Digital Commons Network^™

Neonatal Respiratory Therapy Interface, Kennedy Austin, Evan Manley, Parker Murray, Harrison Oen

Biomedical Engineering

This Final Report reviews and outlines the scope, objectives, and deliverables for the BCPAP Interface Redesign project, aimed at enhancing the functionality, usability, and patient experience of the existing BCPAP interface. It also includes detailed testing results and manufacturing plans for the device prototype. The current system has challenges in universal usability, time constraints, and patient comfort, which this project intends to address effectively. The goal of this project is to reevaluate and redesign the interface of the bubble continuous positive air pressure (BCPAP) machine’s attachment site with the infant. Due to the millions of premature neonates and thousands of …

Role Of Carbonyl Compounds For N-Nitrosamine Formation During Nitrosation: Kinetics And Mechanisms, Yishuai Pan, Florian Breider, Benjamin Barrios, Daisuke Minakata, Huiping Deng, Urs Von Gunten

Michigan Tech Publications

N-Nitrosamines are potential human carcinogens frequently detected in natural and engineered aquatic systems. This study sheds light on the role of carbonyl compounds in the formation of N-nitrosamines by nitrosation of five secondary amines via different pathways. The results showed that compared to a control system, the presence of formaldehyde enhances the formation of N-nitrosamines by a factor of 5-152 at pH 7, depending on the structure of the secondary amines. Acetaldehyde showed a slight enhancement effect on N-nitrosamine formation, while acetone and benzaldehyde did not promote nitrosation reactions. For neutral and basic conditions, the iminium …

Recent Literature, Claire M. Stuyck

North American Bird Bander

No abstract provided.

Eastern Bird Banding Association Annual Meeting, North American Bird Bander

North American Bird Bander

No abstract provided.

Inland Flyway Review - Spring 2023 Report, Vernon Kleen

North American Bird Bander

No abstract provided.

Disclosure Of Support Statement: Increasing Student Transparency About Support From Software Like Chatgpt, James Lipuma, Cristo Leon

STEM for Success Resources

Our latest publication in the Journal of Engineering Research introduces the Disclosure of Support Statement (DSS) tool to enhance transparency and student engagement in academic writing. This innovative tool encourages students to openly discuss and reflect on the various human and software supports utilized in their writing processes, such as professors, peers, and artificial intelligence software tools. The DSS tool seeks to initiate meaningful conversations around academic integrity and the educational journey by promoting ethical considerations and fostering critical thinking. Through a detailed pilot study, our research offers insights into student attitudes towards support mechanisms, setting the stage for further …

An Atlas Of Epithelial Cell States And Plasticity In Lung Adenocarcinoma, Guangchun Han, Ansam Sinjab, Zahraa Rahal, Anne M Lynch, Warapen Treekitkarnmongkol, Yuejiang Liu, Alejandra G Serrano, Jiping Feng, Ke Liang, Khaja Khan, Wei Lu, Sharia D Hernandez, Yunhe Liu, Xuanye Cao, Enyu Dai, Guangsheng Pei, Jian Hu, Camille Abaya, Lorena I Gomez-Bolanos, Fuduan Peng, Minyue Chen, Edwin R Parra, Tina Cascone, Boris Sepesi, Seyed Javad Moghaddam, Paul Scheet, Marcelo V Negrao, John V Heymach, Mingyao Li, Steven M Dubinett, Christopher S Stevenson, Avrum E Spira, Junya Fujimoto, Luisa M Solis, Ignacio I Wistuba, Jichao Chen, Linghua Wang, Humam Kadara

Faculty, Staff and Student Publications

Understanding the cellular processes that underlie early lung adenocarcinoma (LUAD) development is needed to devise intervention strategies1. Here we studied 246,102 single epithelial cells from 16 early-stage LUADs and 47 matched normal lung samples. Epithelial cells comprised diverse normal and cancer cell states, and diversity among cancer cells was strongly linked to LUAD-specific oncogenic drivers. KRAS mutant cancer cells showed distinct transcriptional features, reduced differentiation and low levels of aneuploidy. Non-malignant areas surrounding human LUAD samples were enriched with alveolar intermediate cells that displayed elevated KRT8 expression (termed KRT8+ alveolar intermediate cells (KACs) here), reduced differentiation, increased plasticity and driver …

