Digital Commons Network^™

Serum Alkaline Phosphatase Level In Acromegaly Patients And An Association With Its Level In Saliva], Shiamaa Mohammad Zwain, Sahar Hamdan Alani, Shiamaa Mohammad Huthiafa Alrubaie, Najla Mohammad Zwain

Maaen Journal for Medical Sciences

OBJECTIVE: The study aimed to determine the levels of bone turn over biomarker (ALP) in Iraqi acromegaly patients in addition to find the relationship between these levels in serum and saliva. METHODS: In this cross-sectional study, 20 healthy controls (10 female and 10 male) and 40 patients with acromegaly (22 female and 18 male) who were visiting the National Centre for Diabetes and Endocrinology / AL- Mustansiriya University / Baghdad were included. Every patient was prescribed an octreotide somatostatin analog medication after being diagnosed by a hospital doctor. For both groups, the levels of alkaline phosphatase (ALP) in serum and …

Sr 23-24-27 Cc, Marshall University Faculty Senate

Recommendations

No abstract provided.

The Rna-Binding Protein Msi2 Regulates Autophagy During Myogenic Differentiation, Ruochong Wang, Futaba Kato, Rio Yasui Watson, Aaron M. Beedle, Jarrod A. Call, Yugo Tsunoda, Takeshi Noda, Takaho Tsuchiya, Makoto Kashima, Ayuna Hattori, Takahiro Ito

Pharmacy Faculty Scholarship

Skeletal muscle development is a highly ordered process orchestrated transcriptionally by the myogenic regulatory factors. However, the downstream molecular mechanisms of myogenic regulatory factor functions in myogenesis are not fully understood. Here, we identified the RNA-binding protein Musashi2 (Msi2) as a myogenin target gene and a post-transcriptional regulator of myoblast differentiation. Msi2 knockdown in murine myoblasts blocked differentiation without affecting the expression of MyoD or myogenin. Msi2 overexpression was also sufficient to promote myoblast differentiation and myocyte fusion. Msi2 loss attenuated autophagosome formation via down-regulation of the autophagic protein MAPL1LC3/ATG8 (LC3) at the early phase of myoblast differentiation. Moreover, forced …

Biology Student’S Research Project Examines Toxins, Breast Milk And Nursing Madonnas, Kassidy Lammers

College of Arts and Sciences Newsroom

UD senior biology major Rihanna Domingos’ research project explores the long term impact of harmful chemicals.

Design And Development Of Deep Eutectic Solvent Assisted Pressurized Liquid Extraction Of Nutraceuticals, Harish Babu B

Theses and Dissertations

Over recent decades, the usage of nutraceuticals has been exponentially increasing as alternates to pharmaceutical drugs. However, extraction of these therapeutically significant compounds from their corresponding sources requires the use of volatile organic solvents like hexane, ethanol and chloroform which increases the global warming potential. This problem has been overcome in recent decades by the use of supercritical carbon dioxide (SCO2) as the extraction solvent. Since SCO2 is non-polar in nature, the extraction of polar compounds with better efficiency is questionable.

On the other hand, modernization in solvent engineering has created generations of green solvents like ionic liquids (ILs), deep …

Hybrid Hydrolysis And Fermentation Of Prosopis Juliflora Pods For Biohydrogen Production By Dark Fermentation, Gayathri G

Theses and Dissertations

The rapid consumption of fossil fuels has resulted in the energy crisis and many environmental issues, including air pollution and the greenhouse effect. Hydrogen is the independent source of the highest energy content, with 122 KJ g-1. Biohydrogen produced from lignocellulosic biomass (LCB) is an excellent alternative fuel for its cleanability, renewability and sustainability. Biohydrogen production from dark fermentation using lignocellulosic biomass provides low cost and a sustainable pathway to utilize a vast amount of waste.

