemotherapy. To identify circulating miRNAs useful for predicting recurrence in early-stage LUAD, we performed miRNA microarray analysis with pools of pretreatment plasma samples from patients with stage I LUAD who developed recurrence or remained recurrence-free during the follow-up period. Subsequent validation in 85 patients with stage I LUAD resulted in the development of a circulating miRNA panel comprising miR-23a-3p, miR-320c, and miR-125b-5p and …

Development Of A Practical Nomogram For Personalized Anemia Management In Patients Treated With Ataxia Telangiectasia And Rad3-Related Inhibitor Camonsertib, Ezra Rosen, Timothy A Yap, Elizabeth K Lee, Martin Højgaard, Niharika B Mettu, Stephanie Lheureux, Benedito A Carneiro, Ruth Plummer, Adrian J Fretland, Danielle Ulanet, Yi Xu, Robin Mcdougall, Maria Koehler, Elisa Fontana

Faculty, Staff and Student Publications

PURPOSE: Camonsertib is a highly selective and potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Dose-dependent anemia is a class-related on-target adverse event often requiring dose modifications. Individual patient risk factors for the development of significant anemia complicate the selection of a "one-size-fits-all" ATR inhibitor (ATRi) dose and schedule, possibly leading to suboptimal therapeutic doses in patients at low risk of anemia. We evaluated whether early predictors of anemia could be identified to ultimately inform a personalized dose-modification approach.

PATIENTS AND METHODS: On the basis of preclinical observations and a mechanistic understanding of ATRi-related anemia, we identified several potential …

Stigma On Mental Illness And Help-Seeking Among Nigerians In The United States, Olabode Akinbobola

Walden Dissertations and Doctoral Studies

Although the number of Nigerian immigrants to the United States has increased in the past few years, few studies have explored their mental health experiences. This study explored the lived experience of Nigerian immigrants living in the United States (US). Belief perseverance theory was utilized as a lens of analysis to understand if prior experiences, perceptions, and/or stigma can influence help-seeking behavior and expectations through face-to-face, semi-structured, and audiotaped interviews. The study explored a sample of 10 Nigerian immigrants lived experiences, understanding, perceptions, and stigma of mental illness and whether or not they seek psychological help. Interpretative phenomenological analysis (IPA) …

The Student Movement Volume 108 Issue 16: Next On Ai's Conquest List: Love, Savannah Tyler, Erin Beers, Reagan Mccain, Lauren Kim, Aiko J. Ayala Rios, Amelia Stefanescu, Madison Vath, Katie Davis, Andrew Francis, Anna Rybachek, Sumin Lee, Reagan Westerman, Chris Ngugi, Alyssa Caruthers, Scott Moncrieff

The Student Movement v. 108 (2023-2024)

HUMANS

Dr. Hatfield, Interviewed by Savannah Tyler

Is Love Romantic? An Aromantic Perspective, Interviewed by Erin Beers

Student Experiences at the CTC, Interviewed by Reagan McCain

Viral Jesus Podcast with Dr. Heather Thompson Day, Interviewed by Lauren Kim

ARTS & ENTERTAINMENT

Where AI cannot Beat a human... yet - AI in music, Aiko J. Ayala Rios

Artists and AI: A Liberating New Tool or the Beginning of the End?, Reagan McCain

The History of Black History Month at AU, Amelia Stefanescu

Las Cintas Rojas, Reagan McCain

"The Orange" and Finding Love in the Mundane, Madison Vath

NEWS

AI's Changing Landscape, …