Preclinical Efficacy Of Targeting Epigenetic Mechanisms In Aml With 3q26 Lesions And Evi1 Overexpression, Christine E Birdwell, Warren Fiskus, Tapan M Kadia, Christopher P Mill, Koji Sasaki, Naval Daver, Courtney D Dinardo, Naveen Pemmaraju, Gautam Borthakur, John A Davis, Kaberi Das, Sunil Sharma, Stephen Horrigan, Xinjia Ruan, Xiaoping Su, Joseph D Khoury, Hagop Kantarjian, Kapil N Bhalla

Faculty, Staff and Student Publications

AML with chromosomal alterations involving 3q26 overexpresses the transcription factor (TF) EVI1, associated with therapy refractoriness and inferior overall survival in AML. Consistent with a CRISPR screen highlighting BRD4 dependency, treatment with BET inhibitor (BETi) repressed EVI1, LEF1, c-Myc, c-Myb, CDK4/6, and MCL1, and induced apoptosis of AML cells with 3q26 lesions. Tegavivint (TV, BC-2059), known to disrupt the binding of nuclear β-catenin and TCF7L2/LEF1 with TBL1, also inhibited co-localization of EVI1 with TBL1 and dose-dependently induced apoptosis in AML cell lines and patient-derived (PD) AML cells with 3q26.2 lesions. TV treatment repressed EVI1, attenuated enhancer activity at ERG, TCF7L2, …

Targeting Hypoxia-Inducible Factors: Therapeutic Opportunities And Challenges, Xiaoyi Yuan, Wei Ruan, Bentley Bobrow, Peter Carmeliet, Holger K Eltzschig

Faculty, Staff and Student Publications

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and inhibition have emerged as therapeutic targets in various human diseases. Pharmacologically desirable effects of HIF activation include erythropoiesis stimulation, cellular metabolism optimization during hypoxia and adaptive responses during ischaemia and inflammation. By contrast, HIF inhibition has been explored as a therapy for various cancers, retinal neovascularization and pulmonary hypertension. This Review discusses the biochemical mechanisms that control HIF stabilization and the molecular strategies that can be exploited pharmacologically to activate or inhibit HIFs. In addition, we examine …

A Phase 1 Trial Of 8-Chloro-Adenosine In Relapsed/Refractory Acute Myeloid Leukemia: An Evaluation Of Safety And Pharmacokinetics, Vinod Pullarkat, Lisa S Chen, Joycelynne Palmer, Jianying Zhang, Timothy W Synold, Ralf Buettner, Le Xuan Truong Nguyen, Guido Marcucci, Ni-Chun Tsai, Yan Wang, James O'Hearn, Varsha Gandhi, Steven T Rosen

Faculty, Staff and Student Publications

Background: This study evaluated the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of 8-chloro-adenosine (8-Cl-Ado) in patients with relapsed/refractory acute myeloid leukemia (AML).

Methods: 8-Cl-Ado was administered daily for 5 days; the starting dose was 100 mg/m2 , the highest dose tested was 800 mg/m2 . The end points were toxicity, disease response, and PK/PD measurements.

Results: The predominant nonhematologic toxicity was cardiac with grade ≥3 toxicity. Plasma PK in all patients suggested heterogeneity among patients, yet, some dose-dependency for the accumulation of 8-Cl-Ado. Two 8-Cl-Ado metabolites accumulated at similar levels to 8-Cl-Ado. Cellular PK in eight patients indicated accumulation of …

Neutrophils And Neutrophil Extracellular Traps Cause Vascular Occlusion And Delayed Cerebral Ischemia After Subarachnoid Hemorrhage In Mice, Hussein A Zeineddine, Sung-Ha Hong, Pedram Peesh, Ari Dienel, Kiara Torres, Peeyush Thankamani Pandit, Kanako Matsumura, Shuning Huang, Wen Li, Anjali Chauhan, John P Hagan, Sean P Marrelli, Louise D Mccullough, Spiros L Blackburn, Jaroslaw Aronowski, Devin W Mcbride

Faculty, Staff and Student Publications

Background: After subarachnoid hemorrhage (SAH), neutrophils are deleterious and contribute to poor outcomes. Neutrophils can produce neutrophil extracellular traps (NETs) after ischemic stroke. Our hypothesis was that, after SAH, neutrophils contribute to delayed cerebral ischemia (DCI) and worse outcomes via cerebrovascular occlusion by NETs.