Dark fermentation has considerable potential for hydrogen production because it does not require sunlight, allowing for full-time operation and minimizing bioreactor complexity. The major …

Chimes: February 19, 2024, Calvin University

Chimes

Changes to the Student Senate constitution create a new election structure, aim for clarity by Ethan Meyers

The 49507 Initiative's Wayfinder program now accepting student applications by Savannah Shustack

Kill-a-Watt saves enough energy to run two houses for a month by Maya Oeverman

New Zealand sea lion conservation: A Q&A with ecologist Veronica Frans
by Jacob Westra

Calvin's CCW and Campus Ministries teams collaborate during stressful times for students by Nolan Cowan

January Series speaker offered relatable reflections on neurodivergence by Liana Hirner

While Waiting For Capital To Rain, Matthew Dimick

Buffalo Law Review

No abstract provided.

Cancergpt For Few Shot Drug Pair Synergy Prediction Using Large Pretrained Language Models, Tianhao Li, Sandesh Shetty, Advaith Kamath, Ajay Jaiswal, Xiaoqian Jiang, Ying Ding, Yejin Kim

Faculty, Staff and Student Publications

Large language models (LLMs) have been shown to have significant potential in few-shot learning across various fields, even with minimal training data. However, their ability to generalize to unseen tasks in more complex fields, such as biology and medicine has yet to be fully evaluated. LLMs can offer a promising alternative approach for biological inference, particularly in cases where structured data and sample size are limited, by extracting prior knowledge from text corpora. Here we report our proposed few-shot learning approach, which uses LLMs to predict the synergy of drug pairs in rare tissues that lack structured data and features. …

Functional Data Learning Using Convolutional Neural Networks, Jose Galarza, Tamer Oraby

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we show how convolutional neural networks (CNNs) can be used in regression and classification learning problems for noisy and non-noisy functional data (FD). The main idea is to transform the FD into a 28 by 28 image. We use a specific but typical architecture of a CNN to perform all the regression exercises of parameter estimation and functional form classification. First, we use some functional case studies of FD with and without random noise to showcase the strength of the new method. In particular, we use it to estimate exponential growth and decay rates, the bandwidths of …

A Brief Early History Of The Unlv Department Of Geoscience, Matthew S. Lachniet

Geoscience Faculty Research

This project represents four years of part-time research and investigation. It started as something simple, a need for a spreadsheet for me, as a new Department Chair in January of 2020, to assemble the tenure and promotion timelines of existing faculty based on their employment starting dates. It then expanded to document every Geoscience faculty member, which revealed so many interesting stories along the way. Once it began it was hard to stop, with the research taking on a mind of its own as it meandered down the historical archive of the Department. And why stop with people? Buildings? Fair …

Intouch Week Of February 19, 2024, New York Medical College

InTouch

• NYMC Goes Red for National Heart Month
• Demolition of Section of Building 800 Scheduled for March
• LCME Element of the Week
• Faculty Spotlight: NYMC Research | Stephan Mayer, M.D.

Yealm Mapper Data For Qgis, Shaun Lewin, Gillian Glegg, Olivia Wilson, Thomas Murphy

Faculty of Science and Engineering Datasets

The project has been carried out as part of the DARCEE project (Data Accessibility for River Catchment Environmental Education) funded by NERC (agreement GR352). The purpose is to promote public engagement with environmental science by making data more accessible and useable. The project team have worked with a community group (Yealm Estuary to Moor) to develop a user-friendly bespoke data package for use with QGIS. Users of the data will be able to view the data in map form and carry out simple spatial analysis as well as input their own data to QGIS to create new data. Dataset Description: …

Common Data Set, Georgia Southern University

Georgia Southern Common Datasets

No abstract provided.