Methods: SAH was induced via endovascular perforation, and SAH mice were given either a neutrophil-depleting antibody, a PAD4 (peptidylarginine deiminase 4) inhibitor (to prevent NETosis), DNAse-I (to degrade NETs), or a vehicle control. Mice underwent daily neurological assessment until day 7 and then euthanized for quantification of intravascular brain NETs (iNETs). Subsets of mice were used …

Oxidized Activated Charcoal Nanozymes: Synthesis, And Optimization For In Vitro And In Vivo Bioactivity For Traumatic Brain Injury, Emily A Mchugh, Anton V Liopo, Kimberly Mendoza, Claudia S Robertson, Gang Wu, Zhe Wang, Weiyin Chen, Jacob L Beckham, Paul J Derry, Thomas A Kent, James M Tour

Faculty, Staff and Student Publications

Carbon-based superoxide dismutase (SOD) mimetic nanozymes have recently been employed as promising antioxidant nanotherapeutics due to their distinct properties. The structural features responsible for the efficacy of these nanomaterials as antioxidants are, however, poorly understood. Here, the process-structure-property-performance properties of coconut-derived oxidized activated charcoal (cOAC) nano-SOD mimetics are studied by analyzing how modifications to the nanomaterial's synthesis impact the size, as well as the elemental and electrochemical properties of the particles. These properties are then correlated to the in vitro antioxidant bioactivity of poly(ethylene glycol)-functionalized cOACs (PEG-cOAC). Chemical oxidative treatment methods that afford smaller, more homogeneous cOAC nanoparticles with higher …

Biomarker-Directed Targeted Therapy Plus Durvalumab In Advanced Non-Small-Cell Lung Cancer: A Phase 2 Umbrella Trial, Benjamin Besse, Elvire Pons-Tostivint, Keunchil Park, Sylvia Hartl, Patrick M Forde, Maximilian J Hochmair, Mark M Awad, Michael Thomas, Glenwood Goss, Paul Wheatley-Price, Frances A Shepherd, Marie Florescu, Parneet Cheema, Quincy S C Chu, Sang-We Kim, Daniel Morgensztern, Melissa L Johnson, Sophie Cousin, Dong-Wan Kim, Mor T Moskovitz, David Vicente, Boaz Aronson, Rosalind Hobson, Helen J Ambrose, Sajan Khosla, Avinash Reddy, Deanna L Russell, Mohamed Reda Keddar, James P Conway, J Carl Barrett, Emma Dean, Rakesh Kumar, Marlene Dressman, Philip J Jewsbury, Sonia Iyer, Simon T Barry, Jan Cosaert, John V Heymach

Faculty, Staff and Student Publications

For patients with non-small-cell lung cancer (NSCLC) tumors without currently targetable molecular alterations, standard-of-care treatment is immunotherapy with anti-PD-(L)1 checkpoint inhibitors, alone or with platinum-doublet therapy. However, not all patients derive durable benefit and resistance to immune checkpoint blockade is common. Understanding mechanisms of resistance—which can include defects in DNA damage response and repair pathways, alterations or functional mutations in STK11/LKB1, alterations in antigen-presentation pathways, and immunosuppressive cellular subsets within the tumor microenvironment—and developing effective therapies to overcome them, remains an unmet need. Here the phase 2 umbrella HUDSON study evaluated rational combination regimens for advanced NSCLC following failure …

Real-World Efficacy And Safety Of Amivantamab For Egfr-Mutant Nsclc, Kaiwen Wang, Robyn Du, Nathaniel J Myall, Whitney E Lewis, Natalie Uy, Lingzhi Hong, Ferdinandos Skoulidis, Lauren A Byers, Anne Tsao, Tina Cascone, Jenny Pozadzides, Janet Tu, Marcelo V Negrao, Don L Gibbons, Keunchil Park, Waree Rinsurongkawong, J Jack Lee, David Gandara, Deepti Behl, Catherine A Shu, Jonathan W Riess, Christina Baik, Heather A Wakelee, Ara A Vaporciyan, John V Heymach, Jianjun Zhang, Xiuning Le

Faculty, Staff and Student Publications

Introduction: Amivantamab-vmjw (amivantamab) is a bispecific EGFR/MET antibody approved for patients with advanced NSCLC with EGFR exon 20 insertion mutations, after prior therapy. Nevertheless, the benefits and safety of amivantamab in other EGFR-mutant lung cancer, with or without osimertinib, and with concurrent radiation therapy, are less known.

Methods: We queried the MD Anderson Lung Cancer GEMINI, Fred Hutchinson Cancer Research Center, University of California Davis Comprehensive Cancer Center, and Stanford Cancer Center's database for patients with EGFR-mutant NSCLC treated with amivantamab, not on a clinical trial. The data analyzed included initial response, duration of treatment, and concomitant radiation safety in …

Oxidation Of Hydrogen Sulfide To Polysulfide And Thiosulfate By A Carbon Nanozyme: Therapeutic Implications With An Emphasis On Down Syndrome, Paul J Derry, Anton V Liopo, Karthik Mouli, Emily A Mchugh, Anh T T Vo, Ann Mckelvey, Larry J Suva, Gang Wu, Yan Gao, Kenneth R Olson, James M Tour, Thomas A Kent

Faculty, Staff and Student Publications

Hydrogen sulfide (H2S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H2S is elevated and associated with degraded mitochondrial function. Therefore, removing H2S from the body as a stable oxide could be an approach to reducing the deleterious effects of H2S in DS. In this report we describe the catalytic oxidation of hydrogen sulfide (H2S) to polysulfides (HS2+n−) and thiosulfate (S2O32−) by poly(ethylene glycol) hydrophilic carbon clusters (PEG-HCCs) and poly(ethylene glycol) oxidized activated charcoal (PEG-OACs), examples of oxidized carbon nanozymes (OCNs). We show that OCNs oxidize H2S …

Comprehensive Analysis Identifies Variability In Pi3k Pathway Alterations In Triple-Negative Breast Cancer Subtypes, Reva K Basho, Li Zhao, Jason B White, Lei Huo, Roland L Bassett, Elizabeth A Mittendorf, Alastair Thompson, Jennifer K Litton, Naoto Ueno, Banu Arun, Bora Lim, Vicente Valero, Debu Tripathy, Jianhua Zhang, Beatriz E Adrada, Lumarie Santiago, Elizabeth Ravenberg, Sahil Seth, Clinton Yam, Stacy L Moulder, Senthil Damodaran

Faculty, Staff and Student Publications

Purpose: The PI3K pathway is frequently altered in triple-negative breast cancer (TNBC). Limited cell line and human data suggest that TNBC tumors characterized as mesenchymal (M) and luminal androgen receptor (LAR) subtypes have increased incidence of alterations in the PI3K pathway. The impact of PI3K pathway alterations across TNBC subtypes is poorly understood.

Methods: Pretreatment tumor was evaluated from operable TNBC patients enrolled on a clinical trial of neoadjuvant therapy (NAT; A Robust TNBC Evaluation fraMework to Improve Survival [ClinicalTrials.gov identifier: NCT02276443]). Tumors were characterized into seven TNBC subtypes per Pietenpol criteria (basal-like 1, basal-like 2, immunomodulatory, M, mesenchymal …

Watching The Fall Of Roe V Wade: Media Exposure Relates To Us Women's Alcohol Use Intentions, Stacy M Post, Mary C Jobe, Arianne N Malekzadeh, Katarina E Aubuchon, Rebecca K Hoffman, Michelle L Stock, Lisa Bowleg

Faculty, Staff and Student Publications

OBJECTIVE: The Supreme Court of the United States’ decision in Dobbs v. Jackson Women’s Health Organization in June 2022 overturned Roe v. Wade and ended federal protection of abortion rights. Given the drastic policy changes as a result of the ruling and high exposure to media related to abortion, women opposed to the decision may have experienced distress, which could trigger maladaptive coping strategies, such as alcohol use. The present research examined how consuming abortion-related media in the weeks following the Dobbs decision impacted alcohol use intentions among women of reproductive age residing in the 13 “trigger law” states that …

Foraminifera As A Model Of Eukaryotic Genome Dynamism, Caitlin Timmons, Kristine Le, H. B. Rappaport, Elinor G. Sterner, Xyrus X. Maurer-Alcaláh, Susan T. Goldstein, Laura A. Katz

Biological Sciences: Faculty Publications

In contrast to the canonical view that genomes cycle only between haploid and diploid states, many eukaryotes have dynamic genomes that change content throughout an individual’s life cycle. However, the few detailed studies of microeukaryotic life cycles render our understanding of eukaryotic genome dynamism incomplete. Foraminifera (Rhizaria) are an ecologically important, yet understudied, clade of microbial eukaryotes with complex life cycles that include changes in ploidy and genome organization. Here, we apply fluorescence microscopy and image analysis techniques to over 2,800 nuclei in 110 cells to characterize the life cycle of Allogromia laticollaris strain Cold Spring Harbor (CSH), one of …