Kenyan Free-Tailed Bats Demonstrate Seasonal Birth Pulse Asynchrony With Implications For Virus Maintenance, Tamika J. Lunn, Reilly T. Jackson, Paul W. Webala, Joseph Ogola, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

Ecological information on wildlife reservoirs is fundamental for research targeting prevention of zoonotic infectious disease, yet basic information is lacking for many species in global hotspots of disease emergence. We provide the first estimates of synchronicity, magnitude, and timing of seasonal birthing in Mops condylurus, a putative ebolavirus host, and a co-roosting species, Mops pumilus (formerly Chaerephon pumilus). We show that population-level synchronicity of M. condylurus birthing is wide (~ 8.5 weeks) and even wider in M. pumilus (> 11 weeks). This is predicted to promote the likelihood of filovirus persistence under conditions of bi-annual birthing (two births …

P90rsk Pathway Inhibition Synergizes With Cisplatin In Tmem16a Overexpressing Head And Neck Cancer, Abdulkader Yassin-Kassab, Suman Chatterjee, Nayel Khan, Nathaniel Wang, Vlad C Sandulache, Eric H-B Huang, Timothy F Burns, Umamaheswar Duvvuri

Faculty, Staff and Students Publications

Head and neck squamous cell carcinoma (HNSCC) constitutes one of the most common types of human cancers and often metastasizes to lymph nodes. Platinum-based chemotherapeutic drugs are commonly used for treatment of a wide range of cancers, including HNSCC. Its mode of action relies on its ability to impede DNA repair mechanisms, inducing apoptosis in cancer cells. However, due to acquired resistance and toxic side-effects, researchers have been focusing on developing novel combinational therapeutic strategies to overcome cisplatin resistance. In the current study, we identified p90RSK, an ERK1/2 downstream target, as a key mediator and a targetable signaling node against …

The Frequency Of Pathogenic Variation In The All Of Us Cohort Reveals Ancestry-Driven Disparities, Eric Venner, Karynne Patterson, Divya Kalra, Marsha M Wheeler, Yi-Ju Chen, Sara E Kalla, Bo Yuan, Jason H Karnes, Kimberly Walker, Joshua D Smith, Sean Mcgee, Aparna Radhakrishnan, Andrew Haddad, Philip E Empey, Qiaoyan Wang, Lee Lichtenstein, Diana Toledo, Gail Jarvik, Anjene Musick, Richard A Gibbs

Faculty, Staff and Students Publications

Disparities in data underlying clinical genomic interpretation is an acknowledged problem, but there is a paucity of data demonstrating it. The All of Us Research Program is collecting data including whole-genome sequences, health records, and surveys for at least a million participants with diverse ancestry and access to healthcare, representing one of the largest biomedical research repositories of its kind. Here, we examine pathogenic and likely pathogenic variants that were identified in the All of Us cohort. The European ancestry subgroup showed the highest overall rate of pathogenic variation, with 2.26% of participants having a pathogenic variant. Other ancestry groups …

Genetic Drivers Of Heterogeneity In Type 2 Diabetes Pathophysiology, Ken Suzuki, Ping An, Adam E. Locke, Michael A. Province, Et Al.

2020-Current year OA Pubs

No abstract provided.

Queer Paths Toward Home: Kinship In Speculative Fiction, Audrey Heffers

Online Midwinter Seminar (OMS)

How are we related? Queer(ed) families—typically framed through terms such as Found Family, Chosen Family, or Family of Choice—are more often formed by agency and voluntary participation than they are by legal or genetic connections. For the purposes of this paper, kin will be defined by affect, behavior, and declaration. The three fictional texts—Are You Listening? by Tillie Walden, Life of Melody by Mari Costa, and I Keep My Exoskeletons to Myself by Marisa Crane—will serve as a basis to illustrate how kinship is defined, particularly in queer speculative narratives. Speculative fiction allows for particular metaphors of power. These metaphors …

The Gay Bat Of Gotham: Depictions Of Common Queer Stereotypes And Tropes In The Dc Comics Character Batwoman, Tim Lenz

Online Midwinter Seminar (OMS)

Expansive superhero comic book universes can be thought of as collective, accretional works of Mythopoeia, generating modern mythologies of fantastical characters while also drawing inspiration from ancient myths of the primary world. The DC Comics’ character Batwoman was initially introduced in 1956 as a love interest of Batman/Bruce Wayne, in part to combat scandalous allegations of Batman’s homosexual tendencies towards his young male sidekick Robin. In 2006, writers Greg Rucka, Grant Morrison, Geoff Johns, and Mark Waid reinvented the Batwoman character for modern audiences as the alter ego of ‘Kate Kane,’ Bruce Wayne’s cousin, who was a lesbian of Jewish …

More To The Hobbit Than Meets The Eye: Locating The Feminine In Tolkien’S World, Pieter Conradie

Online Midwinter Seminar (OMS)

Fantasy is finally learning to embrace its power to create and celebrate queerness. Works such as The Forever Sea by Joshua Philip Johnson and The Priory of the Orange Tree by Samantha Shannon feature queer leads, revealing creative capacities to imagine worlds where queerness is at the centre. But something mighty queer is already present in 1937 at the very dawn of modern fantasy. Following emerging interpretations of The Hobbit, I argue that the hero, Bilbo Baggins, exhibits significantly queer characteristics. In this deconstructive reading, Bilbo’s gender will first be reversed, arguing that his domesticity, intense emotional responses and his …

Retreatment Strategies For Cases Containing Calcium Silicate-Based Root Canal Sealers: A Comprehensive Review, Hussain Al Akam, Hyeon-Cheol Kim, Ji Wook Jeong

Faculty, Staff and Student Publications

This review explores the field of retreatment strategies for cases filled with calcium silicate-based root canal sealers. Since the introduction of calcium silicate-based materials in dentistry, calcium silicate-based root canal sealers have become popular among dentists because of their biocompatibility, bioactivity, and sealing ability. Therefore, effective retreatment strategies are indispensable. This article aims to identify the challenges associated with the removal of calcium silicate-based sealers themselves and removal of gutta-percha with the sealers during retreatment, evaluate current techniques and materials, and provide future directions for research in this field. Regarding the strategies of removal of root canal sealers, calcium silicate-based …

Convocation Address At Namal University, Ishrat Husain Dr.

Faculty Research - Talks, Speeches, & Discourse

Nr. Razak Dawood, Ms Aleema Khan, Honourable Members of the Board , Mr. Rector, Faculty members, parents, dear students, Distinguished Ladies and Gentlemen, Let me first of all thank the Chairman and members of the Board of Governors and Rector of the University for conferring this honour and privilege upon me to address the first Convocation of the University. I would like to first of all congratulate the graduating students on successful completion of their degree programs. Your hard work and efforts of last four years have at least borne fruit. Next, let me pay my sincere tribute to the …

Speak Through The Drag—The Hidden (Trans-)/Woman In James Tiptree, Jr.’S ‘The Girl Who Was Plugged In’, Ziyang Zhang

Online Midwinter Seminar (OMS)

In 1973, James Tiptree, Jr. (Alice Sheldon) published a sci-fi novella The Girl Who Was Plugged In and won the Hugo Award for Best Novella in 1974. Its male narrator is a time-traveller from a near-future America, where he works for a capitalist company GTX—Global Transmissions Corporation. The heroine "P. Burke [...] willingly allows her grotesque body to be confined in a hi-tech cabinet while her mind remotely operates the beautiful but soulless cloned body of Delphi" (Hollinger 133).

In my research, I apply a framework of trans-feminism in reading The Girl Who Was Plugged In to challenge the binary …

Panel: The Fair And The Perilous: Online Experiences Of A Queer-Focused Tolkien Podcast, Alicia Fox-Lenz, Leah Hagan, Tim Lenz, Grace Moone

Online Midwinter Seminar (OMS)

The team behind Queer Lodgings: A Tolkien Podcast share the social media realities of producing content centered around LGBTQIA+ readings of Tolkien’s Legendarium. Discussion will include uplifting and diverse community events, backlash against the very idea of queer readings of Tolkien, targeted harassment campaigns involving large conservative media news outlets, and attempted erasure of well-documented historical instances of homophobia in Tolkien spaces. We aim to illuminate some of the darker corners of online fandom, and demonstrate the importance of accepting, tolerant spaces in which queer and diverse fans and scholars can share their personal interpretations of Tolkien’s worlds, characters, and …