Impaired, In Pairs, Cristina Carmody Tilley

Faculty Publications

Rape, like many other one-on-one aggressions, can be treated as both a crime and a tort. But neither body of law responds effectively to these aggressions. Criminal rape prosecution is notoriously difficult, and civil rape suits are notoriously rare. Today, as private law theorists have begun to study tort’s potential to drive social justice on issues of race, gender, and class, it is an ideal time to reassess the terms of civil liability for intimate injury. Culture has long limited “real rape” to premeditated, stranger-on-stranger, aggression. Consequently, tort has long categorized what this Essay terms “non-collaborative sex” as an intentional …

Design And Fabrication Of Two Heterojunction Devices Performance For Photodetectors Applications, Maysoon Hashim Ismaal, Alaa Hussein, Sabah M. Thaba

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Hydrothermal preparations have been made form vanadium oxygen systems V2O5 and VO2 NPs prototype to design photodetectors. In comparison, the films' polycrystalline structure can be seen in analysis of x-ray diffraction (XRD) pattern, which has 7 and 14 peaks with crystallite sizes = 19.59 for V2O5 and, crystallite sizes = 12.92 nm, for VO2. The grains had large, neatly separated conical columnar growth combined grains throughout the surface, with some of the columnar grains coalescing in a few spots, according to the analysis from atomic force microscopy (AFM). It is revealed that the average size of particle of V2O5 =29.58 …

Development Of Customized Mips_32 Core Processor For Image Processing Applications, Omar Nowfal Mohammedtaher, Mohammed Najm, Hassan Awheed Jeiad

Iraqi Journal of Computers, Communications, Control and Systems Engineering

Definitely, image processing operations without advanced and expensive microprocessors consume more time, power, and larger programs. So, improving the reasonable cost of microprocessors is crucial in this situation. This paper proposes an improvement for the MIPS_32 architecture that is called a Customized MIPS_32 (CMIPS_32) to enhance the capabilities of image processing (IP) operations. The proposal aims to increase throughput by minimizing the iterative fetching of instructions required by a certain IP operation into a single customized IP instruction. The architecture of MIPS_32 was developed in two phases. Firstly, the Register File, control unit, and ALU are modified to manipulate the …

Reproductive Biology Of The Jellyfish Outbreak Along The Uae Coastal Waters, Amrutha Aravind

Dissertations

Jellyfish are a ubiquitous occurrence in the world’s oceans. During the past decades, dramatic spatial increases and temporal shifts in jellyfish distributions have been reported around the world. The United Arab Emirates (UAE) coastal area also has experienced several blooms along with severe adverse impacts on its economic facilities. Few studies have been conducted within the Arabian Gulf and the Sea of Oman, to identify the blooming species and the environmental parameters that favor such breakouts. The present study aimed to identify the jellyfish species found along the coastal area of UAE and trying to link their occurrence with seasonal …

A Visual And Spatial Tool For Tracking, Mapping And Forecasting The Dispersal Of Biological Control Agents, Komi Mensah Agboka, John Odindi, Elfatih M. Abdel-Rahman, Onisimo Mutanga, Henri E.Z. Tonnang

All Peer-Reviewed Publications

iPydisp is an open-source, Python-based tool designed to model the spatio-temporal dispersal of insect species such as parasitoids. It provides an accessible interface for interactive spatio-temporal analysis, using cellular automata algorithms for easy data processing and updates. The tool's main features include intuitive data loading, easy setting of dispersal constraints, and dynamic visualization of dispersal patterns. iPydisp has the potential to improve our understanding of parasitoid dispersal and enhance pest management strategies.

Iran's Look East Policy Against Western Countries Through Snyder's Foreign Policy Analysis, Juana Clarentine Emmanuela Greevince De Lucas, Muhammad Rayhan Anandito, Tasya Salsabila Hendrayudha, Septyanto Galan Prakoso

Jurnal Politik

Iran has been in disarray following the United States exit from the JCPOA in 2018. It is due to the increasing number of sanctions reimposed by the West, which harms the Iranian economy. With the current economic downturn, Iran, under President Ebrahim Raisi's leadership, has made efforts to become completely independent from the West by establishing the Look East Policy as its foreign policy. This research analyses why Ebrahim Raisi's administration favoured the Look East Policy as Iranian foreign policy. Data collection techniques used in this study are library research, using secondary data from books, journal articles, official websites, and …

Allicin And Cancer Hallmarks, Wamidh H. Talib, Media Mohammed Baban, Aya O. Azzam, Jenan J. Issa, Alaa Y. Ali, Alia Kh Alsuwais, Sana Allala, Lina T. Al Kury

All Works

Natural products, particularly medicinal plants, are crucial in combating cancer and aiding in the discovery and development of new therapeutic agents owing to their biologically active compounds. They offer a promising avenue for developing effective anticancer medications because of their low toxicity, diverse chemical structures, and ability to target various cancers. Allicin is one of the main ingredients in garlic (Allium sativum L.). It is a bioactive sulfur compound maintained in various plant sections in a precursor state. Numerous studies have documented the positive health benefits of this natural compound on many chronic conditions, including gastric, hepatic, breast, lung, cervical, …

Targeting Cancer Hallmarks With Epigallocatechin Gallate (Egcg): Mechanistic Basis And Therapeutic Targets, Wamidh H. Talib, Dima Awajan, Abdelrahim Alqudah, Razan Alsawwaf, Raha Althunibat, Mahmoud Abu Alroos, Ala’A Al Safadi, Sharif Abu Asab, Rawan W. Hadi, Lina T. Al Kury

All Works

Epigallocatechin gallate (EGCG) is a catechin, which is a type of flavonoid found in high concentrations in green tea. EGCG has been studied extensively for its potential health benefits, particularly in cancer. EGCG has been found to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects in numerous cancer cell lines and animal models. EGCG has demonstrated the ability to interrupt various signaling pathways associated with cellular proliferation and division in different cancer types. EGCG anticancer activity is mediated by interfering with various cancer hallmarks. This article summarize and highlight the effects of EGCG on cancer hallmarks and focused on the impacts of …

Race And The Space In Between: Practitioner Reflections On Anti-Racist Practice In One Froebelian Early Years Setting, V Bamsey, L Mcnair, H Campbell, I Vašinová

Plymouth Institute of Education

The rise of ‘Black Lives Matters’ has brought to the fore a need to unsettle early years praxis that positions race as separate from the individual, as a problem to be solved through the tokenistic provisioning of resources. In this paper, we explore how a team of early years practitioners were able to bridge the space between themselves and the multicultural community in which they worked. An interpretative onto-epistemology supported the crafting of the research design as a case study that provided insight into multiple meanings through participants’ narratives during weekly informal anti-racist reflective meetings, focus group discussions and individual …

Guidelines On The Prevention Of Foot Ulcers In Persons With Diabetes (Iwgdf 2023 Update), Sicco A. Bus, Isabel C.N. Sacco, M Monteiro‐Soares, Anita Raspovic, Joanne Paton, Anne Rasmussen, Lawrence A. Lavery, Netten Jj Van

School of Health Professions

Aims This is the 2023 International Working Group on the Diabetic Foot guideline on the prevention of foot ulcers in persons with diabetes, which updates the 2019 guideline. This guideline is targeted at clinicians and other healthcare professionals. Materials and Methods We followed the Grading of Recommendations, Assessment, Development and Evaluations methodology to devise clinical questions and critically important outcomes in the PICO format, to conduct a systematic review of the medical-scientific literature including, where appropriate, meta-analyses, and to write recommendations and their rationale. The recommendations are based on the quality of evidence found in the systematic review, expert opinion …

Substitute Families And Suicidal Tendencies Of Adolescents And Youths In Kerala, India Today: Bowenian Model For Pastoral Approaches, Antony Thomas Ittikunnath

Loyola Papers

This article analyzes the rising incidence of youth suicide in Kerala through the framework of Bowen’s family systems theory. It argues that dysfunctional family relationships often lead young people to detach and seek substitute communities, which may reinforce negative behaviors. The paper also considers contributing factors such as social media use, unstable relationships, and emotional isolation. As a pastoral response, it proposes a therapeutic approach centered on family systems, particularly addressing parental roles and reducing anxiety within the family unit.

Can Artificial Intelligence Be Used As A Stepping-Stone Towards Face-To-Face Therapy?, Zachary Salcido

University Honors Theses

Artificial Intelligence (AI) has emerged as a transformative tool in various fields, including mental health care and therapy. This study provides a comprehensive review of literature, gathered through Portland State University's Online Library, on the potential of AI as a stepping stone towards face-to-face therapy. The study examines the historical development of AI in mental health, highlighting its development and advancements that have influenced its current implementations.

In addition to its direct applications in therapy, AI is also examined in the context of its role as a facilitator or "stepping stone" in the delivery of mental health care. AI-driven platforms …