Ancient Queer Bodies: The Gender Swapping Prophet, Basil Perkins

Online Midwinter Seminar (OMS)

Through an intersectional approach which positions sexuality and gender in direct

relation to cultural imperialism (O’Sullivan, 2021; Lugones, 2020), I aim to discuss the origins of Tiresias. (S)he is ubiquitous in ancient mythology: showing up in classicized texts such as Sophocles’ Oedipus Rex and Homer’s Odyssey. Interestingly too, Tiresias has been received since antiquity in texts such as Poulenc’s Les Mamelles de Tirésias, Woolf’s Orlando, and MacLaughlin’s Wake, Siren. Each receptive work transforms Tiresias through fantastical contexts and different temporalities. I aim to queer Western notions of temporality, in reading the contemporary along with the ancient. The bulk of my …

Reading, Rending, And Queering The Web Of Story With The Lens Of “Con-Creation” And Process Theology, Cameron Bourquein, Nick Polk

Online Midwinter Seminar (OMS)

Recent scholarship has addressed the connected problems of Tolkien as “Author/Author(ity)” and the exclusivist readings of Tolkien’s work that follow this construction (Chunodkar, Emanuel, Reid). This “constructed Tolkien” seems to parallel common readings of his Legendarium’s own Creator God, Eru—understood as the monolithic “Author” of Ea. Yet “subcreation” within Tolkien’s narrative and extra-narrative works is routinely exhibited not as monolithic but rather as literally (and figuratively) multivocal, and hence inherently queer.

In this paper Cameron will propose that the Legendarium can be read through the lens of “con-creation” (the total choice-making activity of all rational beings) both internally as events …

No Place: The Queer Utopia Of Liminality, Harry Gallagher

Online Midwinter Seminar (OMS)

My proposal is a paper on the inherent queerness of the liminal in Jeff Vandermeer’s works, through examples such as the transitional narrative present in the transformation of the Biologist in Annihilation. Especially pertinent is the inherent fighting of Yonic/Phallic imagery happening between her interpretation of a concrete structure as a tower as opposed to a tunnel, which is important to understanding how the Biologist’s trans-masculinity manifests symbolically in the narrative as antithesis to the other cis women on the expedition. Vandermeer’s liminal space in Dead Astronauts also connects to the characters of Moss, a non-binary life form who exists …

Towards An Ethos Of Discussing In-Corporeal Gender In Fantasy Literature: Part I – A ‘Feminine’ Eldil And A ‘Masculine’ Vala, Luke Shelton

Online Midwinter Seminar (OMS)

Over the course of the COVID-19 pandemic, many people engaged with others on social media in ways that they had not before. During this time, I was excited to see many new interpretive communities begin and to listen to the kinds of conversations these groups would have about Tolkien. One such conversation that stuck out to me was the way in which I saw some fans interpret Tolkien’s description of the physical characteristics of the Valar. I also happened to be reading through C.S. Lewis’ space trilogy when I saw many of these conversations. I felt that there were several …

Tolkien’S Queer Landscape: Three Papers On Middle-Earth’S Heterotopias, Will Sherwood, Marita Arvaniti, Mariana Rios Maldonado

Online Midwinter Seminar (OMS)

The following papers will explore Tolkien’s queer landscapes of Middle-earth: from Arda’s highest peaks and hidden underbellies, to her liminal, fae places, using the lens of Michel Foucault’s heterotopias.

Marita Arvaniti will introduce the panel and discuss Tolkien’s Faerian Drama and its relationship to the much-maligned Tom Bombadil episode, focusing on the queer figure of Tom Bombadil himself and his heterotopic domain.

Mariana Rios Maldonado will analyse the Barrow-downs, Dead Marshes, and Paths of the Dead as symbolic sites of death created during harrowing moments in the history of Middle-earth. These are no-places: spaces of Otherness containing the evil and …